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20 pages, 21330 KiB  
Article
C Band 360° Triangular Phase Shift Detector for Precise Vertical Landing RF System
by Víctor Araña-Pulido, B. Pablo Dorta-Naranjo, Francisco Cabrera-Almeida and Eugenio Jiménez-Yguácel
Appl. Sci. 2025, 15(15), 8236; https://doi.org/10.3390/app15158236 - 24 Jul 2025
Abstract
This paper presents a novel design for precise vertical landing of drones based on the detection of three phase shifts in the range of ±180°. The design has three inputs to which the signal transmitted from an oscillator located at the landing point [...] Read more.
This paper presents a novel design for precise vertical landing of drones based on the detection of three phase shifts in the range of ±180°. The design has three inputs to which the signal transmitted from an oscillator located at the landing point arrives with different delays. The circuit increases the aerial tracking volume relative to that achieved by detectors with theoretical unambiguous detection ranges of ±90°. The phase shift measurement circuit uses an analog phase detector (mixer), detecting a maximum range of ±90°and a double multiplication of the input signals, in phase and phase-shifted, without the need to fulfill the quadrature condition. The calibration procedure, phase detector curve modeling, and calculation of the input signal phase shift are significantly simplified by the use of an automatic gain control on each branch, dwhich keeps input amplitudes to the analog phase detectors constant. A simple program to determine phase shifts and guidance instructions is proposed, which could be integrated into the same flight control platform, thus avoiding the need to add additional processing components. A prototype has been manufactured in C band to explain the details of the procedure design. The circuit uses commercial circuits and microstrip technology, avoiding the crossing of lines by means of switches, which allows the design topology to be extrapolated to much higher frequencies. Calibration and measurements at 5.3 GHz show a dynamic range greater than 50 dB and a non-ambiguous detection range of ±180°. These specifications would allow one to track the drone during the landing maneuver in an inverted cone formed by a surface with an 11 m radius at 10 m high and the landing point, when 4 cm between RF inputs is considered. The errors of the phase shifts used in the landing maneuver are less than ±3°, which translates into 1.7% losses over the detector theoretical range in the worst case. The circuit has a frequency bandwidth of 4.8 GHz to 5.6 GHz, considering a 3 dB variation in the input power when the AGC is limiting the output signal to 0 dBm at the circuit reference point of each branch. In addition, the evolution of phases in the landing maneuver is shown by means of a small simulation program in which the drone trajectory is inside and outside the tracking range of ±180°. Full article
(This article belongs to the Section Applied Physics General)
13 pages, 3166 KiB  
Article
Impedance Characterization and Modeling of Gold, Silver, and PEDOT:PSS Ultra-Thin Tattoo Electrodes for Wearable Bioelectronics
by Antonello Mascia, Riccardo Collu, Nasreddine Makni, Mattia Concas, Massimo Barbaro and Piero Cosseddu
Sensors 2025, 25(15), 4568; https://doi.org/10.3390/s25154568 - 23 Jul 2025
Viewed by 50
Abstract
This study presents a comprehensive evaluation and an equivalent circuit modeling of the skin–electrode impedance characteristics of three types of ultra-thin tattoo electrodes, all based on Parylene C nanofilms but with different active materials: Gold, Silver, and PEDOT:PSS. Their performance was compared to [...] Read more.
This study presents a comprehensive evaluation and an equivalent circuit modeling of the skin–electrode impedance characteristics of three types of ultra-thin tattoo electrodes, all based on Parylene C nanofilms but with different active materials: Gold, Silver, and PEDOT:PSS. Their performance was compared to standard disposable Ag/AgCl electrodes. Impedance measurements were carried out on six human subjects under controlled conditions, assessing the frequency response in the range of 20 Hz to 1 kHz. For each subject, the impedance was recorded six times over one hour to investigate the stability and the temporal performance. The collected data were subsequently analyzed to model the electrical properties and interface behavior of each electrode type. The findings demonstrate that the tattoo electrodes offer impedance levels comparable to those of Ag/AgCl electrodes (in the order of tens of kΩ at 20 Hz), while providing additional benefits such as enhanced conformability, improved skin adhesion, and reduced skin irritation during use. Furthermore, the modeling of the skin–electrode interface through a more detailed equivalent circuit than the single time constant model enables a more detailed interface analysis and description, with fitting algorithm R2 scores of about 0.999 and 0.979 for the impedance magnitude and impedance phase, respectively. The proposed equivalent circuit offers valuable insights for optimizing electrode design, supporting the potential of Parylene C-based tattoo electrodes as promising alternatives for next-generation wearable bioelectronic applications. Full article
(This article belongs to the Special Issue Bioimpedance Measurements and Microelectrodes)
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17 pages, 3179 KiB  
Article
Changes in Physical Parameters of CO2 Containing Impurities in the Exhaust Gas of the Purification Plant and Selection of Equations of State
by Xinyi Wang, Zhixiang Dai, Feng Wang, Qin Bie, Wendi Fu, Congxin Shan, Sijia Zheng and Jie Sun
Fluids 2025, 10(8), 189; https://doi.org/10.3390/fluids10080189 - 23 Jul 2025
Viewed by 47
Abstract
CO2 transport is a crucial part of CCUS. Nonetheless, due to the physical property differences between CO2 and natural gas and oil, CO2 pipeline transport is distinct from natural gas and oil transport. Gaseous CO2 transportation has become the [...] Read more.
CO2 transport is a crucial part of CCUS. Nonetheless, due to the physical property differences between CO2 and natural gas and oil, CO2 pipeline transport is distinct from natural gas and oil transport. Gaseous CO2 transportation has become the preferred scheme for transporting impurity-containing CO2 tail gas in purification plants due to its advantages of simple technology, low cost, and high safety, which are well suited to the scenarios of low transportation volume and short distance in purification plants. The research on its physical property and state parameters is precisely aimed at optimizing the process design of gaseous transportation so as to further improve transportation efficiency and safety. Therefore, it has important engineering practical significance. Firstly, this paper collected and analyzed the research cases of CO2 transport both domestically and internationally, revealing that phase state and physical property testing of CO2 gas containing impurities is the basic condition for studying CO2 transport. Subsequently, the exhaust gas captured by the purification plant was captured after hydrodesulfurization treatment, and the characteristics of the exhaust gas components were obtained by comparing before and after treatment. By preparing fluid samples with varied CO2 content and conducting the flash evaporation test and PV relationship test, the compression factor and density of natural gas under different temperatures and pressures were obtained. It is concluded that under the same pressure in general, the higher the CO2 content, the smaller the compression factor. Except for pure CO2, the higher the CO2 content, the higher the density under constant pressure, which is related to the content of C2 and heavier hydrocarbon components. At the same temperature, the higher the CO2 content, the higher the viscosity under the same pressure; the lower the pressure, the slower the viscosity growth slows down. The higher the CO2 content at the same temperature, the higher the specific heat at constant pressure. With the decrease in temperature, the CO2 content reaching the highest specific heat at the identical pressure gradually decreases. Finally, BWRS, PR, and SRK equations of state were utilized to calculate the compression factor and density of the gas mixture with a molar composition of 50% CO2 and the gas mixture with a molar composition of 100% CO2. Compared with the experimental results, the most suitable equation of state is selected as the PR equation, which refers to the parameter setting of critical nodes of CO2 gas transport. Full article
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24 pages, 5129 KiB  
Article
On the Solidification and Phase Stability of Re-Bearing High-Entropy Superalloys with Hierarchical Microstructures
by Wei-Che Hsu, Takuma Saito, Mainak Saha, Hideyuki Murakami, Taisuke Sasaki and An-Chou Yeh
Metals 2025, 15(8), 820; https://doi.org/10.3390/met15080820 - 22 Jul 2025
Viewed by 221
Abstract
This study presents the design and microstructural investigation of a single-crystal (SX) Re-bearing high-entropy superalloy (HESA-X1) featuring a thermally stable γ–γ′–γ hierarchical microstructure. The alloy exhibits FCC γ nanoparticles embedded within L12-ordered γ′ precipitates, themselves distributed in a γ matrix, with [...] Read more.
This study presents the design and microstructural investigation of a single-crystal (SX) Re-bearing high-entropy superalloy (HESA-X1) featuring a thermally stable γ–γ′–γ hierarchical microstructure. The alloy exhibits FCC γ nanoparticles embedded within L12-ordered γ′ precipitates, themselves distributed in a γ matrix, with the suppression of detrimental topologically close-packed (TCP) phases. To elucidate solidification behavior and phase stability, Scheil–Gulliver and TC-PRISMA simulations were conducted alongside SEM and XRD analyses. Near-atomic scale analysis in 3D using Atom Probe Tomography (APT) revealed pronounced elemental partitioning, with Re strongly segregating to the γ matrix, while Al and Ti were preferentially enriched in the γ′ phase. Notably, Re demonstrated a unique partitioning behavior compared to conventional superalloys, facilitating the formation and stabilization of γ nanoparticles during two-step aging (Ag-2). These γ nanoparticles significantly contribute to improved mechanical properties. Long-term aging (up to 200 h) at 750–850 °C confirmed exceptional phase stability, with minimal coarsening of γ′ and retention of γ nanoparticles. The coarsening rate constant K of γ′ at 750 °C was significantly lower than that of Re-free HESA, confirming the diffusion-suppressing effect of Re. These findings highlight critical roles of Re in enhancing microstructural stability by reducing atomic mobility, enabling the development of next-generation HESAs with superior thermal and mechanical properties for high-temperature applications. Full article
(This article belongs to the Special Issue Solidification and Casting of Metals and Alloys (2nd Edition))
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34 pages, 1835 KiB  
Article
Advancing Neurodegenerative Disease Management: Technical, Ethical, and Regulatory Insights from the NeuroPredict Platform
by Marilena Ianculescu, Lidia Băjenaru, Ana-Mihaela Vasilevschi, Maria Gheorghe-Moisii and Cristina-Gabriela Gheorghe
Future Internet 2025, 17(7), 320; https://doi.org/10.3390/fi17070320 - 21 Jul 2025
Viewed by 123
Abstract
On a worldwide scale, neurodegenerative diseases, including multiple sclerosis, Parkinson’s, and Alzheimer’s, face considerable healthcare challenges demanding the development of novel approaches to early detection and efficient treatment. With its ability to provide real-time patient monitoring, customized medical care, and advanced predictive analytics, [...] Read more.
On a worldwide scale, neurodegenerative diseases, including multiple sclerosis, Parkinson’s, and Alzheimer’s, face considerable healthcare challenges demanding the development of novel approaches to early detection and efficient treatment. With its ability to provide real-time patient monitoring, customized medical care, and advanced predictive analytics, artificial intelligence (AI) is fundamentally transforming the way healthcare is provided. Through the integration of wearable physiological sensors, motion sensors, and neurological assessment tools, the NeuroPredict platform harnesses AI and smart sensor technologies to enhance the management of specific neurodegenerative diseases. Machine learning algorithms process these data flows to find patterns that point out disease evolution. This paper covers the design and architecture of the NeuroPredict platform, stressing the ethical and regulatory requirements that guide its development. Initial development of AI algorithms for disease monitoring, technical achievements, and constant enhancements driven by early user feedback are addressed in the discussion section. To ascertain the platform’s trustworthiness and data security, it also points towards risk analysis and mitigation approaches. The NeuroPredict platform’s capability for achieving AI-driven smart healthcare solutions is highlighted, even though it is currently in the development stage. Subsequent research is expected to focus on boosting data integration, expanding AI models, and providing regulatory compliance for clinical application. The current results are based on incremental laboratory tests using simulated user roles, with no clinical patient data involved so far. This study reports an experimental technology evaluation of modular components of the NeuroPredict platform, integrating multimodal sensors and machine learning pipelines in a laboratory-based setting, with future co-design and clinical validation foreseen for a later project phase. Full article
(This article belongs to the Special Issue Artificial Intelligence-Enabled Smart Healthcare)
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27 pages, 3299 KiB  
Article
Corrosion Stability and Biological Activity of Anodized cpTi for Dental Application
by Aleksandra S. Popović, Minja Miličić Lazić, Dijana Mitić, Lazar Rakočević, Dragana Jugović, Predrag Živković and Branimir N. Grgur
Metals 2025, 15(7), 817; https://doi.org/10.3390/met15070817 - 21 Jul 2025
Viewed by 283
Abstract
The anodic oxidation of titanium implants is a practical, cost-effective method to enhance implant success, especially due to rising hypersensitivity concerns. This study investigated the electrochemical behavior, surface characteristics, and biocompatibility of anodized commercially pure titanium (cpTi, grade IV). Anodization is performed on [...] Read more.
The anodic oxidation of titanium implants is a practical, cost-effective method to enhance implant success, especially due to rising hypersensitivity concerns. This study investigated the electrochemical behavior, surface characteristics, and biocompatibility of anodized commercially pure titanium (cpTi, grade IV). Anodization is performed on polished, cleaned cpTi sheet samples in 1 M H2SO4 using a constant voltage of 15 V for 15 and 45 min. The color of the oxide layer is evaluated using the CIELab color space, while composition is analyzed by a scanning electron microscope (SEM) equipped with an energy dispersive spectrometer (EDS). Additionally, X-ray diffraction (XRD) and X-ray photoelectron spectroscopy (XPS) are performed to identify and monitor the phase transformations of the formed titanium oxides. Corrosion measurements are performed in 9 g L−1 NaCl, pH = 7.4, and show the excellent corrosion stability of the anodized samples in comparison with pure titanium. The biological response is assessed by determining mitochondrial activity and gene expression in human fibroblasts. Anodized surfaces, particularly Ti-45, promote higher mitochondrial activity and the upregulation of adhesion-related genes (N-cadherin and Vimentin) in human gingival fibroblasts, indicating improved biocompatibility and the potential for enhanced early soft tissue integration. Full article
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16 pages, 2975 KiB  
Article
Control Strategy of Distributed Photovoltaic Storage Charging Pile Under Weak Grid
by Yan Zhang, Shuangting Xu, Yan Lin, Xiaoling Fang, Yang Wang and Jiaqi Duan
Processes 2025, 13(7), 2299; https://doi.org/10.3390/pr13072299 - 19 Jul 2025
Viewed by 258
Abstract
Distributed photovoltaic storage charging piles in remote rural areas can solve the problem of charging difficulties for new energy vehicles in the countryside, but these storage charging piles contain a large number of power electronic devices, and there is a risk of resonance [...] Read more.
Distributed photovoltaic storage charging piles in remote rural areas can solve the problem of charging difficulties for new energy vehicles in the countryside, but these storage charging piles contain a large number of power electronic devices, and there is a risk of resonance in the system under weak grid conditions. Firstly, the topology of a photovoltaic storage charging pile is introduced, including a bidirectional DC/DC converter, unidirectional DC/DC converter, and single-phase grid-connected inverter. Then, the maximum power tracking control strategy based on improved conductance micro-increment is derived for a photovoltaic power generation system, and a constant voltage and constant current charge–discharge control strategy is derived for energy storage equipment. Additionally, a segmented reflective charging control strategy is introduced for charging piles, and the quasi-PR controller is introduced for single-phase grid-connected inverters. In addition, an improved second-order general integrator phase-locked loop (SOGI-PLL) based on feed-forward of the grid current is derived. Finally, a simulation model is built to verify the performance of the solar–storage charging pile and lay the technical groundwork for future integrated control strategies. Full article
(This article belongs to the Section Energy Systems)
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13 pages, 1664 KiB  
Article
Inclusion Complex of a Cationic Mono-Choline-β-Cyclodextrin Derivative with Resveratrol: Preparation, Characterization, and Wound-Healing Activity
by Sonia Pedotti, Loredana Ferreri, Giuseppe Granata, Giovanni Gambera, Nicola D’Antona, Claudia Giovanna Leotta, Giovanni Mario Pitari and Grazia Maria Letizia Consoli
Int. J. Mol. Sci. 2025, 26(14), 6911; https://doi.org/10.3390/ijms26146911 - 18 Jul 2025
Viewed by 139
Abstract
Resveratrol is one of the most extensively studied natural products due to its pleiotropic health benefits. However, its low water solubility and limited stability hinder its application in the nutraceutical, cosmetic, and pharmaceutical sectors. In this work, we investigated the ability of a [...] Read more.
Resveratrol is one of the most extensively studied natural products due to its pleiotropic health benefits. However, its low water solubility and limited stability hinder its application in the nutraceutical, cosmetic, and pharmaceutical sectors. In this work, we investigated the ability of a cationic mono-choline-β-cyclodextrin derivative to complex trans-resveratrol. The complex was prepared using a phase solubility method without using organic solvents and was found to be stable after freeze-drying. The complex was characterized by a phase solubility study, NMR spectroscopy, and molecular modeling simulations, which revealed a 1:1 stoichiometry, a stability constant of 2051 M−1 (KC), and structural details. Complexation improved resveratrol’s solubility and dissolution rate, reduced its photoinduced trans-to-cis isomerization, and preserved its radical scavenging activity. The wound-healing activity of the complex was demonstrated via in vitro experiments on human keratinocyte cells. Full article
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19 pages, 2875 KiB  
Review
Streamlining ICI Transformed as a Nonnegative System
by David Hyland
Photonics 2025, 12(7), 733; https://doi.org/10.3390/photonics12070733 - 18 Jul 2025
Viewed by 80
Abstract
More than seventy-five years ago, R. Hanbury Brown and R. Q. Twiss performed the first experiments in quantum optics. At the outset, their results showed great promise for the field of astronomical science, featuring inexpensive hardware, immunity to atmospheric turbulence, and enormous interferometry [...] Read more.
More than seventy-five years ago, R. Hanbury Brown and R. Q. Twiss performed the first experiments in quantum optics. At the outset, their results showed great promise for the field of astronomical science, featuring inexpensive hardware, immunity to atmospheric turbulence, and enormous interferometry baselines. This was put to good use for the determination of stellar diameters up to the present time. However, for two-dimensional imaging with faint objects, the integration times are prohibitive. Recently, in a sequence of papers, the present author developed a stochastic search algorithm to remove this roadblock, reducing millions of hours to minutes or seconds. Also, the author’s paper entitled “The Rise of the Brown-Twiss Effect” summarized the search algorithm and emphasized the mathematical proofs of the algorithm. The current algorithm is a sequence of six lines of code. The goal of the present article is to streamline the algorithm in the form of a discrete-time dynamic system and to reduce the size of the state space. The previous algorithm used initial conditions that were randomly assorted pixel intensities. The intensities were mutually statistically independent and uniformly distributed over the range 0,δ, where δ is a (very small) positive constant. The present formulation employs a transformation requiring the uniformly distributed phase of the fast Fourier transform of the cross correlations of the data as initial conditions. We shall see that this strategy results in the simplest discrete-time dynamic system capable for exploring the alternate features and benefits of compartmental nonnegative dynamic systems. Full article
(This article belongs to the Special Issue Optical Imaging and Measurements: 2nd Edition)
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22 pages, 487 KiB  
Article
Fuzzy Hypothesis Testing for Radar Detection: A Statistical Approach for Reducing False Alarm and Miss Probabilities
by Ahmed K. Elsherif, Hanan Haj Ahmad, Mohamed Aboshady and Basma Mostafa
Mathematics 2025, 13(14), 2299; https://doi.org/10.3390/math13142299 - 17 Jul 2025
Viewed by 177
Abstract
This paper addresses a fundamental challenge in statistical radar detection systems: optimizing the trade-off between the probability of a false alarm (PFA) and the probability of a miss (PM). These two metrics are inversely related and [...] Read more.
This paper addresses a fundamental challenge in statistical radar detection systems: optimizing the trade-off between the probability of a false alarm (PFA) and the probability of a miss (PM). These two metrics are inversely related and critical for performance evaluation. Traditional detection approaches often enhance one aspect at the expense of the other, limiting their practical applicability. To overcome this limitation, a fuzzy hypothesis testing framework is introduced that improves decision making under uncertainty by incorporating both crisp and fuzzy data representations. The methodology is divided into three phases. In the first phase, we reduce the probability of false alarm PFA while maintaining a constant probability of miss PM using crisp data characterized by deterministic values and classical statistical thresholds. In the second phase, the inverse scenario is considered: minimizing PM while keeping PFA fixed. This is achieved through parameter tuning and refined threshold calibration. In the third phase, a strategy is developed to simultaneously enhance both PFA and PM, despite their inverse correlation, by adopting adaptive decision rules. To further strengthen system adaptability, fuzzy data are introduced, which effectively model imprecision and ambiguity. This enhances robustness, particularly in scenarios where rapid and accurate classification is essential. The proposed methods are validated through both real and synthetic simulations of radar measurements, demonstrating their ability to enhance detection reliability across diverse conditions. The findings confirm the applicability of fuzzy hypothesis testing for modern radar systems in both civilian and military contexts, providing a statistically sound and operationally applicable approach for reducing detection errors and optimizing system performance. Full article
(This article belongs to the Special Issue New Advance in Applied Probability and Statistical Inference)
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15 pages, 3596 KiB  
Article
Fuzzy-Aided P–PI Control for Start-Up Current Overshoot Mitigation in Solid-State Lithium Battery Chargers
by Chih-Tsung Chang and Kai-Jun Pai
Appl. Sci. 2025, 15(14), 7979; https://doi.org/10.3390/app15147979 - 17 Jul 2025
Viewed by 114
Abstract
A battery charger for solid-state lithium battery packs was developed and implemented. The power stage used a phase-shifted full-bridge converter integrated with a current-doubler rectifier and synchronous rectification. Dual voltage and current control loops were employed to enable constant-voltage and constant-current charging modes. [...] Read more.
A battery charger for solid-state lithium battery packs was developed and implemented. The power stage used a phase-shifted full-bridge converter integrated with a current-doubler rectifier and synchronous rectification. Dual voltage and current control loops were employed to enable constant-voltage and constant-current charging modes. To improve the lifespan of the output filter capacitor, the current-doubler rectifier was adopted to effectively reduce output current ripple. During the initial start-up phase, as the charger transitions from constant-voltage to constant-current output mode, the use of proportional–integral control in the voltage and current loop error amplifiers may cause current overshoot during the step-rising phase, primarily due to the integral action. Therefore, this study incorporated fuzzy control, proportional control, and proportional–integral control strategies into the current-loop error amplifier. This approach effectively reduced the current overshoot during the step-rising phase, preventing the charger from mistakenly triggering the overcurrent protection mode. The analysis and design considerations of the proposed circuit topology and control loop are presented. Experimental results agree with theoretical predictions, thereby confirming the validity of the proposed approach. Full article
(This article belongs to the Section Electrical, Electronics and Communications Engineering)
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16 pages, 4062 KiB  
Article
Numerical Modeling of Charging and Discharging of Shell-and-Tube PCM Thermal Energy Storage Unit
by Maciej Fabrykiewicz, Krzysztof Tesch and Janusz T. Cieśliński
Energies 2025, 18(14), 3804; https://doi.org/10.3390/en18143804 - 17 Jul 2025
Viewed by 155
Abstract
This paper presents the results of a numerical study on transient temperature distributions and phase fractions in a thermal energy storage unit containing phase change material (PCM). The latent heat storage unit (LHSU) is a compact shell-and-tube exchanger featuring seven tubes arranged in [...] Read more.
This paper presents the results of a numerical study on transient temperature distributions and phase fractions in a thermal energy storage unit containing phase change material (PCM). The latent heat storage unit (LHSU) is a compact shell-and-tube exchanger featuring seven tubes arranged in a staggered layout. Three organic phase change materials are investigated: paraffin LTP 56, fatty acid RT54HC, and fatty acid P1801. OpenFOAM software is utilized to solve the governing equations using the Boussinesq approximation. The discretization of the equations is performed with second-order accuracy in both space and time. The three-dimensional (3D) computational domain corresponds to the inner diameter of the LHSU. Calculations are conducted assuming constant thermal properties of the fluids. The experimental and numerical results indicate that for paraffin LTP56, the charging time is approximately 8% longer than the discharging time. In contrast, the discharging times for fatty acids RT54HC and P1801 exceed their charging times, with time delays of about 14% and 49% for RT54HC and 25% and 30% for P1801, according to experimental and numerical calculations, respectively. Full article
(This article belongs to the Special Issue Advancements in Energy Storage Technologies)
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18 pages, 2314 KiB  
Article
Deletion of Clock Gene Period 2 (Per2) in Astrocytes Shortens Clock Period but Does Not Affect Light-Mediated Phase Shifts in Mice
by Soha A. Hassan, Katrin S. Wendrich and Urs Albrecht
Clocks & Sleep 2025, 7(3), 37; https://doi.org/10.3390/clockssleep7030037 - 17 Jul 2025
Viewed by 210
Abstract
The circadian clock is a self-sustaining oscillator with a period of approximately 24 h, enabling organisms to anticipate daily recurring events, such as sunrise and sunset. Since the circadian period is not exactly 24 h and the environmental day length varies throughout the [...] Read more.
The circadian clock is a self-sustaining oscillator with a period of approximately 24 h, enabling organisms to anticipate daily recurring events, such as sunrise and sunset. Since the circadian period is not exactly 24 h and the environmental day length varies throughout the year, the clock must be periodically reset to align an organism’s physiology with the natural light/dark cycle. This synchronization, known as entrainment, is primarily regulated by nocturnal light, which can be replicated in laboratory settings using a 15 min light pulse (LP) and by assessing locomotor activity. An LP during the early part of the dark phase delays the onset of locomotor activity, resulting in a phase delay, whereas an LP in the late dark phase advances activity onset, causing a phase advance. The clock gene Period 2 (Per2) plays a key role in this process. To investigate its contributions, we examined the effects of Per2 deletion in neurons versus astrocytes using glia-specific GPer2 (Per2/GfapCre) knockout (KO) and neuronal-specific NPer2KO (Per2/NesCre) mice. All groups were subjected to Aschoff type II protocol, where an LP was applied at ZT14 or ZT22 and the animals were released into constant darkness. As control, no LP was applied. Phase shift, period, amplitude, total activity count, and rhythm instability were assessed. Our findings revealed that mice lacking Per2 in neurons (NPer2) exhibited smaller phase delays and larger phase advances compared to control animals. In contrast, mice with Per2 deletion specifically in glial cells including astrocytes (GPer2) displayed normal clock resetting. Interestingly, the absence of Per2 in either of the cell types resulted in a shorter circadian period compared to control animals. These results suggest that astrocytic Per2 is important for maintaining the circadian period but is not required for phase adaptation to light stimuli. Full article
(This article belongs to the Section Animal Basic Research)
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34 pages, 12075 KiB  
Article
Offset Temperature and Amplitude–Frequency Effect on Convection Heat Transfer in Partially Gradient Porous Cavity with Different Outlet Port Locations
by Luma F. Ali and Amjad J. Humaidi
Processes 2025, 13(7), 2279; https://doi.org/10.3390/pr13072279 - 17 Jul 2025
Viewed by 259
Abstract
Based on admirable porous media performance and the popularity of additive manufacturing technology, gradient porous media are progressively being applied in increasing fields. In this study, convection heat transfer within a square vented cavity, partially occupied by two copper metal foam layers of [...] Read more.
Based on admirable porous media performance and the popularity of additive manufacturing technology, gradient porous media are progressively being applied in increasing fields. In this study, convection heat transfer within a square vented cavity, partially occupied by two copper metal foam layers of 10 and 20 PPI saturated with nanofluid, was assessed numerically. The left wall was heated uniformly and non-uniformly by applying multi-frequency spatial heating following a sinusoidal function. Governing equations, including continuity, the Darcy–Brinkmann–Forchheimer model, and local thermal non-equilibrium energy equations, were adopted and solved by employing the finite volume method. The influences of relevant parameters, including nanoparticle concentrations 0%φ10%, Reynolds number (1Re100), inlet and outlet port aspect ratios 0.1D/H0.4, three outlet vent opening locations (So=0 left, (So=H/2D/2) middle, and (So=HD) right), sinusoidal offset temperature (θo=0.5, 1), frequency (f=1, 3, 5), and amplitude (A=01), were examined. The results demonstrate that flow and heat transfer fields are impacted mainly by these parameters. Streamlines are more intensified at the upper-left corner when the outlet opening vent is shifted towards the right-corner upper wall. Fluid- and solid-phase Nusselt number increases Re, D/H, θo, A, and f are raised, specifically when A0.3. The Nusselt number remains constant when the frequency is raised from 3 to 5, definitely when D/H0.25. In uniform and non-uniform heating cases, the Nusselt number of both phases remains constant as the outlet port is shifted right for Re10 and slightly for higher Re as the outlet vent location is translated from left to right. Full article
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19 pages, 4090 KiB  
Article
The Behavior of Divalent Metals in Double-Layered Hydroxides as a Fenton Bimetallic Catalyst for Dye Decoloration: Kinetics and Experimental Design
by Edgar Oswaldo Leyva Cruz, Diana Negrete Godínez, Deyanira Angeles-Beltrán and Refugio Rodríguez-Vázquez
Catalysts 2025, 15(7), 687; https://doi.org/10.3390/catal15070687 - 16 Jul 2025
Viewed by 405
Abstract
This study investigates the influence of divalent metals—(Mg(II), Co(II), and Ni(II)) in layered double hydroxides (LDHs), with a constant trivalent Fe(III) component—on the decoloration of crystal violet and methyl blue dyes via a Fenton-type oxidation reaction. The catalysts, synthesized by co-precipitation and hydrothermal [...] Read more.
This study investigates the influence of divalent metals—(Mg(II), Co(II), and Ni(II)) in layered double hydroxides (LDHs), with a constant trivalent Fe(III) component—on the decoloration of crystal violet and methyl blue dyes via a Fenton-type oxidation reaction. The catalysts, synthesized by co-precipitation and hydrothermal treatment, were tested in both hydroxide and oxide forms under varying agitation conditions (0 and 280 rpm). A 22 × 3 factorial design was used to analyze the effect of the divalent metal type, catalyst phase, and stirring. The Mg/Fe oxide, with the highest BET surface area (144 m2/g) and crystallite size (59.7 nm), showed superior performance—achieving up to 98% decoloration of crystal violet and 97% of methyl blue within 1 h. The kinetic analysis revealed pseudo-second-order and pseudo-first-order fits for crystal violet and methyl blue, respectively. These findings suggest that LDH-based catalysts provide a fast, low-cost, and effective option for dye removal in aqueous systems. Full article
(This article belongs to the Section Environmental Catalysis)
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