Search Results (2,738)

This article examines the concepts of war and peace through the lens of Christian philosophy, integrating anthropological, ethical, and socio-political perspectives. It argues that while conflict is rooted in human biology and social organization, war is not a biological necessity but a culturally constructed phenomenon shaped by ideology, power structures, and moral judgment. Drawing on insights from ethology, political theory, and Christian moral theology, the study analyzes the causes of war in modern mass societies, including nationalism, global capitalism, media influence, and environmental degradation. Central attention is given to the Christian tradition’s balanced approach to war and peace, particularly its articulation of just war theory as a middle path between pacifism and militarism. The article contends that war is inherently irrational, though occasionally morally permissible as a penultimate resort aimed at restoring just peace. Ultimately, it presents Christian ethical messianism as a coherent normative framework for evaluating armed conflict, assigning responsibility, and fostering a durable peace grounded in human dignity, justice, and the moral order. Full article

Leafy green vegetables provide important nutrients for human growth; however, human health is highly compromised through consumption of vegetables contaminated by heavy metals. Therefore, the study aimed to investigate the bioaccumulation of heavy metals in five different leafy green vegetables and soils and determine the human health risks that may arise from consuming those vegetables from Tonga town in Mpumalanga province, South Africa. Soils and five edible leafy vegetables (i.e., lettuce, cabbage, rape, pumpkin leaves, and spinach) were assessed for bio-concentration factor, daily intake of metals, health risk, and target hazard quotient across the study sites. The Si, K, Na, Ca, Mg, Al, and Fe concentrations were high in the soils. In general, vegetables exhibited elevated Ca, Fe, Si, Al, and Sr levels, although spinach had high Na concentrations. The bioconcentration factor showed the following trends: Mg > B > Si > V for trace metals and Cr > Co > Mn > Ni > B for heavy metals in lettuce, spinach, and pumpkin leaves. The human risk index for all vegetables showed that all metals were not likely to induce any health hazards to humans, and the target hazard quotient for B, Si, V, Al, Cr, Mn, Fe, Ni, Zn, and Pb showed potential for substantial health risk hazard. The findings of this study generally reveal that the concentrations of the analysed metals exceeded the permissible limits established by the World Health Organisation and the Food and Agricultural Organisation. Given the high levels of metals detected in the soil and vegetables within the study area, it is important to investigate the potential implications for human health and mitigate both acute and chronic health challenges associated with heavy metal exposure. Furthermore, this study will guide policymakers in developing improved regulations and safety standards for agricultural practices and environmental protection, particularly for vulnerable peri-urban and rural communities. Full article

Background: The tumor microenvironment (TME) plays a central role in pancreatic ductal adenocarcinoma (PDAC) progression, yet how mechanical cues shape stromal cell behavior remains poorly defined. Here, we investigate how dimensional priming of adipose-derived stromal cells (ADSCs) alters their immunomodulatory functions and subsequent impact on PDAC growth. Methods: ADSCs were cultured under two-dimensional (2D) or three-dimensional (3D) conditions and evaluated using in vitro co-culture systems with PDAC organoids and in vivo xenograft models. Stromal phenotype, cytokine secretion, tumor growth, invasion, and immune cell infiltration were assessed. Results: ADSCs cultured in three-dimensional (3D) hydrogels exhibited reduced Caveolin-1 (CAV-1) expression and reprogramming toward a stress-adapted, CAF-like phenotype compared with two-dimensional (2D) cultures. In vitro, 2D-primed ADSCs constrained PDAC organoid growth, increased MMP-2 activity, and required direct cell–cell contact to suppress tumor viability. By contrast, 3D-primed ADSCs preserved organoid structure but markedly enhanced tumor cell migration through soluble factors, accompanied by increased IL-6 and TNF-α and reduced IL-10 secretion during co-culture. In vivo, 3D-primed ADSCs promoted the largest tumors with aggressive invasion and loss of Col-Tgel containment associated with tumor expansion, whereas 2D-primed ADSCs suppressed tumor growth and maintained gel boundaries. Immunohistochemistry confirmed elevated Ki-67 in tumors containing 3D-primed ADSCs, while macrophage infiltration (F4/80⁺) was highest in 2D-primed tumors and lowest in 3D-primed tumors. Conclusions: Dimensional priming fundamentally reprograms ADSC phenotype and alters their stromal–immune interactions, generating a tumor-permissive state that accelerates PDAC progression. These findings identify mechanical cues as critical regulators of stromal plasticity and highlight dimensional priming as a potentially targetable axis within the PDAC microenvironment. Full article

The Atlantic City–South Pass (ACSP) orogenic gold district, Wind River Mountains, Wyoming, occurs in the Archean South Pass Greenstone Belt primarily within greywackes and igneous rocks metamorphosed to the upper greenschist–lower amphibolite facies. Approximately 10 Mt of gold has been produced from pyrite and arsenopyrite-bearing quartz veins in deformation zones at the brittle–ductile transition. Multiple generations of primary and/or pseudosecondary fluid inclusions in gold-bearing quartz veins include one- and two-phase gaseous CO₂-CH₄ ± N₂ inclusions and two- and three-phase gaseous CO₂-CH₄-H₂O inclusions with rare NaCl daughter minerals. These primary/pseudosecondary inclusions show a broad range of homogenization temperatures (T_h) of 177.2 to 420.0 °C, with salinities of halite-bearing inclusions of >26 wt. % NaCl, with a high concentration of CaCl₂. Secondary aqueous inclusions formed at lower values of T_h (80.9 to 243.4 °C, with one outlier of 301.1 °C). Carbon from graphitic schists associated with gold-quartz veins yields values of δ¹³C = −28.5 to −19.1 per mil, suggesting that the light C isotope compositions of some carbonates (δ¹³C = −11.0 to −1.5 per mil) involved exchange reactions with graphite in the schists. Isotopic compositions of sulfur in sulfides (δ³⁴S = −1.0 to 3.6 per mil), oxygen in vein quartz (δ¹⁸O = 7.36 to 10.38 per mil), and hydrogen in fluid inclusions in vein quartz (δD = −125 to −55 per mil) are permissive of both magmatic-hydrothermal and metamorphic dehydration models for the origin of gold mineralization. However, a potential source of magmatic–hydrothermal fluids, the post-metamorphic Louis Lake granodiorite was unlikely to transport gold in a vapor state to become focused into shear zones as previously proposed. We favor a metamorphic dehydration model in which gold was derived from the South Pass supracrustal sequence and deposited in second-order shear zones that are spatially related to the first-order Roundtop Mountain Deformation Zone. Full article

Performance management systems (PMSs) in private secondary education are vital, and although several tried and tested public sector performance measurement models exist, limited private secondary school performance measurement models exist in South Africa. This study aims to empirically validate a South African tailor-made theoretical performance measurement model (developed from a systematic literature review of 220 articles) and determine the relationships between its key antecedents (Academic Excellence, Internal Processes, Learning and Growth, and Resources) and their respective sub-antecedents. Data were collected by distributing a hard-copy questionnaire to appointed coworkers at 12 schools in the eThekwini Municipality of KwaZulu-Natal, in Durban, South Africa. The schoolmaster’s permission and blessing were obtained, and a coworker was appointed to assist with the distribution and collection of the structured 5-point Likert-scale questionnaires. A high response rate of 89% (N = 274; n = 244) was realised. The data were tested for normality and reliability (Cronbach’s alpha coefficients consistently exceeded 0.70), and investigated for evidence of model validity using an exploratory factor analysis. The data were normally distributed and not skewed, and the antecedents could be validated. The model showed evidence of validity, and the respective relationships between the antecedents were determined. Learning and Growth (16.46%) was the most critical antecedent, followed by Student perspective (15.51%), and Resource perspective (12.20%). The Internal perspective for academic excellence was, surprisingly, the least important (7.94%). The results show that all four antecedents are valid and should be used in the performance measurement of private secondary schools. Full article

The observed growth of the global population and concern for the natural environment require the supply of inexpensive food with a low-carbon footprint. These requirements can be met, among others, by insect-derived raw materials, such as insect powders commonly referred to as flours. The aim of this study was to compare and assess the effects of four-month storage of insect powders (cricket, mealworm) and cereal flours (millet, oat, rice) under conditions similar to household storage (room temperature, partially emptied packages) on selected quality characteristics. It was assumed that, due to their different protein–fat composition and high degree of comminution, insect powders may exhibit a different dynamic of changes compared to flours in which starch is the dominant matrix. The scope of the research included the assessment of moisture content, acidity, ash content and total protein content, analysis of the amino acid profile, color parameters in the CIE L*a*b* space, changes in volatile compounds, and determination of heavy metal content (Cd, Pb, Hg, As). The obtained results enabled a comprehensive characterization of the quality stability and nutritional value of the tested raw materials after the storage period. The analyses revealed clear differences between cereal flours and insect powders, resulting from differences in chemical composition and production technology. Insect powders were characterized by a higher protein content and a more favorable amino acid profile compared to cereal flours. In addition, they exhibited lower moisture content, different color, and a distinct aroma profile, which can be attributed both to their production technology and to a higher proportion of hydrophobic components. It was shown that during storage the amino acid composition of the tested flours remained relatively stable, as did color; however, mealworm powder exhibited the lowest color stability. It was also demonstrated that cereal flours are characterized by a greater capacity for water sorption, which is related to their starch matrix, whereas insect powders undergo processes related to lipid degradation, leading to increased acidity and changes in the profile of volatile compounds. Certain safety concerns may arise from the exceeded permissible cadmium content observed in mealworm powder. Full article

Increasing the permissible travel speed of suspended monorails in underground mines improves the efficiency and profitability of hard coal mining. However, increasing the maximum speed requires addressing a number of issues affecting the safety of the crew and the mine infrastructure. The concept of a new emergency braking device presented in this article is intended to protect against excessive temperature increases on friction surfaces during braking. The article presents the results of preliminary numerical simulations, the purpose of which was to calculate the temperature of a wet multi-plate brake, its propagation, and verify the condition for not exceeding the maximum permissible temperature of external surfaces in contact with a potentially explosive atmosphere. Full article

During the operation of above-ground main oil and gas pipelines, their elastic bends occur due to the properties of the soils in which the pipeline bases are installed, climatic factors, and the intersection of geodynamic zones. Exceeding the stress values in the pipeline wall above their permissible values leads to a rupture of the wall metal and major accidents. Most methods for estimating the values of bending stresses in the pipeline wall cannot be implemented during their operation, when the pipeline already has a bend, and the installation of any additional equipment on the pipeline requires additional investments. At the same time, the most widely used method for estimating bending stresses based on data from in-pipe diagnostics does not allow for evaluation in areas with varying internal diameters of the pipeline, as well as right-angle turns. The most promising method for estimating bending stresses is aerial laser scanning of pipelines, which consists of obtaining a cloud of points on the pipeline surface, estimating its spatial position, and calculating stress values. However, this method requires the development of more accurate algorithms for processing laser scanning data, and the method is associated with a number of difficulties that can be eliminated by developing the correct sequence of actions during scanning. Within the framework of this article, an algorithm has been developed for analyzing the coordinates of a cloud of points on the pipeline surface, which makes it possible to estimate the values of bending stresses in the pipeline wall. The influence of the unevenness of the thermal insulation surface on the stress assessment results was also studied, taking into account the minimum angle of the scanned pipeline sector, which ensures the accuracy of determining stress values up to 5% using the developed method. Full article

In this study, phosphorus tailings sand (PTS) was ground into fine powder and incorporated with slag and fly ash to formulate a cementitious material composed solely of solid wastes. The current research aimed to promote the high-value utilization of local solid waste resources in Lianyungang and to explore their potential application in soil stabilization and ground improvement. Through optimization of component dosage and the proportions of alkaline activators, the effects on workability, mechanical properties, drying shrinkage, wet–dry cycles, microstructural evolution, and heavy-metal leaching behavior were comprehensively examined. The findings revealed that at the optimal ratio of PTS–slag powder–fly ash = 5:2.5:2.5, the developed cementitious material demonstrated a 28-day compressive strength of 33.8 MPa, along with 4.5 MPa flexural strength, and 168 mm flow spread. Moreover, the 28-day drying shrinkage reached a minimal value of 0.038%, with reduced mass loss of 6.7% after wet–dry cycling. Furthermore, under non-freezing conditions, the leaching content of Zn, Mn, Pb, and Cu from the PTS-based multi-solid-waste cementitious system remained below the permissible limits for non-hazardous discharge established by Chinese environmental regulations. These findings provide an innovative pathway for the resource-efficient application of phosphorus tailings sand and several solid wastes while offering technical guidance for silt stabilization and ecological restoration efforts in the Lianyungang region, highlighting promising engineering application prospects. Full article

Japanese encephalitis virus (JEV) is a mosquito-borne zoonotic orthoflavivirus that poses a significant global health threat. It causes severe neuroinflammatory disease in humans and reproductive failure in swine. Because of the broad host range and cell tropism of JEV, identifying animal cell lines resistant to infection has been a persistent challenge. In this study, we demonstrate that Madin–Darby bovine kidney (MDBK) cells are resistant to JEV infection yet remain fully permissive to viral replication when transfected with viral genomic RNA. Using immunoblotting, immunofluorescence, and flow cytometry, we show that MDBK cells, unlike the highly susceptible baby hamster kidney (BHK-21) cells used as controls, do not support viral entry but sustain all post-entry stages of the replication cycle. Further investigation confirmed that MDBK cells possess a functional clathrin-mediated endocytic pathway, as evidenced by their susceptibility to bovine viral diarrhea virus, which relies on clathrin-dependent endocytosis for host cell entry. These findings establish MDBK cells as a nonsusceptible cell line for JEV entry despite intact endocytic function, providing a valuable platform for studying virus–host cell interactions and for identifying and validating host cell entry factors, a major challenge in JEV research. Full article

Long underground expressways have emerged as an alternative to surface highways in densely urbanized areas; however, their enclosed geometry, extended length, and steep longitudinal gradients introduce traffic-flow dynamics distinct from those of surface roads. This study investigates the combined and interaction effects of traffic volume, heavy-vehicle ratio, longitudinal gradient, lane number, and lane-changing policy on traffic performance in long underground expressways using microscopic traffic simulation. A hypothetical 20 km underground expressway network was evaluated under 72 systematically designed scenarios. Weighted average speed and throughput were analyzed using nonparametric statistics, generalized linear models with interaction terms, and machine learning-based sensitivity analysis. While traffic volume and heavy-vehicle ratio were confirmed as dominant determinants of performance, a key contribution of this study is the identification of the density-dependent role of lane-changing policies. Under moderate traffic density, permissive lane-changing improves efficiency by enabling vehicles to bypass localized disturbances caused by heavy vehicles and longitudinal gradients, thereby enhancing capacity utilization. In contrast, under high-density conditions, permissive lane-changing amplifies lane-change conflicts and shockwave propagation within the confined underground environment, accelerating traffic instability and performance breakdown. These adverse effects are further intensified by steep uphill gradients. The findings demonstrate that lane-changing policies on long underground expressways should be designed in a context-sensitive manner, balancing efficiency and stability across traffic states. Full article

Power supply for traction substations (TSs) of AC railways has traditionally been provided by 110–220 kV overhead transmission lines (OHL). These OHLs can be damaged during strong winds and ice formation. Furthermore, these lines generate significant electromagnetic fields (EMFs), which adversely affect maintenance personnel, the public, and the environment. Mitigating the resulting damages requires the establishment of protection zones, necessitating significant land allocation. Enhancing the reliability of power supply to traction substations and reducing EMF levels can be achieved through the use of gas-insulated lines (GIL), whose application in the power industry of many countries is continuously increasing. The aim of the research presented in this article was to develop computer models for determining the EMF of a GIL supplying a group of traction substations, taking into account actual traction loads characterized by non-sinusoidal waveforms and asymmetry. To solve this problem, an approach implemented in the Fazonord AC-DC software package, based on the use of phase coordinates, was applied. This allowed for the correct accounting of the skin effect and proximity effect in the massive current-carrying parts of the GIL, as well as the influence of asymmetry and harmonic distortions. The simulation results showed that the use of GIL brings the voltage unbalance factors at the 110 kV busbars of the traction substations within the permissible range, with the maximum values of these coefficients not exceeding 2%. The results of the harmonic distortion assessment demonstrated a significant reduction in harmonic distortion factors in the 110 kV network for the GIL compared to the OHL. The performed electromagnetic field calculations confirmed that the GIL generates magnetic field strengths one order of magnitude lower than those of the OHL. The obtained results lead to the conclusion that the use of gas-insulated lines for powering traction substations is highly effective, ensuring increased reliability, improved power quality, and a reduced negative impact of EMF on personnel, the public, the environment, and electronic equipment. Full article

The issue of overpressure at fire doors in escape passage is often overlooked in traditional tunnel design. Current design approaches tend to overemphasize maintaining positive pressure inside the passage for smoke prevention, which results in excessive resistance when opening fire doors. This can hinder emergency evacuation efficiency and pose a threat to personnel safety. This study focused on a typical 1000-m-long straight escape passage to investigate the overpressure problem of fire doors in highway tunnels from both theoretical and empirical perspectives. Traditional pressure calculations for tunnel escape passages adopt relevant guiding designs from the building category, which may lead to certain errors. Therefore, on this basis, this paper employs pressure calculation equations based on the specific pipeline characteristics of smoke control systems. By solving the pressure calculation equations for the fire doors in escape passages, the thrust required to open the doors in the closed state was analyzed. Results show that the force needed to open a fire door can reach up to 168 N under fire conditions, which far exceeds the allowable limits stipulated in relevant design standards. Furthermore, the results indicate that the maximum allowable length of the escape passage should not exceed 3200 m within acceptable pressure limits through numerical simulation. A mathematical relationship between passage length and fire door pressure was also established, confirming the accuracy of the maximum allowable passage length. This study analyzed the hazards of overpressure in escape passages and proposes a method for determining the maximum permissible passage length, aiming to balance the requirements of smoke control with the safety of personnel evacuation. Full article

Slag entrainment within the mold is a significant cause of surface defects in continuously cast slabs. As a key component for controlling molten steel flow, the structure of the submerged entry nozzle directly influences the flow field characteristics and slag entrainment behavior within the mold. This paper employs a 1:4-scale water–oil physical model combined with numerical simulation to investigate the effects of elliptical and circular submerged entry nozzles on slag entrainment behavior in a wide slab mold under different casting speeds and immersion depths. High-speed cameras were used to visualize meniscus fluctuations and oil droplet entrainment processes. An alternating control variable method was employed to quantitatively delineate a slag-free “safe zone” and a “slag entrainment zone” where oil droplets fall, determining the critical casting speed and critical immersion depth under different operating conditions. The results show that, given the nozzle immersion depth and slag viscosity, the maximum permissible casting speed range without slag entrainment can be obtained, providing a reference for industrial production parameter control. The root mean square (RMS) of surface fluctuations was introduced to characterize the activity of the meniscus flow. It was found that the RMS value decreases with increasing nozzle immersion depth and increases with increasing casting speed, showing a good correlation with the frequency of slag entrainment. Numerical simulation results show that compared with elliptical nozzles, circular nozzles form a more symmetrical flow field structure in the upper recirculation zone, with a left–right vortex center deviation of less than 5%, resulting in higher flow stability near the meniscus and thus reducing the risk of slag entrainment. Full article

Metastatic lesions are the most common malignant tumor of the adrenal gland. While surgery can have a favorable surgical outcome for isolated adrenal metastatic lesions, most adrenal metastases occur in the context of disseminated disease, and the overall prognosis remains poor. Although data are limited, metastatic lesions from diverse solid tumors to the adrenal gland have typically demonstrated poor response to immunotherapy, particularly immune checkpoint inhibitors with programmed cell death protein 1 (PD-1)/programmed death-ligand 1 (PD-L1) blockade. This apparent resistance to immunotherapy suggests that the adrenal gland microenvironment may be influenced by local microenvironmental factors, resulting in an organ microenvironment that is immune tolerant and permissive to tumor growth. However, the current literature on the adrenal gland immune microenvironment is limited, underscoring the need for better understanding of the immunobiology of this critical endocrine organ. Thus, the current scarcity of scientific studies on this topic is a novel opportunity to investigate and develop innovative treatment strategies for adrenal solid cancer metastases. In this literature review, we summarize the available data published on the immunobiology of the adrenal gland and the potential local immune mechanisms that may be contributing to the adrenal gland’s role in promoting resistance to otherwise breakthrough immunotherapy treatments. Full article