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Keywords = performance measures

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34 pages, 9378 KiB  
Article
Contribution of Glazed Additions as Passive Elements of the Reduction in Energy Consumption in Detached Houses
by Hristina Krstić, Dušan Ranđelović, Vladan Jovanović, Marko Mančić and Branislava Stoiljković
Buildings 2025, 15(15), 2715; https://doi.org/10.3390/buildings15152715 (registering DOI) - 1 Aug 2025
Abstract
If implemented properly in architectural design, passive measures can contribute to achieving the desired comfort in a building while reducing its energy consumption. Glazed additions in the form of sunspaces or greenhouses can influence the improvement of building energy efficiency and, at the [...] Read more.
If implemented properly in architectural design, passive measures can contribute to achieving the desired comfort in a building while reducing its energy consumption. Glazed additions in the form of sunspaces or greenhouses can influence the improvement of building energy efficiency and, at the same time, create appealing and pleasant building extensions. Through energy simulations performed using EnergyPlus software, this study aims to analyze the potential contribution of glazed additions to a detached house to reducing energy consumption and creating additional space for living. Research was performed as a case study at the following locations: Niš (Serbia), Berlin (Germany), and Tromsø (Norway). For the purposes of this study, five models (M0–M4) were developed and subjected to analysis across two different scenarios. The results of the conducted research showed that the integration of glazed elements can significantly contribute to energy savings: maximum total annual savings regarding heating and cooling go from 21% for Tromsø, up to 32% for Berlin and 40% for Niš, depending on whether the building to which the glazed element(s) is/are attached is insulated or not and the number and the position of glazed elements. Although glazed additions can create a pleasant microclimate around the house, the overheating observed in the study indicates that proper ventilation and shading are mandatory, especially in more southern locations. Full article
(This article belongs to the Section Architectural Design, Urban Science, and Real Estate)
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16 pages, 4891 KiB  
Article
Effects of Performance Variations in Key Components of CRTS I Slab Ballastless Track on Structural Response Following Slab-Replacement Operations
by Wentao Wu, Hongyao Lu, Yuelei He and Haitao Xia
Materials 2025, 18(15), 3621; https://doi.org/10.3390/ma18153621 (registering DOI) - 1 Aug 2025
Abstract
Slab-replacement operations are crucial for restoring deteriorated CRTS I slab ballastless tracks to operational standards. This study investigates the structural implications of the operation by evaluating the strength characteristics and material properties of track components both prior to and following replacement. Apparent strength [...] Read more.
Slab-replacement operations are crucial for restoring deteriorated CRTS I slab ballastless tracks to operational standards. This study investigates the structural implications of the operation by evaluating the strength characteristics and material properties of track components both prior to and following replacement. Apparent strength was measured using rebound hammer tests on three categories of slabs: retained, deteriorated, and newly installed track slabs. In addition, samples of old and new filling resins were collected and tested to determine their elastic moduli. These empirical data were subsequently used to develop a refined finite-element model that captures both pre- and post-replacement conditions. Under varying temperature loads, disparities in component performance were found to significantly affect stress distribution. Specifically, before replacement, deteriorated track slabs exhibited 10.74% lower strength compared to adjacent retained slabs, whereas, after replacement, new slabs showed a 25.26% increase in strength over retained ones. The elastic modulus of old filling resin was measured at 5.19 kN/mm, 35.13% below the minimum design requirement, while the new resin reached 10.48 kN/mm, exceeding the minimum by 31.00%. Although the slab-replacement operation enhances safety by addressing structural deficiencies, it may also create new weak points in adjacent areas, where insufficient stiffness results in stress concentrations and potential damage. This study offers critical insights for optimizing maintenance strategies and improving the long-term performance of ballastless track systems. Full article
(This article belongs to the Section Construction and Building Materials)
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17 pages, 2920 KiB  
Article
Device Reliability Analysis of NNBI Beam Source System Based on Fault Tree
by Qian Cao and Lizhen Liang
Appl. Sci. 2025, 15(15), 8556; https://doi.org/10.3390/app15158556 (registering DOI) - 1 Aug 2025
Abstract
Negative Ion Source Neutral beam Injection (NNBI), as a critical auxiliary heating system for magnetic confinement fusion devices, directly affects the plasma heating efficiency of tokamak devices through the reliability of its beam source system. The single-shot experiment constitutes a significant experimental program [...] Read more.
Negative Ion Source Neutral beam Injection (NNBI), as a critical auxiliary heating system for magnetic confinement fusion devices, directly affects the plasma heating efficiency of tokamak devices through the reliability of its beam source system. The single-shot experiment constitutes a significant experimental program for NNBI. This study addresses the frequent equipment failures encountered by the NNBI beam source system during a cycle of experiments, employing fault tree analysis (FTA) to conduct a systematic reliability assessment. Utilizing the AutoFTA 3.9 software platform, a fault tree model of the beam source system was established. Minimal cut set analysis was performed to identify the system’s weak points. The research employed AutoFTA 3.9 for both qualitative analysis and quantitative calculations, obtaining the failure probabilities of critical components. Furthermore, the F-V importance measure and mean time between failures (MTBF) were applied to analyze the system. This provides a theoretical basis and practical engineering guidance for enhancing the operational reliability of the NNBI system. The evaluation methodology developed in this study can be extended and applied to the reliability analysis of other high-power particle acceleration systems. Full article
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29 pages, 28274 KiB  
Article
Long-Term Neuroprotective Effects of Hydrogen-Rich Water and Memantine in Chronic Radiation-Induced Brain Injury: Behavioral, Histological, and Molecular Insights
by Kai Xu, Huan Liu, Yinhui Wang, Yushan He, Mengya Liu, Haili Lu, Yuhao Wang, Piye Niu and Xiujun Qin
Antioxidants 2025, 14(8), 948; https://doi.org/10.3390/antiox14080948 (registering DOI) - 1 Aug 2025
Abstract
Hydrogen-rich water (HRW) has shown neuroprotective effects in acute brain injury, but its role in chronic radiation-induced brain injury (RIBI) remains unclear. This study investigated the long-term efficacy of HRW in mitigating cognitive impairment and neuronal damage caused by chronic RIBI. Fifty male [...] Read more.
Hydrogen-rich water (HRW) has shown neuroprotective effects in acute brain injury, but its role in chronic radiation-induced brain injury (RIBI) remains unclear. This study investigated the long-term efficacy of HRW in mitigating cognitive impairment and neuronal damage caused by chronic RIBI. Fifty male Sprague Dawley rats were randomly divided into five groups: control, irradiation (IR), IR with memantine, IR with HRW, and IR with combined treatment. All but the control group received 20 Gy whole-brain X-ray irradiation, followed by daily interventions for 60 days. Behavioral assessments, histopathological analyses, oxidative stress measurements, 18F-FDG PET/CT imaging, transcriptomic sequencing, RT-qPCR, Western blot, and serum ELISA were performed. HRW significantly improved anxiety-like behavior, memory, and learning performance compared to the IR group. Histological results revealed that HRW reduced neuronal swelling, degeneration, and loss and enhanced dendritic spine density and neurogenesis. PET/CT imaging showed increased hippocampal glucose uptake in the IR group, which was alleviated by HRW treatment. Transcriptomic and molecular analyses indicated that HRW modulated key genes and proteins, including CD44, CD74, SPP1, and Wnt1, potentially through the MIF, Wnt, and SPP1 signaling pathways. Serum CD44 levels were also lower in treated rats, suggesting its potential as a biomarker for chronic RIBI. These findings demonstrate that HRW can alleviate chronic RIBI by preserving neuronal structure, reducing inflammation, and enhancing neuroplasticity, supporting its potential as a therapeutic strategy for radiation-induced cognitive impairment. Full article
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26 pages, 3030 KiB  
Article
Predicting Landslide Susceptibility Using Cost Function in Low-Relief Areas: A Case Study of the Urban Municipality of Attecoube (Abidjan, Ivory Coast)
by Frédéric Lorng Gnagne, Serge Schmitz, Hélène Boyossoro Kouadio, Aurélia Hubert-Ferrari, Jean Biémi and Alain Demoulin
Earth 2025, 6(3), 84; https://doi.org/10.3390/earth6030084 (registering DOI) - 1 Aug 2025
Abstract
Landslides are among the most hazardous natural phenomena affecting Greater Abidjan, causing significant economic and social damage. Strategic planning supported by geographic information systems (GIS) can help mitigate potential losses and enhance disaster resilience. This study evaluates landslide susceptibility using logistic regression and [...] Read more.
Landslides are among the most hazardous natural phenomena affecting Greater Abidjan, causing significant economic and social damage. Strategic planning supported by geographic information systems (GIS) can help mitigate potential losses and enhance disaster resilience. This study evaluates landslide susceptibility using logistic regression and frequency ratio models. The analysis is based on a dataset comprising 54 mapped landslide scarps collected from June 2015 to July 2023, along with 16 thematic predictor variables, including altitude, slope, aspect, profile curvature, plan curvature, drainage area, distance to the drainage network, normalized difference vegetation index (NDVI), and an urban-related layer. A high-resolution (5-m) digital elevation model (DEM), derived from multiple data sources, supports the spatial analysis. The landslide inventory was randomly divided into two subsets: 80% for model calibration and 20% for validation. After optimization and statistical testing, the selected thematic layers were integrated to produce a susceptibility map. The results indicate that 6.3% (0.7 km2) of the study area is classified as very highly susceptible. The proportion of the sample (61.2%) in this class had a frequency ratio estimated to be 20.2. Among the predictive indicators, altitude, slope, SE, S, NW, and NDVI were found to have a positive impact on landslide occurrence. Model performance was assessed using the area under the receiver operating characteristic curve (AUC), demonstrating strong predictive capability. These findings can support informed land-use planning and risk reduction strategies in urban areas. Furthermore, the prediction model should be communicated to and understood by local authorities to facilitate disaster management. The cost function was adopted as a novel approach to delineate hazardous zones. Considering the landslide inventory period, the increasing hazard due to climate change, and the intensification of human activities, a reasoned choice of sample size was made. This informed decision enabled the production of an updated prediction map. Optimal thresholds were then derived to classify areas into high- and low-susceptibility categories. The prediction map will be useful to planners in helping them make decisions and implement protective measures. Full article
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22 pages, 9122 KiB  
Article
Computational Mechanics of Polymeric Materials PEEK and PEKK Compared to Ti Implants for Marginal Bone Loss Around Oral Implants
by Mohammad Afazal, Saba Afreen, Vaibhav Anand and Arnab Chanda
Prosthesis 2025, 7(4), 93; https://doi.org/10.3390/prosthesis7040093 (registering DOI) - 1 Aug 2025
Abstract
Background/Objectives: Dental practitioners widely use dental implants to treat traumatic cases. Titanium implants are currently the most popular choice among dental practitioners and surgeons. The discovery of newer polymeric materials is also influencing the interest of dental professionals in alternative options. A comparative [...] Read more.
Background/Objectives: Dental practitioners widely use dental implants to treat traumatic cases. Titanium implants are currently the most popular choice among dental practitioners and surgeons. The discovery of newer polymeric materials is also influencing the interest of dental professionals in alternative options. A comparative study between existing titanium implants and newer polymeric materials can enhance professionals’ ability to select the most suitable implant for a patient’s treatment. This study aimed to investigate material property advantages of high-performance thermoplastic biopolymers such as PEEK and PEKK, as compared to the time-tested titanium implants, and to find the most suitable and economically fit implant material. Methods: Three distinct implant material properties were assigned—PEEK, PEKK, and commercially pure titanium (CP Ti-55)—to dental implants measuring 5.5 mm by 9 mm, along with two distinct titanium (TI6AL4V) abutments. Twelve three-dimensional (3D) models of bone blocks, representing the mandibular right molar area with Osseo-integrated implants were created. The implant, abutment, and screw were assumed to be linear; elastic, isotropic, and orthotropic properties were attributed to the cancellous and cortical bone. Twelve model sets underwent a three-dimensional finite element analysis to evaluate von Mises stress and total deformation under 250 N vertical and oblique (30 degree) loads on the top surface of each abutment. Results: The study revealed that the time-tested titanium implant outperforms PEEK and PEKK in terms of marginal bone preservation, while PEEK outperforms PEKK. Conclusions: This study will assist dental practitioners in selecting implants from a variety of available materials and will aid researchers in their future research. Full article
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21 pages, 12700 KiB  
Article
Optimization of Developed TiO2 NWs-Fe2O3 Modified PES Membranes for Efficient NBB Dye Removal
by Mouna Mansor Hussein, Qusay F. Alsalhy, Mohamed Gar Alalm and M. M. El-Halwany
ChemEngineering 2025, 9(4), 82; https://doi.org/10.3390/chemengineering9040082 (registering DOI) - 1 Aug 2025
Abstract
Current work investigates the fabrication and performance of nanocomposite membranes, modified with varying concentrations of hybrid nanostructures comprising titanium nanowires coated with iron nanoparticles (TiO2 NWs-Fe2O3), for the removal of Naphthol Blue Black (NBB) dye from industrial wastewater. [...] Read more.
Current work investigates the fabrication and performance of nanocomposite membranes, modified with varying concentrations of hybrid nanostructures comprising titanium nanowires coated with iron nanoparticles (TiO2 NWs-Fe2O3), for the removal of Naphthol Blue Black (NBB) dye from industrial wastewater. A series of analytical tools were employed to confirm the successful modification including scanning electron microscopy and EDX analysis, porosity and hydrophilicity measurements, Fourier-transform infrared spectroscopy, and X-Ray Diffraction. The incorporation of TiO2 NWs-Fe2O3 has enhanced membrane performance significantly by increasing the PWF and improving dye retention rates of nanocomposite membranes. At 0.7 g of nanostructure content, the modified membrane (M8) achieved a PWF of 93 L/m2·h and NBB dye rejection of over 98%. The flux recovery ratio (FRR) analysis disclosed improved antifouling properties, with the M8 membrane demonstrating a 73.4% FRR. This study confirms the potential of TiO2 NWs-Fe2O3-modified membranes in enhancing water treatment processes, offering a promising solution for industrial wastewater treatment. These outstanding results highlight the potential of the novel PES-TiO2 NWs-Fe2O3 membranes for dye removal and present adequate guidance for the modification of membrane physical properties in the field of wastewater treatment. Full article
(This article belongs to the Special Issue New Advances in Chemical Engineering)
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21 pages, 3814 KiB  
Article
Features of the Structure of Layered Epoxy Composite Coatings Formed on a Metal-Ceramic-Coated Aluminum Base
by Volodymyr Korzhyk, Volodymyr Kopei, Petro Stukhliak, Olena Berdnikova, Olga Kushnarova, Oleg Kolisnichenko, Oleg Totosko, Danylo Stukhliak and Liubomyr Ropyak
Materials 2025, 18(15), 3620; https://doi.org/10.3390/ma18153620 (registering DOI) - 1 Aug 2025
Abstract
Difficult, extreme operating conditions of parabolic antennas under precipitation and sub-zero temperatures require the creation of effective heating systems. The purpose of the research is to develop a multilayer coating containing two metal-ceramic layers, epoxy composite layers, carbon fabric, and an outer layer [...] Read more.
Difficult, extreme operating conditions of parabolic antennas under precipitation and sub-zero temperatures require the creation of effective heating systems. The purpose of the research is to develop a multilayer coating containing two metal-ceramic layers, epoxy composite layers, carbon fabric, and an outer layer of basalt fabric, which allows for effective heating of the antenna, and to study the properties of this coating. The multilayer coating was formed on an aluminum base that was subjected to abrasive jet processing. The first and second metal-ceramic layers, Al2O3 + 5% Al, which were applied by high-speed multi-chamber cumulative detonation spraying (CDS), respectively, provide maximum adhesion strength to the aluminum base and high adhesion strength to the third layer of the epoxy composite containing Al2O3. On this not-yet-polymerized layer of epoxy composite containing Al2O3, a layer of carbon fabric (impregnated with epoxy resin) was formed, which serves as a resistive heating element. On top of this carbon fabric, a layer of epoxy composite containing Cr2O3 and SiO2 was applied. Next, basalt fabric was applied to this still-not-yet-polymerized layer. Then, the resulting layered coating was compacted and dried. To study this multilayer coating, X-ray analysis, light and raster scanning microscopy, and transmission electron microscopy were used. The thickness of the coating layers and microhardness were measured on transverse microsections. The adhesion strength of the metal-ceramic coating layers to the aluminum base was determined by both bending testing and peeling using the adhesive method. It was established that CDS provides the formation of metal-ceramic layers with a maximum fraction of lamellae and a microhardness of 7900–10,520 MPa. In these metal-ceramic layers, a dispersed subgrain structure, a uniform distribution of nanoparticles, and a gradient-free level of dislocation density are observed. Such a structure prevents the formation of local concentrators of internal stresses, thereby increasing the level of dispersion and substructural strengthening of the metal-ceramic layers’ material. The formation of materials with a nanostructure increases their strength and crack resistance. The effectiveness of using aluminum, chromium, and silicon oxides as nanofillers in epoxy composite layers was demonstrated. The presence of structures near the surface of these nanofillers, which differ from the properties of the epoxy matrix in the coating, was established. Such zones, specifically the outer surface layers (OSL), significantly affect the properties of the epoxy composite. The results of industrial tests showed the high performance of the multilayer coating during antenna heating. Full article
(This article belongs to the Section Metals and Alloys)
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22 pages, 14333 KiB  
Article
A Transient Combustion Study in a Brick Kiln Using Natural Gas as Fuel by Means of CFD
by Sergio Alonso-Romero, Jorge Arturo Alfaro-Ayala, José Eduardo Frias-Chimal, Oscar A. López-Núñez, José de Jesús Ramírez-Minguela and Roberto Zitzumbo-Guzmán
Processes 2025, 13(8), 2437; https://doi.org/10.3390/pr13082437 (registering DOI) - 1 Aug 2025
Abstract
A brick kiln was experimentally studied to measure the transient temperature of hot gases and the compressive strength of the bricks, using pine wood as fuel, in order to evaluate the thermal performance of the actual system. In addition, a transient combustion model [...] Read more.
A brick kiln was experimentally studied to measure the transient temperature of hot gases and the compressive strength of the bricks, using pine wood as fuel, in order to evaluate the thermal performance of the actual system. In addition, a transient combustion model based on computational fluid dynamics (CFD) was used to simulate the combustion of natural gas in the brick kiln as a hypothetical case, with the aim of investigating the potential benefits of fuel switching. The theoretical stoichiometric combustion of both pine wood and natural gas was employed to compare the mole fractions and the adiabatic flame temperature. Also, the transient hot gas temperature obtained from the experimental wood-fired kiln were compared with those from the simulated natural gas-fired kiln. Furthermore, numerical simulations were carried out to obtain the transient hot gas temperature and NOx emissions under stoichiometric, fuel-rich, and excess air conditions. The results of CO2 mole fractions from stoichiometric combustion demonstrate that natural gas may represent a cleaner alternative for use in brick kilns, due to a 44.08% reduction in emissions. Contour plots of transient hot gases temperature, velocity, and CO2 emission inside the kiln are presented. Moreover, the time-dependent emissions of CO2, H2O, and CO at the kiln outlet are shown. It can be concluded that the presence of CO mole fractions at the kiln outlet suggests that the transient combustion process could be further improved. The low firing efficiency of bricks and the thermal efficiency obtained are attributed to uneven temperatures distributions inside the kiln. Moreover, hot gas temperature and NOx emissions were found to be higher under stoichiometric conditions than under fuel-rich or excess of air conditions. Therefore, this work could be useful for improving the thermal–hydraulic and emissions performance of brick kilns, as well as for future kiln design improvements. Full article
(This article belongs to the Special Issue Numerical Simulation of Flow and Heat Transfer Processes)
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28 pages, 4026 KiB  
Article
Multi-Trait Phenotypic Analysis and Biomass Estimation of Lettuce Cultivars Based on SFM-MVS
by Tiezhu Li, Yixue Zhang, Lian Hu, Yiqiu Zhao, Zongyao Cai, Tingting Yu and Xiaodong Zhang
Agriculture 2025, 15(15), 1662; https://doi.org/10.3390/agriculture15151662 (registering DOI) - 1 Aug 2025
Abstract
To address the problems of traditional methods that rely on destructive sampling, the poor adaptability of fixed equipment, and the susceptibility of single-view angle measurements to occlusions, a non-destructive and portable device for three-dimensional phenotyping and biomass detection in lettuce was developed. Based [...] Read more.
To address the problems of traditional methods that rely on destructive sampling, the poor adaptability of fixed equipment, and the susceptibility of single-view angle measurements to occlusions, a non-destructive and portable device for three-dimensional phenotyping and biomass detection in lettuce was developed. Based on the Structure-from-Motion Multi-View Stereo (SFM-MVS) algorithms, a high-precision three-dimensional point cloud model was reconstructed from multi-view RGB image sequences, and 12 phenotypic parameters, such as plant height, crown width, were accurately extracted. Through regression analyses of plant height, crown width, and crown height, and the R2 values were 0.98, 0.99, and 0.99, respectively, the RMSE values were 2.26 mm, 1.74 mm, and 1.69 mm, respectively. On this basis, four biomass prediction models were developed using Adaptive Boosting (AdaBoost), Support Vector Regression (SVR), Gradient Boosting Decision Tree (GBDT), and Random Forest Regression (RFR). The results indicated that the RFR model based on the projected convex hull area, point cloud convex hull surface area, and projected convex hull perimeter performed the best, with an R2 of 0.90, an RMSE of 2.63 g, and an RMSEn of 9.53%, indicating that the RFR was able to accurately simulate lettuce biomass. This research achieves three-dimensional reconstruction and accurate biomass prediction of facility lettuce, and provides a portable and lightweight solution for facility crop growth detection. Full article
(This article belongs to the Section Crop Production)
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13 pages, 892 KiB  
Article
Waist–Calf Circumference Ratio Is Associated with Body Composition, Physical Performance, and Muscle Strength in Older Women
by Cecilia Arteaga-Pazmiño, Alma L. Guzmán-Gurrola, Diana Fonseca-Pérez, Javier Galvez-Celi, Danielle Francesca Aycart, Ludwig Álvarez-Córdova and Evelyn Frias-Toral
Geriatrics 2025, 10(4), 103; https://doi.org/10.3390/geriatrics10040103 (registering DOI) - 1 Aug 2025
Abstract
Background: The waist–calf circumference ratio (WCR) is an index that combines waist and calf circumference measurements, offering a potentially effective method for evaluating the imbalance between abdominal fat and leg muscle mass in older adults. Objective: To assess the association between WCR and [...] Read more.
Background: The waist–calf circumference ratio (WCR) is an index that combines waist and calf circumference measurements, offering a potentially effective method for evaluating the imbalance between abdominal fat and leg muscle mass in older adults. Objective: To assess the association between WCR and indicators of body composition, muscle strength, and physical performance in community-dwelling older women. Methods: This was a cross-sectional study involving 133 older women (≥65 years) from an urban-marginal community in Guayaquil, Ecuador. The WCR was categorized into quartiles (Q1: 2.07–2.57; Q2: 2.58–2.75; Q3: 2.76–3.05; Q4: 3.06–4.76). Body indicators included fat-free mass (FFM), skeletal muscle mass (SMM), appendicular muscle mass (ASM), appendicular muscle mass index (ASMI), visceral fat (VF), fat mass (FM), and fat mass index (FMI). Handgrip strength (HGS) and the Short Physical Performance Battery test (SPPB) score were used to assess muscle strength and function, respectively. Results: The median age of the participants was 75 [IQR: 65–82] years. The mean WCR was 2.92 ± 0.93. Statistically significant associations were found between WCR and VF (p < 0.001), WCR and SMM (p = 0.039), and WCR and ASM (p = 0.016). Regarding muscle function, WCR was associated with HGS (p = 0.025) and SPPB score (p = 0.029). Conclusions: A significant association was observed between WCR and body composition, and muscle strength and function in older women. Full article
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15 pages, 2737 KiB  
Article
Thermogenic Activation of Adipose Tissue by Caffeine During Strenuous Exercising and Recovery: A Double-Blind Crossover Study
by Dany Alexis Sobarzo Soto, Diego Ignácio Valenzuela Pérez, Mateus Rossow de Souza, Milena Leite Garcia Reis, Naiara Ribeiro Almeida, Bianca Miarka, Esteban Aedo-Muñoz, Armin Isael Alvarado Oyarzo, Manuel Sillero-Quintana, Andreia Cristiane Carrenho Queiroz and Ciro José Brito
Metabolites 2025, 15(8), 517; https://doi.org/10.3390/metabo15080517 (registering DOI) - 1 Aug 2025
Abstract
Background/Objectives: To investigate acute caffeine (CAF: 375 mg, ≈4.8 mg/kg body mass) effects on energy expenditure (EE) and substrate kinetics during high-intensity interval exercise in individuals with high (HBAT) versus low (LBAT) brown adipose tissue activity using time-trend polynomial modeling. Methods: This [...] Read more.
Background/Objectives: To investigate acute caffeine (CAF: 375 mg, ≈4.8 mg/kg body mass) effects on energy expenditure (EE) and substrate kinetics during high-intensity interval exercise in individuals with high (HBAT) versus low (LBAT) brown adipose tissue activity using time-trend polynomial modeling. Methods: This is a randomized, double-blind crossover study in which 35 highly-trained males [HBAT-CAF, HBAT-PLA (Placebo), LBAT-CAF, LBAT-PLA] performed 30-min treadmill HIIE. Infrared thermography (IRT) assessed BAT activity by measuring supraclavicular skin temperature (SST). Breath-by-breath ergospirometry measured EE (kcal/min) and carbohydrate (CHO), lipid (LIP), and protein (PTN) oxidation. We applied second- and third-order polynomial regression models to depict the temporal trajectories of metabolic responses. Results: HBAT groups showed 25% higher sustained EE versus LBAT (p < 0.001), amplified by CAF. CHO oxidation exhibited biphasic kinetics: HBAT had 40% higher initial rates (0.75 ± 0.05 vs. 0.45 ± 0.04 g/min; p < 0.001) with accelerated decline (k = −0.21 vs. −0.15/min; p = 0.01). LIP oxidation peaked later in LBAT (40 vs. 20 min in HBAT), with CAF increasing oxidation by 18% in LBAT (p = 0.01). HBAT-CAF uniquely showed transient PTN catabolism (peak: 0.045 g/min at 10 min; k = −0.0033/min; p < 0.001). Conclusions: BAT status determines EE magnitude and substrate-specific kinetic patterns, while CAF exerts divergent modulation, potentiating early glycogenolysis in HBAT and lipolysis in LBAT. The HBAT-CAF synergy triggers acute proteolysis, revealing BAT-mediated metabolic switching. Full article
(This article belongs to the Special Issue Energy Metabolism in Brown Adipose Tissue)
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13 pages, 1750 KiB  
Article
Mineral-Based Synthesis of CuFe2O4 Nanoparticles via Co-Precipitation and Microwave Techniques Using Leached Copper Solutions from Mined Minerals
by Carolina Venegas Abarzúa, Mauricio J. Morel, Gabriela Sandoval-Hevia, Thangavel Kavinkumar, Natarajan Chidhambaram, Sathish Kumar Kamaraj, Nagarajan Dineshbabu and Arun Thirumurugan
Minerals 2025, 15(8), 819; https://doi.org/10.3390/min15080819 (registering DOI) - 1 Aug 2025
Abstract
Environmental sustainability and responsible resource utilization are critical global challenges. In this work, we present a sustainable and circular-economy-based approach for synthesizing CuFe2O4 nanoparticles by directly utilizing copper oxide minerals sourced from Chilean mining operations. Copper sulfate (CuSO4) [...] Read more.
Environmental sustainability and responsible resource utilization are critical global challenges. In this work, we present a sustainable and circular-economy-based approach for synthesizing CuFe2O4 nanoparticles by directly utilizing copper oxide minerals sourced from Chilean mining operations. Copper sulfate (CuSO4) was extracted from these minerals through acid leaching and used as a precursor for nanoparticle synthesis via both chemical co-precipitation and microwave-assisted methods. The influence of different precipitating agents—NaOH, Na2CO3, and NaF—was systematically evaluated. XRD and FESEM analyses revealed that NaOH produced the most phase-pure and well-dispersed nanoparticles, while NaF resulted in secondary phase formation. The microwave-assisted method further improved particle uniformity and reduced agglomeration due to rapid and homogeneous heating. Electrochemical characterization was conducted to assess the suitability of the synthesized CuFe2O4 for supercapacitor applications. Cyclic voltammetry (CV) and galvanostatic charge–discharge (GCD) measurements confirmed pseudocapacitive behavior, with a specific capacitance of up to 1000 F/g at 2 A/g. These findings highlight the potential of CuFe2O4 as a low-cost, high-performance electrode material for energy storage. This study underscores the feasibility of converting primary mined minerals into functional nanomaterials while promoting sustainable mineral valorization. The approach can be extended to other critical metals and mineral residues, including tailings, supporting the broader goals of a circular economy and environmental remediation. Full article
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20 pages, 4980 KiB  
Article
Quinoa Protein/Sodium Alginate Complex-Stabilized Pickering Emulsion for Sustained Release of Curcumin and Enhanced Anticancer Activity Against HeLa Cells
by Yiqun Zhu, Jianan Li, Shuhong Liu, Hongli Yang, Fei Lu and Minpeng Zhu
Foods 2025, 14(15), 2705; https://doi.org/10.3390/foods14152705 (registering DOI) - 1 Aug 2025
Abstract
Quinoa protein isolate (QPI) and sodium alginate (SA) have excellent biocompatibility and functional properties, making them promising candidates for food-grade delivery systems. In this study, we developed, for the first time, a QPI/SA complex-stabilized Pickering emulsion for curcumin encapsulation. The coacervation behavior of [...] Read more.
Quinoa protein isolate (QPI) and sodium alginate (SA) have excellent biocompatibility and functional properties, making them promising candidates for food-grade delivery systems. In this study, we developed, for the first time, a QPI/SA complex-stabilized Pickering emulsion for curcumin encapsulation. The coacervation behavior of QPI and SA was investigated from pH 1.6 to 7.5, and the structural and interfacial characteristics of the complexes were analyzed using zeta potential measurements, Fourier-transform infrared spectroscopy, scanning electron microscopy, and contact angle analysis. The results showed that the formation of QPI/SA complexes was primarily driven by electrostatic interactions, hydrogen bonding, and hydrophobic interactions, with enhanced amphiphilicity observed under optimal conditions (QPI/SA = 5:1, pH 5). The QPI/SA-stabilized Pickering emulsions demonstrated excellent emulsification performance and storage stability, maintaining an emulsification index above 90% after 7 d when prepared with 60% oil phase. In vitro digestion studies revealed stage-specific curcumin release, with sustained release in simulated gastric fluid (21.13%) and enhanced release in intestinal fluid (88.21%). Cytotoxicity assays using HeLa cells confirmed the biocompatibility of QPI/SA complexes (≤500 μg/mL), while curcumin-loaded emulsions exhibited dose-dependent anticancer activity. These findings suggest that QPI/SA holds significant potential for applications in functional foods and oral delivery systems. Full article
(This article belongs to the Section Grain)
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22 pages, 6172 KiB  
Article
Ethnomedicinal Properties of Wild Edible Fruit Plants and Their Horticultural Potential Among Indigenous Isan Communities in Roi Et Province, Northeastern Thailand
by Piyaporn Saensouk, Surapon Saensouk, Thawatphong Boonma, Auemporn Junsongduang, Min Khant Naing and Tammanoon Jitpromma
Horticulturae 2025, 11(8), 885; https://doi.org/10.3390/horticulturae11080885 (registering DOI) - 1 Aug 2025
Abstract
Wild edible fruit plants are integral to the cultural, nutritional, medicinal, and economic practices of Indigenous Isan communities in Roi Et Province, northeastern Thailand, a region characterized by plateau and lowland topography and a tropical monsoon climate. This study aimed to document the [...] Read more.
Wild edible fruit plants are integral to the cultural, nutritional, medicinal, and economic practices of Indigenous Isan communities in Roi Et Province, northeastern Thailand, a region characterized by plateau and lowland topography and a tropical monsoon climate. This study aimed to document the diversity, traditional uses, phenology, and conservation status of these species to inform sustainable management and conservation efforts. Field surveys and ethnobotanical interviews with 200 informants (100 men, 100 women; random ages) were conducted across 20 local communities to identify species diversity and usage patterns, while phenological observations and conservation assessments were performed to understand reproductive cycles and species vulnerability between January and December 2023. A total of 68 species from 32 families were recorded, with peak flowering in March–April and fruiting in May–June. Analyses of Species Use Value (0.19–0.48) and Relative Frequency of Citation (0.15–0.44) identified key species with significant roles in food security and traditional medicine. Uvaria rufa had the highest SUV (0.48) and RFC (0.44). Informant consensus on medicinal applications was strong for ailments such as gastrointestinal and lymphatic disorders. Economically important species were also identified, with some contributing notable income through local trade. Conservation proposed one species as Critically Endangered and several others as Vulnerable. The results highlight the need for integrated conservation strategies, including community-based initiatives and recognition of Other Effective area-based Conservation Measures (OECMs), to ensure the preservation of biodiversity, traditional knowledge, and local livelihoods. Full article
(This article belongs to the Section Medicinals, Herbs, and Specialty Crops)
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