Search Results (82)

Purpose: To review parental pre-pregnancy and pregnancy exposures in relation to pediatric cancer (diagnosis before age 20). Methods: We conducted literature searches using Ovid Medline and Scopus to find primary research studies, review articles, and meta-analyses published from 2014 to 17 March 2021. Results: Strong evidence links increased risk of childhood cancer with maternal diabetes, age, and alcohol and coffee consumption during pregnancy. Both paternal and maternal cigarette smoking before and during pregnancy are associated with childhood cancers. Diethylstilbestrol (DES) exposure in utero has long been known to be causally associated with increased risk of vaginal/cervical cancers in adolescent girls. More recent evidence implicates in utero DES exposure to testicular cancer in young men and possible intergenerational effects on ovarian cancer in the granddaughters of women exposed to DES during pregnancy. There is strong evidence that childhood cancer risk is also associated with both high and very low birth weight and with gestational age. Evidence is also strong for the protective effects of maternal vitamin consumption and a healthy diet during pregnancy. Unlike early studies, those reviewed here show no association between in utero exposure to medical ionizing radiation, which may be explained by reductions over time in radiation doses, avoidance of radiation during pregnancy, and/or by inadequate statistical power to detect small increases in risk, rather than a lack of causal association. Evidence is mixed or conflicting for an association between childhood cancer and maternal obesity, birth order, cesarean/instrumental delivery, and prenatal exposure to diagnostic medical radiation. Evidence is weak or absent for associations between childhood cancer and multiple gestations or assisted reproductive therapies, as well as prenatal exposure to hormones other than DES, and medications. Full article

Background: A national study from China in 2023 predicted that the prevalence of overweight and obesity among children aged 7–18 will increase from 23.4% in 2019 to 32.7% by 2030. Objectives: This study aimed to investigate the longitudinal association between parental feeding practices and children’s body composition and weight status, and to assess the mediation effect of parental feeding practices in the relationship between socioeconomic status and childhood body composition. Methods: This longitudinal observational study was conducted between September and November 2021 in eight primary schools located in Luohu District, Shenzhen. Baseline and two follow-up surveys were administered annually during the same period from 2021 to 2023 (with one-year intervals). A total of 620 third-grade students (aged 8–10 years at baseline) and their parents were ultimately included in the study. Associations between parental feeding practices and children’s weight status and body composition were analyzed using mixed-effects models. The mediation effect of parental feeding practices on the relationship between socioeconomic status and childhood body composition was assessed through bootstrapping analysis. Results: At follow-up, a significant upward trend in the prevalence of central obesity among children was observed. Among all parental feeding dimensions, perceived child weight (PCW) demonstrated a strong association with central obesity after Bonferroni correction (OR = 1.33, 95% CI = 1.16, 1.51); similarly, monitoring (MN) and concern about child weight (CN) were both significantly associated with central obesity as risk factors for central obesity (OR = 1.14, 95% CI = 1.06, 1.23; OR = 1.16, 95% CI = 1.07, 1.27), both p < 0.001. These associations were modified by baseline child sex, parental BMI, and maternal and paternal education levels. However, restriction (RST) was not significantly associated with either body composition or weight status. The relationship between family socioeconomic status (SES) and childhood overweight and obesity was mediated by pressure to eat (PE) (p < 0.05). Conclusions: MN, PCW, and CN are associated with an increased risk of obesity in children. However, no significant association was found between parental feeding practices and changes in children’s body composition. Full article

Background: Breastfeeding is the ideal source of nutrition for babies. Despite its benefits, breastfeeding practices and attitudes vary across cultures, influenced by societal norms, education, and personal experiences. This article shows the attitude differences among female students in Syria and Hungary and how sociocultural aspects impact their attitude towards breastfeeding. Methods: The questionnaire was a part of a multi-section questionnaire presented to 317 Syrian students and 303 Hungarian students. It assessed students’ attitudes towards breastfeeding through the Iowa Infant Feeding Attitude Scale (IIFAS). In addition to cross-tabulations, an exploratory data categorisation method, i.e., cluster analysis, was used in analysing the data. Results: Participants in both countries demonstrated strong agreement with statements highlighting the emotional and nutritional advantages of breastfeeding. In total, 67.2% of the participants disagreed with the idea that formula feeding is more convenient; similarly, 66.3% of them disagreed that breastfeeding causes fathers to feel emotionally excluded. Attitudes toward breastfeeding in public were more divided, reflecting the sensitivity of the topic and varying degrees of acceptance, with 48.7% of respondents disagreeing. Multivariate analysis demonstrated that nationality or age were significant predictors of belonging to various attitude clusters (SBM, SFF, FT): Syrian respondents and younger participants aged 21–30 years were more likely to belong to the Supporters of Breast Milk (SBM) cluster. In addition, paternal education level and urban residence also influenced feeding attitudes. Conclusions: This study shows the differences in attitude among Syrian and Hungarian female students, which is rooted in cultural diversity and its effect on individuals’ decisions. Full article

Background/Objectives: Identifying the factors influencing compliance is essential to improve the effectiveness of interventions. However, no study has examined factors that influence the longitudinal patterns of obesity intervention compliance. We aim to identify the longitudinal trajectories of parental and child compliance using group-based trajectory modeling (GBTM) and assess the influencing factors. Methods: The Diet, ExerCIse, and CarDiovascular hEalth Children (DECIDE-Children) was a 9-month app-assisted obesity prevention intervention targeted 8–10-year-old children. Altogether, 684 child–parent pairs from the intervention group were included. Parents were required to use the mobile app to learn health knowledge, monitor children’s diet and exercise behaviors, manage children’s weight, and received the assessment results. Parental compliance was assessed as the monthly usage times and duration of the mobile app. For child compliance, we used data recorded by parents in the “behavior monitoring” module. We employed group-based trajectory modeling (GBTM) to identify distinct trajectories of parental and child compliance and examined their associations with childhood obesity outcomes. Univariate and multivariate logistic regressions were performed to identify the influencing factors associated with the identified compliance groups. Results: Distinct trajectory groups of parental and child compliance were identified. The compliance trajectories of parents and children are related to the extent of changes in the child’s obesity-related outcomes (waist circumference, waist-to-hip ratio, and body fat percentage. p < 0.05). A majority of parents were classified into the “relatively low compliance” group. Parents in this group was associated with having a daughter (OR: 1.95, 95% CI: 1.17, 3.31) and the father having a higher education level (OR: 1.65, 95% CI: 1.05, 2.60). For children, 20.2% were assigned to the “decreasing compliance” group. Children in this group were more likely to have a younger mother (OR: 1.05, 95% CI: 1.01, 1.10) and parents with poorer compliance (OR: 2.36, 95% CI: 1.16, 5.47). Conclusions: Both student and parental compliance were shown to influence the effectiveness of childhood obesity interventions, highlighting the need to prioritize the assessment and promotion of compliance in such interventions. Child sex, paternal educational level, and maternal age were identified as significant factors associated with compliance, while the level of family involvement was found to play a pivotal role in fostering healthy behaviors in children. These findings suggest that future intervention strategies should place greater emphasis on engaging families and providing targeted supervision and support for populations at risk of lower compliance in order to enhance intervention outcomes. Full article

In this study, droplet digital PCR and deep bisulfite sequencing were used to study the absolute and active rDNA copy number (CN) and the effect of paternal age on human and mouse sperm. The absolute CN ranged from 98 to 404 (219 ± 47) in human and from 98 to 177 (133 ± 14) in mouse sperm. Methylation of the human upstream control element/core promoter (UCE/CP) region and the 5′ external transcribed spacer, as well as that of the mouse CP, the spacer promoter, and 28S rDNA, significantly increased with donor age and absolute CN. Overall, rDNA hypomethylation was much more pronounced in mouse sperm, with 101.7 ± 11.4 copies showing a completely (0%) unmethylated and 11.3 ± 2.8 (8.5%) a slightly methylated (1–10%) CP region, compared to humans with 25.7 ± 9.5 (12%) completely unmethylated and 83.0 ± 19.8 slightly methylated UCE/CP regions. Although the absolute CN was much higher in human sperm, the number of copies with a hypomethylated (0–10%) promoter was comparable in humans (108.7 ± 28.3) and mice (113.0 ± 12.2). However, in mice, the majority (77%) of all copies were completely unmethylated, whereas in humans a high percentage (38%) showed one or two single CpG methylation errors. These different germline methylation dynamics may be due to species differences in reproductive strategies and lifespan. Complete demethylation of the sperm rDNA promoter in mice may be essential for embryonic genome activation, which already occurs at the 2-cell stage in mice and at the 4–8-cell stage in humans. The paternal age effect has been conserved between humans and mice with some notable differences. In humans, the number of hypomethylated (0–10%) copies decreased with age, whereas in mice only the completely unmethylated copies decreased with age. The number of methylated rDNA copies (>1% in mice and >10% in humans) significantly increased with age. Full article

Background: The development of children is shaped by a complex interplay of biological, psychological, and social factors, yet the role of fathers remains underrepresented in research. This study contributes to addressing this gap by examining paternal involvement through the Parent–Child Relationship Scale (P-CRS), an observational tool previously validated for mother–child interactions. Methods: The sample included 204 father–child dyads, with children aged 6 months to 5 years (mean age: 43.3 months), encompassing both clinical and non-clinical groups. Experienced clinicians conducted in vivo observations across 4–5 sessions, scoring interactions along three dimensions: parent, child, and interaction. Results: Confirmatory factor analysis (CFA) validated the P-CRS’s applicability to father–child relationships, confirming its psychometric robustness and alignment with the factors observed in mother–child dyads. Conclusions: These findings highlight the unique and complementary role of fathers in shaping developmental trajectories and underscore the importance of incorporating fathers in parenting interventions and assessments. Additionally, they demonstrate the P-CRS’s effectiveness in capturing the nuanced dynamics of early parent–child relationships. Future research should investigate longitudinal differences in parental roles and expand the P-CRS’s application to diverse family structures. Full article

The postnatal development of gonadal glands in seasonal breeders, particularly small rodent species, is influenced by photoperiodic patterns. However, little research has been conducted on the effects of pattern similarity and age differentiation especially in molecular features. This study compares the postnatal development of gonadal glands and the expression of hypothalamic genes related to reproductive regulation in male offspring of Brandt’s voles (Lasiopodomys brandtii) born under three types of changing photoperiodic patterns: increasing long photoperiod (ILP, 12 h + 3 min/day), natural increasing long photoperiods (NLPs), and decreasing short photoperiods (DSPs, 12 h − 3 min/day), as well as in their paternal voles exposed to these patterns at the same period. Results indicate that over the course of 12 postnatal weeks, gonadal development, including organ masses and serum testosterone levels, exhibited similar profiles between the ILP and NLP groups, which were significantly higher than those observed in DSP offspring. Hypothalamic type 3 iodothyronine deiodinase (Dio3) exhibited significantly higher expression in the DSP group from postnatal week 4 to 8 compared to the other two groups. These physiological and molecular differences gradually decreased with age in offspring, but were never observed in the paternal voles, indicating divergent photoperiodic responses between the two ages. The synchronous profiles observed between hypothalamic Dio3 expression and gonadal activities underscore its crucial role in interpreting photoperiodic signals and regulating gonadal development in Brandt’s voles. Full article

Introduction and Aim: Propranolol is an effective treatment option for infantile hemangiomas, but there is still insufficient information about neurodevelopmental side effects of propranolol. In our study, the neurodevelopmental levels of infantile hemangioma patients receiving propranolol treatment were examined using the Bayley-III test. Method: In our single-center, cross-sectional study, patients were recruited between 1 January 2020 and 31 December 2023. In total, 40 children (n1) diagnosed with hemangioma who received propranolol treatment and 31 children (n2) who were only under observation were included. A control group of 31 healthy children (n3) matched for age and gender was also included. The demographic, clinical, perinatal, and postnatal characteristics of the total 102 children were recorded from their medical records. Neurodevelopmental levels were assessed with the Bayley-III test. The significance level was set at (p < 0.05). Results: The Bayley-III test composite and percentile scores were used to evaluate the neurodevelopmental levels. Significant differences in motor functions were found between the treated and untreated groups compared to the healthy control group (p = 0.006 and p = 0.006). However, no significant differences were found in cognitive, language, and social-emotional skills. Cognitive, language, and motor functions were associated with maternal education level, and additionally, cognitive functions were also associated with paternal education level. Conclusions: Propranolol has a relatively safer side effect profile, and therefore, it has been described as a safe agent. In our study, no significant effect of propranolol on neurodevelopment was observed. The difference in motor skills shown was mainly between the healthy control group (n3) and the treated and untreated group (n1 and n2), which led to the conclusion that the relevant difference could be due to factors other than propranolol itself. Full article

Background/Objectives: This study addresses the significance of mental health concerns by examining the intergenerational transmission of mental health between parents and adolescents. It investigates the serial mediating effects of family resilience, adolescents’ adverse childhood experiences (ACEs), and their ability to flourish in the transmission of mental health from parents to adolescents, with a focus on sex differences. Methods: This study used a sample of 54,434 adolescents aged 12–17 from the 2016–2020 National Survey of Children’s Health (NSCH). Mothers reported on their mental health status and family resilience, and adolescents’ ACEs, flourishing, and mental health problems including depression and anxiety. Serial mediation models were used to assess the hypotheses. Results: The findings revealed that better parental mental health status was associated with fewer mental health problems in adolescents, with significant sex differences observed in these associations. Specifically, in both maternal and paternal models, better parental mental health was linked to higher family resilience, which was associated with fewer ACEs, greater flourishing, and ultimately fewer adolescent mental health problems. Furthermore, maternal mental health had a stronger association with daughters’ mental health, while paternal mental health more strongly influenced sons’. Conclusions: These results highlight the importance of targeted prevention and clinical interventions to disrupt the intergenerational transmission of mental health issues. Full article

Background/Objectives: Oligodontia, the absence of six or more teeth excluding third molars, is a rare genetic condition, unlike hypodontia (missing one or more teeth), which is a relatively common human disease. Methods: To identify the genetic etiology of nonsyndromic oligodontia (NSO) families, we performed mutational analysis and investigated the functional effects of identified EDAR mutations. Whole-exome sequencing was conducted on recruited families with NSO. Bioinformatic analysis identified mutations in oligodontia-causing candidate genes, which were confirmed by Sanger sequencing and segregation within families. The impact of EDAR mutations on the EDA signaling pathway was assessed using luciferase activity analysis. Results: EDAR mutations were identified in three NSO families. A homozygous missense EDAR mutation (NM_022336.4: c.319A>G p.(Met107Val)) was found in the singleton proband of family 1. The proband of family 2 carried compound heterozygous EDAR mutations: a maternal missense mutation (c.319A>G p.(Met107Val)) and a paternal missense variant (c.1270G>A p.(Val424Met)). The proband of family 3 had heterozygous EDAR mutations: a maternal missense mutation (c.389T>A p.(Ile130Asn)) and paternal intronic variants in cis (c.[357-4G>A;440+50C>T]). Luciferase assays confirmed reduced transcriptional activity for all identified missense mutations, while splicing assays revealed altered splicing patterns. Conclusions: In conclusion, recessive EDAR mutations, including novel ones, were identified in NSO families, and their pathological mechanism was explored through transcriptional activity measurements. Full article

Background: The clinical significance of the genetic influence of vitamin D receptor polymorphisms has still not been well-analyzed. Objectives: To verify whether rs1544410, rs7975232 and rs731236 polymorphisms are associated with a higher 10-year fracture risk in postmenopausal women. Methods: The study group was a subset of a pre-defined population as part of the broader epidemiological research called the RAC-OST-POL Study and consisted of 358 postmenopausal women, chosen randomly from Racibórz (Poland) inhabitants (mean baseline age 65 ± 6.9 years, BMI 31.2 ± 5.5 kg/m²). From all participants’ medical history, data concerning co-morbidities, fracture history, the medication used, parental history of bone fractures, cigarettes and alcohol use were taken at baseline. Moreover, rs1544410, rs7975232 and rs731236 polymorphisms were analyzed. Next, over the following 10 years, participants were contacted once a year and questioned concerning new fractures events and their circumstances. Results: We did not find statistically significant main effects on the fracture incidence of single-polymorphism variants. However, there were some significant findings dependent on the co-existence of these polymorphisms and medical factors. Women with a positive history of parental fracture and configuration of CC rs7975232, AA rs731236 and CC rs1544410 had a higher fracture incidence. The risk of bone fracture was also significantly higher in the group of heterozygotes of AC rs7975232 if their BMI value was in the categories of normal weight or overweight, or if they were treated with calcium or vitamin D. Conclusions: Polymorphisms of rs1544410, rs7975232 and rs731236 are connected with the fracture incidence in postmenopausal women. Nevertheless, its influence should be considered with co-existing clinical factors, especially paternal fracture history, prior fracture, BMI value, any osteoporotic treatment or calcium/vit. D supplementation. Full article

Background and Objectives: Recurrent pregnancy loss (RPL) affects numerous couples worldwide and has traditionally been attributed mainly to maternal factors. However, recent evidence highlights significant paternal influences on pregnancy viability and outcomes. This review aims to comprehensively examine male contributions to pregnancy loss, focusing on underlying mechanisms, novel biomarkers, and integrated strategies for improved reproductive success. Materials and Methods: A comprehensive narrative review was conducted by searching databases including PubMed and Embase for the literature published from January 2004 to October 2024. Studies focusing on paternal influences in RPL—encompassing oxidative stress, genetic and epigenetic mechanisms, health conditions, lifestyle factors, environmental exposures, and advancements in sperm proteomics—were included. Inclusion criteria were peer-reviewed articles in English that directly addressed paternal factors in RPL; studies not meeting these criteria were excluded. Results: The review identified that paternal factors such as advanced age, metabolic and cardiovascular health issues, chronic diseases, lifestyle habits (e.g., smoking, alcohol consumption, poor diet), and environmental exposures significantly affect sperm integrity through mechanisms like oxidative stress, DNA fragmentation, and epigenetic alterations. Advanced paternal age and poor health conditions are associated with increased risks of miscarriage and adverse pregnancy outcomes. Novel sperm proteomic biomarkers have been identified, offering potential for enhanced diagnostics and personalized interventions. Integrated approaches involving multidisciplinary assessments, preventive strategies, and genetic counseling are essential for effectively addressing RPL. Conclusions: Integrating paternal factors into clinical evaluations is crucial for effectively addressing recurrent pregnancy loss. Recognizing and modifying paternal risk factors through lifestyle changes, medical interventions, and environmental management can improve pregnancy outcomes. The findings underscore the need for incorporating paternal assessments into standard care and highlight the importance of future research focusing on standardizing diagnostic protocols, expanding studies on paternal contributions, and integrating proteomic biomarkers into clinical practice to facilitate personalized treatment strategies. Full article

Objective: This clinical study aimed to explore the correlation between dental plaque levels in parents and their children. Specifically, the study examined differences in plaque correlation between mother–child and father–child pairs and evaluated the role of parental education in influencing children’s oral hygiene practices. Materials and Methods: A total of 196 subjects were recruited, comprising 49 mother–child and 49 father–child pairs, with children aged 6 to 15 years. Dental plaque was assessed using the O’Leary Plaque Control Record, applying a liquid plaque discloser and explorer. The plaque index was calculated as the percentage of dental surfaces with visible plaque relative to the total surfaces examined. Results: The findings revealed a significant positive correlation between the parental plaque index (IP_PARENTS) and the children’s plaque index (IP_CHILD) (p < 0.001), indicating a strong relationship. While the father’s plaque index (ID_PARENTS(FATHER)) showed a marginally positive effect on IP_CHILD (p = 0.0589), the interaction between father identification and IP_PARENTS had a significant negative impact (p = 0.0344), suggesting that paternal influence on children’s plaque levels may vary. The model accounted for 28% of the variability in IP_CHILD (pseudo R² = 0.2758). Conclusions: The analysis demonstrated a significant association between parental and child plaque levels, with minor differences observed between maternal and paternal influence. No significant effects were found for the age or gender of the children. Overall, increased plaque levels in parents were associated with higher plaque levels in their children, with slight variations depending on the parent’s role. Full article

Background/Objectives: Parental internalizing issues, particularly maternal mental health, can significantly influence adolescents’ mental health by altering parenting behaviors and roles. This study explores the role of parental rejection in moderating the relationship between parental depressive, anxiety, and stress symptoms and adolescents’ mental health and quality of life. Methods: One hundred thirty eight mothers (mean age: 47.96, SD = 5.06 years) and 68 fathers (mean age: 51.07, SD = 5.53 years) of adolescents aged 12–18 completed measures on mental health, parental rejection, and adolescent well-being. Results: Maternal rejection was found to moderate the relationship between maternal anxiety symptoms and adolescents’ quality of life, as well as between maternal anxiety symptoms and adolescents’ mental health problems. Paternal rejection moderated the relationship between paternal stress symptoms and adolescents’ mental health. However, parental rejection did not moderate the relationship between parental depression and adolescents’ quality of life or mental health. Conclusions: These findings highlight the distinct roles of maternal and paternal rejection in adolescent development and suggest that parental mental health, particularly anxiety and stress, has a significant impact on adolescent well-being. Future studies should consider the influence of both parents and focus on longitudinal effects. These results emphasize the need for interventions addressing parental rejection to improve adolescent outcomes. Full article

Background/Objectives: Adolescence is a critical period for experimenting with a wide range of risky behaviors, which are often influenced by family dynamics, including parental monitoring. This study aims to analyze the patterns of exposure to multiple substances and bullying among Croatian students by age and gender in 2022 and examine the association of exposure to multiple substances and bullying with maternal and paternal monitoring. Methods: The data were obtained from the 2022 Health Behaviour in School-aged Children (HBSC) study conducted in Croatia among students aged 11, 13, and 15. Two multinomial logistic regressions were performed separately by age and gender. Results: Exposure to multiple instances of bullying is more common among boys than girls in all three age groups, while exposure to multiple substances varies depending on age. The analysis revealed the strong protective effect of maternal monitoring against both substance use and bullying. Paternal monitoring showed less consistent effects but still indicated that lower paternal monitoring was associated with higher exposure to multiple substances and bullying, particularly at age 13. Conclusions: The patterns of multiple substance use and bullying vary by gender and age, emphasizing the need for tailored intervention strategies. Programs that strengthen parental monitoring, particularly maternal monitoring, should be prioritized. Full article