Search Results (544)

Background: While timely blood transfusion is critical for restoring oxygen-carrying capacity after coronary artery bypass grafting (CABG), allogeneic blood product transfusions are independently associated with increased long-term mortality, necessitating a risk-stratified approach to balance oxygen delivery against immunological complications and infection risks. Methods: We retrospectively analyzed 3376 patients undergoing isolated CABG between 2005 and 2023 at a single tertiary center. Patients who died during their perioperative hospital stay within 30 days were excluded. Transfusion burden was assessed both as the absolute number of blood product units (packed red blood cells, platelet transfusion, fresh frozen plasma) and as a percentage of calculated patient blood volume. The primary outcome was all-cause mortality at 5 years. Flexible Cox regression with penalized smoothing splines, adjusted for EuroSCORE II, was used to model dose–response relationships. Results: From our cohort of 3376 patients, a total of 137 patients (4.05%) received >10 units of packed red blood cells (PRBC) perioperatively. These patients were older (median 71 vs. 68 years, p < 0.001), more often female (29% vs. 15%, p < 0.001), and had higher preoperative risk (EuroSCORE II: 2.53 vs. 1.41, p < 0.001). After 5 years, mortality was 42% in the massive transfusion group versus 10% in controls. Spline regression revealed an exponential increase in mortality with transfused units: 14 units yielded a 1.5-fold higher hazard of death (HR 1.46, 95% CI 1.31–1.64), rising to HR 2.71 (95% CI 2.12–3.47) at 30 units. When transfusion was indexed to blood volume, this relationship became linear and more tightly correlated with mortality, with lower maximum hazard ratios and narrower confidence intervals. Conclusions: Indexing transfusion burden to the percentage of patient blood volume replaced provides a more accurate and clinically actionable predictor of 5-year mortality after CABG than absolute unit counts. Our findings support a shift toward individualized, volume-based transfusion strategies to optimize patient outcomes and resource stewardship in a time of limited availability of blood products. Full article

Chicken anemia virus (CAV) and Eimeria tenella (E. tenella) are economically important pathogens of the poultry industry worldwide. However, the impact of dual infection of these two pathogens in chickens remains unclear. This study investigated the pathogenic effects of dual infection with CAV and E. tenella using two trials. In Trial A, chickens were infected at 21 days of age (D21) with either CAV and E. tenella simultaneously (C₂₁ + T₂₁), CAV alone (C_21a), E. tenella alone (T₂₁), or PBS as a negative control (NC). In Trial B, chickens received CAV at D21 followed by E. tenella at D28 (C₂₁ + T₂₈), CAV alone at D21 (C_21b), E. tenella alone at D28 (T₂₈), or PBS at D21 (NC). Assays of lesion scores (LS), oocysts per gram (OPG) of feces, packed cell volume (PCV), and thymus index (TI) were used to assess variations in pathogenicity. Both the C₂₁ + T₂₁ and C₂₁ + T₂₈ groups showed higher OPG than the group infected with E. tenella alone, with significantly elevated OPG in the secondary infection scenario and more severe lesions in the concurrent co-infection group (p < 0.05). Anemia, indicated by PCV < 27%, was observed in the C₂₁ + T₂₁ group at day 28 and in the C₂₁ + T₂₈ group at day 35, both of which had significantly lower PCV values than the group infected with CAV alone (p < 0.001). Thymus atrophy was most severe in C₂₁ + T₂₁ at 28 days old (p < 0.05; p < 0.01). In this study, preliminary observations suggested that concurrent and secondary infections with CAV and E. tenella showed variable trends that may indicate potential interactions; however, these exploratory findings require more systematic validation in older chickens. Full article

The one-dimensional (1D) Sb(III)-based organic–inorganic hybrid perovskite (AImd)₂¹_∞[SbI₅] (AImd = 1-allylimidazolium) crystallizes in the orthorhombic, centrosymmetric space group Pnma. The structure consists of corner-sharing [SbI₆] octahedra forming 1D chains separated by allylimidazolium cations. Void analysis through Mercury CSD software confirmed a densely packed lattice with a calculated void volume of 1.1%. Integrated quantum theory of atoms in molecules (QTAIM) and non-covalent interactions index (NCI) analyses showed that C–H···I interactions between the cations and the ¹_∞[SbI₅]²⁻ network predominantly stabilize the supramolecular assembly followed by N–H···I hydrogen bonds. The calculated growth morphology (GM) model fits very well to the experimental morphology. UV–Vis diffuse reflectance spectroscopy allowed us to determine the optical band gap to 3.15 eV. Density functional theory (DFT) calculations employing the B3LYP, CAM-B3LYP, and PBE0 functionals were benchmarked against experimental data. CAM-B3LYP best reproduced Sb–I bond lengths, while PBE0 more accurately captured the HOMO–LUMO gap and the associated electronic descriptors. These results support the assignment of an inorganic-to-organic [Sb–I] → π* charge-transfer excitation, and clarify how structural dimensionality and cation identity shape the material’s optoelectronic properties. Full article

This study presents a performance-based concrete mix design methodology rooted in the paste–aggregate binary framework, aiming to reduce binder content while ensuring optimal workability and strength. We found that inter-particle spacing (SPT) and paste rheology jointly govern fresh concrete behavior, with slump increasing nonlinearly with SPT and a critical transition zone around 20–35 µm; paste yield stress controls slump, while plastic viscosity governs segregation resistance. A two-level strength model was developed to predict concrete strength from paste properties based on compactness and hydration (R² = 0.90). Fixing SPT at 25 µm was identified as optimal for achieving balanced flowability with minimal paste volume. This approach effectively decouples aggregate packing optimization from paste calibration, offering a physically interpretable and practical framework for designing sustainable, low-carbon, and low-shrinkage concrete. Full article

Gastrointestinal (GI) parasites not only significantly impact goat health and productivity but can also affect human health due to the zoonotic potential of some species. This study investigates the prevalence of internal parasites within the tropical monsoon ecosystem of southern Thailand, focusing on both phenotypic and molecular characteristics of the parasites and identifying associated risk factors in caprine farming systems. A total of 276 meat goats from Nakhon Si Thammarat province were examined, indicating an overall GI parasite prevalence of 88.8% (245/276), with strongyles and Eimeria spp. identified as the dominant parasites. In addition, mixed parasitic infections were observed in 72.2% of cases, whereas single infections comprised 27.8%. Strongyle-positive fecal samples were cultured and genetically sequenced, revealing the presence of Haemonchus contortus, Trichostrongylus colubriformis, and Oesophagostomum asperum. For associated risk factors, gender and grazing with other herds significantly impacted overall GI parasitic infections, while the gender, breed, and packed cell volume (PCV) affected the strongyle infection. A correlation analysis revealed a substantial relationship between strongyle egg per gram (EPG) counts and clinical parameters, indicating that monitoring animals with low body condition scores (BCS) and high Faffa Malan Chart (FAMACHA) scores could be an effective strategy for controlling strongyle infections. These findings highlight the importance of continued research and effective farm management practices to address strongyle infections in meat goats, improving their health and agricultural productivity in tropical regions. Moreover, the detection of four zoonotic parasites (Giardia spp., H. contortus, T. colubriformis, and Fasciola spp.) indicates the necessity for the routine surveillance and monitoring of zoonotic parasites in goats to mitigate potential human health risks. Full article

The energy consumption of current vertical-lifting underwater monitoring devices mainly falls into two categories: one fully supplied by battery packs; and the other partially by battery packs, with the rest from ocean thermal energy. Constrained by battery capacity, their operation time is limited, making long-term remote operations difficult. This study focuses on a device powered entirely by ocean thermal energy, which realizes the absorption and storage of energy through a phase change heat-exchange system, significantly extending its operation cycle and working area. A composite phase change material of n-hexadecane and graphite with a volume ratio of 9:1 is used. The Fluent software 2022 R1, based on the enthalpy-porosity method, simulates the phase change process of the device to analyze the effects of different structures and seawater temperatures. Results show that with the same phase change material volume and inner diameter of the cylindrical heat exchanger, a smaller outer diameter yields better phase change performance. Lower seawater temperature facilitates solidification. Due to natural convection in the liquid phase, the melting time is 520 s and solidification time is 4800 s, with the melting rate far exceeding the solidification rate. Full article

This study presents a systematic method for mix design for optimizing the aggregate proportions in concrete, aiming to minimize paste volume while ensuring adequate workability. Based on a binary paste–aggregate system model, the method refines the calculation of the aggregate packing density by excluding fine particles smaller than 75 μm and incorporating inter-particle interactions across multiple size fractions. A modified approach for calculating the aggregate’s specific surface area is introduced, which accounts for both intra-fraction particle size variation and particle morphology through image-based shape coefficients. Inter-particle spacing is identified as a key control parameter of concrete flowability. Using this criterion, an optimization strategy is developed to determine the ideal aggregate composition that achieves the required spacing with the least amount of paste. Experimental validation confirms that the model reliably predicts paste demand while maintaining desired workability and compressive strength. This physics-based, interpretable approach offers a practical alternative to data-intensive machine learning models and contributes to more sustainable and efficient concrete mix design. Full article

Background/Objectives: This study aims to investigate the influence of demographic, behavioral, anthropometric, and comorbid factors on brain atrophy in people living with HIV (PLWH). Methods: We conducted a cross-sectional study involving 121 HIV-positive patients, stratified into two groups, those with and without brain atrophy (BA). For each participant, we recorded demographic data, smoking status, physical activity levels, disease and treatment duration, and comorbidities. BA was quantitatively assessed using MRI-derived volumetric measurements of 47 cerebral substructures. Results: Patients with BA exhibited significantly reduced gray matter (GM) and white matter (WM) volumes alongside increased cerebrospinal fluid volumes, both in absolute and percentage measurements. WM atrophy was most pronounced in the frontal, parietal, and temporal lobes, with relative sparing of the occipital lobe. GM atrophy predominantly affected the basal ganglia (notably, the thalamus and putamen) and cortical regions, including the hippocampus, frontal, and parietal lobes. Significant positive correlations were observed between BA and both smoking status (pack–years) and disease duration, while physical activity demonstrated an inverse relationship (higher atrophy risk in those with less than 30 min of daily continuous walking). Non-adherence to antiretroviral therapy (ART) was also associated with BA. Among comorbidities, type 2 diabetes and HIV-associated neurocognitive disorders (HAND) showed the strongest associations with BA. Conclusions: Brain atrophy in PWH is correlated with smoking, physical inactivity, and the duration of HIV infection. Comorbid conditions, such as type II diabetes and HAND, amplify the risk for BA. We consider that early lifestyle interventions and optimized ART may mitigate the neurodegeneration process. Full article

For tropical forests characterized by tall and densely packed trees, even long-wavelength SAR signals may fail to achieve full penetration, posing a significant challenge for retrieving sub-canopy terrain using polarimetric interferometric SAR (InSAR)(PolInSAR) techniques. This paper proposes a single-baseline PolInSAR-based correction method for sub-canopy terrain estimation based on a one-dimensional lookup table (LUT) that links forest height to unpenetrated depth. The approach begins by applying an optimal normal matrix approximation to constrain the complex coherence measurements. Subsequently, the difference between the PolInSAR Digital Terrain Model (DTM) derived from the Random Volume over Ground (RVoG) model and the LiDAR DTM is defined as the unpenetrated depth. A nonlinear iterative optimization algorithm is then employed to estimate forest height, from which a fundamental mapping between forest height and unpenetrated depth is established. This mapping can be used to correct the bias in sub-canopy terrain estimation based on the PolInSAR RVoG model, even with only a small amount of sparse LiDAR DTM data. To validate the effectiveness of the method, experiments were conducted using fully polarimetric P-band airborne SAR data acquired by the European Space Agency (ESA) during the AfriSAR campaign over the Mabounie region in Gabon, Africa, in 2016. The experimental results demonstrate that the proposed method effectively mitigates terrain estimation errors caused by insufficient signal penetration or the limitation of single-interferometric geometry. Further analysis reveals that the availability of sufficient and precise forest height data significantly improves sub-canopy terrain accuracy. Compared with LiDAR-derived DTM, the proposed method achieves an average root mean square error (RMSE) of 5.90 m, representing an accuracy improvement of approximately 38.3% over traditional RVoG-derived InSAR DTM retrieval. These findings further confirm that there exist unpenetrated phenomena in single-baseline low-frequency PolInSAR-derived DTMs of tropical forested areas. Nevertheless, when sparse LiDAR topographic data is available, the integration of fully PolInSAR data with LUT-based compensation enables improved sub-canopy terrain retrieval. This provides a promising technical pathway with single-baseline configuration for spaceborne missions, such as ESA’s BIOMASS mission, to estimate sub-canopy terrain in tropical-rainforest regions. Full article

Cylindrical targets have a high utilization rate, but are difficult to manufacture. A large hollow ITTO segment with thin walls was prepared by cold isostatic pressure and two-stage sintering. The fabrication process yielded a segment with an outer diameter of 153 mm, an inner diameter of 135 mm, and a length of 700 mm, indicating a length to thickness ratio of up to 78. The dense and uniform green bodies ensure the achievement of high density and uniformity of the sintered body throughout its volume. The segment exhibited a high relative density of about 99.5% and a low resistivity of below 3.4 × 10⁻⁴ Ω·cm. The density and resistivity illustrate a minimal inhomogeneity along the length of the segment. The segment exhibits a cubic bixbyite phase and is characterized by densely packed fine grains with an average size of several microns. Therefore, these results establish a substantial foundation for the large-scale production of cylindrical ITTO segments. Full article

After prolonged production, the inter-layer heterogeneity of reservoirs increases. To enhance the utilization of low-permeability layers and improve overall reservoir recovery, this study employed sand-pack models with multiple measurement points and varying permeability, which were connected in parallel to more realistically simulate inter-layer heterogeneity. Plugging efficiency evaluation experiments and oil displacement experiments were conducted. The results demonstrated that, among a gel dispersion, microspheres, and PEG, the gel dispersion exhibited the highest plugging efficiency, reaching 86.57%. The optimized injection parameters for the gel dispersion were found to be a weight percentage of 5%, an injection volume of 0.25 PV, and a single injection round. The recovery rate can be increased by 34.68%. This achieved the optimal profile control for heterogeneous reservoirs and provided a valuable reference for oilfield development. Full article

This study evaluated the feasibility of including grape pomace in the diet of Santa Inês ewes during lactation, aiming to reduce the effects of gastrointestinal nematode (GIN) infections and improve productive performance. Grape pomace, which contains phenolic compounds and tannins, was provided as a dietary supplement, replacing 20% of the concentrate over 28 days of lactation, starting on day 7 after lambing. A total of 18 ewes were used, divided into two groups: supplemented (n = 8) and control (n = 10). The supplemented group showed significant reduction in fecal egg count on day 14 of lactation (p < 0.05) in comparison with the control group. Lambs from the supplemented group had higher weaning weights (p < 0.05). Additionally, the supplemented group showed higher values for packed cell volume and circulating eosinophils, indicating greater resilience to infections. Analysis of anti-L3 IgG against Haemonchus contortus revealed no significant differences between the groups. It is concluded that grape pomace supplementation demonstrated potential to improve hematological and productive parameters in lactating ewes, with more evident effects during early lactation. Although the results suggest a possible complementary role in controlling gastrointestinal nematodes, future studies are needed to confirm and optimize this nutritional strategy. Full article

Background: Logistics and transport, core of many business processes, are continuously optimized to improve efficiency and market competitiveness. The paper describes a modular coordination of vehicle routing and bin packing problems that enables independent instances of the problems to be joined together, with the aim that the vehicle routing solution satisfies all the constraints from real-world applications. Methods: The vehicle routing algorithm is based on an adaptive memory procedure that also incorporates a simple, one-dimensional bin packing problem. This preliminary packing solution is refined by a complex, three dimensional bin packing for each vehicle to identify the infeasible packages. The method iteratively adjusts virtual volumes until reaching near-optimal routes that respect bin-packing constraints. Results: The coordination enables independent applications of an adaptive memory procedure to vehicle routing and a genetic algorithm approach to bin packing while joining them in a computationally tractable way. Such a coordinated approach is applied to a frequently used public benchmark and proven to provide commensurate costs while significantly lowering algorithm complexity. Conclusions: The proposed method is further validated on a real industrial case study and provided additional savings of 14.48% in average daily distance traveled compared to the current industrial standard. Full article

Dy³⁺ single-doped and Dy³⁺/Eu³⁺ co-doped ZnO:B₂O₃:WO₃:Nb₂O₅ glass was successfully synthesized using the melt quenching method. The amorphous character of the prepared samples was confirmed by X-ray diffraction (XRD). The glass transition and crystallization temperatures were examined by differential scanning calorimetry (DSC). Raman spectroscopy was applied to investigate the glass microstructure. Physical properties like the density, molar volume, oxygen molar volume and oxygen packing density of the glass were also determined. The photoluminescence excitation (PLE) and emission (PL) spectra of the resultant glass types were measured. The obtained Dy³⁺ single-doped glass was characterized by strong luminescence at 482 and 574 nm, corresponding to the ⁴F_9/2 → ⁶H_15/2 (blue) and ⁴F_9/2 → ⁶H_13/2 (yellow) transitions, respectively, and weak luminescence at 663 nm and 753 nm due to the ⁴F_9/2 → ⁶H_11/2 (red) and ⁴F_9/2 → ⁶H_9/2 + ⁶F_11/2 (red) transitions. The luminescence results indicate that energy transfer from the Dy³⁺ to Eu³⁺ ions occurs in the proposed glass system. The emitted light from the Dy³⁺ single-doped glass was found to be yellow-orange. The Dy³⁺/Eu³⁺ co-doped samples emitted darker orange light. The obtained results show that the investigated types of glass have the potential to be used as orange light-emitting materials. Full article

Cold stress disrupts broiler homeostasis, and a single intervention may be insufficient for protection. This study examined the effects of early cold conditioning (25 ± 1 °C for 3 h at 5 days) and glutamine (Gln) supplementation on broiler thermotolerance during a 16 ± 1 °C cold challenge at 35 days. A 2 × 3 factorial design assigned 360 Cobb-500 broilers to six treatments (six replicates/treatment, ten birds/replicate) with three Gln levels (0%, 0.3%, and 0.5%) and two temperature conditions: standard temperature and a 7 °C reduction at 5 days old. Supplementing with 0.3% and 0.5% Gln and cold conditioning improved growth performance (p < 0.05), except for feed intake during the grower-finisher phase and overall growth with cold conditioning alone. Adding 0.3% and 0.5% Gln enhanced hemoglobin, total protein, albumin, triiodothyronine (T₃), thyroxine (T₄), antioxidant capacity, catalase (CAT), superoxide dismutase (SOD), heat shock protein 70 (HSP70), interleukin 2 (IL2), IL10, IL4, interferon-γ (INF-γ), and troponin-T levels (p < 0.05). Cold conditioning influenced packed cell volume, T₃, T₄, CAT, HSP70, IL10, INF-γ, and troponin-T levels (p < 0.05). Diet-temperature interaction influenced growth, antioxidant, and immune responses, but not hematological or biochemical indicators. Overall, dietary Gln at 0.3% and 0.5% and early cold conditioning may serve as complementary strategies to mitigate cold stress in broilers. Full article