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2nd Edition: Interventional Therapies and Management in Coronary Artery Disease
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2nd Edition: Interventional Therapies and Management in Coronary Artery Disease

A special issue of Journal of Cardiovascular Development and Disease (ISSN 2308-3425). This special issue belongs to the section "Acquired Cardiovascular Disease".

Deadline for manuscript submissions: 30 September 2025 | Viewed by 1994

Special Issue Editors

Prof. Dr. Tomasz Rakowski

E-Mail Website
Guest Editor
1. 2nd Department of Cardiology, Institute of Cardiology, Jagiellonian University Medical College, 30-688 Kraków, Poland
2. Department of Cardiology and Cardiovascular Interventions, University Hospital, 30-688 Kraków, Poland
Interests: coronary artery disease; acute coronary syndromes; percutaneous coronary interventions; antiplatelet therapy; cardiac imaging
Special Issues, Collections and Topics in MDPI journals
Dr. Łukasz Rzeszutko

E-Mail Website
Guest Editor
1. 2nd Department of Cardiology, Institute of Cardiology, Jagiellonian University Medical College, 30-688 Cracow, Poland
2. Department of Cardiology and Cardiovascular Interventions, University Hospital, 30-688 Cracow, Poland
3. Interventional Cardiology Department, District Hospital, 37-450 Stalowa Wola, Poland
Interests: aortic stenosis; coronary artery obstruction; percutaneous coronary intervention
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Due to the success of the first edition of the Special Issue "Interventional Therapies and Management in Coronary Artery Disease", https://www.mdpi.com/journal/jcdd/special_issues/Interventional_Coronary_Artery, we have launched a second edition.

Coronary artery disease is the leading cause of death worldwide, and numerous research studies are conducted to improve treatment strategies and, finally, patients’ outcomes. During recent years, we have observed rapid progress in invasive and non-invasive diagnostics, as well as in pharmacotherapy and interventional (percutaneous and surgical) techniques.

It is our pleasure to invite you to contribute to this Special Issue on “Interventional Therapies and Management in Coronary Artery Disease”, which is focused on several aspects of coronary artery disease in chronic and acute coronary syndrome patients. Authors are invited to submit original research studies, state-of-the-art reviews, short contributions, and case reports. This Special Issue is mostly focused on invasive and non-invasive coronary diagnostics, pharmacotherapy, coronary revascularization with percutaneous coronary interventions and surgical techniques, epidemiology, and outcome studies.

Prof. Dr. Tomasz Rakowski
Dr. Łukasz Rzeszutko
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Journal of Cardiovascular Development and Disease is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • coronary artery disease
  • myocardial ischemia
  • myocardial viability
  • chronic coronary syndromes
  • acute coronary syndromes
  • MINOCA
  • INOCA
  • coronary revascularization
  • percutaneous coronary interventions
  • coronary artery surgical revascularization
  • coronary artery bypass grafting
  • cardiac imaging

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Related Special Issue

Published Papers (3 papers)

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Research

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14 pages, 1315 KiB  
Article
Long-Term Outcomes of Mitral Valve Repair Versus Replacement in Patients with Ischemic Mitral Regurgitation: A Retrospective Propensity-Matched Analysis
by Ismail M. Elnagar, Rawan Alghamdi, Murtadha H. Alawami, Ahmad Alshammari, Abdulmalik A. Almedimigh, Monirah A. Albabtain, Alaa AlGhamdi, Huda H. Ismail, Mostafa A. Shalaby, Khaled A. Alotaibi and Amr A. Arafat
J. Cardiovasc. Dev. Dis. 2025, 12(4), 109; https://doi.org/10.3390/jcdd12040109 - 22 Mar 2025
Viewed by 255
Abstract
Background: The optimal surgical management of ischemic mitral regurgitation (IMR)—mitral valve repair (MVr) versus mitral valve replacement (MVR)—remains controversial, with limited evidence on long-term outcomes. This study aimed to compare the outcomes of MVr and MVR in patients with IMR, focusing on survival [...] Read more.
Background: The optimal surgical management of ischemic mitral regurgitation (IMR)—mitral valve repair (MVr) versus mitral valve replacement (MVR)—remains controversial, with limited evidence on long-term outcomes. This study aimed to compare the outcomes of MVr and MVR in patients with IMR, focusing on survival and recurrence of mitral regurgitation. Additionally, survival was compared based on preoperative characteristics. Methods: A retrospective cohort analysis was conducted at a tertiary referral center and included 759 patients who underwent surgery for IMR between 2009 and 2021. Propensity score matching identified 140 matched pairs. The outcomes assessed included hospital mortality, long-term survival, recurrence of mitral regurgitation, mitral valve reintervention rates, and echocardiographic changes over time. Results: In the matched cohort, no significant differences were observed in hospital mortality (10% for MVr vs. 10.7% for MVR, p > 0.99) or long-term survival (p = 0.534). However, MVr was associated with a higher rate of recurrent moderate or higher mitral regurgitation (29.04% vs. 10.37%, p < 0.001) compared to MVR. The mitral valve reintervention rates did not differ significantly between the groups. Echocardiographic follow-up revealed significant improvements in left ventricular function and dimensions, with no significant differences between the groups. A subgroup analysis revealed no difference in survival according to the age, gender, ejection fraction, EuroSCORE category, or right ventricular function between the MVr and MVR patients. Conclusions: MVr and MVR for IMR yielded comparable survival rates, but MVr was associated with a higher risk of recurrent MR. The efficacy of both surgical approaches across diverse patient populations was comparable, reinforcing the need for individualized decision-making based on other clinical and anatomical considerations. Full article
(This article belongs to the Special Issue 2nd Edition: Interventional Therapies and Management in Coronary Artery Disease)
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11 pages, 993 KiB  
Article
Evolution of the Percutaneous Coronary Intervention (PCI) and Coronary Artery Bypass Grafting (CABG) Indication and Mortality Rates in Spain from 2010 to 2019
by Óscar Gasulla, Antonio Sarría-Santamera, Ferran A. Mazaira-Font, Cielo García-Montero, Oscar Fraile-Martinez, Diego Cantalapiedra, Manuel F. Carrillo-Rodríguez, Belen Gómez-Valcárcel, Miguel Á. Ortega, Melchor Álvarez-Mon and Angel Asúnsolo
J. Cardiovasc. Dev. Dis. 2024, 11(11), 369; https://doi.org/10.3390/jcdd11110369 - 16 Nov 2024
Viewed by 770
Abstract
Percutaneous coronary intervention (PCI) and coronary artery bypass grafting (CABG) are the main interventional treatments for coronary artery disease (CAD) patients. Both procedures are constantly being perfected and developed. This study aims to analyze the evolution of intervention mortality rates of PCI and [...] Read more.
Percutaneous coronary intervention (PCI) and coronary artery bypass grafting (CABG) are the main interventional treatments for coronary artery disease (CAD) patients. Both procedures are constantly being perfected and developed. This study aims to analyze the evolution of intervention mortality rates of PCI and CABG in recent years in Spain. We use a database of all hospital discharges from CABG and PCI procedures in Spain during two periods, between the years 2010 to 2012 and 2016 to 2019. We elaborate two multivariate regression logistic models to test the differences in mortality between the two periods and the two procedures, adjusting the mortality rates by age, gender, and comorbidities. We find strong evidence that CABG significantly reduced mortality rates, especially in complex patients, while PCI remained almost constant. We also discuss how physicians incorporate the improvement in procedures’ performance into the decision-making for the recommendation of these two procedures in CAD patient management. Full article
(This article belongs to the Special Issue 2nd Edition: Interventional Therapies and Management in Coronary Artery Disease)
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Review

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12 pages, 663 KiB  
Review
Neuroprotective Strategies in Coronary Artery Disease Interventions
by Maurish Fatima, Akbar Bazarbaev, Asama Rana, Ruman Khurshid, Victory Effiom, Nyle Khalid Bajwa, Afsheen Nasir, Katherine Candelario, Sair Ahmad Tabraiz, Samantha Colon, Chanseo Lee, Sedem Dankwa and Irbaz Hameed
J. Cardiovasc. Dev. Dis. 2025, 12(4), 143; https://doi.org/10.3390/jcdd12040143 - 8 Apr 2025
Viewed by 351
Abstract
Neuroprotective strategies in coronary artery interventions are essential due to the rising number of high-risk patients undergoing procedures like coronary artery bypass grafting (CABG), totally endoscopic coronary artery bypass (TECAB), and hybrid revascularization. In this review article, we summarize the neurological complications associated [...] Read more.
Neuroprotective strategies in coronary artery interventions are essential due to the rising number of high-risk patients undergoing procedures like coronary artery bypass grafting (CABG), totally endoscopic coronary artery bypass (TECAB), and hybrid revascularization. In this review article, we summarize the neurological complications associated with coronary artery disease intervention and the risk mitigation strategies. CABG carries significant risks, including ischemic stroke, encephalopathy, seizures, and peripheral nerve injuries. Risk factors include advanced age, hypertension, diabetes, and atherosclerosis. Off-pump CABG minimizes stroke risk by avoiding aortic manipulation and CPB. TECAB and hybrid revascularization have fewer reported neurological complications but still pose risks of stroke and cranial nerve injuries. Pharmacological neuroprotection includes agents such as barbiturates, volatile anesthetics, lidocaine, NMDA receptor antagonists, magnesium, nimodipine, corticosteroids, and aprotinin. Deep hypothermic circulatory arrest (DHCA) is reserved for complex aortic cases requiring a bloodless surgical field. Intraoperative strategies involve cerebral perfusion monitoring, embolic protection devices, and therapeutic hypothermia. Preoperative optimization targets risk factors, arrhythmia prevention, and antiplatelet therapy management. Postoperatively, timely antiplatelet administration, glucose control, hemodynamic stabilization, and cognitive monitoring are critical. Comprehensive neuroprotective approaches, spanning pre- to postoperative phases, aim to reduce neurological complications and enhance outcomes in coronary interventions. Full article
(This article belongs to the Special Issue 2nd Edition: Interventional Therapies and Management in Coronary Artery Disease)
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