Search Results (35)

Glass-based microfluidic devices are essential for applications such as diagnostics and drug discovery, which utilize their optical clarity and chemical stability. This review systematically analyzes pulsed laser micromachining as a transformative technique for fabricating glass-based microfluidic devices, addressing the limitations of conventional methods. By examining three pulse regimes—long (≥nanosecond), short (picosecond), and ultrashort (femtosecond)—this study evaluates how laser parameters (fluence, scanning speed, pulse duration, repetition rate, wavelength) and glass properties influence ablation efficiency and quality. A higher fluence improves the material ablation efficiency across all the regimes but poses risks of thermal damage or plasma shielding in ultrashort pulses. Optimizing the scanning speed balances the depth and the surface quality, with slower speeds enhancing the channel depth but requiring heat accumulation mitigation. Shorter pulses (femtosecond regime) achieve greater precision (feature resolution) and minimal heat-affected zones through nonlinear absorption, while long pulses enable rapid deep-channel fabrication but with increased thermal stress. Elevating the repetition rate improves the material ablation rates but reduces the surface quality. The influence of wavelength on efficiency and quality varies across the three pulse regimes. Material selection is critical to outcomes and potential applications: fused silica demonstrates a superior surface quality due to low thermal expansion, while soda–lime glass provides cost-effective prototyping. The review emphasizes the advantages of laser micromachining and the benefits of a wide range of applications. Future directions should focus on optimizing the process parameters to improve the efficiency and quality of the produced devices at a lower cost to expand their uses in biomedical, environmental, and quantum applications. Full article

Bismuth telluride (Bi₂Te₃) has attracted significant attention due to its broadband ultrafast optical response and strong nonlinearity at high laser fluence in the field of optoelectronic materials. The objective of this work is to study the effect of Al doping on the structure, linear optical properties, and nonlinear optical absorption behavior of Bi₂Te₃ thin films. The amorphous Al-doped Bi₂Te₃ thin films with varying Al doping concentrations were prepared using magnetron co-sputtering. The structure and linear optical properties were characterized using X-ray diffraction, scanning electron microscopy, energy-dispersive X-ray spectroscopy, X-ray photoelectron spectroscopy, spectroscopic ellipsometry, and UV/Vis/NIR spectrophotometry. The third-order nonlinear optical absorption properties of Al: Bi₂Te₃ thin films were investigated using the open-aperture Z-scan system with a 100 fs laser pulse width at a wavelength of 800 nm and a repetition rate of 1 kHz. The results indicate that Al dopant reduces both the refractive index and extinction coefficient and induces a redshift in the optical bandgap. The optical properties of the films can be effectively modulated by varying the Al doping concentration. Compared with undoped Bi₂Te₃ thin films, Al-doped Bi₂Te₃ thin films exhibit larger nonlinear optical absorption coefficients and higher damage thresholds and maintaining high transmittance. These findings provide experimental evidence and a reliable approach for the further optimization and design of ultrafast nonlinear optical devices. Full article

We investigated the influence of the photobleaching (PB) effect on the dosimetry performances of a phosphosilicate single-mode optical fiber (core diameter of 6.6 µm) operated at 638 nm, within the framework of the LUMINA project. Different irradiation tests were performed under ~40 keV mean energy fluence X-rays at a 530 µ Gy(SiO₂)/s dose rate to measure in situ the radiation-induced attenuation (RIA) growth and decay kinetics while injecting a 638 nm laser diode source with powers varying from 500 nW to 1 mW. For injected continuous power values under 1 µW, we did not measure any relevant influence of the photobleaching effect on the fiber radiation sensitivity coefficient of ~140 dB km⁻¹ Gy⁻¹ up to ~30 Gy. Above 1 µW, the fiber radiation sensitivity is significantly reduced due to the PB associated with the signal and can decrease to ~80 dB km⁻¹ Gy⁻¹ at 1 mW, strongly affecting the capability of this fiber to serve as a dosimeter-sensitive element. Higher power values up to 50 µW can still be used by properly choosing a pulsed regime with periodic injection cycles to reduce the PB efficiency and maintain the dosimetry properties. Basing on the acquired data, a simple model of the photobleaching effect on a coil of the investigated fiber is proposed in order to estimate its sensitivity coefficient evolution as a function of the cumulated dose and its fiber length when injecting a certain laser power. Additional studies need to investigate the influence of the temperature and the dose rate on the PB effects since these parameters were fixed during all the reported acquisitions. Full article

The low-light-level absorption coefficient of OH-contained and H₂-impregnated synthetic fused silica material in 193 nm optical lithography application is determined via a laser calorimetry measurement. The fluence and repetition rate dependences of the absorptances of the deep ultraviolet (DUV)-fused silica samples with different thickness are measured. The measured dependences are fitted to a theoretical model, taking into consideration the generation and annealing of laser irradiation induced defects. The surface absorption, the low-light-level linear absorption coefficient, as well as the nonlinear absorption coefficient of the fused silica material are accurately determined via the fitting. The low-light-level linear absorption coefficients determined via the fluence dependence and the repetition rate dependence are in good agreement, demonstrating the reliability of the measured low-light-level absorption coefficient, which is the key parameter to the determination of the internal transmission of the DUV-fused silica material used in the 193 nm optical lithography. Full article

Pulsed laser ablation in liquids (PLAL) is a versatile technique to produce high-purity colloidal nanoparticles. Despite considerable recent progress in increasing the productivity of the technique, there is still significant demand for a practical, cost-effective method for upscaling PLAL synthesis. Here we employ and unveil the fundamentals of multi-beam (MB) PLAL. The MB-PLAL upscaling approach can bypass the cavitation bubble, the main limiting factor of PLAL efficiency, by splitting the laser beam into several beams using static diffractive optical elements (DOEs). A multimetallic high-entropy alloy CrFeCoNiMn was used as a model material and the productivity of its nanoparticles in the MB-PLAL setup was investigated and compared with that in the standard single-beam PLAL. We demonstrate that the proposed multi-beam method helps to bypass the cavitation bubble both temporally (lower pulse repetition rates can be used while keeping the optimum processing fluence) and spatially (lower beam scanning speeds are needed) and thus dramatically increases the nanoparticle yield. Time-resolved imaging of the cavitation bubble was performed to correlate the observed production efficiencies with the bubble bypassing. The results suggest that nanoparticle PLAL productivity at the level of g/h can be achieved by the proposed multi-beam strategy using compact kW-class lasers and simple inexpensive scanning systems. Full article

Background: Justification of imaging procedures such as cone beam computed tomography (CBCT) in radiotherapy makes no doubt. However, the CBCT composite dose is rarely reported or optimized, even though the repeated CBCT cumulative dose can be up to 3% of the prescription dose. This study aimed to evaluate the performance and utility of a new plastic scintillating optical fiber dosimeter for CBCT dosimetric quality assurance (QA) applications before a potential application in patient composite CBCT dosimetry. Methods: The dosimeter, made of 1 mm diameter plastic fiber, was installed under a linear accelerator treatment table and linked to photodetectors. The fiber impact on the fluence and dose delivered was respectively assessed with an electronic portal imaging device (EPID) and EBT3 Gafchromic^® film. The presence of artifacts was visually evaluated on kV images. The dosimeter performances were determined for various acquisition parameters by comparison with ionization chamber values. Results: The maximum impact of the fiber on the fluence measured by the EPID was −1.2% for the 6 MV flattening filter-free beam. However, the fiber did not alter the film dose profile when measured for all the beams tested. The fiber was not visible at energies ≥ 80 kV and was merely visible on the CBCT images. When the rate of images per second or mA was changed, the maximum relative difference between the device and the ionization chamber CTDIs was <5%. Changing collimation led to a −7.2% maximum relative difference with an absolute dose difference that was insignificant (−0.3 mGy). Changing kV was associated with a −8.7% maximum relative difference, as published in the literature. Conclusions: The dosimeter may be a promising device for CBCT recurrent dosimetry quality control or dose optimization. According to these results, further developments are in progress in order to adapt the solution to the measurement of patient composite CBCT doses. Full article

: Lasers are demonstrating high impact in many medical and biological applications. They have different interaction mechanisms within tissues depending on operational parameters, particularly the wavelength. In addition, the optical properties of the examined tissue (i.e., absorption and scattering properties) influence the efficacy of the applied laser. The development of optical biomedical techniques relies on the examination of tissues’ optical properties, which describe the viability of tissue optical evaluation and the effect of light on the tissue. Understanding the optical properties of tissues is necessary for the interpretation and evaluation of diagnostic data, as well as the prediction of light and energy absorption for therapeutic and surgical applications. Moreover, the accuracy of many applications, including tissue removal and coagulation, depends on the tissues' spectroscopic characteristics. In the current paper, a set of ex vivo absorption and scattering coefficients of different types of biological samples (skin, skull, liver and muscle) at 650 nm laser irradiation were retrieved using an integrating phere system paired with the Kubelka–Munk model. The obtained optical parameters were utilized to acquire the local fluence rate within the irradiated tissues based on the Monte Carlo simulation method and the diffusion approximation of the radiative transfer equation. The obtained results reveal that the optical absorption and scattering coefficients control the light propagation and distribution within biological tissues. Such an understanding refers to system design optimization, light delivery accuracy and the minimization of undesirable physiological effects such as phototoxicity or photobleaching. Full article

The photo-induced charge dynamics of textbook wide-bandgap semiconductor ZnO have been investigated on the picosecond time-scale. We performed optical Pump-THz Probe experiments in order to measure the dielectric constant of the material after high-fluence photo-excitation of charge carriers. The technique allows access to both carrier lifetime and scattering rates, and it provides direct access to the intrinsic dielectric function changes upon excitation. A complex dynamic is unveiled in the high-fluence pumping regime, where the relaxation time is in the hundreds of picoseconds range and increases with increasing Pump fluence, while the onset of photoconductivity takes place in a few picoseconds. The plasma frequency and the relaxation time dependence on the Pump fluence are discussed. Full article

There are no effective treatments for patients with extrinsic malignant central airway obstruction (MCAO). In a recent clinical study, we demonstrated that interstitial photodynamic therapy (I-PDT) is a safe and potentially effective treatment for patients with extrinsic MCAO. In previous preclinical studies, we reported that a minimum light irradiance and fluence should be maintained within a significant volume of the target tumor to obtain an effective PDT response. In this paper, we present a computational approach to personalized treatment planning of light delivery in I-PDT that simultaneously optimizes the delivered irradiance and fluence using finite element method (FEM) solvers of either Comsol Multiphysics^® or Dosie™ for light propagation. The FEM simulations were validated with light dosimetry measurements in a solid phantom with tissue-like optical properties. The agreement between the treatment plans generated by two FEMs was tested using typical imaging data from four patients with extrinsic MCAO treated with I-PDT. The concordance correlation coefficient (CCC) and its 95% confidence interval (95% CI) were used to test the agreement between the simulation results and measurements, and between the two FEMs treatment plans. Dosie with CCC = 0.994 (95% CI, 0.953–0.996) and Comsol with CCC = 0.999 (95% CI, 0.985–0.999) showed excellent agreement with light measurements in the phantom. The CCC analysis showed very good agreement between Comsol and Dosie treatment plans for irradiance (95% CI, CCC: 0.996–0.999) and fluence (95% CI, CCC: 0.916–0.987) in using patients’ data. In previous preclinical work, we demonstrated that effective I-PDT is associated with a computed light dose of ≥45 J/cm² when the irradiance is ≥8.6 mW/cm² (i.e., the effective rate-based light dose). In this paper, we show how to use Comsol and Dosie packages to optimize rate-based light dose, and we present Dosie’s newly developed domination sub-maps method to improve the planning of the delivery of the effective rate-based light dose. We conclude that image-based treatment planning using Comsol or Dosie FEM-solvers is a valid approach to guide the light dosimetry in I-PDT of patients with MCAO. Full article

This study demonstrates a passive mode-locked erbium-doped fiber laser with a graphene nanoplatelet-saturable absorber (GNP-SA) that generates ultrashort pulses within femtosecond pulse duration. The GNP-SA is fabricated via a direct transfer approach by mechanically exfoliated graphene on a fiber ferrule. Its characteristics include 0.8% modulation depth, 8.7 MW/cm² saturation fluence, and 36.8% absorbance. The quality of ultrashort pulses is studied with a variation of intracavity circulating powers that is controlled through an optical coupler. By changing the light intensity in the cavity, the optical amplification property in the erbium-doped fiber is also impacted. The increment of the output coupling ratio increases the population inversion in the active gain medium, which leads to the change of lasing wavelength from 1558 to 1532 nm. Using a 50% output coupling ratio, the fiber laser generates 960 fs pulse duration, 11.08 MHz repetition rate, and 6.05 mW output power. This study contributes to the understanding of oscillating light behavior while changing its intracavity power that affects the optical amplification properties. Full article

Optical diagnostics methods are significantly appealing in biological applications since they are non-destructive, safe, and minimally invasive. Laser-induced fluorescence is a promising optical spectrochemical analytical technique widely employed for tissue classification through molecular analysis of the studied samples after excitation with appropriate short-wavelength laser light. On the other hand, diffuse optics techniques are used for tissue monitoring and differentiation based on their absorption and scattering characteristics in the red to the near-infrared spectra. Therefore, it is strongly foreseen to obtain promising results by combining these techniques. In the present work, tissues under different conditions (hydrated/dry skin and native/boiled adipose fat) were distinguished according to their fluorescence emission, absorption, and scattering properties. The selected tissues’ optical absorption and scattering parameters were determined via Kubelka–Munk mathematical model according to the experimental tissue reflectance and transmittance measurements. Such measurements were obtained using an optical configuration of integrating sphere and spectrometer at different laser wavelengths (808, 830, and 980 nm). Moreover, the diffusion equation was solved for the fluence rate at the sample surface using the finite element method. Furthermore, the accuracy of the obtained spectroscopic measurements was evaluated using partial least squares regression statistical analysis with 0.87 and 0.89 R-squared values for skin and adipose fat, respectively. Full article

In this study, we theoretically investigate the response of a germanium thin film under femtosecond pulsed laser irradiation. Electron and lattice temperatures, as well as material-specific optical properties such as dielectric function and reflectivity, were calculated during the irradiation using an extended two-temperature model coupled with the carrier density rate equation and the Drude model. Melting and ablation fluence thresholds were also predicted, resulting in 0.14 J cm⁻² and 0.35 J cm⁻², respectively. An ultrafast change in both optical and thermal properties was detected upon laser irradiation. Results also indicate that thermal melting occurs after germanium takes on a metallic character during irradiation, and that the impact ionization process may have a critical role in the laser-induced thermal effect. Therefore, we suggest that the origin of the thermal modification of germanium surface under femtosecond laser irradiation is mostly due the impact ionization process and that its effect becomes more important when increasing the laser fluence. Full article

Polycrystalline zinc selenide (ZnSe) and Cr²⁺ or Fe²⁺ doped ZnSe are key optical elements in mid-infrared laser systems. The laser-induced damage of the optical elements is the limiting factor for increasing the power and pulse energy of the lasers. In the present work, the optical damage of the ZnSe, Cr²⁺:ZnSe, and Fe²⁺:ZnSe samples induced by a repetitively pulsed Ho³⁺:YAG laser at 2091 nm was studied. The probability of the optical damage and the laser-induced damage threshold (LIDT) were determined for the samples manufactured using different processing techniques. The highest LIDT was found in ZnSe samples annealed in an argon atmosphere. It was also found that the samples annealed in a zinc atmosphere or with hot isostatic pressing resulted in a decrease in the LIDT. The Cr²⁺-doped ZnSe had the lowest LIDT at 2.1 µm compared to Fe²⁺-doped or undoped ZnSe. The LIDT fluence of all tested ZnSe samples decreased with the increase in the pulse repetition rate and the exposure duration. The results obtained may be used to improve the treatment procedures of ZnSe, Cr²⁺:ZnSe, and Fe²⁺:ZnSe polycrystals to further increase their LIDT. Full article

The accurate estimation of skin and skull optical properties over a wide wavelength range of laser radiation has great importance in optogenetics and other related applications. In the present work, using the Kubelka–Munk model, finite-element solution of the diffusion equation, inverse adding-doubling (IAD), and Monte-Carlo simulation, we estimated the refractive index, absorption and scattering coefficients, penetration depth, and the optical fluence distribution in rabbit head tissues ex vivo, after dividing the heads into three types of tissues with an average thickness of skin of 1.1 mm, skull of 1 mm, and brain of 3 mm. The total diffuse reflectance and transmittance were measured using a single integrating sphere optical setup for laser radiation of 532, 660, 785, and 980 nm. The calculated optical properties were then applied to the diffusion equation to compute the optical fluence rate distribution at the boundary of the samples using the finite element method. Monte-Carlo simulation was implemented for estimating the optical fluence distribution through a model containing the three tissue layers. The scattering coefficient decreased at longer wavelengths, leading to an increase in optical fluence inside the tissue samples, indicating a higher penetration depth, especially at 980 nm. In general, the obtained results show good agreement with relevant literature. Full article

A competitive new technology, organic metallic halide perovskite solar cells feature a wide working area, low manufacturing costs, a long lifespan, and a significant amount of large efficacy of power conversion (PCE). The spin-coating technique was utilized for the fabrication of pure CH₃NH₃PbBr₃ (MAPbBr₃) thin films, and these films are implanted with 600 keV silver (Ag) ions at fluency rate of 6 × 10¹⁴ and 4 × 10¹⁴ ions/cm². XRD analysis confirmed the cubic structure of MAPbBr₃. A high grain size was observed at the fluency rate of 4 × 10¹⁴ ions/cm². The UV-Vis spectroscopic technique was used to calculate the optical properties such as the bandgap energy (E_g), refractive index (n), extinction coefficients (k), and dielectric constant. A direct E_g of 2.44 eV was measured for the pristine film sample, whereas 2.32 and 2.36 eV were measured for Ag ion-implanted films with a 4 × 10¹⁴ and 6 × 10¹⁴ ions/cm² fluence rate, respectively. The solar cells of these films were fabricated. The J_sc was 6.69 mA/cm², FF was 0.80, V_oc was 1.1 V, and the efficiency was 5.87% for the pristine MAPbBr₃-based cell. All of these parameters were improved by Ag ion implantation. The maximum values were observed at a fluency rate of 4 × 10¹⁴ ions/cm², where the V_oc was 1.13 V, FF was 0.75, J_sc was 8.18 mA/cm², and the efficiency was 7.01%. Full article