Search Results (1,514)

Deep drilling and horizontal wells, as important means of unconventional oil and gas development, face problems with the high energy consumption but low removal efficiency of traditional well washing equipment, the uneven cleaning of horizontal well intervals, and an insufficient degree of automation. This paper proposes a novel hydraulic drive well washing device which consists of two main units. The wellbore cleaning unit comprises a hydraulic drive cutting–flushing module, a well cleaning mode-switching module, and a filter storage module. The unit uses hydraulic and mechanical forces to perform combined cleaning to prevent mud and sand from settling. By controlling the flow direction of the well washing fluid, it can directly switch between normal and reverse washing modes in the downhole area, and at the same time, it can control the working state of corresponding modules. The assembly control unit includes the chain lifting module and the arm assembly module, which can lift and move the device through the chain structure, allow for the rapid assembly of equipment through the use of a mechanical arm, and protect the reliability of equipment through the use of a centering structure. The device converts some of the hydraulic power into mechanical force, effectively improving cleaning and plugging removal efficiency, prolonging the downhole continuous working time of equipment, reducing manual operation requirements, and comprehensively improving cleaning efficiency and energy utilization efficiency. Full article

The Inner Mongolia Plateau (IMP), situated in the arid and semi-arid ecological transition zone of northern China, is particularly vulnerable to both climate change and human activities. Understanding the spatiotemporal vegetation dynamics and their driving forces is essential for regional ecological management. This study employs Sen’s slope estimation, BFAST analysis, residual trend method and Geodetector to analyze the spatial patterns of Normalized Difference Vegetation Index (NDVI) variability and distinguish between climatic and anthropogenic influences. Key findings include the following: (1) From 1982 to 2022, vegetation cover across the IMP exhibited a significant greening trend. Zonal analysis showed that this spatial heterogeneity was strongly regulated by regional hydrothermal conditions, with varied responses across land cover types and pronounced recovery observed in high-altitude areas. (2) In the western arid regions, vegetation trends were unstable, often marked by interruptions and reversals, contrasting with the sustained greening observed in the eastern zones. (3) Vegetation growth was primarily temperature-driven in the eastern forested areas, precipitation-driven in the central grasslands, and severely limited in the western deserts due to warming-induced drought. (4) Human activities exerted dual effects: significant positive residual trends were observed in the Hetao Plain and southern Horqin Sandy Land, while widespread negative residuals emerged across the southern deserts and central grasslands. (5) Vegetation change was driven by climate and human factors, with recovery mainly due to climate improvement and degradation linked to their combined impact. These findings highlight the interactive mechanisms of climate change and human disturbance in regulating terrestrial vegetation dynamics, offering insights for sustainable development and ecosystem education in climate-sensitive systems. Full article

Obesity and metabolic dysfunction are established risk factors for luminal breast cancer, yet current preclinical models inadequately recapitulate the complex metabolic and immune interactions driving tumorigenesis. To develop and characterize an immunocompetent rat model of luminal breast cancer induced by chronic exposure to a cafeteria diet mimicking Western obesogenic nutrition, female rats were fed a cafeteria diet or standard chow from weaning. Metabolic parameters, plasma biomarkers (including leptin, insulin, IGF-1, adiponectin, and estrone), mammary gland histology, tumor incidence, and gene expression profiles were longitudinally evaluated. Gene expression was assessed by PCR arrays and qPCR. A subgroup underwent dietary reversal to assess the reversibility of molecular alterations. Cafeteria diet induced significant obesity (mean weight 426.76 g vs. 263.09 g controls, p < 0.001) and increased leptin levels without altering insulin, IGF-1, or inflammatory markers. Histological analysis showed increased ductal ectasia and benign lesions, with earlier fibroadenoma and luminal carcinoma development in diet-fed rats. Tumors exhibited luminal phenotype, low Ki67, and elevated PAI-1 expression. Gene expression alterations were time point specific and revealed early downregulation of ID1 and COX2, followed by upregulation of MMP2, THBS1, TWIST1, and PAI-1. Short-term dietary reversal normalized several gene expression changes. Overall tumor incidence was modest (~12%), reflecting early tumor-promoting microenvironmental changes rather than aggressive carcinogenesis. This immunocompetent cafeteria diet rat model recapitulates key metabolic, histological, and molecular features of obesity-associated luminal breast cancer and offers a valuable platform for studying early tumorigenic mechanisms and prevention strategies without carcinogen-induced confounders. Full article

Background/Objectives: This study aims to investigate the effects of caffeinated chewing gum on maximal strength, muscular power, and neural drive to the prime movers during bench press and back squat in resistance-trained men. Methods: Sixteen resistance-trained males participated in a double-blind, randomized trial, chewing either caffeinated gum (4 mg/kg) or placebo gum on two separate occasions, seven days apart. After chewing for 5 min, participants performed a maximal strength test followed by muscular power assessments at 25%, 50%, 75%, and 90% of their one-repetition maximum (1RM), completing with 3, 2, 1, and 1 repetition (s), respectively, for bench press and back squat. Surface electromyography data were recorded for each repetition. Results: Caffeinated gum did not significantly improve one-repetition maximum (1RM) for bench press (p > 0.05), but increased mean frequency (MF) and median frequency (MDF) in anterior deltoid, pectoralis major, and biceps brachii (all p < 0.05) compared to placebo. For back squat, 1RM increased with caffeinated gum, along with higher MF and MDF in vastus medialis (all p < 0.05). Caffeinated gum also improved mean and peak velocities, and mean and peak power outputs at 25–75% 1RM during the bench press (all p < 0.05), along with elevated MDF in pectoralis major and biceps brachii (all p < 0.05). Similar improvements were seen in mean and peak velocities during the back squat at 25–90% 1RM (all p < 0.05), along with higher MF and MDF in vastus medialis and increased normalized root mean square activity in gluteus maximus (all p < 0.05). Conclusions: Caffeinated chewing gum (4 mg/kg) enhanced muscular power (25–75% 1RM) in the bench press and improved maximal strength and muscular power (25–90% 1RM) in the back squat by increasing muscle recruitment in resistance-trained men. Full article

Given that the Sunkoshi River watershed (located in the southern foot of the Himalayas) is sensitive to climate change and its mountain ecosystem provides important services, we aim to evaluate its spatial and temporal variation patterns of vegetation, represented by the Normalized Difference Vegetation Index (NDVI), during 2000–2021 and identify the dominant driving factors of vegetation change. Based on the NDVI dataset (MOD13A1), we used the simple linear trend model, seasonal and trend decomposition using loess (STL) method, and Mann–Kendall test to investigate the spatiotemporal variation features of NDVI during 2000–2021 on multiple scales (annual, seasonal, monthly). We used the partial correlation coefficient (PCC) to quantify the response of the NDVI to land surface temperature (LST), precipitation, humidity, and soil moisture. The results indicate that the annual NDVI in 52.6% of the study area (with elevation of 1–3 km) increased significantly, while 0.9% of the study area (due to urbanization) degraded significantly during 2000–2021. Daytime LST dominates NDVI changes on spring, summer, and winter scales, while precipitation, soil moisture, and nighttime LST are the primary impact factors on annual NDVI changes. After removing the influence of soil moisture, the contributions of climate factors to NDVI change are enhanced. Precipitation shows a 3-month lag effect and a 5-month cumulative effect on the NDVI; both daytime LST and soil moisture have a 4-month lag effect on the NDVI; and humidity exhibits a 2-month cumulative effect on the NDVI. Overall, the study area turned green during 2000–2021. The dominant driving factors of NDVI change may vary on different time scales. The findings will be beneficial for climate change impact assessment on the regional eco-environment, and for integrated watershed management. Full article

Under the continuous disturbance of ecosystems driven by urbanization, landscape fragmentation and the disruption of ecological processes and functions are key challenges in optimizing ecological networks (EN). This study aims to examine the spatiotemporal evolution of topological patterns, ecological processes, and ecosystem services (ES) in Wuhan from the “pattern–process–function” perspective. To overcome the lag in research concerning the coupling of ecological processes, functions, and spatial patterns, we explore the long-term dynamic evolution of ecosystem structure, process, and function by integrating multi-source data, including remote sensing, enabling comprehensive spatiotemporal analysis from 2000 to 2020. Addressing limitations in current EN optimization approaches, we integrate morphological spatial pattern analysis (MSPA), use circuit theory to identify EN components, and conduct spatial optimization accurately. We further assess the effectiveness of two scenario types: “pattern–function” and “pattern–process”. The results reveal a distinct “increase-then-decrease” trend in EN structural attributes: from 2000 to 2020, source areas declined from 39 (900 km²) to 37 (725 km²), while corridor numbers fluctuated before stabilizing at 89. Ecological processes and functions exhibited phased fluctuations. Among water-related indicators, water conservation (as a core function), and modified normalized difference water index (MNDWI, as a key process) predominantly drive positive correlations under the “pattern–function” and “pattern–process” scenarios, respectively. The “pattern–function” scenario strengthens core area connectivity (24% and 4% slower degradation under targeted/random attacks, respectively), enhancing resistance to general disturbances, whereas the “pattern–process” scenario increases redundancy in edge transition zones (21% slower degradation under targeted attacks), improving resilience to targeted disruptions. This complementary design results in a gradient EN structure characterized by core stability and peripheral resilience. This study pioneers an EN optimization framework that systematically integrates identification, assessment, optimization, and validation into a closed-loop workflow. Notably, it establishes a quantifiable, multi-objective decision basis for EN optimization, offering transferable guidance for green infrastructure planning and ecological restoration from a pattern–process–function perspective. Full article

Ultraviolet B (UVB) irradiation drives skin photodamage, prompting exploration of natural therapeutics. This study investigated the reparative effects and mechanisms of crude Gastrodia elata polysaccharides (GP) on UVB-induced acute skin damage. GP was extracted from fresh G. elata via water extraction and alcohol precipitation. It is a homogeneous polysaccharide with a weight-average molecular weight of 808.863 kDa, comprising Ara, Glc, Fru, and GalA. Histopathological analysis revealed that topical application of GP on the dorsal skin of mice effectively restored normal physiological structure, suppressing epidermal hyperplasia and collagen degradation. Biochemical assays showed that GP significantly reduced the activities of MPO and MDA following UVB exposure while restoring the enzymatic activities of SOD and GSH, thereby mitigating oxidative stress. Moreover, GP treatment markedly upregulated the anti-inflammatory cytokines TGF-β and IL-10 and downregulated the pro-inflammatory mediators IL-6, IL-1β, and TNF-α, suggesting robust anti-inflammatory effects. Transcriptomics revealed dual-phase mechanisms: Early repair (day 5) involved GP-mediated suppression of hyper inflammation and accelerated necrotic tissue clearance via pathway network modulation. Late phase (day 18) featured enhanced anti-inflammatory, antioxidant, and tissue regeneration processes through energy-sufficient, low-inflammatory pathway networks. Through a synergistic response involving antioxidation, anti-inflammation, promotion of collagen synthesis, and acceleration of skin barrier repair, GP achieves comprehensive repair of UVB-induced acute skin damage. Our findings not only establish GP as a potent natural alternative to synthetic photoprotective agents but also reveal novel pathway network interactions governing polysaccharide-mediated skin regeneration. Full article

Kallmann syndrome (KS) is a form of hypogonadotropic hypogonadism (HH) characterized by gonadotropin-releasing hormone (GnRH) deficiency and anosmia due to defective neuronal migration. While traditionally considered irreversible, cases of spontaneous improvement of HH have been reported, suggesting residual GnRH neuronal function in some individuals. We present a case of a 29-year-old man with KS who exhibited spontaneous recovery of endogenous testosterone production following the cessation of long-term androgen therapy without the use of alternative hormonal agents. After ceasing testosterone therapy for several months, the patient’s total testosterone levels normalized (407–424 ng/dL), accompanied by increased secondary sexual characteristics, stable gonadotropin levels, and normal testicular volume. Persistent anosmia was noted, suggesting that restoration of reproductive endocrine function can occur independently of olfactory recovery. Genetic testing identified heterozygous mutations in PCSK1 and HS6ST1, genes implicated in GnRH regulation and KS pathogenesis. This case highlights the potential role of genetic variation in spontaneous HH improvement and underscores the need for individualized management strategies, including periodic reassessment of gonadal function and fertility potential. Further research is needed to elucidate the mechanisms driving spontaneous HH improvement, identify predictive biomarkers of reversibility, and explore therapeutic strategies that may promote endogenous GnRH activity in select patients with KS. Full article

High-resolution groundwater storage is essential for effective regional water resource management. While Gravity Recovery and Climate Experiment (GRACE) satellite data offer global coverage, the coarse spatial resolution (0.25–0.5°) limits the data’s applicability at regional scales. Traditional downscaling methods often fail to effectively capture spatial heterogeneity within regions, leading to reduced model performance. To overcome this limitation, a zoned downscaling strategy based on time series clustering is proposed. A K-means clustering algorithm with dynamic time warping (DTW) distance, combined with a random forest (RF) model, was employed to partition the Hexi Corridor region into relatively homogeneous subregions for downscaling. Results demonstrated that this clustering strategy significantly enhanced downscaling model performance. Correlation coefficients rose from 0.10 without clustering to above 0.84 with K-means clustering and the RF model, while correlation with the groundwater monitoring well data improved from a mean of 0.47 to 0.54 in the first subregion (a) and from 0.40 to 0.45 in the second subregion (b). The driving factor analysis revealed notable differences in dominant factors between subregions. In the first subregion (a), potential evapotranspiration (PET) was found to be the primary driving factor, accounting for 33.70% of the variation. In the second subregion (b), the normalized difference vegetation index (NDVI) was the dominant factor, contributing 29.73% to the observed changes. These findings highlight the effectiveness of spatial clustering downscaling methods based on DTW distance, which can mitigate the effects of spatial heterogeneity and provide high-precision groundwater monitoring data at a 1 km spatial resolution, ultimately improving water resource management in arid regions. Full article

Lateritic soils in tropical regions feature cohesive textures and high specific resistance, driving up energy demands for tillage and harvesting machinery. However, current equipment designs lack discrete element models that account for soil moisture variations, and the microscopic effects of water content on lateritic soil deformation remain poorly understood. This study aims to calibrate and validate discrete element method (DEM) models of lateritic soil at varying moisture contents of 20.51%, 22.39%, 24.53%, 26.28%, and 28.04% by integrating the Hertz–Mindlin contact mechanics with bonding and JKR cohesion models. Key parameters in the simulations were calibrated through systematic experimentation. Using Plackett–Burman design, critical factors significantly affecting axial compressive force—including surface energy, normal bond stiffness, and tangential bond stiffness—were identified. Subsequently, Box–Behnken response surface methodology was employed to optimize these parameters by minimizing deviations between simulated and experimental maximum axial compressive forces under each moisture condition. The calibrated models demonstrated high fidelity, with average relative errors of 4.53%, 3.36%, 3.05%, 3.32%, and 7.60% for uniaxial compression simulations across the five moisture levels. Stress–strain analysis under axial loading revealed that at a given surface displacement, both fracture dimensions and stress transfer rates decreased progressively with increasing moisture content. These findings elucidate the moisture-dependent micromechanical behavior of lateritic soil and provide critical data support for DEM-based design optimization of soil-engaging agricultural implements in tropical environments. Full article

The electromechanical composite transmission technology for tracked vehicles demonstrates excellent performance in energy efficiency, mobility, and ride comfort. However, due to frequent operation under harsh conditions, the components of the electric drive system, such as drive motors, are prone to failures. This paper proposes three fault-tolerant control methods for three typical fault scenarios of the electromechanical composite transmission system (ECTS) to ensure the normal operation of tracked vehicles. Firstly, an ECTS and the electromechanical coupling dynamics model of the tracked vehicle are established. Moreover, a double-layer anti-windup PID control for motors and an instantaneous optimal control strategy for the engine are proposed in the fault-free case. Secondly, an anti-windup PID control law for motors and an engine control strategy considering the state of charge (SOC) and driving demands are developed in the case of single-side drive motor failure. Thirdly, a B4 clutch control strategy during starting and a steering brake control strategy are proposed in the case of electric drive system failure. Finally, in the straight-driving condition of the tracked vehicle, the throttle opening is set as 0.6, and the motor failure is triggered at 15 s during the acceleration process. Numerical simulations verify the fault-tolerant control strategies’ feasibility, using the tracked vehicle’s maximum speed and acceleration at 30 s as indicators for dynamic performance evaluation. The simulation results show that under single-motor fault, its straight-line driving power drops by 33.37%; with electric drive failure, the drop reaches 43.86%. The vehicle can still maintain normal straight-line driving and steering under fault conditions. Full article

In recent years, the rapid spread of electric vehicles (EVs) has intensified the competition to develop power units for EVs. In particular, improving the driving range of EVs has become a major topic, and in order to achieve this, many studies have been conducted on improving the efficiency of EV power units. In this study, we propose a multiple-inverter-drive permanent magnet synchronous motor based on an 8-pole, 48-slot structure, which is commonly used as an EV motor. The proposed motor is composed of two completely independent parallel inverters and windings, and intermittent operation is possible; that is, only one inverter and one parallel winding is used depending on the situation. In the proposed motor, we compare losses including stator iron loss, rotor iron loss, and magnet eddy current loss by PWM voltage inputs for some stator winding topologies, we show that the one-side winding arrangement is the most efficient during intermittent operation, and that it is more efficient than normal operation especially in the low-speed, low-torque range. Finally, through a vehicle-driving simulation considering the efficiency map including motor loss and inverter loss, we show that the intentional use of intermittent operation can improve electrical energy consumption. Full article

Vegetation is a fundamental component of terrestrial ecosystems. Understanding how vegetation changes and what drives these evolutions is crucial for developing a high-quality ecological environment and addressing global climate change. Extensive evidence has shown that China has undergone substantial vegetation changes, characterized primarily by greening. To quantify vegetation dynamics in China and assess the contributions of various drivers, we explored the spatiotemporal variations in the kernel Normalized Difference Vegetation Index (kNDVI) from 2001 to 2020, and quantitatively separated the influences of climate and human factors. The kNDVI time series were generated from the MCD19A1 v061 dataset based on the Google Earth Engine (GEE) platform. We employed the Theil-Sen trend analysis, the Mann-Kendall test, and the Hurst index to analyze the historical patterns and future trajectories of kNDVI. Residual analysis was then applied to determine the relative contributions of climate change and human activities to vegetation dynamics across China. The results show that from 2001 to 2020, vegetation in China showed a fluctuating but predominantly increasing trend, with a significant annual kNDVI growth rate of 0.002. The significant greening pattern was observed in over 48% of vegetated areas, exhibiting a clear spatial gradient with lower increases in the northwest and higher amplitudes in the southeast. Moreover, more than 60% of vegetation areas are projected to experience a sustained increase in the future. Residual analysis reveals that climate change contributed 21.89% to vegetation changes, while human activities accounted for 78.11%, being the dominant drivers of vegetation variation. This finding is further supported by partial correlation analysis between kNDVI and temperature, precipitation, and the human footprint. Vegetation dynamics were found to respond more strongly to human influences than to climate drivers, underscoring the leading role of human activities. Further analysis of tree cover fraction and cropping intensity data indicates that the greening in forests and croplands is primarily attributable to large-scale afforestation efforts and improved agricultural management. Full article

In recent decades, environmental requirements for reducing the toxic components emitted from vehicle exhausts have decreased drastically. Technologies for after-treatment of diesel vehicle emissions are being improved continuously in order to meet increasingly stringent regulations. Passenger cars are a significant source of air pollution, especially in urban areas. The EU has decided to phase out internal combustion engines. Stricter Real Driving Emissions (RDE) testing procedures have also been introduced, aiming to assess the emissions of nitrogen oxides (NO_x) and particle number (PN). The present work investigates the interaction between performance and smoke emissions of a diesel vehicle on a pre-established route in an urban environment with an everyday (normal) driving style. The results showed that when the vehicle is technically sound and meets its technical specifications, smoke emissions are within normal limits. Full article

Accurate terrestrial evapotranspiration (ET) estimation is crucial for understanding land–atmosphere interactions, evaluating ecosystem functions, and supporting water resource management, particularly across climatically diverse regions. To address the limitations of traditional ET models, we propose a simple yet robust Sigmoid-RH model that characterizes the nonlinear relationship between relative humidity and ET. Unlike conventional approaches such as the Penman–Monteith or Priestley–Taylor models, the Sigmoid-RH model requires fewer inputs and is better suited for large-scale applications where data availability is limited. In this study, we applied the Sigmoid-RH model to estimate ET over mainland China from 2001 to 2018 by using satellite remote sensing and meteorological reanalysis data. Key driving inputs included air temperature (Ta), net radiation (Rn), relative humidity (RH), and the normalized difference vegetation index (NDVI), all of which are readily available from public datasets. Validation at 20 flux tower sites showed strong performance, with R-square (R²) ranging from 0.26 to 0.93, Root Mean Squard Error (RMSE) from 0.5 to 1.3 mm/day, and Kling-Gupta efficiency (KGE) from 0.16 to 0.91. The model performed best in mixed forests (KGE = 0.90) and weakest in shrublands (KGE = 0.27). Spatially, ET shows a clear increasing trend from northwest to southeast, closely aligned with climatic zones, with national mean annual ET of 560 mm/yr, ranging from less than 200 mm/yr in arid zones to over 1100 mm/yr in the humid south. Seasonally, ET peaked in summer due to monsoonal rainfall and vegetation growth, and was lowest in winter. Temporally, ET declined from 2001 to 2009 but increased from 2009 to 2018, influenced by changes in precipitation and NDVI. These findings confirm the applicability of the Sigmoid-RH model and highlight the importance of hydrothermal conditions and vegetation dynamics in regulating ET. By improving the accuracy and scalability of ET estimation, this model can provide practical implications for drought early warning systems, forest ecosystem management, and agricultural irrigation planning under changing climate conditions. Full article