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Article

8 Citations

3,774 Views

19 Pages

Amelioration of Nicotine-Induced Conditioned Place Preference Behaviors in Mice by an FABP3 Inhibitor

Wenbin Jia,
Ichiro Kawahata,
An Cheng,
Takuya Sasaki,
Toshikuni Sasaoka and
Kohji Fukunaga

Int. J. Mol. Sci.2023, 24(7), 6644;https://doi.org/10.3390/ijms24076644

2 April 2023

We previously demonstrated that fatty acid-binding protein 3 null (FABP3−/−) mice exhibit resistance to nicotine-induced conditioned place preference (CPP). Here, we confirm that the FABP3 inhibitor, MF1 ((4-(2-(1-(2-chlorophenyl)-5-pheny...

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Article

9 Citations

3,368 Views

13 Pages

α-Conotoxin TxID and [S9K]TxID, α3β4 nAChR Antagonists, Attenuate Expression and Reinstatement of Nicotine-Induced Conditioned Place Preference in Mice

Xiaodan Li,
Shen You,
Jian Xiong,
Yamin Qiao,
Jinpeng Yu,
Dongting Zhangsun and
Sulan Luo

Mar. Drugs2020, 18(12), 646;https://doi.org/10.3390/md18120646

16 December 2020

Tobacco smoking has become a prominent health problem faced around the world. The α3β4 nicotinic acetylcholine receptor (nAChR) is strongly associated with nicotine reward and withdrawal symptom. α-Conotoxin TxID, cloned from Conus t...

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Article

20 Citations

3,925 Views

14 Pages

α-Conotoxin TxIB: A Uniquely Selective Ligand for α6/α3β2β3 Nicotinic Acetylcholine Receptor Attenuates Nicotine-Induced Conditioned Place Preference in Mice

Shen You,
Xiaodan Li,
Jian Xiong,
Xiaoyu Zhu,
Dongting Zhangsun,
Xiaopeng Zhu and
Sulan Luo

Mar. Drugs2019, 17(9), 490;https://doi.org/10.3390/md17090490

22 August 2019

α-Conotoxin TxIB is a specific antagonist of α6/α3β2β3(α6β2*) nicotinic acetylcholine receptor (nAChR) with an IC50 of 28 nM. Previous studies have shown that α6β2* nAChRs are abundantly expressed in...

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Article

4 Citations

4,131 Views

13 Pages

Alterations of Amphetamine Reward by Prior Nicotine and Alcohol Treatment: The Role of Age and Dopamine

Andrea Stojakovic,
Syed Muzzammil Ahmad and
Kabirullah Lutfy

Brain Sci.2021, 11(4), 420;https://doi.org/10.3390/brainsci11040420

26 March 2021

Evidence suggests that nicotine and alcohol can each serve as a gateway drug. We determined whether prior nicotine and alcohol treatment would alter amphetamine reward. Also, we examined whether age and dopaminergic neurotransmission are important in...

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