Search Results (917)

Critical transmission lines frequently traverse geologically complex mountainous regions, where harsh environments and variable climatic conditions pose significant geohazard risks. Utilizing 163 Sentinel-1A scenes (January 2018 to October 2023), we employed Multi-Temporal InSAR (MT-InSAR) to derive the deformation field along the transmission corridor. Time-series analysis of the Lingshao (LS) line towers, interpreted through the principles of mining subsidence, revealed the mechanisms behind their differential tilt. Simultaneously, time-series deformation at the tower footings was input to a deep learning model for 365-day prediction; the accuracy and practical applicability of which were rigorously assessed. The results demonstrate that (1) a unidirectional subsidence funnel within the transmission corridor deformation field, in the absence of zonal settlement features, strongly indicates the presence of a goaf beneath the line; (2) the integrated approach combining time-series InSAR with the settlement trough method proves feasible for monitoring transmission tower tilt, as validated through field verification; (3) the magnitude and direction of tower tilt correlate directly with their position in the mining-induced subsidence basin, showing convergent tilt in tensile zones, divergent tilt in compressive zones, and uniform settlement in neutral zones; (4) for the eight selected typical tower footings, predicted deformation values ranged from −284.6 mm to −186.3 mm, showing excellent agreement with measurements through correlation coefficients of 0.989–0.999 and Root Mean Square Error (RMSE) values of 0.54–2.17 mm. The framework enables proactive hazard avoidance during line routing and provides early warning for tower defects, significantly enhancing power infrastructure resilience in mining-affected regions. Full article

With the discovery of amorphous oxide semiconductors, a new era of electronics opened. Indium gallium zinc oxide (IGZO) overcame the problems of amorphous and poly-silicon by reaching mobilities of ~10 cm²/Vs and demonstrating thin-film transistors (TFTs) are easy to manufacture on transparent and flexible substrates. However, mobilities over 30 cm²/Vs have been difficult to reach and other materials have been introduced. Recently, polycrystalline In₂O₃ has demonstrated breakthroughs in the field. In₂O₃ TFTs have attracted attention because of their high mobility of over 100 cm²/Vs, which has been achieved multiple times, and because of their use in scaled devices with channel lengths down to 10 nm for high integration in back-end-of-the-line (BEOL) applications and others. The present review focuses first on the material properties with the understanding of the bandgap value, the importance of the position of the charge neutrality level (CNL), the doping effect of various atoms (Zr, Ge, Mo, Ti, Sn, or H) on the carrier concentration, the optical properties, the effective mass, and the mobility. We introduce the effects of the non-parabolicity of the conduction band and how to assess them. We also introduce ways to evaluate the CNL position (usually at ~E_C + 0.4 eV). Then, we describe TFTs’ general properties and parameters, like the field effect mobility, the subthreshold swing, the measurements necessary to assess the TFT stability through positive and negative bias temperature stress, and the negative bias illumination stress (NBIS), to finally introduce In₂O₃ TFTs. Then, we will introduce vacuum and non-vacuum processes like spin-coating and liquid metal printing. We will introduce the various dopants and their applications, from mobility and crystal size improvements with H to NBIS improvements with lanthanides. We will also discuss the importance of device engineering, introducing how to choose the passivation layer, the source and drain, the gate insulator, the substrate, but also the possibility of advanced engineering by introducing the use of dual gate and 2 DEG devices on the mobility improvement. Finally, we will introduce the recent breakthroughs where In₂O₃ TFTs are integrated in neuromorphic applications and 3D integration. Full article

Seed biochemical composition critically influences the quality and industrial value of oilseed rape (Brassica napus L.). Understanding the genetic basis of seed oil, protein, and fiber content is essential for breeding improved cultivars. Here we conducted a genome-wide association study (GWAS) on 350 diverse winter oilseed rape lines over three years, using near-infrared reflectance spectroscopy (NIRS) to measure seed traits and SNP genotyping for association mapping. We identified numerous SNP markers significantly associated with seed oil, protein, acid detergent fiber (ADF), and neutral detergent fiber (NDF) content. From 18,566 detected SNPs, 3782 met stringent criteria and were used for association mapping, resulting in 3189 significant associations across three years. The highest number of associations was observed for protein (3480), followed by NDF (3662), ADF (3422), and oil (2046). Individual markers explained up to 35% of phenotypic variation, indicating strong genetic control of these traits. Gene ontology enrichment analyses linked candidate genes to key metabolic and regulatory pathways influencing these traits: protein biosynthesis and post-translational modification, lipid metabolism regulated by phosphorylation, and transcriptional control of cell wall polysaccharide synthesis. These findings provide valuable molecular markers that can be validated for further use in marker-assisted selection, supporting the development of rapeseed cultivars with optimized seed quality for food, feed, and industrial applications. Full article

Stack effects in high-rise buildings cause noise, drafts, and elevator door malfunctions during cold weather yet remain difficult to control. Because vertical shafts couple pressures between floors, local fixes at a single lobby can unintentionally disturb the pressure field elsewhere. To analyze these interactions, we developed a measurement-calibrated CONTAM multizone model of a 43-story office building and evaluated representative local countermeasures. Under base winter conditions, the pressure difference across the problematic first-floor high-rise elevator doors is 56 Pa, driving approximately 1300 CMH of airflow through the door line. First-floor depressurization reduces this to 34 Pa (about 30% lower airflow) but simultaneously increases the pressure at the main entrance doors from 19 to 39 Pa. Additional first-floor partitions slightly reduce pressures on upper high-rise floors, whereas opening exterior windows in the high-rise zone increases shaft airflow by 7.7% and further amplifies elevator door pressures. We show that neutral pressure level (NPL) shifts into vertical shafts are a key mechanism limiting the effectiveness of purely local interventions. These results demonstrate that effective countermeasures must be designed at the whole-building scale, jointly controlling pressure redistribution and neutral-pressure-level movement while directing unavoidable pressure transfer toward the exterior envelope and away from sensitive interior spaces. Full article

This study evaluated the in vitro antioxidant and antiproliferative activity of hemp seed (Cannabis sativa L.) protein isolate, protein hydrolysate, and its fractions. The protein hydrolysate was obtained through sequential enzymatic digestion using pepsin and pancreatin, achieving a degree of hydrolysis of 48.11%. The hydrolysate was then fractionated by ultrafiltration. Assays conducted on Caco-2 (colorectal cancer) and THP-1 (leukemia) cell lines revealed that the higher-molecular-weight fraction of (>10 kDa) exhibited the strongest, concentration-dependent antiproliferative effect, as determined by the neutral red uptake (NRU) assay for Caco-2 cells and the MTT assay for THP-1 cells. Furthermore, a significant intracellular antioxidant activity was observed, particularly in the whole hydrolysate and its low-molecular-weight fractions, as measured by the DCFH-DA assay in Caco-2 cells. The results suggest the potential application of hemp seed protein hydrolysate and its fractions as antioxidant and chemoprotective supplements in oncologic therapies. Full article

Underground gas storage (UGS), encompassing hydrogen, natural gas, and compressed air, is a cornerstone of large-scale energy transition strategies, offering seasonal balancing, security of supply, and integration with renewable energy systems. However, the complexity of geological conditions, multiphysics coupling, and operational uncertainties pose significant challenges for UGS design, monitoring, and optimization. Artificial intelligence (AI)—particularly machine learning and deep learning—has emerged as a powerful tool to overcome these challenges. This review systematically examines AI applications in underground storage types such as salt caverns, depleted hydrocarbon reservoirs, abandoned mines, and lined rock caverns using bibliometric and knowledge-graph analysis of 176 publications retrieved from the Web of Science Core Collection. The study revealed a rapid surge in AI-related research on UGS since 2017, with underground hydrogen storage emerging as the most dynamic and rapidly expanding research frontier. The results reveal six dominant research frontiers: (i) AI-assisted geological characterization and property prediction; (ii) physics-informed proxy modeling and multi-physics simulation; (iii) gas–rock–fluid interaction, wettability, and interfacial behavior prediction; (iv) injection-production process optimization; (v) intelligent design and construction of underground storage, especially salt caverns; and (vi) intelligent monitoring, optimization, and risk management. Despite these advances, challenges persist in data scarcity, physical consistency, and generalization. Future efforts should focus on hybrid physics-informed AI, digital twin-enabled operation, and multi-gas comparative frameworks to achieve safe, efficient, and intelligent underground storage systems aligned with global carbon neutrality. Full article

In line with the global goal of achieving climate neutrality, a flexible energy system capable of accommodating the uncertainties induced by renewable energy sources becomes vitally important. This paper investigates the electricity demand flexibility characteristics and develops demand-response (DR) control strategies for grid-interactive buildings. First, a building’s flexible loads are classified into three types, interruptible loads (ILs), shiftable loads (SLs), and adjustable loads (ALs). The load flexibility characteristics, including real-time response capabilities, the time window range, and the adaptive adjustment ratios, are investigated. Second, DR control strategies and their features, which form the basis for achieving different optimization objectives, are detailed. Finally, three DR optimization objectives are proposed, including maximizing load reduction, maximizing economic benefits, and ensuring stable load reduction and recovery. Through case studies of a residential building and an office building, the results demonstrate the effectiveness of these DR strategies for load reduction and cost savings under different DR objectives. For the residential building, our results showed that over 50% of the electricity load could be shifted, resulting in electricity bill savings of over 17.6%. For office buildings, various DR control strategies involving zone temperature resetting, lighting dimming, and water storage utilization can achieve a total electricity load reduction of 28.1% to 63.6% and electricity bill savings of 7.39% to 26.79%. The findings from this study provide valuable benchmarks for assessing electricity flexibility and DR performance for other buildings. Full article

In this study, electrodeposition (ED) combined with a spark discharge-facilitated laser-induced breakdown spectroscopy—referred to as SD-LIBS—was employed for highly sensitive detection of trace chromium (Cr) in aqueous solutions. First, trace Cr ions in water were preconcentrated on the outer surface of an ultra-pure aluminum base by ED, effectively addressing the issue of poor detection sensitivity when LIBS is applied directly to liquid samples. Subsequently, SD-LIBS was employed for the analysis of the chromium (Cr) deposited on the aluminum (Al) exterior, where the spark discharge significantly enhanced the emission intensities of the Cr (I) spectral lines centered at 425.43 nm, 427.48 nm, and 428.90 nm. Based on the calibration curves obtained from standard solutions, the limits for the detection (LoD) with respect to chromium (Cr) under different discharge voltages were determined. With the elevation of discharge voltage over the 0–2 kV range, the LoDs of the neutral chromium (Cr) line I corresponding to 425.43 nm and 428.90 nm, the concentration levels of 3.86 n and 5.13 ng decreased to 1.19 ng and 1.57 ng, respectively, with all values referenced per milliliter. These results demonstrate that spark discharge further improves the detection sensitivity of LIBS in aqueous environments. Overall, the combined ED+SD-LIBS approach exhibits excellent analytical performance for trace metal detection in water, offering promising potential for water quality monitoring applications. Full article

A promising strategy for pancreatic cancer therapy involves developing nanocarriers capable of simultaneously delivering various antitumor substances with diverse physicochemical properties, often resulting in synergistic effects. In the present work, novel biocomposites were developed using amphiphilic N-vinylpyrrolidone polymer incorporating bortezomib (BTZ) and modified with either the DR5-selective TRAIL cytokine (DR5-B) or its fusion with the iRGD effector peptide (DR5-B-iRGD), resulting in AmphPVP-BTZ-DR5-B and AmphPVP-BTZ-DR5-B-iRGD formulations. The release of BTZ was most extensive at acidic pH 5.6, mimicking endolysosomal compartments, while at near-neutral pH 7.4 and alkaline pH 8.2 the release was slower and less complete, indicating a smart pH-responsive behavior suitable for triggered release in the tumor microenvironment. Both AmphPVP-BTZ-DR5-B and AmphPVP-BTZ-DR5-B-iRGD significantly inhibited the growth of pancreatic adenocarcinoma cell lines PANC-1, BxPC-3, and MIA PaCa-2 and induced more rapid internalization of the DR5 receptor in MIA PaCa-2 cells than unmodified particles and free DR5-B or DR5-B-iRGD. Importantly, AmphPVP-BTZ-DR5-B-iRGD exhibited a more pronounced DR5 internalization rate and cytotoxic effect than AmphPVP-BTZ-DR5-B owing to the presence of fusion protein with internalizing iRGD peptide. Both biocomposites induced cell death via the apoptotic pathway while exhibiting minimal cytotoxic effects on healthy cells. Therefore, biocomposites incorporating BTZ and functionalized with DR5-selective TRAIL variants DR5-B or DR5-B-iRGD represent a promising avenue for future studies in pancreatic cancer animal models. Full article

Background: The epithelial-to-mesenchymal transition (EMT) process is necessary for metastasis as it enables tumor cells’ migration and invasion. In the remote organ, tumor cells can develop into metastatic lesions or arrest their proliferation and become dormant, thus suspending metastatic development. EMMPRIN is a membrane glycoprotein, implicated in cell–cell interactions, proliferation, angiogenesis, and EMT. We asked whether neutralizing EMMPRIN with the new anti-EMMPRIN monoclonal antibody hMR18-mAb can inhibit EMT. Methods: We co-cultured tumor cell lines (breast carcinoma MCF-7, MDA-MB-231, or oral squamous cell carcinoma SCC-40) together with U937 monocytic-like cells, with or without hMR18-mAb or its negative control rabbit IgG. Results: We demonstrate that depending on the initial state of the cells along the epithelial–mesenchymal axis (E/M axis), co-culture enhanced the EMT process, whereas hMR18-mAb reversed this effect. The co-culture increased EMT-inducer cytokines in all cell lines (by 2.5-fold), while hMR18-mAb reduced them (by ~55–70% in the breast cancer cells and by 81% in the SCC-40 cells). The co-culture reduced E-cadherin (by 2-fold in MCF-7 and SCC-40 cells) and increased vimentin expression (by 2–3-fold in MDA-MB-231 and SCC-40), while hMR18-mAb reverted this effect. Co-culture enhanced proliferation, migration, and angiogenic potential of the tumor cells, while hMR18-mAb reduced these by ~20%, 30–44% and ~60–80%, respectively. Co-culture reduced the standard markers of dormancy (NR2F1, p21, p27) and stemness (SOX2, Nanog) (by 30–60% in MCF-7 and SCC-40), while hMR18-mAb elevated gene expression of these markers (by 1.5–3.5-fold) in all cell lines, pushing the cells towards dormancy. Conclusions: We conclude that EMMPRIN is a gatekeeper that prevents cells from entering dormancy, and that hMR18-mAb disrupts this effect. As it is the first antibody shown to induce dormancy in tumor cells and stop the development of metastases, this could become a new therapeutic strategy to prevent and treat metastasis. Full article

Within the “One Health, One Medicine” and comparative oncology paradigms, algal extracts have attracted attention, containing natural compounds (NCs) with biological activities, including anti-cancer properties. To characterize the biological effects of a Sphaerococcus coronopifolius extract (SCE), two canine mastocytoma and two normal cell lines were used. After a preliminary screening of three algal extracts, SCE cytotoxicity was measured using Alamar Blue, Sulforhodamine B, and Neutral Red Uptake assays. After assessing the selectivity versus tumor cells and its chemical characterization, SCE mechanisms of action were investigated using RNA-seq, quantitative PCR, flow cytometry and immunoblotting approaches. SCE showed an IC₅₀ comprised between 25 and 35 μg/mL in tumor cell lines, but it also affected normal ones (selectivity index < 2.0). RNA-seq and flow cytometry revealed that SCE negatively affected cell cycle and mevalonate pathway in tumor cells. Additional flow cytometry and immunoblotting investigations suggested a concentration- and time-dependent pro-apoptotic effect of SCE and DNA damage events. In conclusion, SCE demonstrated promising anti-cancer activity in mastocytoma cell lines by targeting the mevalonate pathway, arresting the cell cycle, and inducing apoptosis and DNA damage. Furthermore, the results presented here reinforce the idea that NCs may be promising candidates in comparative anti-cancer chemotherapy. Full article

This article explores Lebanese Christian digital presence within the framework of Sacred Algorithms: Religion in the Digital Age. In a society marked by economic collapse, migration, and religious plurality, digital platforms have become vital arenas for Christian witness, reshaping authority, belonging, and mission. The emergence of online clerical and lay initiatives shows how spiritual authority today is hybrid: rooted in sacramental legitimacy yet co-constructed through algorithmic visibility. The study develops four lines of analysis: the rise of digital spiritual authority in Lebanon and its negotiation within local and diaspora contexts; the ethical and theological challenges of surveillance and religious freedom in fragile environments; the successes and limitations of digital engagement, including the impact on parish life; and a theology of digital witness framed by proximity, synodality, solidarity, and mission in a multi-religious society. The Lebanese case highlights that algorithms are not neutral but powerful gatekeepers of religious presence. The central question is whether digital witness can remain faithful to the Gospel’s call to proximity, community, and transformation without being reduced to metrics of popularity and visibility. Full article

This article reassesses Ezra Pound’s Cathay as translation from Chinese Tang poetry rather than autonomous modernist verse. Building on Pound’s own poetics and compact coordinates from Chinese lyric theory, we argue that Cathay maintains translational fidelity by preserving and sharpening images while accepting losses in prosodic form and thinning some culture-specific encyclopaedias. Methodologically, we conduct a qualitative, contrastive microanalysis of two Li Bai poems “送友人” (Taking Leave of a Friend) and “长干行” (The River-Merchant’s Wife: A Letter), aligning the Chinese text, a neutral interlinear gloss, and Pound’s English version. A coding scheme tracks image handling, cultural markers, prosody, and the balance of phanopoeia, melopoeia, and logopoeia alongside domestication/foreignization choices. Findings show a stable hierarchy—image (phanopoeia)–stance (logopoeia)–sound/form (melopoeia)—that aligns with Chinese esthetic dynamics of yi/xiang (idea/form) and qing/jing (emotion/scene). Pound’s practice preserves correlative imagery (mountains/river/sunset; moss/leaves/butterflies) and voice, while paratextual titling, address terms, folklore allusions, toponyms, and a fifth-month calendar line reveal domestications, distortions, or omissions traceable to mediation via Fenollosa’s notes. We propose mechanism-sensitive criteria for evaluating distant-pair lyric translation: not formal replication, but reconstruction of the poem’s image–scene–emotion economy. On that basis, Cathay functions as translation—at justified costs. Rather than resolving the long-standing debate on Cathay, we offer a mechanism-sensitive account of how, in two central Li Bai poems, Pound’s image-centred poetics yields a limited but defensible form of translational fidelity within a relay-translation setting. Full article

Hydrothermal carbonization (HTC) is an effective method for processing wet sewage sludge without prior drying. This study investigates the influence of temperature (200 °C and 210 °C), residence time (15 and 30 min), and pH (neutral and acidic, pH = 2) on the properties of hydrochar and the liquid fraction. Increasing process severity enhanced carbonization, increasing carbon content from 36% in raw sludge to 43% in acidified samples. Under neutral HTC conditions, ash content exceeded 40%, while acidic conditions reduced it to 28%, indicating mineral dissolution and transfer into the liquid phase. Hydrogen and nitrogen contents remained within 3–6%, contributing to the fuel characteristics. The solid yield decreased from 1.04% in raw sludge to 0.22–0.37% after HTC, confirming intensified organic matter conversion. Acidic conditions significantly improved nutrient release to the liquid phase. PO₄³⁻ concentration increased from 337 to 375 mg/L under neutral conditions to over 675 mg/L, while P₂O₅ exceeded 509 mg/L. Conductivity rose from approximately 2.0 to 4.25 mS/cm, reflecting high ionic content. These results highlight the potential of the liquid fraction as a nutrient-rich stream that can be used for fertilizer recovery, particularly via struvite precipitation, and confirm that precise HTC parameter control supports resource recovery in line with circular economy principles. Full article

Background: Severe traumatic brain injury (TBI) often leads to elevated intracranial pressure (ICP) that requires aggressive management. Inducing burst suppression with deep sedation is an established therapy for refractory intracranial hypertension. Traditionally, barbiturate coma has been used to achieve burst-suppression EEG in TBI patients, but alternative sedative agents (propofol, midazolam, ketamine, dexmedetomidine) are increasingly utilized in modern neurocritical care. This review compares barbiturates with these alternatives for inducing burst suppression in adult TBI, focusing on protocols, mechanisms, efficacy in controlling ICP, safety profiles, and impacts on neurological outcomes. Methods: A search of the literature was performed, including clinical trials, observational studies, and guidelines on deep sedation for ICP control in adult TBI. Studies comparing high-dose barbiturates to other sedatives (propofol, midazolam, ketamine, dexmedetomidine) in the context of burst suppression or severe TBI management were included. Data on sedative protocols (dosing and EEG targets), mechanisms of action, ICP-lowering efficacy, complications, and patient outcomes were extracted and analyzed qualitatively. Results: High-dose barbiturates (e.g., pentobarbital or thiopental) and propofol are both effective at inducing burst-suppression EEG and reducing ICP via cerebral metabolic suppression. Barbiturate coma remains a third-tier intervention reserved for ICP refractory to other treatments. Propofol infusion has become first-line for routine ICP control due to rapid titratability and shorter half-life, though it can also achieve burst suppression at high doses. Midazolam infusions provide sedation and seizure prophylaxis but yield less metabolic suppression and ICP reduction compared to barbiturates or propofol, and are associated with longer ventilation duration and delirium. Ketamine, once avoided for fear of raising ICP, has shown neutral or lowering effects on ICP when used in ventilated TBI patients, thanks to its analgesic properties and maintenance of blood pressure; however, ketamine alone does not reliably produce burst-suppression patterns. Dexmedetomidine offers sedative and anti-delirium benefits with minimal respiratory depression, but it is generally insufficient for deep burst-suppressive sedation and has only a modest effect on ICP. In comparative clinical evidence, propofol and barbiturates both effectively lower ICP, but neither has demonstrated clear improvement in long-term neurological outcome when used prophylactically. Early routine use of barbiturate coma may increase complications (hypotension, immunosuppression), and thus, current practice restricts it to refractory cases. Modern sedation protocols emphasize using the minimal necessary sedation to maintain ICP < 22 mmHg, with continuous EEG monitoring to titrate therapy to a burst-suppression target (commonly 2–5 bursts per minute) when deep coma is employed. Conclusions: In adult TBI patients with intracranial hypertension, propofol-based sedation is favored for first-line ICP control and can achieve burst suppression if needed, whereas high-dose barbiturates are reserved for ICP crises unresponsive to standard measures. Compared to barbiturates, alternative agents (propofol, midazolam, ketamine, dexmedetomidine) offer differing advantages: propofol provides potent, fast-acting metabolic suppression; midazolam adds anticonvulsant sedation for prolonged use at the cost of slower wake-up; ketamine supports hemodynamics and analgesia; dexmedetomidine aids lighter sedation and delirium control. The choice of agent is guided by the clinical scenario, balancing ICP reduction needs against side effect profiles. While all sedatives can transiently reduce ICP, careful monitoring and a tiered therapy approach are essential, as no sedative has conclusively improved long-term neurological outcomes in TBI. EEG monitoring for burst suppression and meticulous titration is required when employing barbiturate or propofol coma. Ongoing research into optimal combinations and protocols may further refine sedation strategies to improve safety and outcomes in severe TBI. Full article