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19 pages, 1803 KiB  
Article
Sustainable Crop Farm Productivity: Weather Effects, Technology Adoption, and Farm Management
by Sun Ling Wang, Ryan Olver and Daniel Bonin
Sustainability 2025, 17(15), 6778; https://doi.org/10.3390/su17156778 - 25 Jul 2025
Abstract
The main purpose of this study is to understand the potential determinants of sustainable field crop farm productivity. This paper considers a multi-input, multi-output production technology to estimate the effects of aridity on farm-level productivity using a stochastic input distance function. By isolating [...] Read more.
The main purpose of this study is to understand the potential determinants of sustainable field crop farm productivity. This paper considers a multi-input, multi-output production technology to estimate the effects of aridity on farm-level productivity using a stochastic input distance function. By isolating the respective weather components of agricultural total factor productivity (TFP), we can better assess the impact on productivity of adopting various technologies and farm practices that might otherwise be masked by changing climate conditions or weather shocks. We make use of data from Phase 3 of the United States Department of Agriculture (USDA) Agricultural Resource Management Survey (ARMS) between 2006 and 2020. We supplement this estimation using field crop farm productivity determinants, including technology adoption and farm practice variables derived from the ARMS Phase 2 data. We identify several factors that affect farm productivity, including many practices that help farmers make more sustainable use of natural resources. The results show that adopting yield monitoring technology, fallowing in previous years, adding or improving tile drainage, and contour farming each improved farm productivity. In particular, during our study period, conservation tillage increased by over 300% across states on average. It is estimated to increase productivity level by approximately 3% for those adopting this practice. Critically, accounting for local weather effects increased the estimated productivity of nearly all farm practices and increased the statistical significance of several variables, indicating that other TFP studies that did not account for climate or weather effects may have underestimated the technical efficiency of farms that adopted these conservation practices. However, the results also show the impacts can be heterogeneous, with effects varying between farms located in the U.S. northern or southern regions. Full article
(This article belongs to the Special Issue Sustainable Agricultural and Rural Development)
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30 pages, 906 KiB  
Article
The Impact of Carbon Trading Market on the Layout Decision of Renewable Energy Investment—Theoretical Modeling and Case Study
by Ning Yan, Shenhai Huang, Yan Chen, Daini Zhang, Qin Xu, Xiangyi Yang and Shiyan Wen
Energies 2025, 18(15), 3950; https://doi.org/10.3390/en18153950 - 24 Jul 2025
Abstract
The Carbon Emissions Trading System (ETS) serves as a market-based mechanism to drive renewable energy (RE) investments, yet its heterogeneous impacts on different stakeholders remain underexplored. This paper treats the carbon market as an exogenous shock and develops a multi-agent equilibrium model incorporating [...] Read more.
The Carbon Emissions Trading System (ETS) serves as a market-based mechanism to drive renewable energy (RE) investments, yet its heterogeneous impacts on different stakeholders remain underexplored. This paper treats the carbon market as an exogenous shock and develops a multi-agent equilibrium model incorporating carbon pricing, encompassing power generation enterprises, power transmission enterprises, power consumers, and the government, to analyze how carbon prices reshape RE investment layouts under dual-carbon goals. Using panel data from Zhejiang Province (2017–2022), a high-energy-consumption region with 25% net electricity imports, we simulate heterogeneous responses of agents to carbon price fluctuations (CNY 50–250/ton). The results show that RE on-grid electricity increases (+0.55% to +2.89%), while thermal power declines (–4.98% to −15.39%) on the generation side. Transmission-side RE sales rise (+3.25% to +9.74%), though total electricity sales decrease (−0.49% to −2.22%). On the consumption side, RE self-generation grows (+2.12% to +5.93%), yet higher carbon prices reduce overall utility (−0.44% to −2.05%). Furthermore, external electricity integration (peaking at 28.5% of sales in 2020) alleviates provincial entities’ carbon cost pressure under high carbon prices. This study offers systematic insights for renewable energy investment decisions and policy optimization. Full article
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42 pages, 3781 KiB  
Article
Modeling Regional ESG Performance in the European Union: A Partial Least Squares Approach to Sustainable Economic Systems
by Ioana Birlan, Adriana AnaMaria Davidescu, Catalina-Elena Tita and Tamara Maria Nae
Mathematics 2025, 13(15), 2337; https://doi.org/10.3390/math13152337 - 22 Jul 2025
Viewed by 179
Abstract
This study aims to evaluate the sustainability performance of EU regions through a comprehensive and data-driven Environmental, Social, Governance (ESG) framework, addressing the increasing demand for regional-level analysis in sustainable finance and policy design. Leveraging Partial Least Squares (PLS) regression and cluster analysis, [...] Read more.
This study aims to evaluate the sustainability performance of EU regions through a comprehensive and data-driven Environmental, Social, Governance (ESG) framework, addressing the increasing demand for regional-level analysis in sustainable finance and policy design. Leveraging Partial Least Squares (PLS) regression and cluster analysis, we construct composite ESG indicators that adjust for economic size using GDP normalization and LOESS smoothing. Drawing on panel data from 2010 to 2023 and over 170 indicators, we model the determinants of ESG performance at both the national and regional levels across the EU-27. Time-based ESG trajectories are assessed using Compound Annual Growth Rates (CAGR), capturing resilience to shocks such as the COVID-19 pandemic and geopolitical instability. Our findings reveal clear spatial disparities in ESG performance, highlighting the structural gaps in governance, environmental quality, and social cohesion. The model captures patterns of convergence and divergence across EU regions and identifies common drivers influencing sustainability outcomes. This paper introduces an integrated framework that combines PLS regression, clustering, and time-based trend analysis to assess ESG performance at the subnational level. The originality of this study lies in its multi-layered approach, offering a replicable and scalable model for evaluating sustainability with direct implications for green finance, policy prioritization, and regional development. This study contributes to the literature by applying advanced data-driven techniques to assess ESG dynamics in complex economic systems. Full article
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26 pages, 1310 KiB  
Review
Combination Strategies with HSP90 Inhibitors in Cancer Therapy: Mechanisms, Challenges, and Future Perspectives
by Yeongbeom Kim, Su Yeon Lim, Hyun-Ouk Kim, Suk-Jin Ha, Jeong-Ann Park, Young-Wook Won, Sehyun Chae and Kwang Suk Lim
Pharmaceuticals 2025, 18(8), 1083; https://doi.org/10.3390/ph18081083 - 22 Jul 2025
Viewed by 243
Abstract
Heat shock protein 90 (HSP90) is a molecular chaperone that plays a pivotal role in the stabilization and functional activation of numerous oncoproteins and signaling molecules essential for cancer cell survival and proliferation. Despite the extensive development and clinical evaluation of HSP90 inhibitors, [...] Read more.
Heat shock protein 90 (HSP90) is a molecular chaperone that plays a pivotal role in the stabilization and functional activation of numerous oncoproteins and signaling molecules essential for cancer cell survival and proliferation. Despite the extensive development and clinical evaluation of HSP90 inhibitors, their therapeutic potential as monotherapies has been limited by suboptimal efficacy, dose-limiting toxicity, and the emergence of drug resistance. Recent studies have demonstrated that combination therapies involving HSP90 inhibitors and other anticancer agents such as chemotherapeutics, targeted therapies, and immune checkpoint inhibitors can enhance anticancer activity, overcome resistance mechanisms, and modulate the tumor microenvironment. These synergistic effects are mediated by the concurrent degradation of client proteins, the disruption of signaling pathways, and the enhancement of antitumor immunity. However, the successful clinical implementation of such combination strategies requires the careful optimization of dosage, administration schedules, toxicity management, and patient selection based on predictive biomarkers. In this review, we provide a comprehensive overview of the mechanistic rationale, preclinical and clinical evidence, and therapeutic challenges associated with HSP90 inhibitor-based combination therapies. We also discuss future directions leveraging emerging technologies including multi-omics profiling, artificial intelligence, and nanoparticle-mediated delivery for the development of personalized and effective combination regimens in oncology. Full article
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19 pages, 5627 KiB  
Article
Reliability Modeling of Wind Turbine Gearbox System Considering Failure Correlation Under Shock–Degradation
by Xiaojun Liu, Ziwen Wu, Yiping Yuan, Wenlei Sun and Jianxiong Gao
Sensors 2025, 25(14), 4425; https://doi.org/10.3390/s25144425 - 16 Jul 2025
Viewed by 272
Abstract
To address traditional methods’ limitations in neglecting the interaction between random shock loads and progressive degradation, as well as failure correlations, this study proposes a dynamic reliability framework integrating Gamma processes, homogeneous Poisson processes (HPP), and mixed Copula functions. The framework develops a [...] Read more.
To address traditional methods’ limitations in neglecting the interaction between random shock loads and progressive degradation, as well as failure correlations, this study proposes a dynamic reliability framework integrating Gamma processes, homogeneous Poisson processes (HPP), and mixed Copula functions. The framework develops a wind turbine gearbox reliability model under shock–degradation coupling while quantifying failure correlations. Gamma processes characterize continuous degradation, with parameters estimated from P-S-N curves. Based on stress–strength interference theory, random shocks within damage thresholds are integrated to form a coupled reliability model. A Gumbel–Clayton–Frank mixed Copula with a multi-layer nested algorithm quantifies failure correlations, with correlation parameters estimated via the RSS principle and genetic algorithms. Validation using a 2 MW gearbox’s planetary gear-stage system covers four scenarios: natural degradation, shock–degradation coupling, and both scenarios with failure correlations. The results show that compared to independent assumptions, the model accelerates reliability decline, increasing failure rates by >37%. Relative to natural degradation-only models, failure rates rise by >60%, validating the model’s effectiveness and alignment with real-world operational conditions. Full article
(This article belongs to the Section Fault Diagnosis & Sensors)
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19 pages, 996 KiB  
Article
Measuring Corporate Resilience Using Dynamic Factor Analysis: Evidence from Listed Companies in China
by Chunguang Sheng and Jingyan Li
Systems 2025, 13(7), 575; https://doi.org/10.3390/systems13070575 - 12 Jul 2025
Viewed by 282
Abstract
The scientific measurement of corporate resilience is a prerequisite for identifying risk vulnerabilities, formulating targeted support policies, and enhancing the stability of the economic system. This paper utilizes data from 2054 listed companies on China’s A-share market from 2007 to 2023 to construct [...] Read more.
The scientific measurement of corporate resilience is a prerequisite for identifying risk vulnerabilities, formulating targeted support policies, and enhancing the stability of the economic system. This paper utilizes data from 2054 listed companies on China’s A-share market from 2007 to 2023 to construct a corporate resilience evaluation system integrating three dimensions: risk resistance, adaptive adjustment, and recovery growth. Using a multi-level dynamic factor analysis, it depicts the multi-dimensional structure of resilience while introducing time series dynamic changes. This study found that corporate resilience has shown a steady upward trend overall, with phased fluctuations before and after major crisis events, which is highly consistent with macro- and microeconomic indicators. And fluctuations are primarily concentrated among low-resilience enterprises. The further analysis of low-resilience enterprises revealed the following: At the industrial level, compared with the primary industry, the secondary and tertiary industries have a higher proportion of low-resilience enterprises. At the regional level, the proportion of low-resilience enterprises in eastern and central regions decreased during shocks, while western regions showed a significant divergence, and northeastern regions consistently underperformed. This study offers empirical evidence and management insights for strengthening corporate resilience and enhancing the resilience of China’s economy. It also offers valuable insights for other countries in addressing external uncertainties and building economic resilience. Full article
(This article belongs to the Section Systems Practice in Social Science)
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16 pages, 1261 KiB  
Review
Extracorporeal Cytokine Adsorption in Sepsis: Current Evidence and Future Perspectives
by Matteo Guarino, Anna Costanzini, Francesco Luppi, Martina Maritati, Carlo Contini, Roberto De Giorgio and Michele Domenico Spampinato
Biomedicines 2025, 13(7), 1684; https://doi.org/10.3390/biomedicines13071684 - 9 Jul 2025
Viewed by 486
Abstract
Background: Sepsis and septic shock are major contributors to global morbidity and mortality. The “cytokine storm,” a hyper-inflammatory response, plays a central role in sepsis pathophysiology, leading to multi-organ failure. Extracorporeal cytokine adsorption therapies, such as CytoSorb, Toraymyxin, Oxiris, HA330/380, and Seraph [...] Read more.
Background: Sepsis and septic shock are major contributors to global morbidity and mortality. The “cytokine storm,” a hyper-inflammatory response, plays a central role in sepsis pathophysiology, leading to multi-organ failure. Extracorporeal cytokine adsorption therapies, such as CytoSorb, Toraymyxin, Oxiris, HA330/380, and Seraph 100 Microbind, aim to mitigate the inflammatory response by removing circulating cytokines and other mediators. Methods: A comprehensive search of Scopus and PubMed was conducted for studies published from January 2020 to May 2025. The search terms included “sepsis,” “septic shock,” and “extracorporeal cytokine adsorption.” Relevant studies, including clinical trials and meta-analyses, were included to assess the efficacy and safety of these therapies. Results: Extracorporeal cytokine adsorption has shown promising results in reducing cytokine levels, improving organ function, and decreasing vasopressor requirements. However, evidence regarding mortality reduction remains inconsistent. Studies have demonstrated benefits in sepsis, ARDS, and cardiogenic shock, improving organ recovery and inflammatory markers. Conclusions: Extracorporeal cytokine adsorption is a potential adjunctive therapy in sepsis management, offering improvements in organ function and inflammatory control. While the mortality benefit remains uncertain, ongoing research and large-scale clinical trials are essential to define its clinical role and optimize its application. Full article
(This article belongs to the Section Cell Biology and Pathology)
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23 pages, 5105 KiB  
Article
Behavioral, Hematological, Histological, Physiological Regulation and Gene Expression in Response to Heat Stress in Amur Minnow (Phoxinus lagowskii)
by Weijie Mu, Jing Wang, Yanyan Zhou, Shibo Feng, Ye Huang and Qianyu Li
Fishes 2025, 10(7), 335; https://doi.org/10.3390/fishes10070335 - 8 Jul 2025
Viewed by 353
Abstract
Rising water temperatures due to climate change pose a significant threat to Phoxinus lagowskii, a cold-water fish that is ecologically vital to the high-latitude regions of China. This study assessed heat stress effects on behavioral, hematological, histological, physiological, and molecular responses in [...] Read more.
Rising water temperatures due to climate change pose a significant threat to Phoxinus lagowskii, a cold-water fish that is ecologically vital to the high-latitude regions of China. This study assessed heat stress effects on behavioral, hematological, histological, physiological, and molecular responses in P. lagowskii. The critical maximum temperature (CTmax) was determined using the loss of equilibrium (LOE) method, with the CTmax reaching 29 °C. Elevated temperatures lead to an increase in the OBR. Fish were subjected to acute heat stress at 28 °C (below CTmax) for 48 h, with samples collected during the 48 h period. RBC, WBC, HGB, and HCT significantly increased during heat stress but decreased 12 h after heat stress. The levels of serum cortisol and blood glucose after heat stress were significantly higher than those in the control group. After heat stress, the height of the ILCM in the gills increased significantly, and the liver exhibited vacuolar degeneration and hypopigmentation. The activities of Na+-K+-ATPase and Ca2+-Mg2+-ATPase in the gills initially increased and then decreased over the duration of heat stress. Most enzyme activities (PK, LDH, PFK, and HK) decreased during heat stress, while LPL and HL levels increased, indicating that lipid metabolism was the primary utilization process under heat stress. There was an increase in SOD activity at 12 h, followed by a decrease at 24 h, and an increase in CAT activity under heat stress. Integrated biomarker response (IBR) and principal component analysis (PCA) were employed to synthesize multi-level responses. The IBR values reached their peak at 3 h and 48 h of heat stress. We observed an upregulation of heat shock proteins (Hsp70, Hsp90, and Hsc70) as well as interleukin-10 (IL-10) in response to heat stress. Our findings offer novel insights into the mechanisms underlying the heat stress response in P. lagowskii, thereby enhancing our understanding of the effects of heat stress on cold-water fish. Full article
(This article belongs to the Special Issue Environmental Physiology of Aquatic Animals)
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16 pages, 654 KiB  
Review
Engaging Broader Stakeholders to Accelerate Group A Streptococcus Vaccine Development
by Dechuan Kong, Hao Pan, Huanyu Wu and Jian Chen
Vaccines 2025, 13(7), 734; https://doi.org/10.3390/vaccines13070734 - 7 Jul 2025
Viewed by 575
Abstract
Group A Streptococcus (GAS) imposes a significant global health burden across all age groups, annually causing over 600 million cases of pharyngitis and more than 18 million severe invasive infections or sequelae. The resurgence of scarlet fever globally and streptococcal toxic shock syndrome [...] Read more.
Group A Streptococcus (GAS) imposes a significant global health burden across all age groups, annually causing over 600 million cases of pharyngitis and more than 18 million severe invasive infections or sequelae. The resurgence of scarlet fever globally and streptococcal toxic shock syndrome (STSS) outbreaks in Japan have brought GAS infections back into the spotlight as a pressing global health concern. Unfortunately, no licensed vaccine against GAS is yet available for clinical use. Our comprehensive review examines the developmental history of GAS vaccines, outlining the research trajectory from early inactivated vaccines to contemporary multivalent, conjugate, multi-antigen, and mRNA-based vaccine platforms. It systematically analyzes clinical trial outcomes of GAS vaccines, highlighting recent advances in both M protein-based and non-M protein vaccine candidates while summarizing promising target antigens. The review concludes with critical strategies to accelerate vaccine commercialization, including enhanced investment in research and development, expanded collaborations, leveraging advanced vaccine technologies, streamlined clinical trials, and strengthened public health advocacy. This review critically evaluates the current evidence and future prospects in GAS vaccine development, emphasizing innovative strategies and engaging broader stakeholders to accelerate GAS vaccine development. Full article
(This article belongs to the Special Issue Development of Vaccines Against Bacterial Infections)
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22 pages, 5131 KiB  
Article
Multi-Region OpenFOAM Solver Development for Compact Toroid Transport in Drift Tube
by Kun Bao, Feng Wang, Chengming Qu, Defeng Kong and Jian Song
Appl. Sci. 2025, 15(13), 7569; https://doi.org/10.3390/app15137569 - 5 Jul 2025
Viewed by 296
Abstract
Compact toroid (CT) injection, with its characteristics of high plasma density and extremely high injection velocity, is considered a highly promising method for core fueling in fusion reactors. Previous studies have lacked investigation into the transport process of CT within drift tubes. To [...] Read more.
Compact toroid (CT) injection, with its characteristics of high plasma density and extremely high injection velocity, is considered a highly promising method for core fueling in fusion reactors. Previous studies have lacked investigation into the transport process of CT within drift tubes. To investigate the dynamic processes of CT in drift tubes, this study developed a compressible magnetohydrodynamics (MHD) solver and a magnetic diffusion solver based on the OpenFOAM platform. They were integrated into a multi-region coupling framework to create a multi-region coupled MHD solver, mhdMRF, for simulating the dynamic behavior of CT in drift tubes and its interaction with finite-resistivity walls. The solver demonstrated excellent performance in simulations of the Orszag–Tang MHD vortex problem, the Brio–Wu shock tube problem, analytical verification of magnetic diffusion, and validation of internal coupling boundary conditions. Additionally, this work innovatively explored the effects of the geometric structure at the end of the inner electrode and finite-resistivity walls on the transport processes of CT. The results indicate that optimizing the geometric structure at the end of the inner electrode can significantly enhance the confinement performance and stability of CT transport. The resistivity of the wall profoundly influences the magnetic field structure and density distribution of CT. Full article
(This article belongs to the Special Issue Plasma Physics: Theory, Methods and Applications)
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39 pages, 1599 KiB  
Article
Toward a Resilient and Sustainable Supply Chain: Operational Responses to Global Disruptions in the Post-COVID-19 Era
by Antonius Setyadi, Suharno Pawirosumarto and Alana Damaris
Sustainability 2025, 17(13), 6167; https://doi.org/10.3390/su17136167 - 4 Jul 2025
Viewed by 528
Abstract
Global supply chains have faced unprecedented disruptions in recent years, ranging from the COVID-19 pandemic to geopolitical tensions and climate-induced shocks. These events have exposed structural vulnerabilities in operational models overly optimized for efficiency at the expense of resilience and sustainability. This conceptual [...] Read more.
Global supply chains have faced unprecedented disruptions in recent years, ranging from the COVID-19 pandemic to geopolitical tensions and climate-induced shocks. These events have exposed structural vulnerabilities in operational models overly optimized for efficiency at the expense of resilience and sustainability. This conceptual paper proposes an integrated framework linking resilience enablers, post-pandemic operational strategies, and sustainability outcomes. Through a synthesis of the interdisciplinary literature across operations management, sustainability science, institutional theory, and organizational behavior, we develop typologies of operational responses—including agile, lean–green, circular, and decentralized models—and connect them to broader Sustainable Development Goals (SDGs). Drawing on systems thinking and the Triple Bottom Line framework, we present a conceptual model that outlines causal relationships between resilience drivers, adaptive operational strategies, and long-term sustainable performance. The paper further discusses policy implications for public and private sectors, offering insights for global sustainability governance. We conclude by outlining a research agenda to empirically test and refine the model through multi-method approaches. This study contributes to theory by reconceptualizing sustainable operations in the context of compound global disruptions and offers a normative direction for future scholarship and practice. Full article
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12 pages, 204 KiB  
Case Report
Multiorgan Failure Resembling Grade 5 (Fatal) Cytokine Release Syndrome in Patient with Multiple Myeloma Following Carfilzomib Infusion: A Case Report
by Strahinja Gligorevic, Nebojsa Brezic, Joshua Jagodzinski, Andjela Radulovic, Aleksandar Peranovic and Igor Dumic
J. Clin. Med. 2025, 14(13), 4723; https://doi.org/10.3390/jcm14134723 - 3 Jul 2025
Viewed by 356
Abstract
Background: Cytokine release syndrome (CRS) is a life-threatening systemic inflammatory condition marked by excessive cytokine production, leading to multi-organ dysfunction. It is commonly associated with T-cell-engaging therapies such as chimeric antigen receptor (CAR) T cells, T-cell receptor bispecific molecules, and monoclonal antibodies. Carfilzomib, [...] Read more.
Background: Cytokine release syndrome (CRS) is a life-threatening systemic inflammatory condition marked by excessive cytokine production, leading to multi-organ dysfunction. It is commonly associated with T-cell-engaging therapies such as chimeric antigen receptor (CAR) T cells, T-cell receptor bispecific molecules, and monoclonal antibodies. Carfilzomib, a proteasome inhibitor, is known to cause a range of adverse effects, primarily hematologic and cardiovascular. However, multiorgan failure grade 5 (fatal), resembling CRS has not been previously reported in association with Carfilzomib. Case Report: A 74-year-old male with relapsed multiple myeloma developed grade 5 multiorgan failure 60 min after the third dose of Carfilzomib, resulting in death within 24 h of symptom onset. The patient tolerated the first doses of Carfilzomib well with only fever and headache developing post infusion. Before the second dose, the patient developed worsening pancytopenia, prompting the discontinuation of Lenalidomide. After the second Carfilzomib infusion, he experienced fever and transient encephalopathy, which resolved with acetaminophen, corticosteroids, and supportive care. However, following the third dose, he rapidly deteriorated—developing fever, tachycardia, hypotension, hypoxia, and encephalopathy. Despite aggressive management with intravenous fluids, broad-spectrum antibiotics, corticosteroids, and tocilizumab, the patient progressed to refractory shock and multi-organ failure, culminating in death within 24 h. A comprehensive infectious workup was negative, ruling out sepsis and suggesting possible Carfilzomib-induced CRS. Conclusion: Grade 5 multiorgan failure with signs and symptoms similar with CRS following Carfilzomib administration is a rare but potentially fatal adverse drug reaction. Further research is needed to better define the risk factors and optimal management strategies for Carfilzomib-induced multiorgan failure and possible CRS. Full article
(This article belongs to the Special Issue Multiple Myeloma: Advances in Diagnosis and Treatment)
27 pages, 7525 KiB  
Article
Coupled Thermo-Mechanical Modeling of Crack-Induced Stress Fields in Thermal Barrier Coatings with Varying Crack Geometries
by Linxi Zhang, Ruifeng Dou, Ningning Liu, Jian Sun, Xunliang Liu and Zhi Wen
Coatings 2025, 15(7), 785; https://doi.org/10.3390/coatings15070785 - 3 Jul 2025
Viewed by 331
Abstract
Under service conditions, randomly distributed cracks in the top coat (TC) layer of thermal barrier coatings (TBCs) lead to local stress concentrations, which serve as the primary drivers of crack propagation and coating delamination. This study systematically analyzes the influence of crack defects [...] Read more.
Under service conditions, randomly distributed cracks in the top coat (TC) layer of thermal barrier coatings (TBCs) lead to local stress concentrations, which serve as the primary drivers of crack propagation and coating delamination. This study systematically analyzes the influence of crack defects on the thermal stress distribution in TBCs, based on their microstructural characteristics, using a multi-physics-coupled finite element model. Numerical analysis of crack characteristics reveals that crack length significantly influences the stress distribution in the coatings, with the maximum tensile stress at the crack tip increasing from 104.02 to 238.51 MPa as the crack half-length extends from 400 to 1000 μm. Shorter cracks induce lower tensile stresses, thereby retarding crack propagation and delaying coating delamination. Crack depth also influences the stress distribution, with the maximum tensile stress decreasing from 205.88 to 101.65 MPa as the crack is buried deeper, from 50 to 200 μm, indicating a more stable stress state less prone to propagation in deeper cracks. For inclined cracks, increasing the inclination angle induces a shift in stress from tensile to compressive, with larger inclination angles exhibiting greater stability. Accordingly, this study proposes a laser scribing strategy to mitigate crack-tip stress concentration, which is validated through comparison with two-dimensional crack models. Laser scribing shortens crack length by interrupting crack continuity, relieves localized thermal expansion strain, effectively suppresses crack growth, and significantly enhances the crack resistance and thermal shock stability of the coating. Full article
(This article belongs to the Special Issue Ceramic and Glass Material Coatings)
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31 pages, 525 KiB  
Article
Environmental Policy Shocks and Manufacturing Resilience: A Multi-Path Mechanism and Regional Heterogeneity Analysis
by Xingyuan Yao, Zheqiu Wang, Kangze Zheng, Qingfan Lin, Weiming Lin and Yufen Zhong
Sustainability 2025, 17(13), 5932; https://doi.org/10.3390/su17135932 - 27 Jun 2025
Viewed by 291
Abstract
Environmental regulation has become a central policy tool for reconciling the tensions between ecological sustainability and industrial development. Although most existing studies focus on its impact on green innovation or firm behavioral change, attention to how environmental regulation affects the structural resilience of [...] Read more.
Environmental regulation has become a central policy tool for reconciling the tensions between ecological sustainability and industrial development. Although most existing studies focus on its impact on green innovation or firm behavioral change, attention to how environmental regulation affects the structural resilience of manufacturing systems under external shocks remains limited. This paper constructs a balanced panel dataset covering 287 prefecture-level cities in mainland China from 2006 to 2021 to quantify the impact of environmental regulation intensity on the resilience of manufacturing development. Manufacturing resilience is assessed through a comprehensive indicator system, including the dimensions of adaptive capacity, recovery potential, and industrial continuity. The empirical results show that environmental regulation has a significant inhibitory effect on manufacturing resilience, and this effect is supported in a number of robustness analyses using instrumental variable estimation and lagged structural tests. Mechanism analysis suggests that, despite the overall negative effect, environmental regulations can indirectly enhance resilience performance by promoting industrial autonomy and digital transformation under certain conditions. Heterogeneity analysis further reveals that the negative effect is more pronounced in regions with higher regulatory intensity, in non-self-employed firms, in industries not subject to U.S. sanctions, and in eastern China. These findings suggest that the dynamic needs of the industrial system should be taken into account in the formulation of environmental policies, and that digital capacity building and autonomy upgrading should be the key paths to mitigate regulatory shocks. Full article
(This article belongs to the Section Environmental Sustainability and Applications)
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14 pages, 448 KiB  
Case Report
Allergy to Lipid Transfer Protein or Hypersensitivity to Non-Steroidal Anti-Inflammatory Drugs?
by Magdalena Rydzyńska, Kinga Lis, Zbigniew Bartuzi, Tomasz Rosada, Magdalena Grześk-Kaczyńska and Natalia Ukleja-Sokołowska
Int. J. Mol. Sci. 2025, 26(13), 5988; https://doi.org/10.3390/ijms26135988 - 22 Jun 2025
Viewed by 447
Abstract
Non-steroidal anti-inflammatory drugs (NSAIDs) can cause hypersensitivity reactions and lead to anaphylactic shock. These drugs also act as cofactors in allergic reactions. Lipid transfer proteins (LTPs), found in plants, represent a unique group of allergens in which cofactors play a crucial role. This [...] Read more.
Non-steroidal anti-inflammatory drugs (NSAIDs) can cause hypersensitivity reactions and lead to anaphylactic shock. These drugs also act as cofactors in allergic reactions. Lipid transfer proteins (LTPs), found in plants, represent a unique group of allergens in which cofactors play a crucial role. This case report describes a 26-year-old female who developed anaphylactic symptoms after ingesting grapes and taking ketoprofen. The patient experienced swelling of the lips, tongue, and throat, as well as shortness of breath, dizziness, and loss of consciousness, after consuming grapes and taking ketoprofen. She had previously used ketoprofen and acetylsalicylic acid without issues but had developed urticaria on several occasions after consuming multi-ingredient dishes. Skin prick tests showed positive results for peanut and orange allergens. Further testing using the ALEX multiparametric test detected antibodies to several LTP allergens. Intradermal tests with ketoprofen yielded a positive result, although irritant reactions could not be ruled out. A provocation test with acetylsalicylic acid (ASA) showed no adverse reactions. Skin tests with ibuprofen were negative, and provocation tests confirmed its tolerance. A diagnosis of LTP allergy and selective ketoprofen allergy was made, with the recommendation to avoid ketoprofen and follow a diet excluding foods from the LTP group. Full article
(This article belongs to the Special Issue Molecular Therapeutic Strategies in Allergic Diseases)
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