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8 Results Found

  • Article
  • Open Access
19 Citations
3,611 Views
16 Pages
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Optimization of Extraction of Bioactive Peptides from Monkfish (Lophius litulon) and Characterization of Their Role in H2O2-Induced Lesion

  • Xiaoxiao Tian,
  • Jiawen Zheng,
  • Baogui Xu,
  • Jiena Ye,
  • Zuisu Yang and
  • Falei Yuan
Mar. Drugs2020, 18(9), 468;https://doi.org/10.3390/md18090468

17 September 2020

Background: Marine fish meat has been widely used for the extraction of bioactive peptides. This study was aimed to optimize the preparation of monkfish muscle peptides (LPs) using response surface methodology (RSM) and explore the antioxidant activi...

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  • Article
  • Open Access
112 Citations
4,818 Views
24 Pages
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Eighteen Novel Bioactive Peptides from Monkfish (Lophius litulon) Swim Bladders: Production, Identification, Antioxidant Activity, and Stability

  • Yan Sheng,
  • Wan-Yi Wang,
  • Ming-Feng Wu,
  • Yu-Mei Wang,
  • Wang-Yu Zhu,
  • Chang-Feng Chi and
  • Bin Wang
Mar. Drugs2023, 21(3), 169;https://doi.org/10.3390/md21030169

7 March 2023

In the study, papain was chosen from five proteases to hydrolyze proteins of monkfish swim bladders for effectively utilizing monkfish (Lophius litulon) processing byproducts, and the hydrolysis conditions of papain were optimized as hydrolysis tempe...

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  • Article
  • Open Access
13 Citations
3,626 Views
17 Pages
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Monkfish (Lophius litulon) Peptides Ameliorate High-Fat-Diet-Induced Nephrotoxicity by Reducing Oxidative Stress and Inflammation via Regulation of Intestinal Flora

  • Xiangyu Ren,
  • Bingtao Miao,
  • Hongjie Cao,
  • Xiaoxiao Tian,
  • Lujia Shen,
  • Zuisu Yang,
  • Falei Yuan and
  • Yaping Ding
Molecules2023, 28(1), 245;https://doi.org/10.3390/molecules28010245

28 December 2022

Background: Renal damage and intestinal flora imbalance due to lipotoxicity are particularly significant in terms of oxidative stress and inflammation, which can be alleviated with bioactive peptides. The monkfish (Lophius litulon) is rich in protein...

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  • Article
  • Open Access
123 Citations
6,383 Views
21 Pages
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Antioxidant Peptides from the Protein Hydrolysate of Monkfish (Lophius litulon) Muscle: Purification, Identification, and Cytoprotective Function on HepG2 Cells Damage by H2O2

  • Xiao-Meng Hu,
  • Yu-Mei Wang,
  • Yu-Qin Zhao,
  • Chang-Feng Chi and
  • Bin Wang
Mar. Drugs2020, 18(3), 153;https://doi.org/10.3390/md18030153

10 March 2020

In the work, defatted muscle proteins of monkfish (Lophius litulon) were separately hydrolyzed by pepsin, trypsin, and in vitro gastrointestinal (GI) digestion methods, and antioxidant peptides were isolated from proteins hydrolysate of monkfish musc...

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  • Article
  • Open Access
24 Citations
4,683 Views
17 Pages
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Monkfish Peptides Mitigate High Fat Diet-Induced Hepatic Steatosis in Mice

  • Jiena Ye,
  • Xiaoxiao Tian,
  • Qiongfen Wang,
  • Jiawen Zheng,
  • Yanzhuo Yang,
  • Baogui Xu,
  • Shuai Zhang,
  • Falei Yuan and
  • Zuisu Yang
Mar. Drugs2022, 20(5), 312;https://doi.org/10.3390/md20050312

5 May 2022

Non-alcoholic fatty liver disease (NAFLD) is a hepatic metabolic syndrome usually accompanied by fatty degeneration and functional impairment. The aim of the study was to determine whether monkfish peptides (LPs) could ameliorate high-fat diet (HFD)-...

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  • Article
  • Open Access
97 Citations
3,458 Views
18 Pages
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Angiotensin-I-Converting Enzyme (ACE)-Inhibitory Peptides from the Collagens of Monkfish (Lophius litulon) Swim Bladders: Isolation, Characterization, Molecular Docking Analysis and Activity Evaluation

  • Yu-Dong Hu,
  • Qing-Hao Xi,
  • Jing Kong,
  • Yu-Qin Zhao,
  • Chang-Feng Chi and
  • Bin Wang
Mar. Drugs2023, 21(10), 516;https://doi.org/10.3390/md21100516

28 September 2023

The objective of this study was to isolate and characterize collagen and angiotensin-I-converting enzyme (ACE)-inhibitory (ACEi) peptides from the swim bladders of monkfish (Lophius litulon). Therefore, acid-soluble collagen (ASC-M) and pepsin-solubl...

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  • Article
  • Open Access
87 Citations
4,203 Views
20 Pages
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Antioxidant Peptides from Monkfish Swim Bladders: Ameliorating NAFLD In Vitro by Suppressing Lipid Accumulation and Oxidative Stress via Regulating AMPK/Nrf2 Pathway

  • Ming-Feng Wu,
  • Qing-Hao Xi,
  • Yan Sheng,
  • Yu-Mei Wang,
  • Wan-Yi Wang,
  • Chang-Feng Chi and
  • Bin Wang
Mar. Drugs2023, 21(6), 360;https://doi.org/10.3390/md21060360

16 June 2023

In this study, we investigate the ameliorating functions of QDYD (MSP2), ARW (MSP8), DDGGK (MSP10), YPAGP (MSP13) and DPAGP (MSP18) from monkfish swim bladders on an FFA-induced NAFLD model of HepG2 cells. The lipid-lowering mechanisms revealed that...

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  • Feature Paper
  • Article
  • Open Access
36 Citations
4,149 Views
14 Pages
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Optimal Production of Protein Hydrolysates from Monkfish By-Products: Chemical Features and Associated Biological Activities

  • José Antonio Vázquez,
  • Araceli Menduíña,
  • Margarita Nogueira,
  • Ana I. Durán,
  • Noelia Sanz and
  • Jesus Valcarcel
Molecules2020, 25(18), 4068;https://doi.org/10.3390/molecules25184068

6 September 2020

The aim of this work was the recovery of protein substrates from monkfish waste (heads and viscera) generated in the on-board processing of this species. Initially, the effect of pH, temperature, and protease concentration was studied on mixtures of...

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