Economic interactions are conducted between economic agents - individuals and collectives, through exchange of natural or artificial entities - goods, services and money, in a myriad of combinations. In this article we adopt a microscopic point of vi...
22 January 2022
Network-based assessments are important for disentangling complex microbial and microbial–host interactions and can provide the basis for microbial engineering. There is a growing recognition that chemical-mediated interactions are important fo...
Various cellular processes require the concerted cooperative action of proteins. The possibility for such synchronization implies the occurrence of specific long-range interactions between the involved protein participants. Bilayer lipid membranes ca...
With the increasing application of robots in human-centred environments, there is increasing motivation for incorporating some degree of human-like social competences. Fields such as psychology and cognitive science not only provide guidance on the t...
29 July 2022
Technology-mediated sexual interactions (TMSI) are interpersonal exchanges via technology of self-created sexual material, including photos, videos, and auditory or text messages. There is little research on the factors that predict both TMSI experie...
Protein micropatterning is a powerful tool for spatial arrangement of transmembrane and intracellular proteins in living cells. The restriction of one interaction partner (the bait, e.g., the receptor) in regular micropatterns within the plasma membr...
Modelling ubiquitous collaborative systems that support people-driven processes represents a major challenge for software designers, since there is no a workflow that helps identify the scenarios in which the interaction among the participants could...
Driven by advances in artificial intelligence, immersive technologies, and related digital innovations, public cultural spaces are undergoing significant mediatization. Although architectural research has addressed this transformation through media a...
Background/Objectives: Zastaprazan (JP-1366) is a novel potassium-competitive acid blocker (P-CAB) used for the treatment of gastroesophageal reflux disease (GERD). To date, its metabolic pathways and metabolism-related drug–drug interactions (...
After conversational agents have been made available to the broader public, we speculate that applying them as a mediator for adaptive environments reduces control complexity and increases user experience by providing a more natural interaction. We i...
The virus–host interaction is dynamic and evolutionary. Viruses have to fight with hosts to establish successful infection. Eukaryotic hosts are equipped with multiple defenses against incoming viruses. One of the host antiviral defenses is the...
30 March 2020
Learning persistence is a critical element for successful online learning. The evidence provided by psychologists and educators has shown that students’ interaction (student-student (SS) interaction, student-instructor (SI) interaction, and stu...
The aging population has brought increased attention to the urgent need to address social isolation and health risks among the elderly. While previous research has established the positive effects of parks in promoting social interaction and health a...
28 March 2019
This study explored the associations between parental Type D personality (TDP), parent–child interactive activities, and children’s hyperactive behaviors. Moreover, the study examined whether parent–child interactive activities medi...
Social media platforms have become central sites of identity construction, where visibility and legitimacy are shaped through algorithmic systems, aesthetic conventions, and platform economies. This paper approaches online personas through the lens o...
China is a populous country and its growing elderly population is pushing the whole country into the maelstrom of an aging society. The media practices and media interactions of empty-nesters have gradually become a real issue that is affecting the d...
5 March 2022
The 2022 Beijing Winter Olympics has created unprecedented opportunities for China’s commercial ice rinks, where improving consumers’ repurchase intention is essential for their high-quality development. This paper explores the mediation...
Insecure and disorganized attachment patterns in children are linked to poor health outcomes over the lifespan. Attachment patterns may be predicted by variables that influence the quality of children’s interactions with their primary caregiver...
The prolonged arms race between plants and their antagonists has resulted in the evolution of multiple plant defence mechanisms to combat attacks by pests and pathogens. Silicon (Si) accumulation occurs mainly in grasses and provides a physical barri...
Plant–plant interactions are a central driver for plant coexistence and community assembly. Chemically mediated plant–plant interactions are represented by allelopathy and allelobiosis. Both allelopathy and allelobiosis are achieved throu...
Background: Boundary-spanning bank employees experience continuous customer interactions that can generate negative emotions and influence how they perceive interpersonal treatment at work. Although emotions are known to shape fairness judgments, lit...
2 September 2022
With the increasing use of smartphones in our lives, technoference has become a new threat to family relationships and child development. The present study explored the impact of technoference in conjugal interactions on child smartphone dependence a...
Research into early screen exposure has raised growing concerns about its impact upon children’s neuropsychological well-being. However, possible pathways remain unclear. This study therefore aimed not only to evaluate the association between s...
Our understanding of microRNA (miRNA) regulation of gene expression and protein translation, as a critical area of cellular regulation, has blossomed in the last two decades. Recently, it has become apparent that in plant-insect interactions, both pl...
This study investigates factors affecting university student-to-student interaction within online learning platforms. A new model was proposed based on the United Theory of Acceptance and Use of Technology (UTAUT). The single-stage cluster-sampling m...
Plant lipids are essential cell constituents with many structural, storage, signaling, and defensive functions. During plant–pathogen interactions, lipids play parts in both the preexisting passive defense mechanisms and the pathogen-induced im...
Drug–drug interactions (DDIs) represent a significant concern in healthcare, particularly for patients undergoing polytherapy. DDIs can lead to a range of outcomes, from decreased therapeutic effectiveness to adverse effects. Salbutamol, a bron...
Drawing on Self-Determination Theory (SDT) and the Classroom Assessment Scoring System (CLASS) framework, this study tested a moderated mediation model in which two dimensions of GenAI-assisted teaching predict children’s creative learning enga...
This study identifies and characterises the Socratic mediation patterns enacted by MIA, an AI-based conversational agent used in distance higher education. A deductive content analysis was conducted on 737 conversations using six categories: explorat...
The number of publications on live online teaching and distance learning has significantly increased over the past two years since the outbreak and worldwide spread of the COVID-19 pandemic, but more research is needed on effective methodologies and...
We present a method to rapidly identify hydrogen-mediated interactions in proteins (e.g., hydrogen bonds, hydrogen bonds, water-mediated hydrogen bonds, salt bridges, and aromatic π-hydrogen interactions) through heavy atom geometry alone, that is...
The specific binding of the ubiquitous ‘marker of self’ protein CD47 to the SIRP
Exploitative competition and interference competition differ in the way they affect re-source availability for competitors: in the former, organisms reduce resource availability for the competitors; in the latter, one organism actively prevents the c...
Uptake transporters (e.g., members of the SLC superfamily of solute carriers) and export proteins (e.g., members of the ABC transporter superfamily) are important determinants for the pharmacokinetics of drugs. Alterations of drug transport due to co...
Exploring the construction of effective payment mechanisms for rural residents could break the dilemma of the value of a single investment by the government in environmental governance and promote the process of sustainable rural domestic sewage trea...
Drug–drug interactions (DDIs) can cause drug toxicities, reduced pharmacological effects, and adverse drug reactions. Studies aiming to determine the possible DDIs for an investigational drug are part of the drug discovery and development process and...
Hydrogen atoms play a crucial role in the aggregation of organic (bio)molecules through diverse number of noncovalent interactions that they mediate, such as electrostatic in proton transfer systems, hydrogen bonding, and CH–π interactions,...
Viruses manipulate host cellular machinery to propagate their life cycle, with one key strategy being the mimicry of short linear motifs (SLiMs) found in host proteins. While databases continue to expand with virus–host protein–protein in...
Anaphylaxis is an acute and life-threatening systemic reaction. Food, drug, aero-allergen and insect sting are known to induce anaphylaxis. Mast cells and basophils are known to mediate Immunoglobulin E (IgE)-dependent anaphylaxis, while macrophages,...
Human cytochrome P450 CYP3A4 is involved in the processing of more than 35% of current pharmaceuticals and therefore is responsible for multiple drug-drug interactions (DDI). In order to develop a method for the detection and prediction of the possib...
The lipid matrix of cellular membranes is an elastic liquid crystalline medium. Its deformations regulate the functionality and interactions of membrane proteins,f membrane-bound peptides, lipid and protein-lipid domains. Gramicidin A (gA) is a pepti...
Eukaryotic gene expression is regulated through chromatin conformation, in which enhancers and promoters physically interact (E–P interactions). How such chromatin-mediated E–P interactions affect gene expression is not yet fully understo...
Amifampridine is a drug used for the treatment of Lambert–Eaton myasthenic syndrome (LEMS) and was approved by the Food and Drug Administration (FDA) of the United States (US) in 2018. It is mainly metabolized by N-acetyltransferase 2 (NAT2); h...
Carbon-based materials show unique chemicophysical properties, and they have been successfully used in many catalytic processes, including the production of chemicals and energy. The introduction of heteroatoms (N, B, P, S) alters the electronic prop...
Modifications of the activity of Cytochrome 450 (CYP) enzymes by compounds in food might impair medical treatments. These CYP-mediated food–drug interactions (FDI) play a major role in drug clearance in the intestine and liver. Inter-individual...
Kinsenoside, the herb-derived medicine isolated from the plant Anoect chilus, has diverse pharmacological actions, and it is considered to be a promising antihyperlipidemic drug candidate. This study evaluates the effects of kinsenoside on CYP enzyme...
Because proteins are fundamental to most biological processes, many genetic diseases can be traced back to single nucleotide variants (SNVs) that cause changes in protein sequences. However, not all SNVs that result in amino acid substitutions cause...
The kidney is critical in the human body’s excretion of drugs and their metabolites. Renal transporters participate in actively secreting substances from the proximal tubular cells and reabsorbing them in the distal renal tubules. They can affe...
Drug metabolism is a major determinant of drug concentrations in the body. Drug-drug interactions (DDIs) caused by the co-administration of multiple drugs can lead to alteration in the exposure of the victim drug, raising safety or effectiveness conc...
This exploratory study examines whether chatbot-mediated written interaction supports adult B2 English learners’ performance in online interaction, pluricultural competence, and mediation in Official Language Schools (OLS) in Spain. The interve...
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