Search Results (4,251)

To facilitate the successful achievement of the goals outlined in the 2030 Agenda for Sustainable Development, it is imperative to accelerate the advancement of green technological innovation effectiveness (GTIE). This study aims to synthesize three types of drivers and seven concurrent driving factors of green technological innovation effectiveness identified in existing theories, constructing a multiple concurrent mechanism model for such effectiveness. The fuzzy-set Qualitative Comparative Analysis (fsQCA) method is employed to identify the configurational conditions leading to high green technological innovation effectiveness. Furthermore, the robustness of these configurations is verified through panel decomposition, while Necessary Condition Analysis (NCA) is applied to test the necessity of the factors within these configurations and to conduct further examination. The results reveal that high green technological innovation effectiveness is driven by three types of multiple concurrent mechanisms: the “Demand–Pull and Technology–Push and Porter Effect-Driven” configuration type, the “Demand–Pull & Technology–Push-Driven” type, and the “Demand–Pull & Porter Effect-Driven” type. This paper’s contributions are threefold. First, it investigates the configurational drivers of green technological innovation effectiveness. Second, it uses Necessary Condition Analysis (NCA) to identify necessary conditions within these multiple concurrent effects, deepening insight into the drivers. Third, it reveals three patterns driving green innovation in industries and proposes corresponding sustainable manufacturing policy recommendations. Full article

Flat soda–lime–silicate glass is the dominant glass type used in contemporary buildings. This paper provides a comprehensive and integrated review of the scientific principles and technological processes that underpin its manufacture, processing, and structural performance. The discussion spans the glass transition and the nature of the glassy state; the network structure of soda–lime–silicate glass, with its inherent lack of long-range order; and its physical and mechanical properties, including fracture. The industrial production of flat soda–lime–silicate glass (melting, float-forming, and annealing) and its subsequent processing (thermal tempering, chemical strengthening, and coating) are described in detail, with emphasis on how they influence residual stresses, surface and edge quality, and structural reliability. Environmental considerations and ongoing advances in energy efficiency and decarbonisation are also examined. By linking the fundamentals of glass science to modern structural design standards, particularly the forthcoming Eurocode 10 for glass structures, the article seeks to equip structural engineers with an informed understanding of glass as a high-performance material for innovative and sustainable design. Full article

In 2025, the U.S. Food and Drug Administration (FDA) approved 44 new drugs, reflecting a slight decrease compared to previous years but maintaining the overall trends in pharmaceutical innovation. Biologics accounted for 25% of approvals, including nine monoclonal antibodies (mAbs), two antibody–drug conjugates (ADCs), and one fusion protein, with cancer remaining the primary therapeutic focus. TIDES, comprising three oligonucleotides and one peptide, continued to consolidate their presence in the market, with the three oligonucleotides featuring N-acetylgalactosamine (GalNAc) for liver-targeted delivery. Small molecules dominate the remainder, with a high prevalence of N-aromatic moieties and fluorine atoms present in most of the molecules. Peptide manufacturing and sustainability concerns, including PFAS usage, remain key challenges. Despite these advances, the high cost of innovative therapies limits access, particularly in low- and middle-income countries. This report provides a structural and chemical analysis of the newly approved drugs, highlighting trends in molecular design, therapeutic areas, and technological innovations shaping modern drug discovery. Full article

Spray-induced gene silencing (SIGS) represents a transformative paradigm in sustainable pest management, utilizing the exogenous application of double-stranded RNA (dsRNA) to achieve sequence-specific silencing of essential genes in arthropod pests. Unlike transgenic approaches, sprayable RNA interference (RNAi) biopesticides offer superior versatility across crop systems, flexible application timing, and a more favorable regulatory and public acceptance profile. The 2023 U.S. EPA registration of Ledprona, the first sprayable dsRNA biopesticide targeting Leptinotarsa decemlineata, marks a significant milestone toward the commercialization of non-transformative RNAi technologies. Despite the milestone, large-scale field deployment faces critical bottlenecks, primarily environmental instability, enzymatic degradation by nucleases, and variable cellular uptake across pest taxa. This review critically analyzes the mechanistic basis of spray-applied RNAi and synthesizes the recent technological breakthroughs designed to overcome physiological and environmental barriers. We highlight advanced delivery strategies, including nuclease inhibitor co-application, liposome encapsulation, and nanomaterial-based formulations that enhance persistence on plant foliage and uptake efficiency. Furthermore, we discuss how innovations in microbial fermentation have drastically reduced synthesis costs, rendering industrial-scale production economically viable. Finally, we outline the roadmap for broad adoption, addressing essential factors such as biosafety assessment, environmental fate, resistance management protocols, and the path toward cost-effective manufacturing. Full article

This study investigates the crucial role energy leaders play in driving strategic energy management (SEM) and accelerating cost savings within a manufacturing organization and consequently, the industrial sector. Whereas energy efficiency can be seen as an innovative business practice with irrefutable cost benefits, its effective implementation requires strategic leadership and a structured approach. This research analyzes data collected from 120 participants representing 71 companies attending the Energy Bootcamp events organized by the U.S. Department of Energy’s (DOE) Better Plants program. The collected data focused on the state of SEM implementation, the presence and responsibilities of energy leaders, and the formation and function of energy teams. The findings reveal a significant gap between the perceived importance of SEM and its actual adoption, highlighting the need for strong leadership to drive behavioral changes by championing energy efficiency initiatives. Results indicate that effective energy leaders possess a diverse skill set, including the ability to secure top management buy-in, foster a culture of energy consciousness, and collaborate across departments. This study emphasizes the importance of empowering energy leaders with clearly defined roles and responsibilities as well as the authority to build and lead cross-functional energy teams. Furthermore, integrating energy management into existing organizational structures and leveraging readily available resources are identified as key factors for successful implementation. This research underscores how dedicated leadership and effective SEM practices help achieve industrial energy efficiency goals, providing practical insights for organizations seeking to improve performance and contribute to a resilient future. Full article

The rise of the circular economy and e-commerce has led to the emergence of e-commerce closed-loop supply chains (ECLSCs). In practice, investing in process innovation (PI) is key to improving profitability and competitiveness. However, manufacturers at the downstream of ECLSCs often face financial constraints and quality uncertainty of used products, while research on how to select financing strategies under these conditions remains limited. To explore the optimal financing scheme for the ECLSC, this study investigates two financing schemes: bank financing (BF) and FinTech platform financing (FPF), which offers a combination of debt financing (DF) and equity financing (EF). Some key findings are derived. For the ECLSC, the FPF scheme is more profitable when the unit manufacturing cost for new components exceeds the threshold or PI costs are relatively low. Additionally, the FPF performs better when the FPF interest rate is low and the DF ratio is high. The BF is more beneficial when consumer sensitivity to recycling prices or service is low. The FPF enables the ECLSC to achieve maximum profits and minimize environmental impact within a specific range. Furthermore, the financing models are extended to incorporate considerations of fairness, where the optimal financing scheme is primarily influenced by the manufacturing cost. Full article

Tax incentives play a crucial role in enhancing firm dynamism and aiding a nation in becoming a significant trade power. Drawing on data from the Annual Survey of Industrial Firms Database and the Chinese Customs Database for the period 2010 to 2013, this study employs a difference-in-differences approach to assess the impact of China’s transition from a business tax to a value-added tax (RBTVAT) on the export diversification of manufacturing firms. The findings indicate that the tax reform significantly decreases the number of export categories, increases export value, and elevates the export unit price for manufacturing firms. Specifically, by promoting specialized production and encouraging the manufacture of products with higher export tax rebate rates, the reforms have led firms to narrow their range of export categories. This effect is particularly pronounced among firms experiencing higher financing constraints, lower profitability, weaker innovation capabilities, and larger size. Furthermore, a consistent negative impact is observed for both state-owned and non-state-owned enterprises. These results provide novel insights and empirical evidence for understanding the relationship between tax reform and export diversification. Full article

Small- and medium-sized enterprises (SMEs) are central to sustainable development in transition economies, yet their financial fragility often limits resilience and the capacity to invest in innovation and responsible practices. Despite growing interest in SME, financial health and its role in sustainability, empirical evidence from small transition economies like Montenegro remains scarce, particularly on how liquidity and profitability dynamics underpin conditions for SDG-aligned growth. This study addresses this gap by analyzing how core financial indicators—cash position, capital structure, and working capital efficiency—affect liquidity and profitability among 345 Montenegrin SMEs across manufacturing, services, and trade. Using OLS and robust regression models, results reveal that a higher cash-to-revenue ratio and moderate leverage significantly enhance both short-term solvency and profitability, while working capital efficiency shows nuanced effects and sector-specific patterns emerge in capital-intensive industries. These findings highlight financial management as a foundation for SME resilience, creating financial preconditions for innovation and digital investments in aligned with SDGs (goals 8, 9, 12). Policy recommendations focus on improving finance access and financial literacy to foster innovation-driven, sustainable SME models aligned with the 2030 Agenda. Full article

Background: Solid organ transplantation (SOT) is a life-saving treatment for patients with end-stage diseases and/or organ failure. However, access to healthy organs is often limited by challenges in organ preservation. Furthermore, upon transplantation, ischemia–reperfusion injury (IRI) can lead to increased organ rejection or graft failures. The work presented aims to address both challenges using an innovative nanomedicine platform for simultaneous drug and oxygen delivery. In recent studies, resveratrol (RSV), a natural antioxidant, anti-inflammatory, and reactive oxygen species (ROS) scavenging agent, has been reported to protect against IRI by inhibiting ferroptosis. Here, we report the design, development, and scalable manufacturing of the first-in-class dual-function perfluorocarbon-nanoemulsion (PFC-NE) perfusate for simultaneous oxygen and antioxidant delivery, equipped with a near-infrared fluorescence (NIRF) reporter, longitudinal, non-invasive NIRF imaging of perfusate flow through organs/tissues during machine perfusion. Methods: A Quality-by-Design (QbD)-guided optimization was used to formulate a triphasic PFC-NE with 30% w/v perfluorooctyl bromide (PFOB). Drug-free perfluorocarbon nanoemulsions (DF-NEs) and RSV-loaded nanoemulsions (RSV-NEs) were produced at 250–1000 mL scales using M110S, LM20, and M110P microfluidizers. Colloidal attributes, fluorescence stability, drug loading, and RSV release were evaluated using DLS, NIRF imaging, and HPLC, respectively. PFC-NE oxygen loading and release kinetics were evaluated during perfusion through the BMI OrganBank^® machine with the MEDOS HILITE^® oxygenator and by controlled flow of oxygen. The in vitro antioxidant activity of RSV-NE was measured using the oxygen radical scavenging antioxidant capacity (ORAC) assay. The cytotoxicity and ferroptosis inhibition of RSV-NE were evaluated in RAW 264.7 macrophages. Results: PFC-NE batches maintained a consistent droplet size (90–110 nm) and low polydispersity index (<0.3) across all scales, with high reproducibility and >80% PFOB loading. Both DF-NE and RSV-NE maintained colloidal and fluorescence stability under centrifugation, serum exposure at body temperature, filtration, 3-month storage, and oxygenation. Furthermore, RSV-NE showed high drug loading and sustained release (63.37 ± 2.48% at day 5) compared with the rapid release observed in free RSV solution. In perfusion studies, the oxygenation capacity of PFC-NE consistently exceeded that of University of Wisconsin (UW) solution and demonstrated stable, linear gas responsiveness across flow rates and FiO₂ (fraction of inspired oxygen) inputs. RSV-NE displayed strong antioxidant activity and concentration-dependent inhibition of free radicals. RSV-NE maintained higher cell viability and prevented RAS-selective lethal compound 3 (RSL3)-induced ferroptosis in murine macrophages (macrophage cell line RAW 264.7), compared to the free RSV solution. Morphological and functional protection against RSL3-induced ferroptosis was confirmed microscopically. Conclusions: This study establishes a robust and scalable PFC-NE platform integrating antioxidant and oxygen delivery, along with NIRF-based non-invasive live monitoring of organ perfusion during machine-supported preservation. These combined features position PFC-NE as a promising next-generation acellular perfusate for preventing IRI and improving graft viability during ex vivo machine perfusion. Full article

Background and Objectives: Academic point-of-care (POC) manufacturing enables the in-hospital design and production of patient-specific medical devices within certified environments, integrating clinical practice, engineering, and translational research. This model represents a new academic ecosystem that accelerates innovation while maintaining compliance with medical device regulations. Gregorio Marañón University Hospital has established one of the first ISO 13485-certified academic manufacturing facilities in Spain, providing on-site production of anatomical models, surgical guides, and custom implants for oral and maxillofacial surgery. This study presents a retrospective review of all devices produced between April 2017 and September 2025, analyzing their typology, materials, production parameters, and clinical applications. Materials and Methods: A descriptive, retrospective study was conducted on 442 3D-printed medical devices fabricated for oral and maxillofacial surgical cases. Recorded variables included device classification, indication, printing technology, material type, sterilization method, working and printing times, and clinical utility. Image segmentation and design were performed using 3D Slicer and Meshmixer. Manufacturing used fused deposition modeling (FDM) and stereolithography (SLA) technologies with PLA and biocompatible resin (Biomed Clear V1). Data were analyzed descriptively. Results: During the eight-year period, 442 devices were manufactured. Biomodels constituted the majority (approximately 68%), followed by surgical guides (20%) and patient-specific implants (7%). Trauma and oncology were the leading clinical indications, representing 45% and 33% of all devices, respectively. The orbital region was the most frequent anatomical site. FDM accounted for 63% of the printing technologies used, and PLA was the predominant material. The mean working time per device was 3.4 h and mean printing time 12.6 h. Most devices were applied to preoperative planning (59%) or intraoperative use (35%). Conclusions: Academic POC manufacturing offers a sustainable, clinically integrated model for translating digital workflows and additive manufacturing into daily surgical practice. The eight-year experience of Gregorio Marañón University Hospital demonstrates how academic production units can enhance surgical precision, accelerate innovation, and ensure regulatory compliance while promoting education and translational research in healthcare. Full article

The European forest-based sector faces a perfect storm of demographic, geopolitical, climatic, and policy-driven challenges. These multipronged, oftentimes interlinked factors are particularly consequential for export-oriented, forest-rich economies like Sweden. This study provides a qualitative scenario analysis to assess potential futures for the Swedish forest sector towards 2050, focusing on the impacts of key drivers: geopolitical alignment, European Union (EU) policy implementation, economic and demographic trends, technological progress, and climate change. Two critical uncertainties—Europe’s geopolitical positioning and the policy balance between wood use and forest conservation—form the axes for four contrasting scenarios. Results indicate that, across all futures, volume-based manufacturing in Sweden is expected to stagnate or decline due to high costs and weak EU demand, with bulk production shifting to the Global South. Long-term viability hinges on a strategic shift to high-value segments (e.g., specialty packaging solutions, biochemicals, construction components) and the adoption of advanced technologies. Concurrently, the sector must adapt to increased forest disturbances and diversify tree species, despite industry processes being optimized for current conifers. The study concludes that without a decisive transition from commodity production to innovative, value-added strategies, the Swedish forest sector’s competitiveness and resilience are at serious risk. Full article

The inner spacer module, which profoundly affects the final performance of a device, is a critical component in GAA NSFET (Gate-all-around Nanosheet Field Effect Transistor) manufacturing and necessitates systematic optimization and fundamental innovation. This work aims to develop an advanced SiGe etching process with high selectivity, uniformity and low damage to achieve an ideal inner spacer structure for logic GAA NSFETs. For three distinct dry etching technologies, ICP (Inductively Coupled Plasma Technology), RPS (Remote Plasma Source) and Gas Etching, we evaluated their potential and comparative advantages for inner spacer cavity etching under the same experimental conditions. The experimental results demonstrated that Gas Etching technology possesses the uniquely high selectivity of the SiGe sacrificial layer, making it the most suitable approach for inner spacer cavity etching to reduce Si nanosheet damage. Based on the results, in the stacked structures, the SiGe/Si selectivity ratio exhibited in Gas Etching is ~9 times higher than ICP and ~2 times higher than RPS. Through systematic optimization of pre-clean conditions, temperature and chamber pressure control, we successfully achieved a remarkable performance target of cavity etching: the average SiGe/Si etching selectivity is ~56, the inner spacer shape index is 0.92 and the local etching distance variation is only 0.65 nm across different layers. These findings provide valuable guidance for equipment selection in highly selective SiGe etching and offer critical insights into key process module development for GAA NSFETs. Full article

Metal additive manufacturing (AM) generates complex microstructures through extreme thermal gradients and rapid solidification, critically influencing mechanical performance and industrial qualification. This review synthesizes recent advances in cellular automata (CA) and phase-field (PF) modeling to predict grain-scale microstructure evolution during AM. CA methods provide computational efficiency, enabling large-domain simulations and excelling in texture prediction and multi-layer builds. PF approaches deliver superior thermodynamic fidelity for interface dynamics, solute partitioning, and nonequilibrium rapid solidification through CALPHAD coupling. Hybrid CA–PF frameworks strategically balance efficiency and accuracy by allocating PF to solidification fronts and CA to bulk grain competition. Recent algorithmic innovations—discrete event-inspired CA, GPU acceleration, and machine learning—extend scalability while maintaining predictive capability. Validated applications across Ni-based superalloys, Ti-6Al-4V, tool steels, and Al alloys demonstrate robust process–microstructure–property predictions through EBSD and mechanical testing. Persistent challenges include computational scalability for full-scale components, standardized calibration protocols, limited in situ validation, and incomplete multi-physics coupling. Emerging solutions leverage physics-informed machine learning, digital twin architectures, and open-source platforms to enable predictive microstructure control for first-time-right manufacturing in aerospace, biomedical, and energy applications. Full article

Maxillofacial skeletal reconstruction presents significant challenges due to anatomical complexity, functional requirements, and aesthetic demands. Traditional materials such as titanium and autogenous bone grafts have limitations, prompting interest in Polyetheretherketone (PEEK), a versatile thermoplastic polymer with advantages like biocompatibility, radiolucency, and elasticity similar to human bone. This multi-year case series evaluates the clinical outcomes of PEEK implants used in 56 cases on 53 patients for maxillofacial reconstruction, primarily for trauma (44 patients) and deformity (9 patients). PEEK implants were applied to various facial regions including the orbit, zygoma, mandible, and maxilla. The majority of surgeries utilised virtual surgical planning. Patient-specific implants were fabricated using 3D imaging technologies, allowing customisation for optimal fit and functionality. The mean patient age was 37 years with a split of 37 to 16 females. Some complications were noted such as infection and paraesthesia. However, the majority of patients experienced positive outcomes. The findings support PEEK implants as a safe, effective, and adaptable material for maxillofacial surgery, with potential for further advancements in material properties and surgical technologies to improve long-term outcomes. Full article

Despite substantial growth in eco-innovation (EI) research, most studies rely on cross-sectional data, limiting understanding of the temporal dynamics of EI and its determinants under varying macroeconomic conditions. This study addresses this gap by analysing panel data from Spanish manufacturing firms across three phases of the business cycle: pre-crisis expansion (2004–2007), the global financial crisis (2008–2013), and recovery (2014–2016). We investigate the drivers of two distinct types of eco-innovation: efficiency EI (energy and material savings) and environmental EI (reducing environmental harm), focusing on the role of regulation, institutional interventions, and firm-level innovation capacities. Using a random-effects panel probit model that accounts for unobserved firm heterogeneity, we examine how these drivers operate across different macroeconomic contexts. Our findings reveal that regulation consistently fosters EI, while the influence of subsidies, R&D capacity, and collaborative networks is more context-dependent, particularly during economic downturns. The results highlight the cumulative, path-dependent, and cyclical nature of EI, providing novel insights into the conditions that enable firms to sustain green innovation over time. Drivers of eco-innovation differ systematically between efficiency- and environment-oriented strategies, and these differences remain stable over the business cycle, implying distinct underlying mechanisms and policy implications. Accordingly, policy design—particularly during economic downturns—should distinguish between reinforcing incentives for internal efficiency improvements and sustaining regulatory and financial support for environmental EI. Full article