Methods of Potentially Improving Drug Permeation and Bioavailability

Dear Colleagues,

Drug permeation and bioavailability remain critical challenges in pharmaceutical development, particularly for compounds with poor solubility, low permeability, or extensive first-pass metabolism. This Special Issue of Pharmaceutics aims to explore innovative approaches to enhance drug absorption, ensuring optimal therapeutic outcomes.

We invite original research and review articles focusing on both physical and chemical methods for improving drug permeation and bioavailability. Studies investigating novel formulation strategies, nanotechnology-based delivery systems, permeability enhancers, and prodrug approaches are particularly welcome. Additionally, we encourage submissions exploring physical techniques to enhance transdermal, oral, or intranasal drug delivery.

This issue will feature in vitro, ex vivo and in vivo studies evaluating the efficacy and safety of these strategies in overcoming biological barriers, such as the intestinal epithelium, skin, blood-brain barrier, and intranasal tissues. Mechanistic insights into drug transport, metabolism, and absorption will be of particular interest, along with computational models predicting permeability enhancement.

By compiling cutting-edge research in this field, this Special Issue aims to provide valuable insights into next-generation drug delivery technologies, ultimately facilitating the development of more effective therapeutic interventions. Researchers working on innovative solutions to improve drug permeation and bioavailability are encouraged to contribute to this issue.

Dr. Wihan Pheiffer
Prof. Dr. Dewald Steyn
Prof. Dr. Sias Hamman
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-anonymized peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Pharmaceutics is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.