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Search Results (1,541)

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Keywords = magnetic driving

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21 pages, 8352 KiB  
Article
Research on Vibration Characteristics of Electric Drive Systems Based on Open-Phase Self-Fault-Tolerant Control
by Wenyu Bai, Yun Kuang, Zhizhong Xu, Yawen Wang and Xia Hua
Appl. Sci. 2025, 15(15), 8707; https://doi.org/10.3390/app15158707 - 6 Aug 2025
Abstract
This paper presents an electromechanical coupling model integrating an equivalent magnetic network (EMN) model of a dual three-phase permanent magnet synchronous motor (DTP-PMSM) with the dynamic model of a helical planetary gear transmission system. Using this model, this study analyzes the dynamic characteristics [...] Read more.
This paper presents an electromechanical coupling model integrating an equivalent magnetic network (EMN) model of a dual three-phase permanent magnet synchronous motor (DTP-PMSM) with the dynamic model of a helical planetary gear transmission system. Using this model, this study analyzes the dynamic characteristics of an electric drive system, specifically motor phase current, electromagnetic torque, and gear meshing force, under self-fault-tolerant control strategies. Simulation and experimental results demonstrate that the self-fault-tolerant control strategy enables rapid fault tolerance during open-phase faults, significantly reducing system fault recovery time. Meanwhile, compared to the open-phase faults conditions, the self-fault-tolerant control effectively suppresses most harmonic components within the system; only the second harmonic amplitude of the electromagnetic torque exhibited an increase. This harmonic disturbance propagates to the gear system through electromechanical coupling, synchronously amplifying the second harmonic amplitude in the gear system’s vibration response. This study demonstrates that self-fault-tolerant control strategies significantly enhance the dynamic response performance of the electric drive system under open-phase faults conditions. Furthermore, this study also investigates the electromechanical coupling mechanism through which harmonics generated by this strategy affect the gear system’s dynamic response, providing theoretical support for co-optimization electromechanical coupling design and fault-tolerant control in high-reliability electric drive transmission systems. Full article
(This article belongs to the Section Mechanical Engineering)
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27 pages, 30231 KiB  
Article
Modelling and Simulation of a 3MW, Seventeen-Phase Permanent Magnet AC Motor with AI-Based Drive Control for Submarines Under Deep-Sea Conditions
by Arun Singh and Anita Khosla
Energies 2025, 18(15), 4137; https://doi.org/10.3390/en18154137 - 4 Aug 2025
Viewed by 207
Abstract
The growing need for high-efficiency and reliable propulsion systems in naval applications, particularly within the evolving landscape of submarine warfare, has led to an increased interest in multiphase Permanent Magnet AC motors. This study presents a modelling and simulation approach for a 3MW, [...] Read more.
The growing need for high-efficiency and reliable propulsion systems in naval applications, particularly within the evolving landscape of submarine warfare, has led to an increased interest in multiphase Permanent Magnet AC motors. This study presents a modelling and simulation approach for a 3MW, seventeen-phase Permanent Magnet AC motor designed for submarine propulsion, integrating an AI-based drive control system. Despite the advantages of multiphase motors, such as higher power density and enhanced fault tolerance, significant challenges remain in achieving precise torque and variable speed, especially for externally mounted motors operating under deep-sea conditions. Existing control strategies often struggle with the inherent nonlinearities, unmodelled dynamics, and extreme environmental variations (e.g., pressure, temperature affecting oil viscosity and motor parameters) characteristic of such demanding deep-sea applications, leading to suboptimal performance and compromised reliability. Addressing this gap, this research investigates advanced control methodologies to enhance the performance of such motors. A MATLAB/Simulink framework was developed to model the motor, whose drive system leverages an AI-optimised dual fuzzy-PID controller refined using the Harmony Search Algorithm. Additionally, a combination of Indirect Field-Oriented Control (IFOC) and Space Vector PWM strategies are implemented to optimise inverter switching sequences for precise output modulation. Simulation results demonstrate significant improvements in torque response and control accuracy, validating the efficacy of the proposed system. The results highlight the role of AI-based propulsion systems in revolutionising submarine manoeuvrability and energy efficiency. In particular, during a test case involving a speed transition from 75 RPM to 900 RPM, the proposed AI-based controller achieves a near-zero overshoot compared to an initial control scheme that exhibits 75.89% overshoot. Full article
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20 pages, 4209 KiB  
Article
Evaluation of Maximum Torque per Ampere Control Method for Interior Permanent Magnet Machine Drives on dSpace with Emphasis on Potential Practical Issues for High Energy Efficiency
by Osman Emre Özçiflikçi, Mikail Koç and Serkan Bahçeci
Energies 2025, 18(15), 4118; https://doi.org/10.3390/en18154118 - 3 Aug 2025
Viewed by 133
Abstract
Interior-mounted permanent magnet (IPM) machines have been widely used in recent years due to their high efficiency, high torque/power densities, and so on. These machines can produce reluctance torque whereas their surface-mounted (SPM) counterparts cannot. Hence, IPMs are attractive in industrial applications that [...] Read more.
Interior-mounted permanent magnet (IPM) machines have been widely used in recent years due to their high efficiency, high torque/power densities, and so on. These machines can produce reluctance torque whereas their surface-mounted (SPM) counterparts cannot. Hence, IPMs are attractive in industrial applications that require high torque density. Id=0 control is commonly adopted to drive permanent magnet (PM) machines, and the strategy is attractive due to its simplicity. However, although it is suitable for SPMs, adopting it in IPMs sacrifices the reluctance torque that can be obtained from the machine. Hence, it is vital to control IPMs using the maximum torque per ampere (MTPA) strategy. This paper adopts the MTPA strategy for a 4.1 kW prototype IPM machine. Test system configuration is discussed step by step by paying particular attention to potential practical issues and inspirational discussions on their solutions. The issues associated with misaligned rotor positions or whistling problems pertinent to inappropriate power conversion strategies are addressed to overcome such issues in practical IPM drives. Comprehensive discussions and extensive comparisons of well-matched simulation and experimental results of both Id=0- and MTPA-controlled drives at different evaluation metrics will be quite insightful to achieve efficiency-optimized IPM drives. Full article
(This article belongs to the Special Issue Advances in Control Strategies of Permanent Magnet Motor Drive)
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33 pages, 4142 KiB  
Review
Advances in Wettability-Engineered Open Planar-Surface Droplet Manipulation
by Ge Chen, Jin Yan, Junjie Liang, Jiajia Zheng, Jinpeng Wang, Hongchen Pang, Xianzhang Wang, Zihao Weng and Wei Wang
Micromachines 2025, 16(8), 893; https://doi.org/10.3390/mi16080893 - 31 Jul 2025
Viewed by 324
Abstract
Firstly, this paper reviews the fundamental theories of solid surface wettability and contact angle hysteresis. Subsequently, it further introduces four typical wettability-engineered surfaces with low hysteresis (superhydrophobic, superamphiphobic, super-slippery, and liquid-like smooth surfaces). Finally, it focuses on the latest research progress in the [...] Read more.
Firstly, this paper reviews the fundamental theories of solid surface wettability and contact angle hysteresis. Subsequently, it further introduces four typical wettability-engineered surfaces with low hysteresis (superhydrophobic, superamphiphobic, super-slippery, and liquid-like smooth surfaces). Finally, it focuses on the latest research progress in the field of droplet manipulation on open planar surfaces with engineered wettability. To achieve droplet manipulation, the core driving forces primarily stem from natural forces guided by bioinspired gradient surfaces or the regulatory effects of external fields. In terms of bioinspired self-propelled droplet movement, this paper summarizes research inspired by natural organisms such as desert beetles, cacti, self-aligning floating seeds of emergent plants, or water-walking insects, which construct bioinspired special gradient surfaces to induce Laplace pressure differences or wettability gradients on both sides of droplets for droplet manipulation. Moreover, this paper further analyzes the mechanisms, advantages, and limitations of these self-propelled approaches, while summarizing the corresponding driving force sources and their theoretical formulas. For droplet manipulation under external fields, this paper elaborates on various external stimuli including electric fields, thermal fields, optical fields, acoustic fields, and magnetic fields. Among them, electric fields involve actuation mechanisms such as directly applied electrostatic forces and indirectly applied electrocapillary forces; thermal fields influence droplet motion through thermoresponsive wettability gradients and thermocapillary effects; optical fields cover multiple wavelengths including near-infrared, ultraviolet, and visible light; acoustic fields utilize horizontal and vertical acoustic radiation pressure or acoustic wave-induced acoustic streaming for droplet manipulation; the magnetic force acting on droplets may originate from their interior, surface, or external substrates. Based on these different transport principles, this paper comparatively analyzes the unique characteristics of droplet manipulation under the five external fields. Finally, this paper summarizes the current challenges and issues in the research of droplet manipulation on the open planar surfaces and provides an outlook on future development directions in this field. Full article
(This article belongs to the Special Issue Advanced Microfluidic Chips: Optical Sensing and Detection)
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17 pages, 3944 KiB  
Article
Functionalized Magnetic Nanoparticles as Recyclable Draw Solutes for Forward Osmosis: A Sustainable Approach to Produced Water Reclamation
by Sunith B. Madduri and Raghava R. Kommalapati
Separations 2025, 12(8), 199; https://doi.org/10.3390/separations12080199 - 29 Jul 2025
Viewed by 301
Abstract
Magnetic nanoparticles (MNPs), especially iron oxide (Fe3O4), display distinctive superparamagnetic characteristics and elevated surface-area-to-volume ratios, facilitating improved physicochemical interactions with solutes and pollutants. These characteristics make MNPs strong contenders for use in water treatment applications. This research investigates the [...] Read more.
Magnetic nanoparticles (MNPs), especially iron oxide (Fe3O4), display distinctive superparamagnetic characteristics and elevated surface-area-to-volume ratios, facilitating improved physicochemical interactions with solutes and pollutants. These characteristics make MNPs strong contenders for use in water treatment applications. This research investigates the application of iron oxide MNPs synthesized via co-precipitation as innovative draw solutes in forward osmosis (FO) for treating synthetic produced water (SPW). The FO membrane underwent surface modification with sulfobetaine methacrylate (SBMA), a zwitterionic polymer, to increase hydrophilicity, minimize fouling, and elevate water flux. The SBMA functional groups aid in electrostatic repulsion of organic and inorganic contaminants, simultaneously encouraging robust hydration layers that improve water permeability. This adjustment is vital for sustaining consistent flux performance while functioning with MNP-based draw solutions. Material analysis through thermogravimetric analysis (TGA), scanning electron microscopy (SEM), and Fourier-transform infrared spectroscopy (FTIR) verified the MNPs’ thermal stability, consistent morphology, and modified surface chemistry. The FO experiments showed a distinct relationship between MNP concentration and osmotic efficiency. At an MNP dosage of 10 g/L, the peak real-time flux was observed at around 3.5–4.0 L/m2·h. After magnetic regeneration, 7.8 g of retrieved MNPs generated a steady flow of ~2.8 L/m2·h, whereas a subsequent regeneration (4.06 g) resulted in ~1.5 L/m2·h, demonstrating partial preservation of osmotic driving capability. Post-FO draw solutions, after filtration, exhibited total dissolved solids (TDS) measurements that varied from 2.5 mg/L (0 g/L MNP) to 227.1 mg/L (10 g/L MNP), further validating the effective dispersion and solute contribution of MNPs. The TDS of regenerated MNP solutions stayed similar to that of their fresh versions, indicating minimal loss of solute activity during the recycling process. The combined synergistic application of SBMA-modified FO membranes and regenerable MNP draw solutes showcases an effective and sustainable method for treating produced water, providing excellent water recovery, consistent operational stability, and opportunities for cyclic reuse. Full article
(This article belongs to the Section Purification Technology)
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15 pages, 4614 KiB  
Article
Energy-Efficient Current Control Strategy for Drive Modules of Permanent Magnetic Actuators
by Hyoung-Kyu Yang, Jin-Seok Kim and Jin-Hong Kim
Electronics 2025, 14(15), 2972; https://doi.org/10.3390/electronics14152972 - 25 Jul 2025
Viewed by 207
Abstract
This paper proposes an energy-efficient current control strategy for drive modules of permanent magnetic actuators (PMAs) to reduce the cost and volume of DC-link capacitors. The drive module of the PMA does not receive the input power from an external power source during [...] Read more.
This paper proposes an energy-efficient current control strategy for drive modules of permanent magnetic actuators (PMAs) to reduce the cost and volume of DC-link capacitors. The drive module of the PMA does not receive the input power from an external power source during operation. Instead, the externally charged DC-link capacitors are used as internal backup power sources to guarantee the reliable operation even in the case of an emergency. Therefore, it is important to use the charged energy efficiently within the limited DC-link capacitors. However, conventional control strategies using a voltage open loop have trouble reducing the energy waste. This is because the drive module with the voltage open loop uses unnecessary energy even after the PMA mover has finished its movement. To figure it out, the proposed control strategy adopts a current control loop to save energy even if the displacement of the PMA mover is unknown. In addition, the proposed strategy can ensure the successful operation of the PMA by using the driving force analysis. The efficacy of the proposed strategy is verified through the experimental test. It would be expected that the proposed strategy can reduce the cost and volume of the PMA drive system. Full article
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19 pages, 4344 KiB  
Article
Modeling of a C-Frame Reluctance-Enhanced Shaded-Pole Induction Motor—Study of Shaded-Coil Design
by Selma Čorović and Damijan Miljavec
Actuators 2025, 14(8), 368; https://doi.org/10.3390/act14080368 - 24 Jul 2025
Viewed by 266
Abstract
Shaded-pole induction motors are the most frequently used single-phase electric motors in low power applications. Their main advantages are reliability, robustness, low level of noise and vibration, relatively simple manufacturing technology and cost effectiveness. These motors are the driving units of choice in [...] Read more.
Shaded-pole induction motors are the most frequently used single-phase electric motors in low power applications. Their main advantages are reliability, robustness, low level of noise and vibration, relatively simple manufacturing technology and cost effectiveness. These motors are the driving units of choice in the applications where the variable speed and high starting torque are not of utmost importance, in spite of the fact that they are characterized by inferior efficiency, power factor and starting torque compared to their single-phase counterparts. They are equipped with auxiliary massive copper coils at the stator side, which makes them self-starting, and strongly influence the motor characteristics. This study deals with the numerical modeling and analysis of a shaded-pole induction motor with a C-shaped stator frame. The analysis was performed using 2D finite element-based transient magnetic numerical modeling. The primary objective was to investigate the influence of the number and size of the auxiliary shaded coils on the output torque speed characteristic. We explored the possibility of reducing the amount of material used while preserving the crucial/nominal properties of the motor. Our results have important implications in manufacturing simplification, which may be important for the eco-design of small motors and actuators, including their recycling and/or reuse process. Full article
(This article belongs to the Section High Torque/Power Density Actuators)
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20 pages, 2341 KiB  
Article
Magnetic Field Measurement of Various Types of Vehicles, Including Electric Vehicles
by Hiromichi Fukui, Norihiro Minami, Masatoshi Tanezaki, Shinichi Muroya and Chiyoji Ohkubo
Electronics 2025, 14(15), 2936; https://doi.org/10.3390/electronics14152936 - 23 Jul 2025
Viewed by 632
Abstract
Since around the year 2000, following the introduction of electric vehicles (EVs) to the market, some people have expressed concerns about the level of magnetic flux density (MFD) inside vehicles. In 2013, we reported the results of MFD measurements for electric vehicles (EVs), [...] Read more.
Since around the year 2000, following the introduction of electric vehicles (EVs) to the market, some people have expressed concerns about the level of magnetic flux density (MFD) inside vehicles. In 2013, we reported the results of MFD measurements for electric vehicles (EVs), hybrid electric vehicles (HEVs), and internal combustion engine vehicles (ICEVs). However, those 2013 measurements were conducted using a chassis dynamometer, and no measurements were taken during actual driving. In recent years, with the rapid global spread of EVs and plug-in hybrid electric vehicles (PHEVs), the international standard IEC 62764-1:2022, which defines methods for measuring magnetic fields (MF) in vehicles, has been issued. In response, and for the first time, we conducted new MF measurements on current Japanese vehicle models in accordance with the international standard IEC 62764-1:2022, identifying the MFD levels and their sources at various positions within EVs, PHEVs, and ICEVs. The measured MFD values in all vehicle types were below the reference levels recommended by the International Commission on Non-Ionizing Radiation Protection (ICNIRP) for public exposure. Furthermore, we performed comparative measurements with the MF data obtained in 2013 and confirmed that the MF levels remained similar. These findings are expected to provide valuable insights for risk communication with the public regarding electromagnetic fields, particularly for those concerned about MF exposure inside electrified vehicles. Full article
(This article belongs to the Special Issue Innovations in Electromagnetic Field Measurements and Applications)
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24 pages, 9734 KiB  
Article
Investigating the Influence of PWM-Driven Cascaded H-Bridges Multilevel Inverter on Interior Permanent Magnet Synchronous Motor Power Losses
by Claudio Nevoloso, Gioacchino Scaglione, Giuseppe Schettino, Antonino Oscar Di Tommaso, Fabio Viola, Ciro Spataro and Rosario Miceli
Energies 2025, 18(15), 3911; https://doi.org/10.3390/en18153911 - 22 Jul 2025
Viewed by 260
Abstract
This paper presents an accurate analysis of the power losses of an interior permanent magnet synchronous motor fed by a cascaded H-bridge multilevel inverter. The main goal of this study is to investigate the impact of the cascaded h-bridge inverter, multicarrier PWM strategies, [...] Read more.
This paper presents an accurate analysis of the power losses of an interior permanent magnet synchronous motor fed by a cascaded H-bridge multilevel inverter. The main goal of this study is to investigate the impact of the cascaded h-bridge inverter, multicarrier PWM strategies, and inverter switching frequency on the synchronous motor power losses. With this aim in mind, a detailed frequency domain power analysis was carried out on motor power losses at different operating points in the frequency–torque plane. Motor power losses were further categorized into fundamental and harmonic power losses. This evaluation involved driving the power converter using six distinct multicarrier PWM strategies at four different switching frequencies. Additionally, a comparison was conducted with a conventional two-level PWM inverter to quantify the reduction in motor power losses. The experimental results show that the cascaded h-bridge inverter guarantees a notable increase in the motor efficiency, up to 7%, and losses in segregation at the fundamental frequency, if compared to the standard two-level PWM inverter, especially at low speed and with partial-load conditions. Such results mark out the cascaded H-bridge inverter as a valuable choice, also with regard to low-voltage drive applications. Full article
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18 pages, 6767 KiB  
Article
Study on Air-Cooled Structure of Direct-Drive Outer-Rotor Permanent Magnet Synchronous Generator for Wind Power Generation
by Xudong Yang, Ke Li, Yiguang Chen, Haiying Lv and Jingjuan Du
Appl. Sci. 2025, 15(14), 8008; https://doi.org/10.3390/app15148008 - 18 Jul 2025
Viewed by 245
Abstract
Direct-drive permanent magnet synchronous generators (DD-PMSGs) have been widely adopted in wind power generation systems owing to their distinctive advantages, including direct-drive operation, high power density, and superior energy conversion efficiency. However, the high power density of the generator inevitably leads to heat [...] Read more.
Direct-drive permanent magnet synchronous generators (DD-PMSGs) have been widely adopted in wind power generation systems owing to their distinctive advantages, including direct-drive operation, high power density, and superior energy conversion efficiency. However, the high power density of the generator inevitably leads to heat generation issues, which affect the reliability of the generator. To address the thermal issues in the 4.5 MW direct-drive permanent magnet synchronous generator (DD-PMSG), this paper proposes a novel forced air-cooling ventilation system. Through comprehensive computational fluid dynamics (CFD) simulations and fundamental thermodynamic analysis, the cooling performance is systematically evaluated to determine the optimal width of the stator ventilation ducts. Furthermore, based on the temperature distribution of the stator and rotor, three optimization schemes for non-uniform core segments are proposed. By comparing the ventilation cooling performance under three structural schemes, the optimal structural scheme is provided for the generator. Finally, the feasibility of the heat dissipation scheme and the accuracy of the simulation calculations are verified by fabricating a prototype and setting up an experimental platform. The above conclusions and research results can provide some reference for the design of the core ventilation ducts structure of subsequent wind turbines. Full article
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17 pages, 4431 KiB  
Article
Wheeled Permanent Magnet Climbing Robot for Weld Defect Detection on Hydraulic Steel Gates
by Kaiming Lv, Zhengjun Liu, Hao Zhang, Honggang Jia, Yuanping Mao, Yi Zhang and Guijun Bi
Appl. Sci. 2025, 15(14), 7948; https://doi.org/10.3390/app15147948 - 17 Jul 2025
Viewed by 314
Abstract
In response to the challenges associated with weld treatment during the on-site corrosion protection of hydraulic steel gates, this paper proposes a method utilizing a magnetic adsorption climbing robot to perform corrosion protection operations. Firstly, a magnetic adsorption climbing robot with a multi-wheel [...] Read more.
In response to the challenges associated with weld treatment during the on-site corrosion protection of hydraulic steel gates, this paper proposes a method utilizing a magnetic adsorption climbing robot to perform corrosion protection operations. Firstly, a magnetic adsorption climbing robot with a multi-wheel independent drive configuration is proposed as a mobile platform. The robot body consists of six joint modules, with the two middle joints featuring adjustable suspension. The joints are connected in series via an EtherCAT bus communication system. Secondly, the kinematic model of the climbing robot is analyzed and a PID trajectory tracking control method is designed, based on the kinematic model and trajectory deviation information collected by the vision system. Subsequently, the proposed kinematic model and trajectory tracking control method are validated through Python3 simulation and actual operation tests on a curved trajectory, demonstrating the rationality of the designed PID controller and control parameters. Finally, an intelligent software system for weld defect detection based on computer vision is developed. This system is demonstrated to conduct defect detection on images of the current weld position using a trained model. Full article
(This article belongs to the Section Applied Physics General)
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15 pages, 5296 KiB  
Article
Study on Multiple-Inverter-Drive Method for IPMSM to Improve the Motor Efficiency
by Koki Takeuchi and Kan Akatsu
World Electr. Veh. J. 2025, 16(7), 398; https://doi.org/10.3390/wevj16070398 - 15 Jul 2025
Viewed by 289
Abstract
In recent years, the rapid spread of electric vehicles (EVs) has intensified the competition to develop power units for EVs. In particular, improving the driving range of EVs has become a major topic, and in order to achieve this, many studies have been [...] Read more.
In recent years, the rapid spread of electric vehicles (EVs) has intensified the competition to develop power units for EVs. In particular, improving the driving range of EVs has become a major topic, and in order to achieve this, many studies have been conducted on improving the efficiency of EV power units. In this study, we propose a multiple-inverter-drive permanent magnet synchronous motor based on an 8-pole, 48-slot structure, which is commonly used as an EV motor. The proposed motor is composed of two completely independent parallel inverters and windings, and intermittent operation is possible; that is, only one inverter and one parallel winding is used depending on the situation. In the proposed motor, we compare losses including stator iron loss, rotor iron loss, and magnet eddy current loss by PWM voltage inputs for some stator winding topologies, we show that the one-side winding arrangement is the most efficient during intermittent operation, and that it is more efficient than normal operation especially in the low-speed, low-torque range. Finally, through a vehicle-driving simulation considering the efficiency map including motor loss and inverter loss, we show that the intentional use of intermittent operation can improve electrical energy consumption. Full article
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31 pages, 2741 KiB  
Article
Power Flow Simulation and Thermal Performance Analysis of Electric Vehicles Under Standard Driving Cycles
by Jafar Masri, Mohammad Ismail and Abdulrahman Obaid
Energies 2025, 18(14), 3737; https://doi.org/10.3390/en18143737 - 15 Jul 2025
Viewed by 384
Abstract
This paper presents a simulation framework for evaluating power flow, energy efficiency, thermal behavior, and energy consumption in electric vehicles (EVs) under standardized driving conditions. A detailed Simulink model is developed, integrating a lithium-ion battery, inverter, permanent magnet synchronous motor (PMSM), gearbox, and [...] Read more.
This paper presents a simulation framework for evaluating power flow, energy efficiency, thermal behavior, and energy consumption in electric vehicles (EVs) under standardized driving conditions. A detailed Simulink model is developed, integrating a lithium-ion battery, inverter, permanent magnet synchronous motor (PMSM), gearbox, and a field-oriented control strategy with PI-based speed and current regulation. The framework is applied to four standard driving cycles—UDDS, HWFET, WLTP, and NEDC—to assess system performance under varied load conditions. The UDDS cycle imposes the highest thermal loads, with temperature rises of 76.5 °C (motor) and 52.0 °C (inverter). The HWFET cycle yields the highest energy efficiency, with PMSM efficiency reaching 92% and minimal SOC depletion (15%) due to its steady-speed profile. The WLTP cycle shows wide power fluctuations (−30–19.3 kW), and a motor temperature rise of 73.6 °C. The NEDC results indicate a thermal increase of 75.1 °C. Model results show good agreement with published benchmarks, with deviations generally below 5%, validating the framework’s accuracy. These findings underscore the importance of cycle-sensitive analysis in optimizing energy use and thermal management in EV powertrain design. Full article
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32 pages, 1397 KiB  
Review
Prognostic Significance of the Comprehensive Biomarker Analysis in Colorectal Cancer
by Vera Potievskaya, Elizaveta Tyukanova, Marina Sekacheva, Zaki Fashafsha, Anastasia Fatyanova, Mikhail Potievskiy, Elena Kononova, Anna Kholstinina, Ekatherina Polishchuk, Peter Shegai and Andrey Kaprin
Life 2025, 15(7), 1100; https://doi.org/10.3390/life15071100 - 14 Jul 2025
Viewed by 739
Abstract
Colorectal carcinoma remains one of the primary contributors to cancer deaths; however, it is also considered a preventable type of cancer, because the prognosis of the disease is directly dependent on its timely detection. Developing accurate risk prediction models for colorectal cancer is [...] Read more.
Colorectal carcinoma remains one of the primary contributors to cancer deaths; however, it is also considered a preventable type of cancer, because the prognosis of the disease is directly dependent on its timely detection. Developing accurate risk prediction models for colorectal cancer is crucial for identifying individuals at both low and high risk, as risk stratification determines the need for additional interventions, which carry their own risks. The development of new non-invasive diagnostic methods based on biomaterial analysis, alongside standard diagnostic techniques such as colonoscopy with biopsy, computed tomography scanning, and magnetic resonance imaging, can address multiple objectives: improving screening accuracy, providing a comprehensive assessment of minimal residual disease, identifying patients at a high risk of colorectal cancer, and evaluating the effectiveness of ongoing treatments. The lack of sensitive diagnostic methods drives contemporary research toward the discovery of new tools for detecting tumor cells, particularly through the examination of biological materials, including blood, exhaled air, and tumor tissue itself. In this article, we analyze current studies regarding biomarkers in colorectal cancer and prognostic significance. Full article
(This article belongs to the Section Physiology and Pathology)
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46 pages, 3177 KiB  
Review
Recent Advancements in Lateral Flow Assays for Food Mycotoxin Detection: A Review of Nanoparticle-Based Methods and Innovations
by Gayathree Thenuwara, Perveen Akhtar, Bilal Javed, Baljit Singh, Hugh J. Byrne and Furong Tian
Toxins 2025, 17(7), 348; https://doi.org/10.3390/toxins17070348 - 11 Jul 2025
Viewed by 666
Abstract
Mycotoxins are responsible for a multitude of diseases in both humans and animals, resulting in significant medical and economic burdens worldwide. Conventional detection methods, such as enzyme-linked immunosorbent assay (ELISA), high-performance liquid chromatography (HPLC), and liquid chromatography-tandem mass spectrometry (LC-MS/MS), are highly effective, [...] Read more.
Mycotoxins are responsible for a multitude of diseases in both humans and animals, resulting in significant medical and economic burdens worldwide. Conventional detection methods, such as enzyme-linked immunosorbent assay (ELISA), high-performance liquid chromatography (HPLC), and liquid chromatography-tandem mass spectrometry (LC-MS/MS), are highly effective, but they are generally confined to laboratory settings. Consequently, there is a growing demand for point-of-care testing (POCT) solutions that are rapid, sensitive, portable, and cost-effective. Lateral flow assays (LFAs) are a pivotal technology in POCT due to their simplicity, rapidity, and ease of use. This review synthesizes data from 78 peer-reviewed studies published between 2015 and 2024, evaluating advances in nanoparticle-based LFAs for detection of singular or multiplex mycotoxin types. Gold nanoparticles (AuNPs) remain the most widely used, due to their favorable optical and surface chemistry; however, significant progress has also been made with silver nanoparticles (AgNPs), magnetic nanoparticles, quantum dots (QDs), nanozymes, and hybrid nanostructures. The integration of multifunctional nanomaterials has enhanced assay sensitivity, specificity, and operational usability, with innovations including smartphone-based readers, signal amplification strategies, and supplementary technologies such as surface-enhanced Raman spectroscopy (SERS). While most singular LFAs achieved moderate sensitivity (0.001–1 ng/mL), only 6% reached ultra-sensitive detection (<0.001 ng/mL), and no significant improvement was evident over time (ρ = −0.162, p = 0.261). In contrast, multiplex assays demonstrated clear performance gains post-2022 (ρ = −0.357, p = 0.0008), largely driven by system-level optimization and advanced nanomaterials. Importantly, the type of sample matrix (e.g., cereals, dairy, feed) did not significantly influence the analytical sensitivity of singular or multiplex lateral LFAs (Kruskal–Wallis p > 0.05), confirming the matrix-independence of these optimized platforms. While analytical challenges remain for complex targets like fumonisins and deoxynivalenol (DON), ongoing innovations in signal amplification, biorecognition chemistry, and assay standardization are driving LFAs toward becoming reliable, ultra-sensitive, and field-deployable platforms for high-throughput mycotoxin screening in global food safety surveillance. Full article
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