248 Results Found

Theranostics utilize ligands that chelate radionuclides and selectively bind with cancer-specific membrane antigens. In the case of prostate cancer (PCa), the state-of-the-art lutetium-177-PSMA combines the radioactive β-emitter ¹⁷⁷Lu with Vipiv...

The growing demand for rare earth elements (REE) requires the search for economically viable materials to efficiently recover REE from various solutions. Our research aims to investigate the potential of using a combination of the ion exchangers Lewa...

Peptide receptor radionuclide therapy (PRRT) using Lutetium-177 (¹⁷⁷Lu) based radiopharmaceuticals has emerged as a therapeutic area in the field of nuclear medicine and oncology, allowing for personalized medicine. Since the first market authorizati...

For the first time, nickel-aluminum layered double hydroxides containing holmium, thulium or lutetium cations were successfully synthesized via the coprecipitation method followed by hydrothermal treatment. X-ray diffraction data show the formation o...

In this article, we describe a NO₂ sensor consisting of a coating based on lutetium bisphthalocyanine (LuPc₂) in mesoporous silica. The sensor exploits the absorption spectrum change of this material which strongly and reversibly decreases in contact...

Background: Therapy using lutetium-177 dotatate (¹⁷⁷LU) was approved in Europe for the treatment of advanced neuroendocrine tumors (NETs) in 2017. Since then, it has become part of the strategies in the treatment of NETs, making it now possible to ev...

Gold nanoparticles (AuNPs) have been extensively studied in cancer treatment research since they have special physicochemical characteristics such as facile surface functionalization with various chemical groups, low toxicity, favorable biocompatibil...

Crystalline defects such as oxygen vacancies have been studied little by electron paramagnetic resonance (EPR) spectroscopy for silicate-based luminescent materials. In this study, lutetium oxyorthosilicate powders were prepared by the sol–gel...

Defect complexes consisting of point defects induced by the doping of rare earth elements (Nd, Er) into lutetium oxide (Lu₂O₃) host were investigated with respect to defect formation energies and defect configurations using atomistic simulations with...

A new series of luminescent heterometallic europium(III)–lutetium(III) terephthalate metal–organic frameworks, namely (Eu_xLu_1−x)₂bdc₃·nH₂O, was synthesized using a direct reaction in a water solution. At the Eu³⁺ concentratio...

Patients suffering from metastatic castration-resistant prostate cancer (mCRPC) have a poor prognosis. As a further treatment option ¹⁷⁷Lutetium (Lu) prostate-specific membrane antigen (PSMA) radioligand therapy gained a significant interest of many...

Lutetium-177 (Lu-177)-labelled radioligand therapies (RLT) targeting prostate-specific membrane antigen (PSMA) present a promising treatment for patients with progressive metastasized castration-resistant prostate cancer (mCRPC). Personalized dosimet...

Coal fly ash hollow aluminosilicate microspheres (cenospheres) of stabilized composition (glass phase—95.4; (SiO₂/Al₂O₃)_glass—3.1; (Si/Al)_at. = 2.6) were used to fabricate lutetium-176 encapsulated aluminosilicate microspheres as precurso...

This study investigates a novel approach toward enhancing the efficacy of Lutetium-177 (Lu-177) radiopharmaceutical therapy by combining it with gold nanoparticles (AuNPs) in the HepG2 hepatic cancer cell line. Lu-177, known for its effective β...

Background and purpose. Chimeric antigen receptor (CAR) T cells have been relatively ineffective against solid tumors. Low-dose radiation which can be delivered to multiple sites of metastases by targeted radionuclide therapy (TRT) can elicit immunos...

Lutetium-177-PSMA ([177Lu]-PSMA-617), a radiolabeled small molecule, binds with high affinity to prostate-specific membrane antigen (PSMA), enabling targeted radiation therapy to metastatic prostate lesions. Our objective was to retrospectively analy...

Background: The combination of Lutetium-177 (Lu-177) PSMA-617 radioligand therapy (RLT) with androgen receptor pathway inhibitors (ARPIs) has shown promise in metastatic castration-resistant prostate cancer (mCRPC). However, real-world data on the ef...

Castration resistant prostate cancer (CRPC) is characterized by an aggressive biological behavior with a relatively short survival time, especially in progressive tumors pretreated with new hormonal agents and taxane chemotherapy. [177Lu]-Lutetium-PS...

Prostate cancer is one of the most common malignancies in men, and advanced or metastatic disease remains associated with substantial morbidity and mortality. Therapeutic progress in recent years has been driven by the introduction of targeted treatm...

Targeting of cholecystokinin-2 receptor (CCK2R) expressing tumors using radiolabeled minigastrin (MG) analogs is hampered by rapid digestion of the linear peptide in vivo. In this study, a new MG analog stabilized against enzymatic degradation was in...

Neuroendocrine neoplasms (NENs) constitute a heterogenous group of tumors originating from neuroendocrine cells scattered throughout the body. Peptide Receptor Radionuclide Therapy (PRRT) is a treatment of choice of unresectable metastasized progress...

We present the analytic forms of the principal Hugoniots of actinium (Ac) and the lanthanide promethium (Pm), which have both never been measured or calculated before, as well as those of terbium (Tb), thulium (Tm), and lutetium (Lu), the three least...

Men with high-risk localized prostate cancer (PCa) often have poor long-term outcomes, underscoring the need for improved neoadjuvant strategies beyond the current standard of care. Radioligand therapy with ¹⁷⁷Lutetium-PSMA-617 (¹⁷⁷Lu-PSMA-617) has e...

1C1m-Fc, a promising anti-TEM-1 DOTA conjugate, was labeled with ⁶⁴Cu to target cancer cells for PET imaging and predicting the efficacy and safety of a previously studied [¹⁷⁷Lu]Lu-1C1m-Fc companion therapy. DOTA-conjugated 1C1m-Fc was characterized...

Background: PRRT can be an option for all-grade GEP-NETs, but selecting patients is challenging. In this scenario, clinical-pathological and radiological characteristics, such as pre-treatment Ga-68 DOTA PET/CT, might have the potential to help. Meth...

Background: the primary challenge with implant infections is the formation of biofilm, which harbors dormant bacteria that reduce the effectiveness of antibiotics and amplify antibiotic resistance, exacerbating the global antimicrobial resistance cri...

The new intermetallic compound Ru₁₁Lu₂₀ was obtained as black single crystals during an attempted comproportionation reaction of lutetium(III) chloride, LuCl₃, with metallic lutetium in the presence of ruthenium metal at 950 °C. Ru₁₁Lu₂₀ crystallizes...

Portable radiation detectors are widely used in environmental radiation detection and medical imaging due to their portability feature, high detection efficiency, and large field of view. Lutetium-yttrium oxyorthosilicate (LYSO) is a widely used scin...

Three pyrrolidine-derived phenanthroline diamides were studied as ligands for lutetium trinitrate. The structural features of the complexes have been studied using various spectral methods and X-ray. The presence of halogen atoms in the structure of...

The decay of terbium-161 results in the emission of β¯-particles as well as conversion and Auger electrons, which makes terbium-161 interesting for therapeutic purposes. The aim of this study was to use dual-isotope SPECT imaging in order to demonstr...

There has been considerable interest in inorganic scintillators based on lutetium due to their favorable physical properties. Despite their advantages, lutetium-based scintillators could face issues because of the natural occurring radioisotope of ¹⁷...

Melanoma incidence continues to rise, and while therapeutic approaches for early stage cases are effective, metastatic melanoma continues to be associated with high mortality. Immune checkpoint blockade (ICB) has demonstrated clinical success with ap...

Background: Neuroendocrine neoplasms (NENs) are a rare group of tumors with a different clinical course, prognosis and location. Radioligand therapy (RLT) can be used as a first or second line of treatment. It is registered in gastroenteropancreatic...

Using two independent theoretical methods based on the pseudo-relativistic Hartree–Fock (HFR) and the fully relativistic Multiconfigurational Dirac–Hartree–Fock (MCDHF) approaches, we computed the radiative parameters (transition pr...

Background/Objectives: The FDA and EMA approvals of the theranostic radiopharmaceuticals [⁶⁸Ga]Ga-/[¹⁷⁷Lu]Lu-DOTA-TATE represent milestones in SSTR2-targeted radioligand development. The use of a single precursor for both diagnostic and therapeutic a...

Introduction: The increasing costs of cancer care have raised the need for economic evaluations that integrate treatment efficacy and resource utilization. This study aimed to assess the economic value of Lutetium-177 (¹⁷⁷Lu)–prostate-specific...

Background: Neuroendocrine tumors—are relatively rare but increasingly diagnosed malignancies originating from diffuse neuroendocrine cells, most commonly affecting the gastroenteropancreatic system. Due to their long asymptomatic development a...

Melanoma is a cancer with increasing incidence and there is a need for alternatives to immunotherapy within effective approaches to treatment of metastatic melanoma. We performed comparative radioimmunotherapy (RIT) of experimental B16-F10 melanoma w...

Technological factors and processes contributing to the scintillation mechanism have been considered in quaternary garnet ceramics doped with Ce(Gd,Lu)₃Al₂Ga₃O₁₂. The super-stoichiometric additive of gadolinium in the material composition or its co-d...

In this paper, an NO₂ optical fiber sensor is presented for pollution monitoring in road traffic applications. This sensor exploits the simultaneous transmission of visible light, as a measurement signal, and UV light, for the recovery of the NO₂ sen...

Background: Despite the therapeutic advances made in castration-sensitive prostate cancer, progression to castration-resistant disease is inevitable. Lutetium-177 vipivotide tetraxetan (¹⁷⁷Lu-PSMA-617) is a novel radioligand approved for use in metas...

Due to the high atomic number of lutetium and the low phonon energy of the fluoride matrix, Lu-based fluoride nanoparticles doped with active lanthanide ions are potential candidates as bioprobes in both X-ray computed tomography and luminescent imag...

Peptide receptor radionuclide therapy (PRRT) is a successful targeted radionuclide therapy in neuroendocrine tumors (NETs). However, complete responses remain elusive. Combined treatments anticipate synergistic effects and thus better responses by co...

For patients with metastatic castration-resistant prostate cancer (mCRPC), the survival benefit of classic treatment options with chemotherapy and drugs targeting androgen signaling is limited. Therefore, beta and alpha radionuclide therapy (RNT) hav...

Peptide Receptor Radionuclide Therapy (PRRT) offers radiomolecular precision medicine for somatostatin receptor (SSTR)-positive advanced neuroendocrine neoplasms (NEN). In cases resistant to Lutetium-177-labeled DOTATATE or DOTATOC PRRT, alpha-therap...

Single crystals of ternary chalcogenides with the composition BaLu₂Ch₄ (Ch = S, Se and Te; orthorhombic, Pnma; a = 1211.4–1353.6, b = 395.6–438.5, c = 1427.8–1593.6 pm) could be obtained after attempts to synthesize ternary lutetium(III) nitride chal...

The fibroblast activation protein (FAP) is heavily expressed in fibroblasts associated with the tumor microenvironment, while the prostate-specific membrane antigen (PSMA) is expressed in the neovasculature of malignant angiogenic processes. Previous...

Peptide receptor radionuclide therapy (PRRT) has been one of the most successful and exciting examples of theranostics in nuclear medicine in recent decades and is now firmly embedded in many treatment algorithms for unresectable or metastatic neuroe...

Luminescent, heterometallic terbium(III)–lutetium(III) terephthalate metal-organic frameworks (MOFs) were synthesized via direct reaction between aqueous solutions of disodium terephthalate and nitrates of corresponding lanthanides by using two...

Theranostic radioisotope pairs such as Gallium-68 (⁶⁸Ga) for Positron Emission Tomography (PET) and Lutetium-177 (¹⁷⁷Lu) for radioisotopic therapy, in conjunction with nanoparticles (NPs), are an emerging field in the treatment of cancer. The present...