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Keywords = long-period fiber grating

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25 pages, 4883 KB  
Article
LPFG Biosensor for IL-6 Detection in Murine Serum Samples Associated with Ischemic Disease
by Brenda Vertti-Cervantes, Karina González-León, Marcos García-Juárez, Georgina Beltrán-Pérez, Omar Montes-Narváez, Valentín López-Gayou, Oscar González-Flores, Hugo Martínez-Gutiérrez and Raúl Jacobo Delgado Macuil
Sensors 2026, 26(9), 2855; https://doi.org/10.3390/s26092855 - 2 May 2026
Viewed by 1396
Abstract
Nowadays, optical fiber-based biosensors are widely used in various fields, particularly in medical diagnostics and the selection of appropriate treatments for certain diseases. One example is cerebral ischemic disease, where many biomarkers are released and provide valuable information about the severity and progression [...] Read more.
Nowadays, optical fiber-based biosensors are widely used in various fields, particularly in medical diagnostics and the selection of appropriate treatments for certain diseases. One example is cerebral ischemic disease, where many biomarkers are released and provide valuable information about the severity and progression of the disease. In this study, a long-period fiber grating (LPFG) biosensor was developed using a standard single-mode optical fiber and monoclonal antibody (IL-6 mAb) as the biological recognition element to detect IL-6, which is a protein associated with the inflammatory process. The assembly of the LPFG biosensor was characterized through optical and electronic microscopy to observe morphological changes at different stages of fabrication and the detection process. Additionally, micro-infrared spectroscopy was employed to identify functional groups in the protein region linked to the presence of IL-6. Experimental data were analyzed using principal component analysis, confirming the biosensor’s ability to detect IL-6 and providing insights into its fabrication process. Full article
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14 pages, 2318 KB  
Article
A Flexible Wearable Data Glove Based on Hybrid Fiber-Optic Sensing for Hand Motion Monitoring
by Jing Li, Xiangting Hou, Ke Du, Huiying Piao and Cheng Li
Materials 2026, 19(8), 1525; https://doi.org/10.3390/ma19081525 - 10 Apr 2026
Viewed by 549
Abstract
Wearable data gloves often suffer from electromagnetic interference, insufficient substrate stability, and limited capability for multi-degree-of-freedom motion measurement. To address these limitations, a flexible glove incorporating a hybrid POF-FBG sensing scheme was designed and fabricated. Plastic optical fibers (POFs) were side-polished and patterned [...] Read more.
Wearable data gloves often suffer from electromagnetic interference, insufficient substrate stability, and limited capability for multi-degree-of-freedom motion measurement. To address these limitations, a flexible glove incorporating a hybrid POF-FBG sensing scheme was designed and fabricated. Plastic optical fibers (POFs) were side-polished and patterned with long-period gratings to improve sensitivity to wrist flexion-extension and abduction-adduction. Then fiber Bragg gratings (FBGs) were embedded in a polydimethylsiloxane substrate and encapsulated using thermoplastic polyurethane fixtures to reduce the influence of skin stretching and improve measurement accuracy of finger-joint angle. Moreover, a thermoplastic polyurethane skeleton with an adaptive sliding-rail structure was 3D printed to maintain the stability of the sensor placement at the joints. Experimental results demonstrated the mean absolute errors of 4.06°, 1.38° and 1.70° for wrist flexion-extension, abduction-adduction and finger-joint bending, respectively, along with excellent gesture classification using a support vector machine algorithm, which indicates great potential in virtual reality interaction and hand rehabilitation applications. Full article
(This article belongs to the Special Issue Advances in Optical Fiber Materials and Their Applications)
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14 pages, 3673 KB  
Article
Use of the Feature Scaling and Machine Learning Techniques on Optical Fiber Biosensors for the Detection of Neuroprotector IL-10 in Serum of a Murine Model with Cerebral Ischemia
by R. I. Bandala-Daniel, L. Ocelotl-Zayas, R. Delgado-Macuil, K. González-León, M. García-Juárez, S. Muñoz-Aguirre, J. Castillo-Mixcóatl and G. Beltrán-Pérez
Sensors 2026, 26(4), 1174; https://doi.org/10.3390/s26041174 - 11 Feb 2026
Cited by 1 | Viewed by 457
Abstract
Typically, response analysis of optical fiber biosensors focuses on changes in amplitude and wavelength shifts in the biosensor spectrum; therefore, not all of the spectral range is used for this analysis. On the other hand, if the entire spectrum is used, it is [...] Read more.
Typically, response analysis of optical fiber biosensors focuses on changes in amplitude and wavelength shifts in the biosensor spectrum; therefore, not all of the spectral range is used for this analysis. On the other hand, if the entire spectrum is used, it is possible to leverage the current data in the spectrum and thus improve the performance of the biosensor. To do this, it is necessary to analyze a large amount of data present in each measured spectrum. This task can be made easier by using dimensionality reduction techniques. In addition, it is necessary to establish which spectral regions provide relevant information. Scaling techniques are mathematical data preprocessing tools used in machine learning to adjust the numerical scale of variables so that they have comparable weight and even highlight those characteristics that provide more information. To our knowledge, the use of these techniques in the development of optical fiber biosensors is not very common, which is why we believe they represent an attractive topic of study in this area. With the help of scaling techniques, we can modify the scale of the data so that all the information contained in the spectrum is used, regardless of its magnitude. In this work, two biosensors based on a chirped long period fiber grating (CLPFG) and a chirped Mach–Zehnder interferometer (CMZI) were developed for the detection of interleukin-10 (IL-10). Principal component analysis (PCA) was used as a dimensionality reduction technique together with a support vector machine (SVM) classifier with four different scaling techniques, standardization, minimum–maximum scaling, robust scaling, and a custom transformer, to compare the IL-10 detection performance of the biosensors. The results showed that robust scaling in CMZI performed best in detecting IL-10, with an F1-score equal to 1, as well as better reliability in detecting the protein. Full article
(This article belongs to the Special Issue Sensor for Biomedical and Machine Learning Applications)
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44 pages, 1721 KB  
Systematic Review
Vibration-Based Predictive Maintenance for Wind Turbines: A PRISMA-Guided Systematic Review on Methods, Applications, and Remaining Useful Life Prediction
by Carlos D. Constantino-Robles, Francisco Alberto Castillo Leonardo, Jessica Hernández Galván, Yoisdel Castillo Alvarez, Luis Angel Iturralde Carrera and Juvenal Rodríguez-Reséndiz
Appl. Mech. 2026, 7(1), 11; https://doi.org/10.3390/applmech7010011 - 26 Jan 2026
Cited by 2 | Viewed by 2540
Abstract
This paper presents a systematic review conducted under the PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) framework, analyzing 286 scientific articles focused on vibration-based predictive maintenance strategies for wind turbines within the context of advanced Prognostics and Health Management (PHM). The [...] Read more.
This paper presents a systematic review conducted under the PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) framework, analyzing 286 scientific articles focused on vibration-based predictive maintenance strategies for wind turbines within the context of advanced Prognostics and Health Management (PHM). The review combines international standards (ISO 10816, ISO 13373, and IEC 61400) with recent developments in sensing technologies, including piezoelectric accelerometers, microelectromechanical systems (MEMS), and fiber Bragg grating (FBG) sensors. Classical signal processing techniques, such as the Fast Fourier Transform (FFT) and wavelet-based methods, are identified as key preprocessing tools for feature extraction prior to the application of machine-learning-based diagnostic algorithms. Special emphasis is placed on machine learning and deep learning techniques, including Support Vector Machines (SVM), Random Forest (RF), Convolutional Neural Networks (CNN), Long Short-Term Memory networks (LSTM), and autoencoders, as well as on hybrid digital twin architectures that enable accurate Remaining Useful Life (RUL) estimation and support autonomous decision-making processes. The bibliometric and case study analysis covering the period 2020–2025 reveals a strong shift toward multisource data fusion—integrating vibration, acoustic, temperature, and Supervisory Control and Data Acquisition (SCADA) data—and the adoption of cloud-based platforms for real-time monitoring, particularly in offshore wind farms where physical accessibility is constrained. The results indicate that vibration-based predictive maintenance strategies can reduce operation and maintenance costs by more than 20%, extend component service life by up to threefold, and achieve turbine availability levels between 95% and 98%. These outcomes confirm that vibration-driven PHM frameworks represent a fundamental pillar for the development of smart, sustainable, and resilient next-generation wind energy systems. Full article
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10 pages, 2349 KB  
Article
Long Period Grating Modified with Quasi-2D Perovskite/PAN Hybrid Nanofibers for Relative Humidity Measurement
by Dingyi Feng, Changjiang Zhang, Syed Irshad Haider, Jing Tian, Jiandong Wu, Fu Liu and Biqiang Jiang
Nanomaterials 2026, 16(2), 99; https://doi.org/10.3390/nano16020099 - 12 Jan 2026
Cited by 2 | Viewed by 566 | Correction
Abstract
Metal halide perovskites have emerged as promising photoactive materials for highly efficient photodetectors; however, the inherent instability of perovskite materials in oxygen and moisture limits their practical applications. In this study, the highly moisture-sensitive characteristics of the quasi-2D perovskite nanocrystals were used to [...] Read more.
Metal halide perovskites have emerged as promising photoactive materials for highly efficient photodetectors; however, the inherent instability of perovskite materials in oxygen and moisture limits their practical applications. In this study, the highly moisture-sensitive characteristics of the quasi-2D perovskite nanocrystals were used to fabricate a long-period grating (LPG) humidity sensor based on the perovskite/polyacrylonitrile (PAN) hybrid nanofibers film. The pure-bromide quasi-2D perovskite nanocrystals were in situ synthesized and encapsulated in the PAN matrix on the fiber grating via an electrospinning technique. Humidity-induced variation in the complex permittivity of perovskites can alter the evanescent field of the co-propagating cladding modes, resulting in changes in both resonant amplitude and wavelength in the transmission spectrum of the LPG. These effects yielded an intensity sensitivity of ~0.21 dB/%RH and a wavelength sensitivity of ~18.2 pm/%RH, respectively, in the relative humidity range of 50–80%RH. The proposed LPG sensor demonstrated a good performance, indicating its potential application in the humidity-sensing field. Full article
(This article belongs to the Special Issue Nanomaterials for Optical Fiber Sensing)
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18 pages, 5762 KB  
Article
Intrinsically Safe Optical Fiber Hydrogen Sensor Using Pt-SiO2 Coated Long-Period Fiber Grating
by Xuhui Zhang, Liang Guo, Xinran Wei, Fangzhou Mao, Yuzhang Liang, Junsheng Wang and Wei Peng
Nanomaterials 2026, 16(2), 95; https://doi.org/10.3390/nano16020095 - 12 Jan 2026
Viewed by 520
Abstract
Hydrogen, a promising clean energy carrier, needs safe detection due to its flammability. Conventional electrical hydrogen sensors have drawbacks like high operating temperatures, poor selectivity and ignition risks. We propose an optical sensor using long-period fiber gratings (LPGs) coated with Pt-SiO2 nanomaterials. [...] Read more.
Hydrogen, a promising clean energy carrier, needs safe detection due to its flammability. Conventional electrical hydrogen sensors have drawbacks like high operating temperatures, poor selectivity and ignition risks. We propose an optical sensor using long-period fiber gratings (LPGs) coated with Pt-SiO2 nanomaterials. It works via catalytic reaction: H2 reacts with O2 on Pt nanoparticles, releasing heat that shifts LPG’s resonant wavelength. Structural characterization showed porous SiO2 with uniform Pt, ensuring efficiency and stability. Experiments proved it sensitively responds to 0.5–2.5% H2 (max wavelength shift 7.544 nm), with fast response/recovery, good repeatability/reversibility. Logistic fitting (R2 = 0.999) confirmed strong correlation. This sensor, safe, sensitive and stable, has great potential for real-time H2 monitoring in critical environments. Full article
(This article belongs to the Special Issue Advanced Low-Dimensional Materials for Sensing Applications)
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12 pages, 2485 KB  
Article
Electrical Modification of Self-Assembled Polymer-Stabilized Periodic Microstructures in a Liquid Crystal Composite
by Miłosz S. Chychłowski, Marta Kajkowska, Jan Bolek, Oleksandra Gridyakina, Bartosz Bartosewicz, Bartłomiej Jankiewicz and Piotr Lesiak
Polymers 2025, 17(24), 3342; https://doi.org/10.3390/polym17243342 - 18 Dec 2025
Cited by 1 | Viewed by 720
Abstract
Utilization of natural processes can reduce the complexity and production cost of any device by limiting the necessary steps in the production scheme, especially when it comes to fibers with periodic changes in refractive index. One such process is the nematic–isotropic phase separation [...] Read more.
Utilization of natural processes can reduce the complexity and production cost of any device by limiting the necessary steps in the production scheme, especially when it comes to fibers with periodic changes in refractive index. One such process is the nematic–isotropic phase separation of liquid crystal-based composite confined in 1D space. In this paper, we analyze the behavior of polymer-stabilized liquid crystal-based self-assembled periodic structures in an external electric field. We performed a detailed analysis regarding the reorientation of liquid crystal molecules under two orthogonal directions of the external electric field applied to the examined sample. It was demonstrated that the period of the polymerized structure remains constant until full reorientation, as the electric field induces the formation of new periodic defects in LC orientation. Consequently, the structure’s effective birefringence changes quite drastically, and this observed change depends on the direction of the electric field vector. The obtained results seem promising when it comes to application of the proposed periodic structures as voltage or electric field sensors operating as long-period fiber gratings or fiber Bragg gratings for the visible or near-infrared spectral regions. Full article
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12 pages, 5567 KB  
Article
A Long-Period Grating Based on Double-Clad Fiber for Multi-Parameter Sensing
by Wenchao Li, Hongye Wang, Xinyan Ze, Shuqin Wang, Xiangwei Hao, Yan Bai, Shuanglong Cui, Jian Xing and Xuelan He
Photonics 2025, 12(12), 1235; https://doi.org/10.3390/photonics12121235 - 17 Dec 2025
Viewed by 535
Abstract
This paper proposes a long-period grating (LPG) based on double-clad fibers (DCFs) for multi-parameter sensing. The sensor consists of cascaded-input single-mode fibers (SMF), DCF, and output SMF. Multi-parameter detection is realized by utilizing the different sensing characteristics of the resonance peak under different [...] Read more.
This paper proposes a long-period grating (LPG) based on double-clad fibers (DCFs) for multi-parameter sensing. The sensor consists of cascaded-input single-mode fibers (SMF), DCF, and output SMF. Multi-parameter detection is realized by utilizing the different sensing characteristics of the resonance peak under different physical parameters. The experiment results show that within the temperature range of 30–100 °C, the maximum sensitivity is 66.37 pm/°C. For the refractive index (RI) measurement, the tested range is 1.3309–1.3888 and the maximum sensitivity is −45.84 nm/RIU. Regarding curvature detection, the tested range is 0.6928–1.6971 m−1 and the maximum sensitivity is −2.022 nm/m−1. In addition, the sensor has a symmetrical structure, so its measurement is not restricted by the incident direction of light, thus having flexibility in practical use. This research not only contributes to the advancement of optical fiber sensor technology but also has significant implications for practical applications in industry, the environment, and healthcare. Full article
(This article belongs to the Special Issue Advances in Optical Fiber Sensing Technology)
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35 pages, 9700 KB  
Review
Structure-Modulated Long-Period Fiber Gratings: A Review
by Tianyu Du, Hongwei Ding, Feng Wang, You Li and Yiwei Ma
Photonics 2025, 12(11), 1097; https://doi.org/10.3390/photonics12111097 - 7 Nov 2025
Cited by 2 | Viewed by 1059
Abstract
Structure-Modulated Long-Period Fiber Gratings (SM-LPFGs) represent an advancement in fiber optic sensor technology, moving beyond traditional photosensitivity-based fabrication to achieve enhanced performance through the direct physical modification of the geometry of the fiber. This review provides a comprehensive analysis of the primary fabrication [...] Read more.
Structure-Modulated Long-Period Fiber Gratings (SM-LPFGs) represent an advancement in fiber optic sensor technology, moving beyond traditional photosensitivity-based fabrication to achieve enhanced performance through the direct physical modification of the geometry of the fiber. This review provides a comprehensive analysis of the primary fabrication techniques enabling this approach, including CO2 laser inscription, femtosecond laser micromachining, electric-arc discharge, chemical etching, and fusion tapering. The central focus of this work is the elucidation of the definitive structure–performance relationship, systematically detailing how engineered geometries such as helical profiles, micro-tapers, and asymmetric grooves unlock novel sensing capabilities. We demonstrate how these specific structures are strategically designed to induce circular birefringence for torsion measurement, enhance evanescent field interaction for ultra-sensitive refractive index detection, and create localized stress concentrations for high-resolution strain and vector bending sensing. Furthermore, the review surveys the practical implementation of these sensors in critical application domains, including structural health monitoring, biomedical diagnostics, and environmental sensing. Finally, we conclude by summarizing key achievements and identifying promising future research directions, such as the development of hybrid fabrication processes, the integration of machine learning for advanced signal demodulation, and the path towards industrial-scale production. Full article
(This article belongs to the Special Issue Optical Fiber Sensors: Design and Application)
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23 pages, 5532 KB  
Article
Pulsed CO2 Laser-Fabricated Cascades of Double Resonance Long Period Gratings for Sensing Applications
by Tinko Eftimov, Sanaz Shoar Ghaffari, Georgi Dyankov, Veselin Vladev and Alla Arapova
Micromachines 2025, 16(8), 959; https://doi.org/10.3390/mi16080959 - 20 Aug 2025
Viewed by 939
Abstract
We present a detailed theoretical and experimental study of cascaded double resonance long period gratings (C DR LPGs) for fabricated sensing applications. The matrix description of cascaded LPGs is presented, and several important particular cases are considered related to the regular and turn [...] Read more.
We present a detailed theoretical and experimental study of cascaded double resonance long period gratings (C DR LPGs) for fabricated sensing applications. The matrix description of cascaded LPGs is presented, and several important particular cases are considered related to the regular and turn around point (TAP) gratings. A pulsed CO2 laser was used to fabricate ordinary and cascaded DR LPGs in a photosensitive optical fiber. The responses of the fabricated C DR LPGs to surrounding refractive index (SRI) temperature as well to longitudinal strain have been studied. A statistical comparison of the SRI sensitivities of ordinary and cascaded DR LPGs is presented to outline the capabilities and advantages of cascaded DR gratings. It was experimentally established that the temperature dependence of the wavelength split at the TAP follows a logarithmic dependence and the sensitivity to temperature is inversely proportional to the temperature itself. We evaluate the temperature stability needed for SRI-based sensing application and the importance of fine-tuning to the operational point slightly after the TAP to ensure maximum sensitivity of the sensor. Full article
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11 pages, 5491 KB  
Article
A 5 kW Near-Single-Mode Oscillating–Amplifying Fiber Laser Employing a Broadband Output Coupler with Simultaneous Raman Suppression and Spectral Narrowing
by Jiazheng Wu, Miao Yu, Yi Cao, Shiqi Jiang, Shihao Sun and Junlong Wang
Photonics 2025, 12(8), 813; https://doi.org/10.3390/photonics12080813 - 14 Aug 2025
Viewed by 1932
Abstract
In this work, we propose and demonstrate a novel approach to suppressing stimulated Raman scattering in an oscillating–amplifying integrated fiber laser (OAIFL) by changing the spectral bandwidth of the output-coupler fiber Bragg gratings (OC-FBGs). The reflectance bandwidth of the fiber Bragg grating (FBG) [...] Read more.
In this work, we propose and demonstrate a novel approach to suppressing stimulated Raman scattering in an oscillating–amplifying integrated fiber laser (OAIFL) by changing the spectral bandwidth of the output-coupler fiber Bragg gratings (OC-FBGs). The reflectance bandwidth of the fiber Bragg grating (FBG) in the oscillating section was systematically investigated as a critical parameter for SRS mitigation. Three types of long-period FBGs with distinct reflectance bandwidths (1.2 nm, 1.3 nm, and 2 nm) were comparatively studied as output couplers. The experimental results demonstrated a direct correlation between FBG bandwidth and SRS suppression efficiency, with the configuration of the OC-FBG with a 2 nm bandwidth achieving optimal suppression performance. Concurrently, the output power was enhanced to 5.02 kW with improved power scalability. And excellent beam quality was obtained with M2 < 1.3. Remarkably, in the architecture of this laser, increasing the bandwidth of the output couplers in the oscillating section had a relatively minor effect on the optical-to-optical (O-O) efficiency, which reached up to 78%. Additionally, this modification also reduced the 3 dB bandwidth of the laser output, thereby achieving a beam output with enhanced monochromaticity. Full article
(This article belongs to the Special Issue High-Power Fiber Lasers)
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23 pages, 9523 KB  
Article
Experimental Investigation of the Long-Term Deflection Behavior of Prestressed Concrete Double Tees
by Yong Zhao, Guoming Chen, Yanming Liu and Zhiqiang Gao
Buildings 2025, 15(16), 2844; https://doi.org/10.3390/buildings15162844 - 12 Aug 2025
Viewed by 1360
Abstract
This study investigates the long-term flexural performance of prestressed concrete double tees under sustained loading. Six full-scale specimens were subjected to a comprehensive experimental program, including a 320-day storage period following prestress release, a short-term flexural test, and a 990-day sustained loading phase. [...] Read more.
This study investigates the long-term flexural performance of prestressed concrete double tees under sustained loading. Six full-scale specimens were subjected to a comprehensive experimental program, including a 320-day storage period following prestress release, a short-term flexural test, and a 990-day sustained loading phase. Mid-span deflections were measured using a string-line method, while the effective prestress in tendons was continuously monitored with fiber Bragg grating (FBG) sensors. Results showed a pronounced increase in camber during the storage phase, with long-term camber reaching approximately three times the initial value. Under short-term loading, the slabs exhibited a clear bilinear moment–deflection behavior. During sustained loading, most of the long-term deflection developed in the early stages, and an inverse relationship between load level and deflection growth was observed. Additionally, data from 20 short-term tests were compiled, and a bilinear stiffness model was proposed to estimate flexural stiffness in the cracked state. These findings contribute to a deeper understanding of long-term deformation in prestressed concrete double tees and provide reference data for serviceability evaluation and design refinement. Full article
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11 pages, 2799 KB  
Article
Development of LPFG-Based Seawater Concentration Monitoring Sensors Packaged by BFRP
by Zhe Zhang, Tongchun Qin, Yuping Bao and Jianping He
Micromachines 2025, 16(7), 810; https://doi.org/10.3390/mi16070810 - 14 Jul 2025
Cited by 1 | Viewed by 891
Abstract
Leveraging the sensitivity of long-period fiber grating (LPFG) to changes in the environmental refractive index, an LPFG-based seawater concentration monitoring sensor is proposed. Considering the highly saltine and alkali characteristics of the sensor’s operating environment, the proposed sensor is packaged by basalt fiber-reinforced [...] Read more.
Leveraging the sensitivity of long-period fiber grating (LPFG) to changes in the environmental refractive index, an LPFG-based seawater concentration monitoring sensor is proposed. Considering the highly saltine and alkali characteristics of the sensor’s operating environment, the proposed sensor is packaged by basalt fiber-reinforced polymer (BFRP), and the sensor’s sensitivities were studied by sodium chloride and calcium chloride solution concentration experiments and one real-time sodium chloride solution concentration monitoring experiment. The test results show the wavelength of LPFG, a 3 dB bandwidth and a peak loss of LPFG’s spectrogram change with changes in the concentration of sodium chloride or calcium chloride solutions, but only the wavelength has a good linear relationship with the change in solution concentration, and the sensing coefficient is −0.160 nm/% in the sodium chloride solution and −0.225 nm/% in the calcium chloride solution. The real-time monitoring test further verified the sensor’s sensing performance, with an absolute measurement error of less than 1.8%. The BFRP packaged sensor has good corrosion resistance and a simple structure, and it has a certain application value in the monitoring of salinity in the marine environment and coastal soil. Full article
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41 pages, 5928 KB  
Review
Advances in Optical Microfibers: From Fabrication to Functionalization and Sensing Applications
by Joanna Korec-Kosturek and Joanna E. Moś
Materials 2025, 18(11), 2418; https://doi.org/10.3390/ma18112418 - 22 May 2025
Cited by 7 | Viewed by 2790
Abstract
Currently, optical fibers play a leading role in telecommunications, serve as special transmission components for industrial applications, and form the basis of highly sensitive sensor elements. One of the most commonly used modifications is the reduction in the initial dimensions of the cladding [...] Read more.
Currently, optical fibers play a leading role in telecommunications, serve as special transmission components for industrial applications, and form the basis of highly sensitive sensor elements. One of the most commonly used modifications is the reduction in the initial dimensions of the cladding and core to a few or several micrometers, allowing the evanescent wave emerging from the tapered region to interact with the surrounding environment. As a result, the microfiber formed in this way is highly sensitive to any changes in its surroundings, making it an ideal sensing element. This article primarily focuses on reviewing the latest trends in science involving various types of optical microfibers, including tapers, rings, loops, coils, and tapered fiber Bragg gratings. Additionally, it discusses the most commonly used materials for coating fiber optic elements—such as metals, oxides, polymers, organic materials, and graphene—which enhance sensitivity to specific physical factors and enable selectivity in the developed sensors. Full article
(This article belongs to the Special Issue Research on New Optoelectronic Materials and Devices)
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16 pages, 3858 KB  
Article
Feasibility and Safety of Endoscopic Balloon-Assisted Laser Treatment (EBLT) for Gastroesophageal Reflux Disease: Functional, Structural, and Gene Expression Analysis in Preclinical Model
by Boram Cha, Hyejin Kim, Van Gia Truong, Sun-Ju Oh, Seok Jeong and Hyun Wook Kang
Photonics 2025, 12(5), 421; https://doi.org/10.3390/photonics12050421 - 28 Apr 2025
Viewed by 1411
Abstract
Gastroesophageal reflux disease (GERD) is a prevalent disorder caused by lower esophageal sphincter (LES) dysfunction, often requiring long-term treatment. This study assessed the feasibility of endoscopic balloon-assisted laser treatment (EBLT) using a porcine GERD model. One week after GERD induction, EBLT was performed [...] Read more.
Gastroesophageal reflux disease (GERD) is a prevalent disorder caused by lower esophageal sphincter (LES) dysfunction, often requiring long-term treatment. This study assessed the feasibility of endoscopic balloon-assisted laser treatment (EBLT) using a porcine GERD model. One week after GERD induction, EBLT was performed on three animals, while one served as a control. A 980 nm continuous-wave laser was delivered at 30 W for 90 s (energy = 2700 J and power density = 2.17 W/cm2) in a circumferential, non-contact manner using a balloon-assisted catheter. Real-time mucosal temperature monitoring was achieved using a fiber Bragg grating (FBG) sensor integrated with the balloon, maintaining temperatures below 40 °C. Endoscopic ultrasound and manometry were used to evaluate LES thickness and pressure before and after treatment. After a 12-week observation period, esophageal tissues were harvested for histological and gene expression analysis. Compared to the control, the treated group showed an increase in LES thickness (3.6 ± 0.2 mm vs. 1.5 mm) and relative LES pressure changes (2.9 ± 1.6 vs. 0.6). Upregulation of fibrosis- and hypertrophy-related genes suggested structural remodeling of the LES. No adverse effects or mucosal injury were observed. These findings support EBLT as a promising and minimally invasive strategy for GERD treatment. Full article
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