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Communication

18 Citations

5,742 Views

11 Pages

Tumor-Targeted Delivery of the p53-Activating Peptide VIP116 with PEG-Stabilized Lipodisks

Sara Lundsten,
Víctor Agmo Hernández,
Lars Gedda,
Tina Sarén,
Christopher J. Brown,
David P. Lane,
Katarina Edwards and
Marika Nestor

Nanomaterials2020, 10(4), 783;https://doi.org/10.3390/nano10040783

19 April 2020

Stapled peptides targeting the interaction between p53 and its negative regulators MDM2 and MDM4 have exhibited great potential as anti-cancer drugs, albeit with room for improvement in formulation and tumor specificity. Lipid bilayer disks (lipodisk...

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Article

2 Citations

5,131 Views

19 Pages

Adhesion and Structural Changes of PEGylated Lipid Nanocarriers on Silica Surfaces

Philipp Grad,
Katarina Edwards and
Víctor Agmo Hernández

Physchem2021, 1(2), 133-151;https://doi.org/10.3390/physchem1020009

15 July 2021

PEGylated lipid nanoparticles have a continuously expanding range of applications, particularly within pharmaceutical areas. Hereby, it is shown with the help of the Quartz Crystal Microbalance with Dissipation monitoring (QCM-D) and other surface se...

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Article

16 Citations

5,706 Views

21 Pages

Tailoring the Lamellarity of Liposomes Prepared by Dual Centrifugation

Jonas K. Koehler,
Lars Gedda,
Leonie Wurster,
Johannes Schnur,
Katarina Edwards,
Heiko Heerklotz and
Ulrich Massing

Pharmaceutics2023, 15(2), 706;https://doi.org/10.3390/pharmaceutics15020706

20 February 2023

Dual centrifugation (DC) is a new and versatile technique for the preparation of liposomes by in-vial homogenization of lipid-water mixtures. Size, size distribution, and entrapping efficiencies are strongly dependent on the lipid concentration durin...

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Review

74 Citations

12,232 Views

18 Pages

Melittin-Based Nano-Delivery Systems for Cancer Therapy

Anqi Wang,
Yuan Zheng,
Wanxin Zhu,
Liuxin Yang,
Yang Yang and
Jinliang Peng

Biomolecules2022, 12(1), 118;https://doi.org/10.3390/biom12010118

12 January 2022

Melittin (MEL) is a 26-amino acid polypeptide with a variety of pharmacological and toxicological effects, which include strong surface activity on cell lipid membranes, hemolytic activity, and potential anti-tumor properties. However, the clinical a...

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