Search Results (582)

Hydrogen offers an effective pathway for the large-scale storage of renewable energy. For a tourist city located in a plateau region rich in renewable energy, hydrogen shows great potential for reducing carbon emissions and utilizing uncertain renewable energy. Herein, the wind–solar–hydrogen stand-alone and grid-connected systems in the plateau tourist city of Lijiang City in Yunnan Province are modeled and techno-economically evaluated by using the HOMER Pro software (version 3.14.2) with the multi-criteria decision analysis models. The system is composed of 5588 kW solar photovoltaic panels, an 800 kW wind turbine, a 1600 kW electrolyzer, a 421 kWh battery, and a 50 kW fuel cell. In addition to meeting the power requirements for system operation, the system has the capacity to provide daily electricity for 200 households in a neighborhood and supply 240 kg of hydrogen per day to local hydrogen-fueled buses. The stand-alone system can produce 10.15 × 10⁶ kWh of electricity and 93.44 t of hydrogen per year, with an NPC of USD 8.15 million, an LCOE of USD 0.43/kWh, and an LCOH of USD 5.26/kg. The grid-connected system can generate 10.10 × 10⁶ kWh of electricity and 103.01 ton of hydrogen annually. Its NPC is USD 7.34 million, its LCOE is USD 0.11/kWh, and its LCOH is USD 3.42/kg. This study provides a new solution for optimizing the configuration of hybrid renewable energy systems, which will develop the hydrogen economy and create low-carbon-emission energy systems. Full article

Origen’s prosopological exegesis, derived from a technique developed for Homeric interpretation by the Alexandrian grammarians and applied by Christian interpreters to some texts of the Scriptures, has been already studied in its principal aspects by a few scholars in the 1980s, especially M.-J. Rondeau and B. Neuschäfer. However, the discovery of a corpus of 29 Greek homilies which have been attributed to Origen makes necessary a reexamination of the previous studies, in order to verify (and possibly correct) their results. This study aims to present such a comparison, analyzing some examples of prosopological exegesis in the new Homilies on the Psalms in the light of other examples in Origen’s remaining literary oeuvre; furthermore, it aims to show that Origen adopted (and adapted) an exegetical technique typical of the Alexandrian Homeric philology. Full article

Autism spectrum disorder (ASD) is a complex neurodevelopmental condition with early-life origins. Maternal obesity has been associated with increased ASD risk, yet the mechanisms and timing of susceptibility remain unclear. Using a mouse model combining in vitro fertilization (IVF) and embryo transfer, we separated the effects of pre-conception and gestational obesity. We found that maternal high fat diet (HFD) exposure prior to conception alone was sufficient to induce ASD-like behaviors in male offspring—including altered vocalizations, reduced sociability, and increased repetitive grooming—without anxiety-related changes. These phenotypes were absent in female offspring and those exposed only during gestation. Cortical transcriptome analysis revealed dysregulation and isoform shifts in genes implicated in ASD, including Homer1 and Zswim6. Whole-genome bisulfite sequencing of hippocampal tissue showed hypomethylation of an alternative Homer1 promoter, correlating with increased expression of the short isoform Homer1a, which is known to disrupt synaptic scaffolding. This pattern was specific to mice with ASD-like behaviors. Our findings show that pre-conceptional maternal obesity can lead to lasting, isoform-specific transcriptomic and epigenetic changes in the offspring’s brain. These results underscore the importance of maternal health before pregnancy as a critical and modifiable factor in ASD risk. Full article

The Union of the Comoros, located in the Indian Ocean, faces persistent energy challenges due to its geographic isolation, heavy dependence on imported fossil fuels, and underdeveloped electricity infrastructure. This study investigates the techno-economic optimization of a hybrid microgrid designed to supply electricity to a rural village in Grande Comore. The proposed system integrates photovoltaic (PV) panels, wind turbines, a diesel generator, and battery storage. Detailed modeling and simulation were conducted using HOMER Energy, accompanied by a sensitivity analysis on solar irradiance, wind speed, and diesel price. The results indicate that the optimal configuration consists solely of PV and battery storage, meeting 100% of the annual electricity demand with a competitive levelized cost of energy (LCOE) of 0.563 USD/kWh and zero greenhouse gas emissions. Solar PV contributes over 99% of the total energy production, while wind and diesel components remain unused under optimal conditions. Furthermore, the system generates a substantial energy surplus of 63.7%, which could be leveraged for community applications such as water pumping, public lighting, or future system expansion. This study highlights the technical viability, economic competitiveness, and environmental sustainability of 100% solar microgrids for non-interconnected island territories. The approach provides a practical and replicable decision-support framework for decentralized energy planning in remote and vulnerable regions. Full article

Multiple studies, starting with Preston’s work in 1975, have suggested that gross domestic product per capita (GDPPC) is an important explanatory factor for understanding differentials in life expectancy at birth (LEB) in countries around the world. This proposition was tested in the present study using two-period cross-sectional regression across a large number of both advanced and developing countries and 16 socioeconomic factors, including GDPPC. The best-performing regression equations in the periods around 2000 and 2015 included four to six of these factors (government effectiveness, safe sanitation, poverty and contraception, plus, in the circa-2000 period, the Gini index and CO₂ emissions); perhaps surprisingly, these equations did not include GDPPC. The results were examined in greater detail for the world’s 15 most populous countries, helping to identify key drivers of LEB growth for each of these countries from circa 2000 to 2015. The fact that GDPPC drops out of the best equations calls into question the view that economic growth is the correct primary target for nations seeking to increase their average life expectancy. Full article

With rising energy costs and the need for sustainable power solutions in urban South African settings, grid-tied renewable energy systems have become viable alternatives for reducing dependence on traditional grid supply. This study investigates the techno-economic feasibility of a grid-connected hybrid photovoltaic (PV) and battery storage system designed for a commercial facility located in Johannesburg, South Africa—an area characterized by a subtropical highland climate. We conducted the analysis using the HOMER Grid software and evaluated the performance of the proposed PV/battery system against the baseline grid-only configuration. Simulation results indicate that the optimal systems, comprising 337 kW of flat-plate PV and 901 kWh of lithium-ion battery storage, offers a significant reduction in electricity expenditure, lowering the annual utility cost from $39,229 to $897. The system demonstrates a simple payback period of less than two years and achieves a net present value (NPV) of approximately $449,491 over a 25-year project lifespan. In addition to delivering substantial cost savings, the proposed configuration also enhances energy resilience. Sensitivity analyses were conducted to assess the impact of variables such as inflation rate, discount rate, and load profile fluctuations on system performance and economic returns. The results affirm the suitability of hybrid grid-tied PV/battery systems for cost-effective, sustainable urban energy solutions in climates with high solar potential. Full article

Introduction: There are no validated clinical diagnostic criteria for chronic traumatic encephalopathy or traumatic encephalopathy syndrome (TES). To understand the historical clinical condition, its applicability to modern day athletes, and the pathogenesis of clinical problems, we examined the literature describing boxers from the 20th century, with specific attention paid to neurological findings and characteristics of clinical disease progression. Methods: Data were extracted for 243 boxers included in 45 articles published between 1928 and 1999, including cases from articles originally published in German. The presence or absence of 22 neurological signs and features were extracted. Results: The most common neurological problems were slurring dysarthria (49%), gait disturbances (44%), and memory loss (36%), with several other problems that were less frequent, including hyperreflexia (25%), ataxia (22%), increased tone (19%), and extensor Babinski sign (16%). Frank dementia appeared in some cases (17%). There were significantly fewer neurological deficits reported in boxers who fought in the latter part of the 20th century compared to boxers who fought earlier in the century. For more than half of the cases, there were no comments about whether the neurological problems were progressive (145, 60%). A progressive condition was described in 71 cases (29%) and a stationary or improving condition was described in 27 cases (11%). Canonical neurodegenerative disease-like progression was described in 15 cases (6%). Discussion: Neurological problems associated with boxing-related neurotrauma during the 20th century are the foundation for present-day TES. However, the clinical signs and features in the 20th century differ in most ways from the modern criteria for TES. Full article

Glutamate and dopamine receptors play a crucial role in regulating synaptic plasticity throughout the sleep–wake cycle. These receptors form various heterocomplexes in synaptic areas; however, the role of this protein interactome in sleep–wake cycles remains unclear. Co-immunoprecipitation experiments were conducted to observe the complexation of the NMDA glutamate receptor (NMDAR) subunits GluN2A and GluN2B, metabotropic glutamate receptors mGluR1/5, and dopamine receptors (D1R and D2R) with the scaffold protein Homer in the synaptic membranes of the hippocampus after six hours of sleep deprivation (SD) in rats. Our findings indicate that the level of Homer in the GluN2A/mGluR1/D1R interactome decreased during SD, while the content of Homer remained unchanged in the GluN2B/mGluR1/D2R heterocomplex. Moreover, Homer immunoprecipitated a reduced amount of inositol trisphosphate receptor (IP3R) in the microsomal and synaptic fractions, confirming the dissociation of the ternary supercomplex Homer/mGluR1/IP3R during SD. Additionally, our findings indicate that SD increases the synaptic content of the AMPA receptor (AMPAR) subunit GluA1. Unlike AMPAR, NMDAR subunits in synaptic membranes do not undergo significant changes. Furthermore, the G-to-F actin ratio decreases during SD. Changes in the assembly of actin filaments occur due to the dephosphorylation of cofilin. These results suggest that SD causes the dissociation of the GluN2A/mGluR1/D1R/Homer/IP3R heterocomplex in synaptic and endoplasmic membranes. Full article

Off-grid and isolated rural communities in developing countries with limited resources require energy supplies for daily residential use and social, economic, and commercial activities. The use of data from space assets and space-based solar power is a feasible solution for addressing ground-based energy insecurity when harnessed in a hybrid manner. Advances in space solar power systems are recognized to be feasible sources of renewable energy. Their usefulness arises due to advances in satellite and space technology, making valuable space data available for smart grid design in these remote areas. In this case study, an isolated village in Namibia, characterized by high levels of solar irradiation and limited wind availability, is identified. Using NASA data, an autonomous hybrid system incorporating a solar photovoltaic array, a wind turbine, storage batteries, and a backup generator is designed. The local load profile, solar irradiation, and wind speed data were employed to ensure an accurate system model. Using HOMER Pro software V 3.14.2 for system simulation, a more advanced AI optimization was performed utilizing Grey Wolf Optimization and Harris Hawks Optimization, which are two metaheuristic algorithms. The results obtained show that the best performance was obtained with the Grey Wolf Optimization algorithm. This method achieved a minimum energy cost of USD 0.268/kWh. This paper presents the results obtained and demonstrates that advanced optimization techniques can enhance both the hybrid system’s financial cost and energy production efficiency, contributing to a sustainable electricity supply regime in this isolated rural community. Full article

Electricity in rural Alaska is provided by more than 200 standalone microgrid systems powered predominantly by diesel generators. Incorporating renewable energy generation and storage to these systems can reduce their reliance on costly imported fuel and improve sustainability; however, uncertainty remains about optimal grid architectures to minimize cost, including how and when to incorporate long-duration energy storage. This study implements a novel, multi-pronged approach to assess the techno-economic feasibility of future energy pathways in the community of Kotzebue, which has already successfully deployed solar photovoltaics, wind turbines, and battery storage systems. Using real community load, resource, and generation data, we develop a series of comparison models using the HOMER Pro software tool to evaluate microgrid architectures to meet over 90% of the annual community electricity demand with renewable generation, considering both battery and hydrogen energy storage. We find that near-term planned capacity expansions in the community could enable over 50% renewable generation and reduce the total cost of energy. Additional build-outs to reach 75% renewable generation are shown to be competitive with current costs, but further capacity expansion is not currently economical. We additionally include a cost sensitivity analysis and a storage capacity sizing assessment that suggest hydrogen storage may be economically viable if battery costs increase, but large-scale seasonal storage via hydrogen is currently unlikely to be cost-effective nor practical for the region considered. While these findings are based on data and community priorities in Kotzebue, we expect this approach to be relevant to many communities in the Arctic and Sub-Arctic regions working to improve energy reliability, sustainability, and security. Full article

Skeletal muscle is one of the largest tissues in the body. It is of great significance to analyze the molecular mechanism of skeletal muscle development for the further study of meat quality improvement and muscle diseases. CircRNA has been reported to be involved in many biological processes, but further research is needed in skeletal muscle. In this study, we detected the authenticity, stability, and spatio-temporal expression characteristics of circHOMER1 and its effect on the proliferation, apoptosis, and differentiation of muscle cells, and analyzed its possible molecular mechanism. The results showed that circHOMER1 exists in the skeletal muscle of the Ningxiang pig, is more stable than linear RNA, and is significantly upregulated in adipose tissue and during the early growth of myoblasts. In terms of function, overexpression of circHOMER1 significantly promoted the expression levels of proliferation marker genes and proteins and significantly increased the EdU positive cell rate, optical density (OD) value (at 450 nm), and proportion of S-phase cells. Overexpression of circHOMER1 also significantly promoted the expression levels of apoptosis marker genes and proteins and significantly increased the proportions of cells in Q2 (with late apoptosis) and Q3 (with early apoptosis). Overexpression of circHOMER1 significantly inhibited the expression levels of differentiation marker genes and proteins, significantly inhibited the differentiation index, and decreased the proportion of 5-nucleus muscle fibers. Conversely, opposite results were obtained after circHOMER1 interference. In terms of molecules mechanism, subcellular localization analysis showed that circHOMER1 was mainly distributed in cytoplasm, and mechanism analysis showed that circHOMER1 participated in myoblast development by forming a 4-element interaction network with 4 miRNAs, 2 lncRNAs, and 20 mRNAs, and possibly regulated myoblast development by encoding 79 amino acids. To sum up, we verified that circHOMER1 promoted the proliferation and apoptosis of myoblasts and inhibited their differentiation. It may regulate the development of myoblasts through ceRNA or by encoding small peptides. These results provided a reference for the regulation mechanism of muscle development and the breeding of Ningxiang pigs. Full article

Background: Chemotherapy-induced peripheral neuropathy (CIPN) is a common, debilitating side effect of cancer treatment. Characterized by symptoms like pain, numbness, and muscle weakness, CIPN significantly impacts patients’ quality of life. Current management strategies vary, with limited consensus on effective treatments. This scoping review aims to explore comprehensive rehabilitation interventions for CIPN, focusing on enhancing patient well-being and functional abilities. Methods: A scoping review, guided by Arksey and O’Malley’s framework and Levac et al.’s refinements, was conducted to assess rehabilitation programs for CIPN. Searches across six databases were performed, with inclusion and exclusion criteria focusing on studies with physical rehabilitation interventions. Data were charted, detailing interventions, demographics, and outcomes. Results were synthesized descriptively and presented narratively with tables. Results: The review included 24 studies covering diverse cancer types and treatments, involving a total of 1167 participants. Various interventions for CIPN were assessed, and results were thematically categorized according to exercise category. Physical modalities like ultrasound and exercise showed promise in symptom relief for colorectal and breast cancer patients. No distinct advantage was found in the timing of exercise interventions. Complementary therapies such as acupuncture and yoga demonstrated effectiveness in managing CIPN symptoms. Conclusions: This review highlights the effectiveness of diverse physical and complementary interventions in managing CIPN, advocating for their integration into standard protocols. It emphasizes the need for holistic, patient-centered approaches that combine exercises, physical therapy, and complementary therapies to improve patient outcomes. These findings set a direction for future research and clinical practices focused on comprehensive and personalized CIPN management strategies. Full article

In recent years, population growth, the enhancement of carbon emissions generation, and higher energy consumption have caused the movement to nearly zero-energy buildings. Additionally, the various strategies, phase change materials (PCMs) are suitable for reducing the energy consumption of a building. The focus of this study is to investigate the results of three scenarios that explore all the effective parameters for selecting a suitable Phase Change Material (PCM) for hot climate conditions in Saudi Arabia. The first scenario worked on choosing the best phase change material based on the climatic conditions and the selected area. To complete the optimization, the best thickness and placement of the two-layer phase change material were investigated in the second and third scenarios. The results indicated that optimized building using PCM 29 with 50 mm thickness reduced the energy consumption and carbon dioxide production by 20.72% and 21.05%, respectively. Furthermore, the outcomes of the study on two-layer phase change materials with different arrangements illustrated that the most proper location of PCMs caused 255.38 MWh of electricity consumption and 155.71 × 10³ kg of carbon dioxide production. Finally, as a novel integration, the results of using one-layer and two-layer PCM were added to the HOMER software to find the optimal hybrid energy systems. The findings showed that by integrating photovoltaic panels, diesel generation, batteries, and the grid, the cost of energy reached USD 0.162. Additionally, the grid purchase by using one-layer and two-layer phase change material was decreased by 21.2% and 24.3% compared to the base case. Full article

Many communities in the Brazilian Amazon region remain without reliable access to electricity due to geographical barriers and the high cost of connecting to the national grid. This study aims to evaluate the techno-economic feasibility of implementing battery storage systems in an existing isolated solar–diesel microgrid located in Tunui-Cachoeira, in the district of São Gabriel da Cachoeira (AM). The analysis uses an energy balance methodology, implemented through the HOMER Pro simulation platform, to assess three scenarios: (i) without batteries, (ii) with lithium-ion batteries, and (iii) with lead–acid batteries. Technical and economic indicators such as net present cost (NPC), levelized cost of energy (LCOE), diesel consumption, and renewable fraction were compared. The results indicate that incorporating lead–acid batteries yields the lowest LCOE (1.99 R$/kWh) and the highest renewable fraction (96.8%). This demonstrates that adding energy storage systems significantly enhances the performance and cost-effectiveness of microgrids, offering a viable path to electrify remote and hard-to-reach communities in the Amazon. Full article

Background/Objectives: Children and adolescents with cerebral palsy (CP) often experience associated functional limitations, diseases, or impairments. Included in these associated concerns are mental health symptoms/disorders and academic concerns. There has been an increasing research focus on the mental health of youth with CP over the past 5 years, and there is a need to synthesize this research. This review aims to synthesize the most recent research on the mental and behavioral health of youth with CP. Methods: A literature search on research focused on mental health, academic functioning, and mental and behavioral treatment for youth with CP was conducted in August of 2024 and limited to the last 5 years to highlight the most recent developments in this area of research. Four hundred and forty-eight articles were screened, and thirty-eight articles were included in this review. Results: Based on this literature review, children with CP have high rates of mental health diagnoses across multiple diagnostic areas, including autism spectrum disorder, attention-deficit hyperactivity disorder, intellectual developmental disorder, anxiety, and depression. Academic concerns are common for children with CP. Intervention studies have focused on both child and parent interventions. Conclusions: Research over the past 5 years has added to prevalence estimates of mental health disorders in the pediatric CP population. Considering the high rates of mental health symptoms found in children with CP, future research should focus further on mental health interventions for this population. Full article