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Article

5 Citations

2,181 Views

20 Pages

The Autonomous Fusion Activity of Human Cytomegalovirus Glycoprotein B Is Regulated by Its Carboxy-Terminal Domain

Nina Reuter,
Barbara Kropff,
Xiaohan Chen,
William J. Britt,
Heinrich Sticht,
Michael Mach and
Marco Thomas

Viruses2024, 16(9), 1482;https://doi.org/10.3390/v16091482

18 September 2024

The human cytomegalovirus (HCMV) glycoprotein B (gB) is the viral fusogen required for entry into cells and for direct cell-to-cell spread of the virus. We have previously demonstrated that the exchange of the carboxy-terminal domain (CTD) of gB for...

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Article

14 Citations

4,077 Views

16 Pages

Antibodies Targeting KSHV gH/gL Reveal Distinct Neutralization Mechanisms

Thomas Fricke,
Anna K. Großkopf,
Armin Ensser,
Marija Backovic and
Alexander S. Hahn

Viruses2022, 14(3), 541;https://doi.org/10.3390/v14030541

5 March 2022

Kaposi’s sarcoma herpesvirus (KSHV) is associated with a significant disease burden, in particular in Sub-Sahara Africa. A KSHV vaccine would be highly desirable, but the mechanisms underlying neutralizing antibody responses against KSHV remain...

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Article

1 Citations

1,776 Views

17 Pages

A Single Amino Acid Substitution in the Transmembrane Domain of Glycoprotein H Functionally Compensates for the Absence of gL in Pseudorabies Virus

Melina Vallbracht,
Marina Schnell,
Annemarie Seyfarth,
Walter Fuchs,
Richard Küchler,
Thomas C. Mettenleiter and
Barbara G. Klupp

Viruses2024, 16(1), 26;https://doi.org/10.3390/v16010026

22 December 2023

Herpesvirus entry requires the coordinated action of at least four viral glycoproteins. Virus-specific binding to a cellular receptor triggers a membrane fusion cascade involving the conserved gH/gL complex and gB. Although gB is the genuine herpesvi...

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Article

8 Citations

3,432 Views

15 Pages

Immunization of Rabbits with Recombinant Human Cytomegalovirus Trimeric versus Monomeric gH/gL Protein Elicits Markedly Higher Titers of Antibody and Neutralization Activity

Xinle Cui,
Zhouhong Cao,
Shuishu Wang,
Michael Flora,
Stuart P. Adler,
Michael A. McVoy and
Clifford M. Snapper

Int. J. Mol. Sci.2019, 20(13), 3158;https://doi.org/10.3390/ijms20133158

28 June 2019

Congenital human cytomegalovirus (HCMV) infection and HCMV infection of immunosuppressed patients cause significant morbidity and mortality, and vaccine development against HCMV is a major public health priority. HCMV envelope glycoproteins gB, gH, a...

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Review

66 Citations

6,414 Views

12 Pages

ACE2-Independent Alternative Receptors for SARS-CoV-2

Suhyeon Lim,
Monica Zhang and
Theresa L. Chang

Viruses2022, 14(11), 2535;https://doi.org/10.3390/v14112535

16 November 2022

Severe acute respiratory syndrome-related coronavirus (SARS-CoV-2), the causative agent of coronavirus disease 2019 (COVID-19), is highly contagious and remains a major public health challenge despite the availability of effective vaccines. SARS-CoV-...

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