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191 Results Found

  • Article
  • Open Access
4 Citations
1,538 Views
16 Pages

10 March 2025

In recent years, advances in diagnosing and classifying diseases using machine learning (ML) have grown exponentially. However, due to the many privacy regulations regarding personal data, pooling together data from multiple sources and storing them...

  • Article
  • Open Access
29 Citations
7,751 Views
19 Pages

Retinal Disease Diagnosis Using Deep Learning on Ultra-Wide-Field Fundus Images

  • Toan Duc Nguyen,
  • Duc-Tai Le,
  • Junghyun Bum,
  • Seongho Kim,
  • Su Jeong Song and
  • Hyunseung Choo

Ultra-wide-field fundus imaging (UFI) provides comprehensive visualization of crucial eye components, including the optic disk, fovea, and macula. This in-depth view facilitates doctors in accurately diagnosing diseases and recommending suitable trea...

  • Article
  • Open Access
48 Citations
7,674 Views
27 Pages

Designing computer-aided diagnosis (CAD) systems that can automatically detect ocular diseases (ODs) has become an active research field in the health domain. Although the human eye might have more than one OD simultaneously, most existing systems ar...

  • Article
  • Open Access
8 Citations
4,934 Views
11 Pages

FundusNet: A Deep-Learning Approach for Fast Diagnosis of Neurodegenerative and Eye Diseases Using Fundus Images

  • Wenxing Hu,
  • Kejie Li,
  • Jake Gagnon,
  • Ye Wang,
  • Talia Raney,
  • Jeron Chen,
  • Yirui Chen,
  • Yoko Okunuki,
  • Will Chen and
  • Baohong Zhang

Early-stage detection of neurodegenerative diseases is crucial for effective clinical treatment. However, current diagnostic methods are expensive and time-consuming. In this study, we present FundusNet, a deep-learning model trained on fundus images...

  • Review
  • Open Access
75 Citations
11,512 Views
33 Pages

Automated Glaucoma Screening and Diagnosis Based on Retinal Fundus Images Using Deep Learning Approaches: A Comprehensive Review

  • Mohammad J. M. Zedan,
  • Mohd Asyraf Zulkifley,
  • Ahmad Asrul Ibrahim,
  • Asraf Mohamed Moubark,
  • Nor Azwan Mohamed Kamari and
  • Siti Raihanah Abdani

Glaucoma is a chronic eye disease that may lead to permanent vision loss if it is not diagnosed and treated at an early stage. The disease originates from an irregular behavior in the drainage flow of the eye that eventually leads to an increase in i...

  • Article
  • Open Access
11 Citations
3,381 Views
21 Pages

Self-FI: Self-Supervised Learning for Disease Diagnosis in Fundus Images

  • Toan Duc Nguyen,
  • Duc-Tai Le,
  • Junghyun Bum,
  • Seongho Kim,
  • Su Jeong Song and
  • Hyunseung Choo

Self-supervised learning has been successful in computer vision, and its application to medical imaging has shown great promise. This study proposes a novel self-supervised learning method for medical image classification, specifically targeting ultr...

  • Article
  • Open Access
4 Citations
2,246 Views
25 Pages

Computer-Aided Diagnosis of Diabetic Retinopathy Lesions Based on Knowledge Distillation in Fundus Images

  • Ernesto Moya-Albor,
  • Alberto Lopez-Figueroa,
  • Sebastian Jacome-Herrera,
  • Diego Renza and
  • Jorge Brieva

17 August 2024

At present, the early diagnosis of diabetic retinopathy (DR), a possible complication of diabetes due to elevated glucose concentrations in the blood, is usually performed by specialists using a manual inspection of high-resolution fundus images base...

  • Article
  • Open Access
1 Citations
2,833 Views
20 Pages

17 July 2024

Many diseases produce pathological changes in the fundus; analyzing the retinopathy of the fundus could help diagnose diseases in time. A fundus camera is a medical imaging device that specializes in taking fundus images to diagnose hypertension, cor...

  • Article
  • Open Access
49 Citations
6,539 Views
11 Pages

Development of a Fundus Image-Based Deep Learning Diagnostic Tool for Various Retinal Diseases

  • Kyoung Min Kim,
  • Tae-Young Heo,
  • Aesul Kim,
  • Joohee Kim,
  • Kyu Jin Han,
  • Jaesuk Yun and
  • Jung Kee Min

21 April 2021

Artificial intelligence (AI)-based diagnostic tools have been accepted in ophthalmology. The use of retinal images, such as fundus photographs, is a promising approach for the development of AI-based diagnostic platforms. Retinal pathologies usually...

  • Data Descriptor
  • Open Access
42 Citations
21,049 Views
16 Pages

Retinal Fundus Multi-Disease Image Dataset (RFMiD) 2.0: A Dataset of Frequently and Rarely Identified Diseases

  • Sachin Panchal,
  • Ankita Naik,
  • Manesh Kokare,
  • Samiksha Pachade,
  • Rushikesh Naigaonkar,
  • Prerana Phadnis and
  • Archana Bhange

28 January 2023

Irreversible vision loss is a worldwide threat. Developing a computer-aided diagnosis system to detect retinal fundus diseases is extremely useful and serviceable to ophthalmologists. Early detection, diagnosis, and correct treatment could save the e...

  • Article
  • Open Access
34 Citations
4,267 Views
13 Pages

29 September 2021

High myopia is a global ocular disease and one of the most common causes of blindness. Fundus images can be obtained in a noninvasive manner and can be used to monitor and follow up on many fundus diseases, such as high myopia. In this paper, we prop...

  • Article
  • Open Access
20 Citations
4,571 Views
18 Pages

29 September 2023

Fundus diseases cause damage to any part of the retina. Untreated fundus diseases can lead to severe vision loss and even blindness. Analyzing optical coherence tomography (OCT) images using deep learning methods can provide early screening and diagn...

  • Data Descriptor
  • Open Access
222 Citations
37,224 Views
14 Pages

Retinal Fundus Multi-Disease Image Dataset (RFMiD): A Dataset for Multi-Disease Detection Research

  • Samiksha Pachade,
  • Prasanna Porwal,
  • Dhanshree Thulkar,
  • Manesh Kokare,
  • Girish Deshmukh,
  • Vivek Sahasrabuddhe,
  • Luca Giancardo,
  • Gwenolé Quellec and
  • Fabrice Mériaudeau

3 February 2021

The world faces difficulties in terms of eye care, including treatment, quality of prevention, vision rehabilitation services, and scarcity of trained eye care experts. Early detection and diagnosis of ocular pathologies would enable forestall of vis...

  • Article
  • Open Access
46 Citations
6,627 Views
17 Pages

Extraction of Blood Vessels in Fundus Images of Retina through Hybrid Segmentation Approach

  • Ramakrishnan Sundaram,
  • Ravichandran KS,
  • Premaladha Jayaraman and
  • Venkatraman B

13 February 2019

A hybrid segmentation algorithm is proposed is this paper to extract the blood vessels from the fundus image of retina. Fundus camera captures the posterior surface of the eye and the captured images are used to diagnose diseases, like Diabetic Retin...

  • Proceeding Paper
  • Open Access

13 November 2025

Diabetic retinopathy (DR), an eye disease that is a threatening cause of irreversible blindness, always challenging to detect and diagnose on time. There are many ophthalmic invasive procedures which exist in medical science for the diagnosis of ocul...

  • Article
  • Open Access
35 Citations
5,565 Views
20 Pages

Deep Learning-Based Detection of Pigment Signs for Analysis and Diagnosis of Retinitis Pigmentosa

  • Muhammad Arsalan,
  • Na Rae Baek,
  • Muhammad Owais,
  • Tahir Mahmood and
  • Kang Ryoung Park

18 June 2020

Ophthalmological analysis plays a vital role in the diagnosis of various eye diseases, such as glaucoma, retinitis pigmentosa (RP), and diabetic and hypertensive retinopathy. RP is a genetic retinal disorder that leads to progressive vision degenerat...

  • Article
  • Open Access
53 Citations
5,393 Views
19 Pages

Medinoid: Computer-Aided Diagnosis and Localization of Glaucoma Using Deep Learning

  • Mijung Kim,
  • Jong Chul Han,
  • Seung Hyup Hyun,
  • Olivier Janssens,
  • Sofie Van Hoecke,
  • Changwon Kee and
  • Wesley De Neve

29 July 2019

Glaucoma is a leading eye disease, causing vision loss by gradually affecting peripheral vision if left untreated. Current diagnosis of glaucoma is performed by ophthalmologists, human experts who typically need to analyze different types of medical...

  • Article
  • Open Access
3,600 Views
17 Pages

Hybrid Deep Learning Model for Cataract Diagnosis Assistance

  • Zonghong Feng,
  • Kai Xu,
  • Liangchang Li and
  • Yong Wang

4 December 2024

With the population aging globally, cataracts have become one of the main causes of vision impairment. Early diagnosis and treatment of cataracts are crucial for preventing blindness. However, the use of deep learning models for assisting in the diag...

  • Article
  • Open Access
415 Views
27 Pages

A Hierarchical Deep Learning Architecture for Diagnosing Retinal Diseases Using Cross-Modal OCT to Fundus Translation in the Lack of Paired Data

  • Ekaterina A. Lopukhova,
  • Gulnaz M. Idrisova,
  • Timur R. Mukhamadeev,
  • Grigory S. Voronkov,
  • Ruslan V. Kutluyarov and
  • Elizaveta P. Topolskaya

The paper focuses on automated diagnosis of retinal diseases, particularly Age-related Macular Degeneration (AMD) and diabetic retinopathy (DR), using optical coherence tomography (OCT), while addressing three key challenges: disease comorbidity, sev...

  • Article
  • Open Access
37 Citations
5,173 Views
16 Pages

7 November 2018

Fundus vessel analysis is a significant tool for evaluating the development of retinal diseases such as diabetic retinopathy and hypertension in clinical practice. Hence, automatic fundus vessel segmentation is essential and valuable for medical diag...

  • Article
  • Open Access
3 Citations
3,240 Views
18 Pages

Exploring the Feasibility of Opportunistic Diabetic Retinopathy Screening with Handheld Fundus Cameras in Primary Care: Insights from Doctors and Nurses

  • Sílvia Rêgo,
  • Matilde Monteiro-Soares,
  • Marco Dutra-Medeiros,
  • Cláudia Camila Dias and
  • Francisco Nunes

30 October 2024

Aims: This study aims to assess the perspective of doctors and nurses regarding the clinical settings and barriers to implementing opportunistic diabetic retinopathy screening with handheld fundus cameras. Design: This study was a cross-sectional, on...

  • Case Report
  • Open Access
9 Citations
5,324 Views
7 Pages

Tear Liquid for Predictive Diagnosis of Alzheimer’s Disease

  • Salvatore Del Prete,
  • Daniela Marasco,
  • Rosalaura Sabetta,
  • Antonio Del Prete,
  • Federica Zito Marino,
  • Renato Franco,
  • Salvatore Troisi,
  • Mario Troisi and
  • Gilda Cennamo

25 August 2021

The common approach of the diagnosis of Alzheimer’s Disease (AD) is made with an analysis of the cerebrospinal fluid or the study of retinal fundus and the plaques formation through optical corneal tomography (OCT), or more simply with a fundus camer...

  • Communication
  • Open Access
27 Citations
5,170 Views
14 Pages

Identifying the Edges of the Optic Cup and the Optic Disc in Glaucoma Patients by Segmentation

  • Srikanth Tadisetty,
  • Ranjith Chodavarapu,
  • Ruoming Jin,
  • Robert J. Clements and
  • Minzhong Yu

11 May 2023

With recent advancements in artificial intelligence, fundus diseases can be classified automatically for early diagnosis, and this is an interest of many researchers. The study aims to detect the edges of the optic cup and the optic disc of fundus im...

  • Article
  • Open Access
639 Views
22 Pages

With the growing use of deep learning in medical image analysis, automated classification of fundus images is crucial for the early detection of fundus diseases. However, the complexity of fluorescein fundus angiography (FFA) images poses challenges...

  • Article
  • Open Access
26 Citations
10,607 Views
18 Pages

18 October 2023

Eye diseases can result in various challenges and visual impairments. These diseases can affect an individual’s quality of life and general health and well-being. The symptoms of eye diseases vary widely depending on the nature and severity of...

  • Article
  • Open Access
3 Citations
2,607 Views
8 Pages

X-Linked Retinoschisis Masquerading Uveitis

  • Luca Mautone,
  • Johannes Birtel,
  • Yevgeniya Atiskova,
  • Vasyl Druchkiv,
  • Nicole Stübiger,
  • Martin S. Spitzer and
  • Simon Dulz

29 May 2023

X-linked retinoschisis (XLRS) shows features also seen in patients with uveitis and is recognized as an uveitis masquerade syndrome. This retrospective study aimed to describe characteristics of XLRS patients with an initial uveitis diagnosis and to...

  • Case Report
  • Open Access
5 Citations
3,540 Views
8 Pages

19 December 2021

Background and Objectives: Pigmented paravenous retinochoroidal atrophy (PPRCA) is a rare disease with bilateral retinal pigment epithelium and choroidal atrophy. We present a case of PPRCA using multimodal imaging studies. Case summary: A 61-year-ol...

  • Article
  • Open Access
8 Citations
2,905 Views
21 Pages

19 April 2022

Fundus is the only structure that can be observed without trauma to the human body. By analyzing color fundus images, the diagnosis basis for various diseases can be obtained. Recently, fundus image segmentation has witnessed vast progress with the d...

  • Article
  • Open Access
5 Citations
3,944 Views
17 Pages

31 January 2023

Artificial intelligence (AI) represents a growing and promising branch of computer science that is expanding the horizon of prediction, screening, and disease monitoring. The use of multimodal imaging in retinal diseases is particularly advantageous...

  • Article
  • Open Access
44 Citations
3,828 Views
13 Pages

28 December 2022

Diabetic retinopathy (DR) is an eye disease triggered due to diabetes, which may lead to blindness. To prevent diabetic patients from becoming blind, early diagnosis and accurate detection of DR are vital. Deep learning models, such as convolutional...

  • Interesting Images
  • Open Access
2,029 Views
7 Pages

Multimodal Imaging Techniques in Monitoring a Patient with Ocular Decompression Retinopathy

  • Justyna Mędrzycka,
  • Paulina Szabelska,
  • Magdalena Rerych,
  • Radosław Różycki and
  • Joanna Gołębiewska

Ocular decompression retinopathy (ODR) is characterized by multiple retinal hemorrhages. It is a rare complication associated with rapid decrease of intraocular pressure (IOP). The course of ODR is usually asymptomatic and self-limiting, which was co...

  • Article
  • Open Access
1 Citations
1,326 Views
4 Pages

Coats’ Retinitis or Retinoblastoma in a 3-Year-Old Girl: A Case Report

  • Alvydas Paunksnis,
  • Daiva Imbrasienė,
  • Rasa Liutkevičienė,
  • Kristina Rilienė,
  • Evaldas Keleras and
  • Rimantas Kėvalas

17 March 2012

Coats’ disease is an idiopathic disorder defined by an abnormal development of retinal vessels with a progressive deposition of intraretinal or subretinal exudates, leading to exudative retinal detachment. The most difficult task is to differentiate...

  • Article
  • Open Access
23 Citations
4,088 Views
20 Pages

A Generic Pixel Pitch Calibration Method for Fundus Camera via Automated ROI Extraction

  • Tengfei Long,
  • Yi Xu,
  • Haidong Zou,
  • Lina Lu,
  • Tianyi Yuan,
  • Zhou Dong,
  • Jiqun Dong,
  • Xin Ke,
  • Saiguang Ling and
  • Yingyan Ma

7 November 2022

Pixel pitch calibration is an essential step to make the fundus structures in the fundus image quantitatively measurable, which is important for the diagnosis and treatment of many diseases, e.g., diabetes, arteriosclerosis, hereditary optic atrophy,...

  • Article
  • Open Access
3 Citations
2,185 Views
12 Pages

Deep Learner System Based on Focal Color Retinal Fundus Images to Assist in Diagnosis

  • Yanli Zou,
  • Yujuan Wang,
  • Xiangbin Kong,
  • Tingting Chen,
  • Jiangna Chen and
  • Yiqun Li

18 September 2023

Retinal diseases are a serious and widespread ophthalmic disease that seriously affects patients’ vision and quality of life. With the aging of the population and the change in lifestyle, the incidence rate of retinal diseases has increased yea...

  • Article
  • Open Access
77 Citations
11,901 Views
19 Pages

Identification of Diabetic Retinopathy Using Weighted Fusion Deep Learning Based on Dual-Channel Fundus Scans

  • Grace Ugochi Nneji,
  • Jingye Cai,
  • Jianhua Deng,
  • Happy Nkanta Monday,
  • Md Altab Hossin and
  • Saifun Nahar

19 February 2022

It is a well-known fact that diabetic retinopathy (DR) is one of the most common causes of visual impairment between the ages of 25 and 74 around the globe. Diabetes is caused by persistently high blood glucose levels, which leads to blood vessel agg...

  • Article
  • Open Access
46 Citations
4,293 Views
11 Pages

23 November 2021

With recent advancements in machine learning, especially in deep learning, the prediction of eye diseases based on fundus photography using deep convolutional neural networks (DCNNs) has attracted great attention. However, studies focusing on identif...

  • Article
  • Open Access
58 Citations
8,977 Views
16 Pages

2 February 2019

Analysis of retinal fundus images is essential for eye-care physicians in the diagnosis, care and treatment of patients. Accurate fundus and/or retinal vessel maps give rise to longitudinal studies able to utilize multimedia image registration and di...

  • Article
  • Open Access
36 Citations
4,769 Views
21 Pages

One of the most serious and dangerous ocular problems in premature infants is retinopathy of prematurity (ROP), a proliferative vascular disease. Ophthalmologists can use automatic computer-assisted diagnostic (CAD) tools to help them make a safe, ac...

  • Article
  • Open Access
22 Citations
7,069 Views
16 Pages

Deep Feature Vectors Concatenation for Eye Disease Detection Using Fundus Image

  • Radifa Hilya Paradisa,
  • Alhadi Bustamam,
  • Wibowo Mangunwardoyo,
  • Andi Arus Victor,
  • Anggun Rama Yudantha and
  • Prasnurzaki Anki

Fundus image is an image that captures the back of the eye (retina), which plays an important role in the detection of a disease, including diabetic retinopathy (DR). It is the most common complication in diabetics that remains an important cause of...

  • Article
  • Open Access
674 Views
11 Pages

Screening for retinal disease is increasingly performed by general practitioners and other non-ophthalmologist clinicians in primary care, especially where access to ophthalmology is limited and diagnostic accuracy may be suboptimal. To investigate t...

  • Communication
  • Open Access
5 Citations
3,197 Views
9 Pages

17 December 2022

Glaucoma disease is the second leading cause of blindness in the world. This progressive ocular neuropathy is mainly caused by uncontrolled high intraocular pressure. Although there is still no cure, early detection and appropriate treatment can stop...

  • Review
  • Open Access
12 Citations
4,007 Views
16 Pages

Clinical Use of Optical Coherence Tomography Angiography in Retinal Diseases

  • Figen Batıoğlu,
  • Özge Yanık,
  • Sibel Demirel and
  • Emin Özmert

The advent of optical coherence tomography angiography (OCTA) is one of the cornerstones of fundus imaging. Essentially, its mechanism depends on the visualization of blood vessels by using the flow of erythrocytes as an intrinsic contrast agent. Alt...

  • Case Report
  • Open Access
1 Citations
3,492 Views
7 Pages

Cat-scratch disease (CSD) is an infectious disease caused by Bartonella henselae, presenting with fever and lymphadenopathy following contact with felines. The ocular manifestations include neuroretinitis, characterised by optic nerve swelling and a...

  • Review
  • Open Access
19 Citations
5,391 Views
14 Pages

Advancements in Glaucoma Diagnosis: The Role of AI in Medical Imaging

  • Clerimar Paulo Bragança,
  • José Manuel Torres,
  • Luciano Oliveira Macedo and
  • Christophe Pinto de Almeida Soares

The progress of artificial intelligence algorithms in digital image processing and automatic diagnosis studies of the eye disease glaucoma has been growing and presenting essential advances to guarantee better clinical care for the population. Given...

  • Article
  • Open Access
6 Citations
2,342 Views
15 Pages

Color fundus images are now widely used in computer-aided analysis systems for ophthalmic diseases. However, fundus imaging can be affected by human, environmental, and equipment factors, which may result in low-quality images. Such quality fundus im...

  • Article
  • Open Access
51 Citations
7,938 Views
23 Pages

Automatic Classification of Colour Fundus Images for Prediction Eye Disease Types Based on Hybrid Features

  • Ahlam Shamsan,
  • Ebrahim Mohammed Senan and
  • Hamzeh Salameh Ahmad Shatnawi

Early detection of eye diseases is the only solution to receive timely treatment and prevent blindness. Colour fundus photography (CFP) is an effective fundus examination technique. Because of the similarity in the symptoms of eye diseases in the ear...

  • Case Report
  • Open Access
11 Citations
7,405 Views
7 Pages

Imaging of a Cilioretinal Artery Embolisation

  • Marion R. Munk,
  • Rukhsana G. Mirza and
  • Lee M. Jampol

4 September 2014

Retinal artery occlusion can be the first indicator of a significant cardiovascular disorder and the need for treatment. We present the case of a 69-year-old man with a cilioretinal artery occlusion and retinal ischemia. Retinal imaging, in particul...

  • Article
  • Open Access
4 Citations
3,978 Views
14 Pages

FITC-Labeled RGD Peptides as Novel Contrast Agents for Functional Fluorescent Angiographic Detection of Retinal and Choroidal Neovascularization

  • Seung Woo Choi,
  • Hye Kyoung Hong,
  • Jehwi Jeon,
  • Ji Young Choi,
  • Minah Kim,
  • Pilhan Kim,
  • Byung Chul Lee and
  • Se Joon Woo

21 July 2023

The development of choroidal neovascularization (CNV) is a crucial factor in the pathophysiology and prognosis of exudative age-related macular degeneration (AMD). Therefore, the detection of CNV is essential for establishing an appropriate diagnosis...

  • Article
  • Open Access
1,193 Views
15 Pages

Cup and Disc Segmentation in Smartphone Handheld Ophthalmoscope Images with a Composite Backbone and Double Decoder Architecture

  • Thiago Paiva Freire,
  • Geraldo Braz Júnior,
  • João Dallyson Sousa de Almeida and
  • José Ribamar Durand Rodrigues Junior

11 April 2025

Glaucoma is a visual disease that affects millions of people, and early diagnosis can prevent total blindness. One way to diagnose the disease is through fundus image examination, which analyzes the optic disc and cup structures. However, screening p...

  • Article
  • Open Access
12 Citations
2,945 Views
15 Pages

8 September 2022

Doctors usually diagnose a disease by evaluating the pattern of abnormal blood vessels in the fundus. At present, the segmentation of fundus blood vessels based on deep learning has achieved great success, but it still faces the problems of low accur...

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