Diet and Age-Related Eye Diseases
A special issue of Nutrients (ISSN 2072-6643). This special issue belongs to the section "Nutrition and Metabolism".
Deadline for manuscript submissions: 15 October 2025 | Viewed by 801
Special Issue Editor
Interests: retina; age-related macular degeneration; diabetic retinopathy; retinal vascular occlusion; intermittent fasting; magnesium; oxidative stress
Special Issue Information
Dear Colleagues,
Vision is one of our most precious senses, and while there is active medical discussion on how to maintain healthy vision, dietary habits for eye health often receive less attention. However, ensuring a healthy diet is one of the most preventive and noninvasive methods essential not only for overall well-being but also, critically, for maintaining eye health.
The vital role played by nutrition in preserving sight and preventing age-related eye diseases such as macular degeneration, cataracts, and glaucoma has been well established. A diet rich in vitamins C and E, zinc, lutein, zeaxanthin, and omega-3 fatty acids has been associated with a lower risk of these conditions, supporting neuro-retinal function and protecting against oxidative damage. Certain supplements, such as the AREDS2 formula, show promise in slowing down the progression of age-related macular degeneration.
Glycation, a non-enzymatic reaction between sugars and proteins or lipids, leads to the formation of advanced glycation end-products (AGEs), which contribute to oxidative stress, inflammation, and ocular degeneration. Low-glycemic diets or fasting decrease the formation of AGEs while also activating ketone production and Sirtuin 1 (a nutrient-sensing deacetylase), which exert anti-inflammatory effects and enhance mitochondrial function, thereby improving the function of vascular endothelial cells and retinal pigment epithelial cells. Intermittent fasting and low-glycemic diets have shown potential benefits for individuals at risk of vision loss due to diabetic retinopathy and age-related macular degeneration.
This Special Issue of Nutrients aims to explore the intricate relationship between diet and eye health through the latest research, potentially shedding light on dietary recommendations and interventions for maintaining optimal vision throughout life.
Prof. Dr. Eun-young Choi
Guest Editor
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Keywords
- eye health
- nutrition
- oxidative stress
- dietary interventions
- glaucoma
- age-related macular degeneration
- retinal vascular occlusion
- cataract
- oxidative damage
- diabetic retinopathy
- dry eye disease
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