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3,409 Results Found

  • Article
  • Open Access
3 Citations
2,455 Views
14 Pages

Functional Network Connectivity for Components of Depression-Related Psychological Fragility

  • Ian D. Evans,
  • Christopher F. Sharpley,
  • Vicki Bitsika,
  • Kirstan A. Vessey,
  • Emmanuel Jesulola and
  • Linda L. Agnew

22 August 2024

Psychological resilience (PR) is known to be inversely associated with depression. While there is a growing body of research examining how depression alters activity across multiple functional neural networks, how differences in PR affect these netwo...

  • Article
  • Open Access
202 Views
17 Pages

10 February 2026

Background: Resting-state functional MRI (rs-fMRI) studies typically rely on linear Pearson correlation to characterize brain connectivity, potentially overlooking the distributional characteristics of functional networks. This study introduces a ker...

  • Article
  • Open Access
8 Citations
3,834 Views
19 Pages

Neurofeedback of real-time functional magnetic resonance imaging (rtfMRI) can enable people to self-regulate motor-related brain regions and lead to alteration of motor performance and functional connectivity (FC) underlying motor execution tasks. Nu...

  • Article
  • Open Access
21 Citations
8,504 Views
14 Pages

The study of resting-state functional brain networks is a powerful tool to understand the neurological bases of a variety of disorders such as Autism Spectrum Disorder (ASD). In this work, we have studied the differences in functional brain connectiv...

  • Article
  • Open Access
3 Citations
2,718 Views
13 Pages

The Effect of APOE ɛ4 on the Functional Connectivity in Frontoparietal Network in Hypertensive Patients

  • Dandan Wang,
  • Chang Xu,
  • Wenxiao Wang,
  • Hui Lu,
  • Junying Zhang,
  • Furu Liang and
  • Xin Li

Allele 4 of the apolipoprotein E gene (APOE ε4) and hypertension are considered risk factors for Alzheimer’s Disease (AD). The detection of differences in cognitive function and brain networks between hypertensive patients who are APOE...

  • Article
  • Open Access
7 Citations
4,400 Views
13 Pages

On the Variability of Functional Connectivity and Network Measures in Source-Reconstructed EEG Time-Series

  • Matteo Fraschini,
  • Simone Maurizio La Cava,
  • Luca Didaci and
  • Luigi Barberini

22 December 2020

The idea of estimating the statistical interdependence among (interacting) brain regions has motivated numerous researchers to investigate how the resulting connectivity patterns and networks may organize themselves under any conceivable scenario. Ev...

  • Article
  • Open Access
1,339 Views
17 Pages

Olfactory Network Functional Connectivity as a Marker for Parkinson’s Disease Severity

  • Senal Peiris,
  • Anupa Ekanayake,
  • Jiaming Lu,
  • Rommy Elyan,
  • Katie Geesey,
  • Ross Cottrill,
  • Paul Eslinger,
  • Xuemei Huang and
  • Prasanna Karunanayaka

20 August 2025

Olfactory impairment was assessed in akinetic-rigid (PDAR) and tremor-predominant (PDT) subtypes of Parkinson’s disease (PD), classified based on motor symptoms. Seventeen PDAR, fifteen PDT, and twenty-four cognitively normal (CN) participants...

  • Article
  • Open Access
4 Citations
6,064 Views
13 Pages

Examining Insula–Default Mode Network Functional Connectivity and Its Relationship with Heart Rate Variability

  • Marlene Nogueira,
  • Juliana da Silva Magalhães,
  • Adriana Sampaio,
  • Sónia Sousa and
  • Joana F. Coutinho

Background: The Default Mode Network (DMN) is involved in self-referential and emotional processes, while the insula integrates emotional and interoceptive signals. Functional connectivity between the insula and the DMN is proposed to enhance these p...

  • Article
  • Open Access
19 Citations
5,001 Views
25 Pages

10 November 2023

Strengthening and optimizing the spatial structure and functional connectivity of green space ecological networks can not only relieve the tight urban space and provide biodiversity protection but also promote the virtuous cycle of the urban ecosyste...

  • Article
  • Open Access
54 Citations
8,236 Views
14 Pages

Functional Connectivity between the Resting-State Olfactory Network and the Hippocampus in Alzheimer’s Disease

  • Jiaming Lu,
  • Nicole Testa,
  • Rebecca Jordan,
  • Rommy Elyan,
  • Sangam Kanekar,
  • Jianli Wang,
  • Paul Eslinger,
  • Qing X. Yang,
  • Bing Zhang and
  • Prasanna R. Karunanayaka

25 November 2019

Olfactory impairment is associated with prodromal Alzheimer’s disease (AD) and is a risk factor for the development of dementia. AD pathology is known to disrupt brain regions instrumental in olfactory information processing, such as the primar...

  • Article
  • Open Access
3 Citations
4,932 Views
16 Pages

17 December 2021

Objectives: Functional connectivity triggered by naturalistic stimuli (e.g., movie clips), coupled with machine learning techniques provide great insight in exploring brain functions such as fluid intelligence. However, functional connectivity is mul...

  • Article
  • Open Access
1 Citations
4,956 Views
16 Pages

8 April 2025

Functional differences in key brain networks, including the dorsal attention network (DAN), control network (CN), and default mode network (DMN), have been identified in individuals with obsessive–compulsive disorder (OCD). However, the precise...

  • Article
  • Open Access
18 Citations
5,866 Views
19 Pages

Changes in the Functional Brain Network of Children Undergoing Repeated Epilepsy Surgery: An EEG Source Connectivity Study

  • Giulia Iandolo,
  • Nitish Chourasia,
  • Georgios Ntolkeras,
  • Joseph R. Madsen,
  • Christos Papadelis,
  • Ellen Grant,
  • Phillip L. Pearl,
  • Fabrizio Taffoni and
  • Eleonora Tamilia

About 30% of children with drug-resistant epilepsy (DRE) continue to have seizures after epilepsy surgery. Since epilepsy is increasingly conceptualized as a network disorder, understanding how brain regions interact may be critical for planning re-o...

  • Article
  • Open Access
13 Citations
4,664 Views
15 Pages

7 February 2023

Objective: To identify patterns of social dysfunction in adolescents with autism spectrum disorder (ASD), study the potential linkage between social brain networks and stereotyped behavior, and further explore potential targets of non-invasive nerve...

  • Article
  • Open Access
4 Citations
2,854 Views
16 Pages

How Functional Connectivity Measures Affect the Outcomes of Global Neuronal Network Characteristics in Patients with Schizophrenia Compared to Healthy Controls

  • Kamil Jonak,
  • Magdalena Marchewka,
  • Arkadiusz Podkowiński,
  • Agata Siejka,
  • Małgorzata Plechawska-Wójcik,
  • Robert Karpiński and
  • Paweł Krukow

13 January 2023

Modern computational solutions used in the reconstruction of the global neuronal network arrangement seem to be particularly valuable for research on neuronal disconnection in schizophrenia. However, the vast number of algorithms used in these analys...

  • Article
  • Open Access
4 Citations
2,474 Views
11 Pages

Resting State Functional Connectivity between Dorsal Attentional Network and Right Inferior Frontal Gyrus in Concussed and Control Adolescents

  • Stephen J. Suss,
  • Anna Manelis,
  • Joao Paulo Lima Santos,
  • Cynthia L. Holland,
  • Richelle S. Stiffler,
  • Hannah B. Bitzer,
  • Sarrah Mailliard,
  • Madelyn Shaffer,
  • Kaitlin Caviston and
  • Amelia Versace
  • + 3 authors

20 April 2022

Concussion among adolescents continues to be a public health concern. Yet, the differences in brain function between adolescents with a recent concussion and adolescents with no history of concussion are not well understood. Although resting state fu...

  • Article
  • Open Access
6 Citations
2,412 Views
10 Pages

29 December 2022

The corticocortical vestibular network (CVN) plays an important role in maintaining balance and stability. In order to clarify the specific relationship between the CVN and the balance ability of patients with mild cognitive impairment (MCI), we recr...

  • Article
  • Open Access
6 Citations
4,166 Views
11 Pages

Mild cognitive impairment (MCI) is an intermediate stage between normal aging and dementia, and a significant number of individuals with MCI progress to develop dementia. Depression is prevalent in MCI patients and has been found to influence the dis...

  • Article
  • Open Access
26 Citations
6,919 Views
17 Pages

Increased Resting State Triple Network Functional Connectivity in Undergraduate Problematic Cannabis Users: A Preliminary EEG Coherence Study

  • Claudio Imperatori,
  • Chiara Massullo,
  • Giuseppe Alessio Carbone,
  • Angelo Panno,
  • Marta Giacchini,
  • Cristina Capriotti,
  • Elisa Lucarini,
  • Benedetta Ramella Zampa,
  • Eric Murillo-Rodríguez and
  • Benedetto Farina
  • + 1 author

28 February 2020

An increasing body of experimental data have suggested that aberrant functional interactions between large-scale networks may be the most plausible explanation of psychopathology across multiple mental disorders, including substance-related and addic...

  • Article
  • Open Access
3,167 Views
29 Pages

27 March 2025

Background: In functional magnetic resonance imaging (fMRI), functional network connectivity (FNC) captures temporal coupling among intrinsic connectivity networks (ICNs). Traditional FNC analyses often rely on linear models, which may overlook compl...

  • Article
  • Open Access
11 Citations
5,786 Views
26 Pages

Differentiating Individuals with and without Alcohol Use Disorder Using Resting-State fMRI Functional Connectivity of Reward Network, Neuropsychological Performance, and Impulsivity Measures

  • Chella Kamarajan,
  • Babak A. Ardekani,
  • Ashwini K. Pandey,
  • Sivan Kinreich,
  • Gayathri Pandey,
  • David B. Chorlian,
  • Jacquelyn L. Meyers,
  • Jian Zhang,
  • Elaine Bermudez and
  • Bernice Porjesz
  • + 2 authors

28 April 2022

Individuals with alcohol use disorder (AUD) may manifest an array of neural and behavioral abnormalities, including altered brain networks, impaired neurocognitive functioning, and heightened impulsivity. Using multidomain measures, the current study...

  • Article
  • Open Access
40 Citations
9,146 Views
23 Pages

EEG Mental Stress Assessment Using Hybrid Multi-Domain Feature Sets of Functional Connectivity Network and Time-Frequency Features

  • Ala Hag,
  • Dini Handayani,
  • Thulasyammal Pillai,
  • Teddy Mantoro,
  • Mun Hou Kit and
  • Fares Al-Shargie

20 September 2021

Exposure to mental stress for long period leads to serious accidents and health problems. To avoid negative consequences on health and safety, it is very important to detect mental stress at its early stages, i.e., when it is still limited to acute o...

  • Article
  • Open Access
1 Citations
1,249 Views
17 Pages

Aberrant Salience Network Functional Connectivity in Resting-State and Fear-Related Autobiographical Memory Recall in Female Adolescents with Borderline Personality Disorder

  • Elena De Rossi,
  • Chiara Di Maggio,
  • Claudio Imperatori,
  • Marilina Covuccia,
  • Giuseppe A. Carbone,
  • Arianna Terrinoni,
  • Chiara Massullo,
  • Vincenzo Guidetti,
  • Mario Brinciotti and
  • Benedetto Farina
  • + 1 author

25 October 2025

Objectives. Identity disturbance and instability in Borderline Personality Disorder (BPD) are associated with impairments in the integration of emotional autobiographical memory (EAM). At the neurophysiological level, it has been suggested that EAM d...

  • Feature Paper
  • Article
  • Open Access
5 Citations
3,164 Views
16 Pages

26 June 2024

Over the past decade and a half, dynamic functional imaging has revealed low-dimensional brain connectivity measures, identified potential common human spatial connectivity states, tracked the transition patterns of these states, and demonstrated mea...

  • Article
  • Open Access
371 Views
15 Pages

30 December 2025

Objectives: Innovative, evidence-based interventions for developmental dyslexia (DD) are necessary. While traditional methods remain valuable, newer approaches, such as cognitive–motor training, show the potential to improve literacy skills for...

  • Article
  • Open Access
3 Citations
3,557 Views
16 Pages

The brain–computer interface (BCI) is a promising technology where a user controls a robot or computer by thinking with no movement. There are several underlying principles to implement BCI, such as sensorimotor rhythms, P300, steady-state visually e...

  • Article
  • Open Access
12 Citations
4,159 Views
19 Pages

27 November 2021

While significant progress has been achieved in studying resting-state functional networks in a healthy human brain and in a wide range of clinical conditions, many questions related to their relationship to the brain’s cellular constituents re...

  • Article
  • Open Access
1,976 Views
14 Pages

Measurement of Functional Brain Network Connectivity in People with Orthostatic Tremor

  • Connor J. Phipps,
  • David Whitney,
  • James Shou,
  • Diego Torres-Russotto and
  • David E. Warren

27 February 2024

Orthostatic tremor is a rare movement disorder characterized by a sensation of unsteadiness and leg tremor while standing. It has been hypothesized that the disorder is attributable to dysregulation of a central oscillatory network in the brain. This...

  • Article
  • Open Access
11 Citations
4,003 Views
13 Pages

Functional Network Connectivity Reveals the Brain Functional Alterations in Breast Cancer Survivors

  • Tatyana Bukkieva,
  • Maria Pospelova,
  • Aleksandr Efimtsev,
  • Olga Fionik,
  • Tatyana Alekseeva,
  • Konstantin Samochernych,
  • Elena Gorbunova,
  • Varvara Krasnikova,
  • Albina Makhanova and
  • Maxim Shevtsov
  • + 3 authors

26 January 2022

Different neurological and psychiatric disorders such as vertebrobasilar insufficiency, chronic pain syndrome, anxiety, and depression are observed in more than 90% of patients after treatment for breast cancer and may cause alterations in the functi...

  • Feature Paper
  • Article
  • Open Access
8 Citations
3,573 Views
21 Pages

27 June 2021

River system network (RSN) connectivity is important to maintain the environmental and ecological functions of wetlands. Quantitative evaluation of connectivity can provide crucial support for efforts to improve wetland connectivity and to restore an...

  • Article
  • Open Access
2 Citations
2,459 Views
13 Pages

Differences in EEG Functional Connectivity in the Dorsal and Ventral Attentional and Salience Networks Across Multiple Subtypes of Depression

  • Ian D. Evans,
  • Christopher F. Sharpley,
  • Vicki Bitsika,
  • Kirstan A. Vessey,
  • Rebecca J. Williams,
  • Emmanuel Jesulola and
  • Linda L. Agnew

31 January 2025

Depression remains one of the most widespread and costly mental disorders, with the current first-line treatment efficacy of about a third, possibly due to its heterogeneous nature. Consequently, there is a need to identify reliable biomarkers for sp...

  • Article
  • Open Access
8 Citations
4,099 Views
16 Pages

The Effect of Light Sedation with Midazolam on Functional Connectivity of the Dorsal Attention Network

  • Junkai Wang,
  • Yachao Xu,
  • Gopikrishna Deshpande,
  • Kuncheng Li,
  • Pei Sun and
  • Peipeng Liang

22 August 2021

Altered connectivity within and between the resting-state networks (RSNs) brought about by anesthetics that induce altered consciousness remains incompletely understood. It is known that the dorsal attention network (DAN) and its anticorrelations wit...

  • Article
  • Open Access
688 Views
14 Pages

Altered Functional Connectivity of Amygdala Subregions with Large-Scale Brain Networks in Schizophrenia: A Resting-State fMRI Study

  • Rasha Rudaid Alharthi,
  • Duaa Banaja,
  • Adnan Alahmadi,
  • Jaber Hussain Alsalah,
  • Arwa Baeshen,
  • Ali H. Alghamdi,
  • Magbool Alelyani and
  • Njoud Aldusary

Objective: This study aimed to investigate the functional connectivity (FC) of three amygdala subregions—the laterobasal amygdala (LBA), centromedial amygdala (CMA), and superficial amygdala (SFA)—with large-scale brain networks in indivi...

  • Article
  • Open Access
22 Citations
6,891 Views
15 Pages

Network Entropy for the Sequence Analysis of Functional Connectivity Graphs of the Brain

  • Chi Zhang,
  • Fengyu Cong,
  • Tuomo Kujala,
  • Wenya Liu,
  • Jia Liu,
  • Tiina Parviainen and
  • Tapani Ristaniemi

25 April 2018

Dynamic representation of functional brain networks involved in the sequence analysis of functional connectivity graphs of the brain (FCGB) gains advances in uncovering evolved interaction mechanisms. However, most of the networks, even the event-rel...

  • Article
  • Open Access
5 Citations
4,210 Views
17 Pages

Introduction: Although the putamen has a significant role in reward-seeking and motivated behaviors, including eating and food-seeking, minorities’ diminished returns (MDRs) suggest that individual-level risk and protective factors have weaker effect...

  • Article
  • Open Access
11 Citations
2,889 Views
13 Pages

Scale-Free Functional Brain Networks Exhibit Increased Connectivity, Are More Integrated and Less Segregated in Patients with Parkinson’s Disease following Dopaminergic Treatment

  • Orestis Stylianou,
  • Zalan Kaposzta,
  • Akos Czoch,
  • Leon Stefanovski,
  • Andriy Yabluchanskiy,
  • Frigyes Samuel Racz,
  • Petra Ritter,
  • Andras Eke and
  • Peter Mukli

Dopaminergic treatment (DT), the standard therapy for Parkinson’s disease (PD), alters the dynamics of functional brain networks at specific time scales. Here, we explore the scale-free functional connectivity (FC) in the PD population and how...

  • Article
  • Open Access
15 Citations
4,779 Views
15 Pages

Treatment of bipolar depression poses a significant clinical challenge. Lamotrigine is one of a few efficacious drugs, however, it needs to be titrated very slowly and response can only be assessed after 10–12 weeks. With only a proportion of patient...

  • Article
  • Open Access
5 Citations
4,364 Views
16 Pages

Odor Pleasantness Modulates Functional Connectivity in the Olfactory Hedonic Processing Network

  • Veit Frederik Kepler,
  • Manuel S. Seet,
  • Junji Hamano,
  • Mariana Saba,
  • Nitish V. Thakor,
  • Stavros I. Dimitriadis and
  • Andrei Dragomir

19 October 2022

Olfactory hedonic evaluation is the primary dimension of olfactory perception and thus central to our sense of smell. It involves complex interactions between brain regions associated with sensory, affective and reward processing. Despite a recent in...

  • Article
  • Open Access
12 Citations
3,910 Views
11 Pages

25 March 2022

Large-scale functional connectivity is an important indicator of the brain’s normal functioning. The abnormalities in the connectivity pattern can be used as a diagnostic tool to detect various neurological disorders. The present paper describe...

  • Article
  • Open Access
3 Citations
3,766 Views
13 Pages

Associations between Elemental Metabolic Dynamics and Default Mode Network Functional Connectivity Are Altered in Autism

  • Paul Curtin,
  • Janina Neufeld,
  • Austen Curtin,
  • Christine Austin,
  • Johan Isaksson,
  • Karl Lundin Remnelius,
  • Hjalmar Nobel Norrman,
  • Manish Arora and
  • Sven Bölte

28 January 2023

Autism is a neurodevelopmental condition associated with atypical social communication, cognitive, and sensory faculties. Recent advances in exposure biology suggest that biomarkers of elemental uptake and metabolism measured in hair samples can yiel...

  • Article
  • Open Access
7 Citations
4,492 Views
20 Pages

10 February 2022

Aim. Handwriting abilities in children with dyslexia (DYS) are not well documented in the current literature, and the presence of graphomotor impairment in addition to spelling impairment in dyslexia is controversial. Using resting-state functional c...

  • Article
  • Open Access
13 Citations
3,967 Views
19 Pages

KCS-FCnet: Kernel Cross-Spectral Functional Connectivity Network for EEG-Based Motor Imagery Classification

  • Daniel Guillermo García-Murillo,
  • Andrés Marino Álvarez-Meza and
  • Cesar German Castellanos-Dominguez

This paper uses EEG data to introduce an approach for classifying right and left-hand classes in Motor Imagery (MI) tasks. The Kernel Cross-Spectral Functional Connectivity Network (KCS-FCnet) method addresses these limitations by providing richer sp...

  • Article
  • Open Access
4 Citations
3,287 Views
16 Pages

3 October 2020

Background: Nucleus accumbens (NAc) is a brain structure with a well-established role in the brain reward processing system. Altered function of the NAc is shown to have a role in the development of food addiction and obesity. However, less is known...

  • Article
  • Open Access
11 Citations
4,059 Views
10 Pages

Functional Connectivity-Derived Optimal Gestational-Age Cut Points for Fetal Brain Network Maturity

  • Josepheen De Asis-Cruz,
  • Scott Douglas Barnett,
  • Jung-Hoon Kim and
  • Catherine Limperopoulos

The architecture of the human connectome changes with brain maturation. Pivotal to understanding these changes is defining developmental periods when transitions in network topology occur. Here, using 110 resting-state functional connectivity data se...

  • Article
  • Open Access
1,582 Views
18 Pages

4 September 2025

Alexithymia is regarded as one of the risk factors for several prevalent mental disorders, and there is a growing need for convenient and objective methods to assess alexithymia. Therefore, this study proposes a method for constructing models to asse...

  • Article
  • Open Access
33 Citations
5,736 Views
15 Pages

Brain Functional Connectivity in Low- and High-Grade Gliomas: Differences in Network Dynamics Associated with Tumor Grade and Location

  • Luca Pasquini,
  • Mehrnaz Jenabi,
  • Onur Yildirim,
  • Patrick Silveira,
  • Kyung K. Peck and
  • Andrei I. Holodny

8 July 2022

Brain tumors lead to modifications of brain networks. Graph theory plays an important role in clarifying the principles of brain connectivity. Our objective was to investigate network modifications related to tumor grade and location using resting-st...

  • Review
  • Open Access
8 Citations
5,733 Views
21 Pages

24 December 2022

Studying how spatially discrete neuroanatomical regions across the brain interact is critical to advancing our understanding of the brain. Traditional neuroimaging techniques have led to many important discoveries about the nature of these interactio...

  • Article
  • Open Access
7 Citations
4,818 Views
10 Pages

Mirror neuron network (MNN) is associated with one’s ability to recognize and interpret others’ actions and emotions and has a crucial role in cognition, perception, and social interaction. MNN connectivity and its relation to social attributes, such...

  • Article
  • Open Access
14 Citations
3,024 Views
20 Pages

Functional Connectivity within the Frontal–Striatal Network Differentiates Checkers from Washers of Obsessive-Compulsive Disorder

  • Jianping Yu,
  • Minyao Xie,
  • Shasha Song,
  • Ping Zhou,
  • Fangzheng Yuan,
  • Mengyuan Ouyang,
  • Chun Wang,
  • Na Liu and
  • Ning Zhang

Background: Obsessive-compulsive disorder (OCD) is a psychiatric disorder with high clinical heterogeneity manifested by the presence of obsessions and/or compulsions. The classification of the symptom dimensional subtypes is helpful for further expl...

  • Article
  • Open Access
8 Citations
2,987 Views
11 Pages

Resting-State Functional Connectivity Differences in College Students with and without Food Insecurity

  • Nicolas Guerithault,
  • Samuel M. McClure,
  • Chinedum O. Ojinnaka,
  • B. Blair Braden and
  • Meg Bruening

14 May 2022

We used functional magnetic resonance imaging (fMRI) to investigate cross-sectional differences in functional connectivity across cognitive networks at rest among age and sex matched college students with very low food security [food insecurity (FI);...

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