Search Results (1,638)

The rising global burden of chronic diseases highlights the limitations of traditional dietary guidelines. Precision Nutrition (PN) aims to deliver personalized dietary advice to optimize individual health, and the effective implementation of PN fundamentally relies on comprehensive and accurate dietary data. However, conventional dietary assessment methods often suffer from quantification errors and poor adaptability to dynamic changes, leading to inaccurate data and ineffective guidance. Machine learning (ML) offers a powerful suite of tools to address these limitations, enabling a paradigm shift across the nutritional management pipeline. Using dietary data as a thematic thread, this article outlines this transformation and synthesizes recent advances across dietary assessment, in-depth mining, and nutritional intervention. Additionally, current challenges and future trends in this domain are also further discussed. ML is driving a critical shift from a subjective, static mode to an objective, dynamic, and personalized paradigm, enabling a loop nutrition management framework. Precise food recognition and nutrient estimation can be implemented automatically with ML techniques like computer vision (CV) and natural language processing (NLP). Integrating with multiple data sources, ML is conducive to uncovering dietary patterns, assessing nutritional status, and deciphering intricate nutritional mechanisms. It also facilitates the development of personalized dietary intervention strategies tailored to individual needs, while enabling adaptive optimization based on users’ feedback and intervention effectiveness. Although challenges regarding data privacy and model interpretability persist, ML undeniably constitutes the vital technical support for advancing PN into practical reality. Full article

Agriculture provides food and nutrition security essential for improving livelihoods. However, the region has been experiencing extreme weather events, which cause challenges ranging from reduced agricultural production to threatening food insecurity and lower income. The study aims to evaluate the susceptibility of smallholder farmers to climate change and identify key sustainable agricultural interventions through a systematic review and bibliometric analysis. The Scopus database retrieved the literature on sustainable agriculture following the Preferred Reporting Items for Systematic Reviews and Meta-Analysis guidelines. Publication trends, co-occurrence of citations, and thematic evolution were analysed. The findings show that conservation agriculture and climate-smart agriculture and their role in improving climate resilience among smallholder farmers were the commonly studied interventions. The adoption of these interventions by farmers can positively aid in attaining the Sustainable Development Goals and the Agenda 2063 Goals. This will help mitigate climate change effects while improving agricultural production, fostering entrepreneurship, and enhancing nutrition and livelihoods in South Africa. The findings from the study can inform policymakers in designing localised, scalable, and evidence-based solutions to improve smallholder farmers’ level of resilience. Institutional and governmental support for smallholder farmers in implementing sustainable interventions is important. Full article

A wide range of non-microbial contaminants—such as heavy metals, pesticide residues, antibiotics, as well emerging foodborne contaminants like micro- and nanoplastics and persistent organic pollutants—can enter the human body through daily diet and exert subtle yet chronic effects that are increasingly recognized to be gut microbiota-dependent. However, the relationships among multi-contaminant exposure profiles, dynamic microbial community structures, microbial metabolites, and diverse clinical or subclinical phenotypes are highly non-linear and multidimensional, posing major challenges to traditional analytical approaches. Artificial intelligence (AI) is emerging as a powerful tool to untangle the complex interactions between foodborne non-microbial contaminants, the gut microbiota, and host health. This review synthesizes current knowledge on how key classes of non-microbial food contaminants modulate gut microbial composition and function, and how these alterations, in turn, influence intestinal barrier integrity, immune homeostasis, metabolic regulation, and systemic disease risk. We then highlight recent advances in the application of AI techniques, including machine learning (ML), deep learning (DL), and network-based methods, to integrate multi-omics and exposure data, identify microbiota and metabolite signatures of specific contaminants, and infer potential causal pathways within “contaminant–microbiota–host” axes. Finally, we discuss current limitations, such as data heterogeneity, small-sample bias, and interpretability gaps, and propose future directions for building standardized datasets, explainable AI frameworks, and human-relevant experimental validation pipelines. Overall, AI-enabled analysis offers a promising avenue to refine food safety risk assessment, support precision nutrition strategies, and develop microbiota-targeted interventions against non-microbial food contaminants. Full article

Background: Croatia has the highest prevalence of obesity among European Union member states, with more than 65% of adults classified as overweight or obese. Understanding public perceptions and behaviours related to body weight is essential for designing effective prevention and treatment strategies. Objective: This study compared Croatian adults’ satisfaction with body weight, physical fitness, and dietary habits in 2022 and 2024, exploring potential behavioural changes following national awareness campaigns and the introduction of new anti-obesity measures. Methods: Data were collected via computer-assisted web interviews (CAWI) from representative national samples of adults aged 18 years and older (N = 798; 398 in 2022, 400 in 2024). Analyses used descriptive statistics, Chi-square or Fisher’s exact tests for categorical variables, and independent t-tests for continuous variables. Results: In both years, fewer than half of respondents were satisfied with their body weight or physical fitness. Obesity prevalence rose slightly among men (from 18.9% to 25.4%), while rates among women remained stable. Although 93% of women and 78% of men were aware of BMI, only 21% knew their exact value. Individuals with obesity were significantly more dissatisfied with their body shape (p < 0.001). One-third reported dieting within the past six months, and only one in ten sought medical advice for weight management. Lack of time and the high cost of healthy foods were the most frequently cited barriers to healthier lifestyles. Conclusions: Body weight satisfaction and lifestyle habits among Croatian adults remain suboptimal. Targeted, gender-sensitive, and web-based interventions are needed to promote awareness, improve self-perception accuracy, and enhance obesity prevention efforts. Full article

Background: Acute coronary syndrome (ACS) encompasses ST-elevation myocardial infarction, non-ST-elevation myocardial infarction, and unstable angina. While optimal medical therapy (OMT) is central to secondary prevention, lifestyle interventions—particularly dietary modification—remain underutilised despite their potential impact on long-term outcomes. Objective: To review the current evidence regarding dietary interventions post-ACS, their implementation, adherence, and effects on cardiovascular risk factors and clinical outcomes. Methods: A narrative literature review was performed using PubMed, including studies published in English from 2000 onwards. Keywords included “acute coronary syndrome,” “diet,” “cardiovascular disease,” “outcomes,” “adherence,” “wine,” and “intermittent fasting,” combined with Boolean operators AND/OR. Animal studies were excluded. The latest search was conducted in October 2025. Results: Mediterranean-style diets, when combined with OMT and lifestyle interventions (exercise, smoking cessation, alcohol moderation), consistently improve cardiovascular risk factors and reduce recurrent ischemic events and mortality. Clinical trials and cohort studies demonstrate long-term benefits, including reductions in all-cause mortality and major adverse cardiovascular events, particularly in patients adhering to structured dietary programmes within cardiac rehabilitation. Evidence for other dietary modifications, including low-fat diets, increased fibre, antioxidant supplementation, and intermittent fasting, was more limited, often derived from small or short-term studies focusing on surrogate endpoints. Real-world adherence to dietary guidelines remains suboptimal, especially in high-risk and obese populations. Preliminary studies suggest intermittent fasting and moderate red wine consumption may confer additional cardiovascular benefits, though larger, long-term trials are needed. Conclusions: Dietary modification is a key, yet underutilised component of secondary prevention post-ACS. A Mediterranean-style, whole-food diet integrated with OMT and supported by structured cardiac rehabilitation programmes offers the most evidence-based strategy to improve risk factor control and long-term outcomes. Future research should focus on pragmatic, long-term trials assessing hard cardiovascular endpoints and implementation strategies to enhance adherence across diverse populations. Full article

Food allergies in school-aged children are a growing public health concern, requiring coordinated strategies to ensure safety in educational settings. This study aimed to evaluate the safety conditions for children and young people with food allergies in public schools of the municipality of Matosinhos, Portugal. A descriptive, cross-sectional, quantitative study was conducted during the 2022/2023 academic year, targeting coordinating teachers from all public schools. Data were collected using a structured questionnaire based on national guidelines for managing food allergies in schools. Results revealed significant gaps in preparedness: 35.99% of respondents reported the absence of a formal document on food allergies, 66.01% indicated no school training plan on the topic, and bar and canteen staff were often excluded from training (50.00% and 42.00%, respectively). Furthermore, 83.02% stated that preventive measures were not consistently adopted, and 49.99% felt insufficiently trained to act in emergencies. Based on these findings, an intervention project with tailored training sessions for coordinating teachers was proposed to improve safety and inclusion for students with food allergies. The study highlights the urgent need for standardized protocols, inclusive training, and preventive measures in schools to mitigate risks and foster a safe learning environment for children with food allergies. Full article

Background/Objectives: The global epidemic of type 2 diabetes (T2D) is a critical public health issue, particularly in New Zealand, where prevalence rates are high, especially among Māori and Pacific people. Recent research indicates that dietary interventions, particularly carbohydrate reduction, can lead to the remission or reversal of T2D. However, little is known about how such approaches perform when implemented in routine New Zealand primary care, particularly within high-risk and underserved populations. This study aimed to evaluate changes in HbA1c, diabetes status, and cardiometabolic outcomes among adults with prediabetes and T2D engaged in such a model of care. Methods: This study reports findings from a retrospective, observational, real-world, multi-site clinical audit (service evaluation) of a holistic model of care implemented in three primary care practices in New Zealand. The model of care is characterised by a three-pronged approach: whole food, carbohydrate reduction; a health-coach, behaviour-change-based delivery approach; and community- or peer-based initiatives. Audit data from 106 patients with prediabetes (PD) and T2D were analysed (median follow-up 19 months; IQR 6–32) to assess changes in glycosylated haemoglobin (HbA1c) levels, diabetes status, and cardiometabolic outcomes. Results: We observed an overall reduction in HbA1c (median change −3 mmol/mol (IQR: −7 to 3), p = 0.004), with 32% of patients with T2D at baseline achieving reversal and 44% of those with PD attaining normoglycaemia at final follow-up. Weight loss was associated with greater HbA1c reduction (0.56 mmol/mol decrease per kg lost) and additional improvements seen in lowered alanine aminotransferase (ALT). HDL cholesterol showed a small decline (r = 0.31), and triglycerides and blood pressure showed no significant change, indicating that these measures remained broadly stable over the evaluation period. Conclusions: Given the retrospective and uncontrolled audit design, findings should be interpreted with appropriate caution. However, the consistent improvements observed across multiple practices suggest that carbohydrate-reduction strategies within holistic models of care can meaningfully improve diabetes outcomes in real-world primary care settings. Future research should evaluate longer-term sustainability, implementation fidelity, and the applicability of this model at scale, particularly for Māori and Pacific communities. Full article

Bacterial Chondronecrosis with Osteomyelitis (BCO) lameness is an infection of opportunistic bacteria in the structural skeletal bones impacting multiple animal species, particularly poultry species. BCO lameness results in significant financial losses to industrial poultry production and increases the risk of foodborne illnesses, posing a major threat to consumers’ food safety. As BCO lameness is an inherent risk of fast body weight gain in poultry species, especially broiler chickens, abundant studies have been conducted in broilers and turkeys. Nevertheless, BCO lameness incidence in ducks remains elusive. Thus, this is the first survey investigating the prevalence of BCO lameness cases in ducks. The survey was conducted in commercial duck farms in Indonesia, the fourth biggest duck-producing country globally. Two hundred birds from four commercial duck farms in Mojokerto, East Java, Indonesia, were necropsied to examine their lameness lesions in the femoral head and proximal tibia. Of the 44% birds showing BCO lameness lesions, 3% were evidently clinically lame birds, particularly exhibiting limping gait. Femoral head separation (FHS) and tibial head necrosis (THN) are the most frequently observed lesions in ducks, representing a mild-to-moderate BCO lameness state. Based on the results of this study, intervention measures to boost the immune system and skeletal bone integrity of ducks are urgently required. Full article

Autistic children often experience eating difficulties due to sensory processing, food selectivity, and other eating behaviors. As a result, the feeding process can be particularly challenging for caregivers and professionals in healthcare and educational settings. This scoping review describes interventions that address feeding difficulties, focused on improving food acceptance and reducing challenging eating-related behavior in autistic children under 6 years. The review was conducted and reported in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA-ScR) guidelines. We searched the PubMed, Web of Science (WOS), and PsycINFO databases, as well as manually examined reference lists, to identify relevant articles. Nineteen studies were selected by two independent reviewers for inclusion in the review. Among the selected studies, a variety of effective feeding strategies were categorized into three groups: applied behavior analysis (ABA)-based interventions, a combination of ABA-based strategies with others, and emerging strategies beyond ABA. These interventions have been reported to increase the acceptance of foods and reduce challenging mealtime behaviors of autistic children. Future research should focus on developing comprehensive interventions to improve the quality of life of autistic children, their families, and their communities. Full article

Docosahexaenoic acid (DHA) is a long-chain omega-3 fatty acid essential for neurodevelopment, immune regulation, and key physiological functions during early life. In low- and middle-income countries (LMICs), limited access to DHA-rich foods contributes to disparities in intake and health outcomes. This narrative review describes the current evidence on dietary patterns of DHA intake and supplementation from pregnancy through childhood in LMICs and highlights the implications of these patterns for child health. The review is based on a systematic search conducted in PubMed using Medical Subject Heading (MeSH) terms related to DHA, dietary patterns, health outcomes, and LMICs. Studies published between 2014 and 2025 were screened using Covidence software. Eligible studies included observational, interventional, and review designs that reported DHA through dietary intake, supplementation, or measurement in biological samples during pregnancy, lactation, infancy, or childhood. Data extraction followed the PICOS (Population, Intervention, Comparison, Outcome, Study Design) framework. A total of 76 studies were included. Across LMICs, DHA intake was consistently insufficient among pregnant and lactating women, infants, and children. Reported dietary sources were generally low in DHA content. Intake or supplementation was associated with neurodevelopment, immune response, pregnancy outcomes, and cardiometabolic health, although findings were sometimes mixed or modified by gene–environment interactions. Results varied by study design, contextual factors, income level, and geographic access. Large gaps remain in nationally representative intake data. Despite its physiological relevance, DHA intake remains inadequate in LMICs during early life. This review underscores the importance of improving DHA intake in vulnerable populations and identifies evidence gaps to guide future research and inform context-specific nutrition strategies. Full article

Background: Men treated with androgen deprivation therapy (ADT) for prostate cancer are at risk for cognitive decline. Patient genetics and endocrine state may shape gut microbiome features that relate to cognition. Methods: We studied a subsample of 79 prostate cancer survivors with prior ADT exposure previously enrolled in a randomized controlled exercise trial comparing three training modalities (strength training, Tai Chi training, or stretching control) who completed an additional food-frequency questionnaire and remote Montreal Cognitive Assessment (MoCA) and provided saliva and stool for APOE genotyping, salivary testosterone, and 16S rRNA sequencing. We used beta regression for MoCA (scaled 0–1), linear models for testosterone, alpha diversity regressions, PERMANOVA for beta diversity, and DESeq2 for genus-level differential abundance, with false-discovery correction. Results: Compared to post-stretching control, post-strength training testing was associated with higher MoCA scores whereas post-Tai Chi testing was not. APOE ε4 carriers exhibited a greater testosterone increase with strength training than non-carriers. Testosterone, and its interactions with exercise modality and APOE ε2 status, was related to presence/absence-based community structure; APOE ε4 interacted with exercise intervention to influence alpha diversity. At the genus level, exercise was linked to lower levels of Bacteroidota taxa (including Muribaculaceae) and higher levels of Enterobacteriaceae; APOE ε4 status was linked to higher Megamonas and lower Rikenellaceae RC9 levels; and higher salivary testosterone levels were linked to higher Prevotellaceae taxa and Succinivibrio levels. Higher MoCA scores were associated with lower abundances of several Firmicutes genera. Conclusions: Endocrine state and APOE genotype may condition the gut microbiome’s response to exercise intervention in ADT-treated prostate cancer survivors, with downstream associations with cognition. These findings could inform precision survivorship strategies pairing strength training with genotype- and hormone-informed microbiome monitoring to optimize cognitive performance. Full article

This study estimates the prevalence of food insecurity and coping mechanisms among low-income rural households in Sri Lanka, collecting primary data from 400 households in the Ayagama Divisional Secretariat in Rathnapura District. The results uncover that around 38.1% of the households faced food scarcity within a year prior to the survey date, with 77.9% being uncertain about maintaining a nutritious diet in the next 30 days. Notably, household dietary diversity scores reveal that they are either moderately (62%) or severely (22.3%) lacking essential nutrients, irrespective of the gender of the household head. The leading cause is the unaffordability of protein-rich foods and certain fruits. Coping strategies are primarily short-term and consumption-based, such as purchasing food on credit and reducing meal sizes, which propagate future food insecurity. The findings underscore the need for government interventions that combine short-term safety nets with long-term agricultural productivity improvements, alongside nutrition-sensitive practices and market stabilisation to enhance food availability and affordability. Consequently, targeted social protection programmes for vulnerable groups, combined with livelihood support and climate-resilient agriculture, could reduce reliance on harmful coping mechanisms. Lastly, this study proposes integrating food security goals within broader development frameworks and community initiatives as pivotal for long-term stability and resilience. Full article

Background and Objectives: Fibromyalgia (FM) is associated with chronic pain, oxidative stress, low-grade inflammation, and disturbances in signalling along the gut–brain axis. These pathways may be modulated by plant-derived phytonutrients. This narrative review summarises mechanistic and clinical evidence on phytonutrient-based strategies in FM. Materials and Methods: Following SANRA guidelines, we searched PubMed, Web of Science, Scopus and ScienceDirect for human and relevant preclinical studies published between 2005 and October 2025 that evaluated phytonutrient-rich dietary patterns or isolated bioactives in relation to FM symptoms or underlying mechanisms. Results: There is a consistent association between FM and increased oxidative damage and reduced antioxidant defences. Adopting plant-based diets, particularly Mediterranean-type and low-FODMAP diets, has been linked to improvements in pain, fatigue, sleep, and gastrointestinal symptoms, as well as modest gains in quality of life. However, the effects on inflammatory markers are conflicting. Trials of selected bioactive compounds, such as coenzyme Q10, curcumin-based formulations, L-carnitine and certain probiotics, suggest beneficial effects on symptoms, whereas others show little or no effect. Studies of the microbiome indicate a loss of butyrate-producing bacteria and altered microbial metabolites. Early dietary or probiotic interventions may partially mitigate these changes to some extent. Preclinical studies have identified SIRT1 as a potential mediator, but there is a lack of human data. Reporting on safety, dosage and formulation is often inadequate. Conclusions: Given the narrative design of this review and the methodological heterogeneity of the included studies, the overall certainty of the evidence cannot be formally graded and should be regarded as limited and heterogeneous. Nevertheless, current data supports phytonutrient-rich, food-based approaches as adjuncts rather than alternatives to standard FM care. Well-designed randomised trials with standardised outcomes and reporting of dose, formulation and relevant biomarkers are needed to identify the most effective strategies and the patient subgroups most likely to benefit. Full article

Background/Objective: Alzheimer’s disease (AD) is a neurodegenerative condition characterized by oxidative stress, neuroinflammation, amyloidogenesis, and tau-related pathology. This study investigated the macronutrient and phytochemical composition of strawberry (S), lemon (L), and lemon juice-assisted strawberry (S/L) extracts and evaluated their neuroprotective efficacy relative to selenium (Se) in an aluminum chloride (AlCl₃)-induced rat model of AD. Methods: Macronutrients and phenolics were quantified in S, L, and S/L, and the extracts were profiled using high-performance liquid chromatography and electrospray ionization tandem mass-spectrometry. Male Sprague–Dawley rats received AlCl₃ with or without S, L, S/L, or Se, and their cognitive performance was assessed using the Morris water maze, Y-maze, and conditioned avoidance tests. Markers of oxidative status, inflammation, cholinergic function, apoptotic signaling, and Wnt3/β-catenin pathway activity were quantified in the brain tissue, and cortico-hippocampal morphology was examined. Results: The S/L extract showed the highest carbohydrate, protein, and lipid content. The total phenolic content was highest in S/L (60.46 mg gallic acid equivalents/g), followed by L (55.08) and S (44.75), with S/L also being the richest in gallic, ellagic, and chlorogenic acids. S/L attenuated AlCl₃-induced cognitive deficits, restored antioxidant status, suppressed neuroinflammation, improved cholinergic indices, modulated apoptotic signaling, and downregulated amyloidogenic and NLRP3 inflammasome markers, consistent with histological evidence of neuronal preservation. Conclusions: Lemon juice-assisted extraction enhanced the macronutrient and phenolic richness and multitarget neuroprotection of strawberries. S/L co-extracts represent promising functional food–derived adjuvants for AD management and support integrative compositional–mechanistic profiling to optimize natural product–based interventions. Full article

Background/Objectives: This 8-week randomized pilot intervention trial examined the effects of Greek yogurt (GY) supplementation on markers of bone turnover and inflammation in older adult exercisers. Methods: A total of 48 participants aged 55+ completed this 8-week intervention: 33 exercisers randomized to exercisers receiving GY (GYEX, n = 18, 12 females) and exercisers without GY (NYEX, n = 15, 12 females), and a group of 15 age-matched, community-dwelling, non-exercisers also receiving GY (GYNE, n = 15, 10 females). Exercisers were enrolled in a moderate-intensity community-based exercise program. GYEX and GYNE supplemented their diet with two daily servings of 175 g of GY (17 g protein, 225 mg calcium per serving). Assessments at baseline and week 8 included dietary intake, body composition, and fasting blood samples for bone markers and pro-inflammatory cytokines. Results: Body mass increased modestly across groups (time effect, p = 0.033), with no changes in body fat. C-terminal telopeptide of type I collagen (bone resorption marker) increased 14% in GYEX (time × group interaction, p = 0.022). Osteoprotegerin (bone formation regulator) decreased overall by 4% (time effect, p = 0.002). Dickkopf-1 (bone formation inhibitor) increased by 13% (p = 0.008) in GYNE but not in exercisers (time × group interaction, p = 0.018). Interleukin 1β and interleukin 6 showed significant interactions (p = 0.043 and p = 0.023), where interleukin 1β increased by 80% (p = 0.007) and interleukin 6 decreased by 89% (p < 0.001) in GYNE, but remained stable in exercisers. Tumor necrosis factor alpha remained unchanged. Conclusions: Although the observed effects of GY on the assessed biomarkers were limited and should be interpreted cautiously due to pilot design and statistical constraints, they highlight the need for longer interventions to determine whether whole-food dairy proteins can meaningfully support skeletal and immune health in older adults. Full article