Search Results (343)

Nanoparticles combining gold and iron oxide are promising for a wide range of biomedical applications, including photothermal therapy, radiotherapy enhancement, drug delivery, and diagnostic imaging. However, their long-term biodistribution and safety profile remain largely unexplored. Here, we synthesized Fe₃O₄@AuNP core–satellite nanoparticles (Fe₃O₄@AuNPs) using femtosecond laser ablation, functionalized them with 15 kDa polyethylene glycol (PEG), and characterized them using a panel of physicochemical techniques. Healthy C57BL/6 mice received an intravenous injection of Fe₃O₄@AuNPs at 730 mg Au/kg and 82 mg Fe/kg, respectively. Biodistribution was monitored by computed tomography (CT) and magnetic resonance imaging (MRI) over 12 months, after which gold and iron concentrations were measured ex vivo, and long-term toxicity was assessed via histology and blood biochemistry. Nanoparticles accumulated predominantly in the liver and spleen. Quantitative analysis of CT images revealed a gradual decrease in gold content, while MRI showed a progressive reduction in negative contrast in the liver between 6 and 12 months, suggesting possible changes in the Fe₃O₄ core structure. Over the one-year observation period, no differences in behavior or body weight gain were detected between the treated and control groups. Histological examination revealed no pathological changes other than mild age-related alterations. These findings provide a baseline for the long-term behavior of laser-ablated core–satellite Fe₃O₄@AuNPs, which is essential for their further development in diagnostic and theranostic applications. Full article

As semiconductor packaging technology evolves from two-dimensional to three-dimensional integration, the through-glass via (TGV) technique, as a core interconnect method in advanced packaging, is emerging as a strong candidate to replace through-silicon vias (TSVs) and plated through-holes (PTHs) in organic substrates. Glass substrates offer excellent electrical insulation, low dielectric loss, tunable thermal expansion coefficients, and the potential for large-scale panel-level manufacturing. However, issues related to TGV hole quality, metallization uniformity, and thermomechanical reliability remain key bottlenecks limiting their large-scale industrialization. This investigation provides a comparative review of non-laser and laser machining for TGVs to address the above problems. First, the technical background and core advantages of TGVs are outlined. Second, this study details non-laser processing methods, including sandblasting erosion, mechanical drilling, the photosensitive glass method, electrochemical discharge machining (ECDM), deep reactive ion etching (DRIE), and others. Third, laser processing methods, covering laser ablation drilling, laser-induced deep etching (LIDE), femtosecond laser-assisted wet etching and others, are given focus. Moreover, this study analyzes typical applications of TGVs in 3D/2.5D packaging, MEMS devices, optoelectronic integration, and others. In addition, the machining processes of non-laser and laser-based TGVs, such as mechanical machining, ECDM, and LIDE, are compared, and key process challenges, technical trade-offs, and reliability failure mechanisms are discussed. Finally, this review looks ahead to future trends, aiming to provide a systematic technical reference for researchers in the TGV field. Full article

The linear and third-order nonlinear optical (NLO) properties of a water-soluble perylenediimide derivative, N,N′-di(2-(trimethylammonium iodide) ethylene) perylenediimide (TAIPDI), doped with semiconductor nanoparticles (NPs), were systematically investigated under femtosecond laser excitation. ZnO and TiO₂ NPs were synthesized using a pulsed laser ablation technique. Nanocomposite systems were prepared by incorporating different concentrations of ZnO and TiO₂ NPs into the TAIPDI dye solution. The optical properties were characterized using UV–visible absorption spectroscopy together with open- and closed-aperture Z-scan measurements at 800 nm. Linear absorption measurements revealed concentration-dependent modifications in the optical band gap, indicating electronic interaction between the dye molecules and the semiconductor NPs. Open-aperture Z-scan results demonstrated strong nonlinear absorption (NLA) behavior dominated by two-photon absorption and excited-state absorption processes. Closed-aperture measurements showed a negative nonlinear refractive (NLR) index, corresponding to self-defocusing behavior. Both the NLA coefficient and the NLR index increased with increasing NP concentration, resulting in a significant enhancement of the third-order nonlinear susceptibility of the nanocomposite systems. In addition, optical limiting measurements revealed a pronounced reduction in the limiting threshold with increasing nanoparticle concentration, demonstrating improved laser attenuation capability. These findings indicate that ZnO@TAIPDI and TiO₂@TAIPDI nanocomposites are promising candidates for applications in optical limiting, all-optical switching, and advanced photonic devices. Full article

Background/Objectives: The technique used for flap creation in laser in situ keratomileusis (LASIK) may influence postoperative optical quality and visual outcomes. This prospective randomized paired-eye study compared higher-order aberrations (HOAs) and visual acuity outcomes following femtosecond laser-assisted versus mechanical microkeratome-assisted LASIK. Materials and Methods: Forty-four patients (88 eyes) underwent bilateral LASIK. In each patient, one eye was randomly assigned to high-frequency femtosecond laser flap creation (Femto LDV), and the fellow eye to mechanical microkeratome flap creation (Amadeus II). Inclusion criteria were stable refraction, central corneal thickness ≥ 520 µm, and normal corneal topography. HOAs were measured using Hartmann–Shack wavefront aberrometry over a 6 mm pupil diameter. Uncorrected and corrected distance visual acuity (UDVA and CDVA) were evaluated preoperatively and postoperatively at 1 day, 1 week, and 1, 3, and 6 months. Results: Both techniques induced significant postoperative changes in specific Zernike coefficients and an increase in total HOA root mean square (RMS) values (p < 0.05). A reduction in spherical aberration (Z4,0) was observed in both groups, while technique-specific changes were noted in individual aberration components including an increase in horizontal trefoil (Z3,3) in the femtosecond and a decrease in horizontal coma (Z5,1) in the microkeratome group. However, paired-eye comparisons revealed no statistically significant differences in total HOA six months postoperative. Despite comparable aberrometric outcomes, femtosecond-treated eyes demonstrated significantly better UDVA and CDVA at all postoperative time points (p < 0.05). Conclusions: Femtosecond laser-assisted and microkeratome-assisted LASIK resulted in comparable changes in higher-order aberrations, despite differing pattern in individual aberration components. The observed differences in visual acuity outcomes were not reflected in wavefront metrics, suggesting that postoperative visual performance may be influenced by factors. Full article

The extreme thermal loads encountered in fourth-generation synchrotron radiation sources and X-ray free-electron lasers (XFEL) impose stringent requirements on X-ray optical components. Conventional materials such as beryllium and silicon increasingly exhibit limitations under high-energy conditions, including insufficient thermal conductivity, limited radiation stability, and significant absorption losses, rendering them inadequate for next-generation high-energy X-ray optics. In this context, single-crystal diamond, with its high thermal conductivity, low absorption coefficient, and excellent mechanical strength and radiation resistance, has emerged as a promising candidate for high-energy X-ray refractive optics. This review systematically summarizes recent advances in the fabrication and performance optimization of diamond X-ray refractive lenses for high-energy applications. Starting from the evolving demands of modern synchrotron radiation facilities and XFEL, the fundamental requirements for materials and structural design in high-energy X-ray optics are analyzed. Through comparisons with representative materials, the advantages of diamond in thermal management and transmission performance are highlighted. Major micro- and nanofabrication techniques, including femtosecond laser processing, focused ion beam milling, and plasma etching, are comprehensively reviewed, with emphasis on their respective characteristics in terms of processing efficiency, precision control, and damage introduction. The emerging trend of hybrid fabrication strategies is also discussed. Furthermore, the effects of surface roughness, subsurface damage, and crystal defects on wavefront quality and focusing performance are examined, along with corresponding post-processing and surface correction methods. Finally, current challenges related to large-size single-crystal growth, high-precision low-damage fabrication, and long-term operational stability are discussed, and future development directions for diamond-based X-ray refractive optical components are outlined. Full article

Direct welding of fused silica to pure titanium (Ti) foil using conventional methods faces significant challenges, such as poor interfacial wettability, insufficient joint strength, and the need for interlayers or surface pretreatments. Existing femtosecond (fs) laser welding techniques for these materials often require high-energy millijoule (mJ)-level pulses or alloy interlayers. Moreover, reports on direct microjoule (μJ)-level fs laser welding of Ti foil to fused silica remain scarce. This study successfully demonstrates a direct welding process for pure Ti foil and fused silica using μJ-level fs laser pulses under ambient conditions, achieving joints with a maximum shear strength of 9.19 MPa. Microstructural analysis revealed an elemental interdiffusion region at the weld interface, supported by mechanical interlocking effects. X-ray photoelectron spectroscopy (XPS) confirmed the occurrence of interfacial chemical reactions, forming titanium silicide (TiSi₂) and titanium oxide (TiO₂). Additionally, a 24 h water immersion test of a square sealed cavity revealed outstanding hermeticity, with no water ingress. This work provides a simple, efficient, and robust solution for high-strength, additive-free bonding of fused silica to Ti foil under low-energy processing conditions. Full article

With the advancement of computing and transmission technologies, there has been a growing demand for quartz oscillators and resonators, whose performance is evaluated by the quality coefficient (Figure of Merit, FoM). High-frequency, miniaturized fabrication is the design goal, and process optimization and innovative design methods need to be emphasized. Based on the 1978 Institute of Electrical and Electronics Engineers standard definition, the old design parameters of AT-cut quartz crystal sheet are retained to analyze the structural loss factor, dielectric loss factor, frequency, admittance, quality factor, and error value with the fundamental frequency increased from 76.8 to 96 MHz. In this study, COMSOL Multiphysics is used to simulate and analyze the quartz resonator by introducing the femtosecond laser quartz microvia machining technique from the literature, improving the electrode and inverted wet etching process, and incorporating the structural loss factor and dielectric loss factor into the quartz resonator model to observe the changes in the quality factor, the percentage of the quality factor error, and the values of the eigen-frequency and the error of the frequency. We analyze the trend of loss factor, frequency value, and error value and analyze the process advantages and disadvantages of femtosecond laser drilling electrodes, coated electrodes, inverted wet etching, inverted dry etching, and single-side and double-side etching to provide a reference for the design of future process components. Full article

Diamond antireflection techniques are of high interest for optical windows operating at extreme conditions. Herein, diamond antireflective microstructures in mid-infrared (MIR) spectral range were theoretically designed and experimentally fabricated. Finite difference time domain (FDTD) simulations were used to optimize the transmission performance of the diamond microstructures. Based on the simulation results, the optimized microstructures were fabricated by femtosecond (fs) laser direct writing (1030 nm, 300 fs, 25 kHz) followed by wet etching. After wet etching, the laser-modified zones and the accumulated graphitized clusters were effectively removed, thereby achieving the desired depth. The influences of laser power and scanning strategy on the morphology evolution of diamond microstructures were investigated. It was found that at the optimal conditions, the transmittance of the diamond increased from 70.9% to 81.4% (single-side) over a broad spectrum from 8 to 22 μm. This work demonstrates a promising hybrid fs laser/wet etching technique for diamond antireflective microstructures in MIR spectral range. Full article

Silicon carbide (SiC), owing to its excellent physical and chemical properties, has emerged as a leading third-generation semiconductor material. Conventional diamond wire cutting faces challenges in producing ultra-large, ultra-thin wafers. In contrast, the femtosecond laser has attracted significant attention in recent years due to its low kerf loss and high slicing speed. However, during femtosecond laser stealth slicing, spherical aberration induced by the refractive index mismatch between air and the SiC crystal severely degrades the slicing quality. Based on the analysis and calculation of wavefront aberration at a specific focal depth of 175 μm, we designed and implemented a static aberration correction method to reduce the thickness of the modified layer and improve the slicing quality. This method effectively mitigates focus elongation caused by refractive index mismatch, thereby reducing the modified layer thickness and the tensile stress required for wafer separation, while improving the surface quality of the separated wafers. Furthermore, this method eliminates the need for active optical components in aberration correction, simplifying the system and avoiding errors associated with the limited response speed of active optics. The technique demonstrates potential for practical application in industrial wafer slicing. Full article

The interaction between plasmonic nanoparticles and organic dye molecules plays an important role in varied photonic and optoelectronic applications. In this work, we systematically investigate the optical properties of a water-soluble perylenediimide derivative, N,N′-di(2-(trimethylammonium iodide) ethylene) perylenediimide (TAIPDI), in the presence of different concentrations of silver nanoparticles (AgNPs) under femtosecond (fs) laser excitation. The AgNPs were synthesized via the laser ablation technique. The influence of AgNP concentration on the linear, fluorescence, and nonlinear optical properties of the TAIPDI dye was explored through UV–visible absorption spectroscopy, fluorescence emission measurements, and open- and closed-aperture Z-scan techniques. The Ag NP–TAIPDI dye hybrid systems (Ag@TAIPDI nanocomposites) exhibited pronounced reverse saturable absorption and self-defocusing behavior, indicating a negative nonlinear refractive index. Both the nonlinear absorption coefficient and refractive index increased markedly with rising AgNP concentration, leading to a significant enhancement in the third-order nonlinear susceptibility. Fluorescence studies further revealed a concentration-dependent emission enhancement due to metal-enhanced fluorescence arising from surface plasmon resonance-induced local field amplification. The Ag@TAIPDI nanocomposites also demonstrated strong optical limiting performance, with the limiting threshold decreasing as the AgNP concentration increased. These findings highlight the synergistic role of plasmon–exciton coupling and thermal lensing in enhancing the nonlinear response of such nanocomposites. The results establish AgNPs–TAIPDI dye hybrid systems as promising materials for all-optical switching, optical limiting, and photonic device applications. Full article

Fiber Bragg gratings (FBGs) have evolved from passive sensing elements into actively programmable photonic components, enabling dynamic wavelength control across diverse applications. This review provides a comprehensive and systematic overview of active wavelength control technologies for FBGs, deliberately excluding passive sensing applications. We systematically categorize the fundamental tuning mechanisms—including mechanical, thermal, optothermal, electro-optic, nonlinear optical, and hybrid approaches—and compare their performance characteristics in terms of tuning range, speed, precision, and trade-offs. Key enhancement techniques, such as mechanical amplification, thermal packaging, femtosecond laser fabrication, and FPGA-based interrogation, are examined. The transformative impact of actively controlled FBGs is elucidated across three major application domains: tunable and narrow-linewidth fiber lasers, reconfigurable microwave photonic systems, and emerging fields including quantum information processing and biomedical imaging. A consolidated technology map visualizes the connections between enabling techniques and applications. Finally, we critically analyze core challenges—performance trade-offs, control complexity, and integration bottlenecks—and outline future research directions driven by novel materials, artificial intelligence, and quantum technologies. This review offers a structured framework for understanding active FBGs as programmable photonic primitives, providing actionable insights for researchers and engineers in academia and industry. Full article

Laser surface texturing (LST) structures or laser-induced periodic surface structures (LIPSS) are typically created using laser pulses with durations ranging from femtoseconds to nanoseconds. However, nanosecond pulsed lasers, as cost-effective and more productive alternatives, can also be used to generate LST structures on stainless steel (SS) surfaces, making these structures more suitable for industrial applications. In this study, pulsed laser processing is employed to create LST structures on SS (AISI 304), with varying pulse and accumulated fluences, effective pulse counts, and scan parameters, such as pulse-to-pulse distance (pitch) and hatch spacing between scanning lines. A methodology for calculating oxidation density on processed AISI 304 surfaces is presented. Oxidation density, defined as the ratio of the oxidized area to the total processed area, is determined as a function of accumulated fluence, laser power, pulse-to-pulse distance, and hatch spacing. Optical images of the surfaces are analyzed, and oxidation regions are identified using machine learning techniques. The images are converted to grayscale, and machine learning algorithms are applied to classify the images into oxidation and non-oxidation regions based on pixel intensity values. This approach identifies the optimal threshold for separating the two regions by maximizing inter-class variance. Experimental modeling using response surface methodology is applied to experimentally generated data. Optimization algorithms are then employed to determine the process parameters that maximize pulsed laser irradiation performance while minimizing surface oxidation and processing time. This paper also presents a novel method for characterizing oxidation density using image segmentation and machine learning. The results provide a comprehensive understanding of the process and offer optimized models, contributing valuable insights for practical applications. Full article

Femtosecond laser processing has emerged as a promising post-deposition method for tailoring the properties of dielectric thin films, offering localized modification without thermal damage. This study investigates the effect of sub-ablative femtosecond laser irradiation on the nonlinear optical response of a TiO₂ single-layer coating deposited on soda-lime glass by electron-beam evaporation. The coating was modified using 35 fs pulses at 800 nm delivered at a repetition rate of 1 kHz and a fluence of 0.083 J/cm² while varying the number of pulses per spot. The effective nonlinear refractive index (n_2,eff) and effective nonlinear absorption coefficient (β_eff) were measured using the z-scan technique with femtosecond excitation. The as-deposited TiO₂ coating exhibited a negative effective nonlinear refractive index, signifying a self-defocusing nonlinear response, while femtosecond laser irradiation leads to pronounced changes in the effective nonlinear parameters. An increase in the magnitude of both effective nonlinear coefficients and a reversal of the sign of the effective nonlinear refractive index are experimentally observed after irradiation with higher pulse numbers. These findings provide experimental evidence that sub-ablative femtosecond laser processing can be used as a post-deposition tool to control the nonlinear optical response of TiO₂ thin films. Full article

To address the issue of low closed-loop feedback bandwidth caused by the long latency of Carrier-Envelope Phase (CEP) measurement systems for amplified femtosecond laser pulses, and to meet the requirements for real-time single-shot measurement in 10 kHz repetition rate systems, this paper proposes a microsecond-level low-latency CEP measurement technique based on a Field-Programmable Gate Array (FPGA). To tackle the problem of non-uniform spectral sampling resulting from nonlinear wavelength-frequency mapping, the system implements a real-time linear interpolation algorithm for the interference spectrum. This approach effectively suppresses computational spurious peaks introduced by non-uniform sampling and significantly reduces measurement errors. Adopting a fully pipelined parallel processing architecture, the system achieves a CEP processing latency of approximately 89 μs, representing an improvement of 2–3 orders of magnitude compared to traditional Central Processing Unit (CPU)-based solutions. Hardware-in-the-loop testing, conducted by injecting a known sinusoidal phase modulation into the interference spectrum of a 10 kHz laser amplification system, demonstrates that the computational error of the proposed algorithm is less than 30 mrad. This work paves the way for achieving single-shot CEP feedback locking in high-repetition-rate laser amplification systems. Full article

Distributed acoustic sensing (DAS) systems have been widely employed in oil and gas resource exploration, pipeline monitoring, traffic and transportation, structural health monitoring, hydrophone usage, and perimeter security due to their ability to perform large-scale distributed acoustic measurements. Conventional DAS relies on Rayleigh backscattering (RBS) from standard single-mode fibers (SMFs), which inherently limits the signal-to-noise ratio (SNR) and sensing robustness. Ultra-weak fiber Bragg grating (UWFBG) arrays can significantly enhance backscattering intensity and thereby improve DAS performance. This review provides a comprehensive overview of recent advances in UWFBG arrays for high-performance DAS. We introduce major inscription techniques for UWFBG arrays, including the drawing tower grating method, ultraviolet (UV) exposure through UV-transparent coating fiber technologies, and femtosecond laser direct writing methods. Furthermore, we summarize the applications of UWFBG arrays in DAS systems for the enhancement of RBS intensity, suppression of fading, improvement of frequency response, and phase noise compensation. Finally, the prospects of UWFBG-enhanced DAS technologies are discussed. Full article