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Review

25 Citations

8,071 Views

22 Pages

Cell-Adhesion Properties of β-Subunits in the Regulation of Cardiomyocyte Sodium Channels

Samantha C. Salvage,
Christopher L.-H. Huang and
Antony P. Jackson

Biomolecules2020, 10(7), 989;https://doi.org/10.3390/biom10070989

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1 July 2020

Voltage-gated sodium (Nav) channels drive the rising phase of the action potential, essential for electrical signalling in nerves and muscles. The Nav channel α-subunit contains the ion-selective pore. In the cardiomyocyte, Nav1.5 is the main N...

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Article

1 Citations

6,755 Views

25 Pages

Quantum Mechanical Aspects in the Pathophysiology of Neuropathic Pain

Sager Nawafleh,
Abdallah Barjas Qaswal,
Obada Alali,
Fuad Mohammed Zayed,
Ahmed Mahmoud Al-Azzam,
Khaled Al-Kharouf,
Mo’ath Bani Ali,
Moath Ahmad Albliwi,
Rawan Al-Hamarsheh and
Aiman Suleiman
+ 7 authors

Brain Sci.2022, 12(5), 658;https://doi.org/10.3390/brainsci12050658

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17 May 2022

Neuropathic pain is a challenging complaint for patients and clinicians since there are no effective agents available to get satisfactory outcomes even though the pharmacological agents target reasonable pathophysiological mechanisms. This may indica...

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Article

6 Citations

7,785 Views

15 Pages

Real-Time In Vivo Imaging of Mouse Left Ventricle Reveals Fluctuating Movements of the Intercalated Discs

Fuyu Kobirumaki-Shimozawa,
Tomohiro Nakanishi,
Togo Shimozawa,
Takako Terui,
Kotaro Oyama,
Jia Li,
William E. Louch,
Shin’ichi Ishiwata and
Norio Fukuda

Nanomaterials2020, 10(3), 532;https://doi.org/10.3390/nano10030532

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16 March 2020

Myocardial contraction is initiated by action potential propagation through the conduction system of the heart. It has been thought that connexin 43 in the gap junctions (GJ) within the intercalated disc (ID) provides direct electric connectivity bet...

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