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Article

10 Citations

2,193 Views

16 Pages

Specific Tumor Localization of Immunogenic Lipid-Coated Mesoporous Silica Nanoparticles following Intraperitoneal Administration in a Mouse Model of Serous Epithelial Ovarian Cancer

Achraf Noureddine,
Benjamin Marwedel,
Lien Tang,
Lorel Y. Medina and
Rita E. Serda

Cancers2023, 15(18), 4626;https://doi.org/10.3390/cancers15184626

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19 September 2023

Immunogenic lipid-coated mesoporous silica nanoparticles (ILM) present pathogen-associated molecular patterns (PAMPs) on the nanoparticle surface to engage pathogen-associated receptors on immune cells. The mesoporous core is capable of loading addit...

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Article

734 Views

18 Pages

Hexapeptide-Liposome Nanosystem for the Delivery of Endosomal pH Modulator to Treat Acute Lung Injury

Yuting Ji,
Qian Wang,
Rujing Lin,
Mimi Pang,
Liya Sun,
Jiameng Gong,
Huiqiang Ma,
Shan-Yu Fung and
Hong Yang

J. Funct. Biomater.2025, 16(12), 450;https://doi.org/10.3390/jfb16120450

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1 December 2025

The overactivation of endosomal Toll-like receptor (TLR) in macrophages plays an important role in the pathogenesis of acute lung injury (ALI). There is currently still a lack of nano-formulated and macrophage-targeted endosomal TLR inhibitors that h...

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Review

18 Citations

5,381 Views

35 Pages

Understanding In Vivo Fate of Nucleic Acid and Gene Medicines for the Rational Design of Drugs

Shintaro Fumoto,
Tsuyoshi Yamamoto,
Kazuya Okami,
Yuina Maemura,
Chisato Terada,
Asako Yamayoshi and
Koyo Nishida

Pharmaceutics2021, 13(2), 159;https://doi.org/10.3390/pharmaceutics13020159

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26 January 2021

Nucleic acid and genetic medicines are increasingly being developed, owing to their potential to treat a variety of intractable diseases. A comprehensive understanding of the in vivo fate of these agents is vital for the rational design, discovery, a...

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