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20 pages, 6556 KB  
Article
Comprehensive Analysis of Microstructure and Mechanical, Operational, and Technological Properties of AISI 321 Austenitic Stainless Steel at Electron Beam Freeform Fabrication
by Sergey V. Panin, Mengxu Qi, Dmitry Yu. Stepanov, Mikhail V. Burkov, Valery E. Rubtsov, Yury V. Kushnarev and Igor Yu. Litovchenko
Constr. Mater. 2025, 5(3), 62; https://doi.org/10.3390/constrmater5030062 (registering DOI) - 30 Aug 2025
Abstract
The aim of this study was to investigate microstructure and the mechanical and operational characteristics of thick and thin walls 3D-built by electron beam additive manufacturing (EBAM). In addition, the milling parameters (rotation speed, feed, and cutting width) were optimized based on simultaneous [...] Read more.
The aim of this study was to investigate microstructure and the mechanical and operational characteristics of thick and thin walls 3D-built by electron beam additive manufacturing (EBAM). In addition, the milling parameters (rotation speed, feed, and cutting width) were optimized based on simultaneous assessments of Ra roughness on the machined surfaces and material removing rate values. The wall dimensions did not exert a noticeable effect on their chemical compositions, as compared with the original wires used for 3D printing. In comparison, the strength characteristics of the wrought steel (cold-rolled plate) were higher due to finer grains, with both ferrite content and dislocation density being greater as well. In the 3D building process, multiple thermal cycles gave rise to the formation of elongated columnar grains, reducing the strength characteristics. The corrosion rate of the wrought steel was almost twice those of the 3D-printed blanks because of the higher content of both ferrite and twins. By assessing the machinability of the EBAM-built blanks using the stationary milling machine, the cutting forces were comparable due to similar mechanical properties (including microhardness). To improve the removing rate values and reduce the cutting forces, it is recommended to enhance the cutting speeds while not increasing the feeds. For the semi-industrial milling machine, both linear multiple regression and nonlinear neural network models were applied. An integrated approach was proposed that rationally determined both additive manufacturing and post-processing parameters based on a combination of express assessment and analysis of the mechanical, operational, and technological characteristics of built products within a single laboratory complex. Full article
(This article belongs to the Special Issue Mineral and Metal Materials in Civil Engineering)
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11 pages, 16124 KB  
Article
Wideband Circularly Polarized 1-D Connected Array Antennas with Slant Slot Feeders and Gradient Artificial Dielectric Layers
by Taeho Yu, Dongju Choi, Jin Myeong Heo and Gangil Byun
Appl. Sci. 2025, 15(17), 9568; https://doi.org/10.3390/app15179568 (registering DOI) - 30 Aug 2025
Abstract
This paper proposes wideband circularly polarized (CP) 1-D connected array antennas with slant slot feeders and gradient artificial dielectric layers (ADLs). The slant slot feeder introduces an identical electric field (E-field) along the x- and y-directions. Three slabs consisting [...] Read more.
This paper proposes wideband circularly polarized (CP) 1-D connected array antennas with slant slot feeders and gradient artificial dielectric layers (ADLs). The slant slot feeder introduces an identical electric field (E-field) along the x- and y-directions. Three slabs consisting of multiple ADLs are stacked above the slot feeder. Due to the different boundary conditions of a 1-D connected array in the zx- and zy-planes, the guided wave in the slabs exhibits different multipath lengths along the x- and y-directions, leading to a 90° phase difference between the Ex and Ey components. Moreover, the cascaded slabs are designed with gradient effective permittivities for a gradual impedance transition from the guided mode to the radiating mode, allowing for wideband matching and CP performance. To validate the proposed design approach, an 8 × 1 array was fabricated and measured. The antenna shows a 1.96:1 (10.1–20 GHz) impedance bandwidth (VSWR < 2) and a 1.46:1 (12–17.5 GHz) 3 dB axial ratio bandwidth in measurement. The array exhibits an average right-hand CP boresight gain of 12.39 dBic. Moreover, we produced a frequency-invariant beam pattern with an average half-power beamwidth (HPBW) of 24.77° and a standard deviation below 3.63° over 12–18 GHz for the target pattern, with a HPBW of 26°, demonstrating wideband electronic warfare performance using the proposed array. Full article
(This article belongs to the Special Issue Antenna System: From Methods to Applications)
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13 pages, 3361 KB  
Article
Design and Optimization of a Broadband Stripline Kicker for Low Beam Emittance Ring Accelerators
by Sakdinan Naeosuphap, Sarunyu Chaichuay, Siriwan Jummunt and Porntip Sudmuang
Particles 2025, 8(3), 78; https://doi.org/10.3390/particles8030078 (registering DOI) - 29 Aug 2025
Abstract
The performance and beam quality of the new fourth-generation synchrotron light source with ultra-low emittance are highly susceptible to coupled-bunch instabilities. These instabilities arise from the interaction between the bunched electron beam and the surrounding vacuum chamber installations. To mitigate these effects, the [...] Read more.
The performance and beam quality of the new fourth-generation synchrotron light source with ultra-low emittance are highly susceptible to coupled-bunch instabilities. These instabilities arise from the interaction between the bunched electron beam and the surrounding vacuum chamber installations. To mitigate these effects, the installation of a transverse bunch-by-bunch feedback system is planned. This system will comprise a button-type beam position monitor (BPM) for beam signal detection, a digital feedback controller, a broadband power amplifier, and a broadband stripline kicker as the primary actuator. One of the critical challenges lies in the development of the stripline kicker, which must be optimized for high shunt impedance and wide bandwidth while minimizing beam-coupling impedance. This work focuses on the comprehensive design of the stripline kicker intended for transverse (horizontal and vertical) bunch-by-bunch feedback in the Siam Photon Source II (SPS-II) storage ring. The stripline kicker design also incorporates features to enable its use for beam excitation in the SPS-II tune measurement system. The optimization process involves analytical approximations and detailed numerical electromagnetic field analysis of the stripline’s 3D geometry, focusing on impedance matching, field homogeneity, power transmission, and beam-coupling impedance. The details of engineering design are discussed to ensure that it meets the fabrication possibilities and stringent requirements of the SPS-II accelerator. Full article
(This article belongs to the Special Issue Generation and Application of High-Power Radiation Sources 2025)
37 pages, 2779 KB  
Review
Constructing Hetero−Microstructures in Additively Manufactured High−Performance High−Entropy Alloys
by Yuanshu Zhao, Zhibin Wu, Yongkun Mu, Yuefei Jia, Yandong Jia and Gang Wang
Entropy 2025, 27(9), 917; https://doi.org/10.3390/e27090917 - 29 Aug 2025
Abstract
High−entropy alloys (HEAs) have shown great promise for applications in extreme service environments due to their exceptional mechanical properties and thermal stability. However, traditional alloy design often struggles to balance multiple properties such as strength and ductility. Constructing heterogeneous microstructures has emerged as [...] Read more.
High−entropy alloys (HEAs) have shown great promise for applications in extreme service environments due to their exceptional mechanical properties and thermal stability. However, traditional alloy design often struggles to balance multiple properties such as strength and ductility. Constructing heterogeneous microstructures has emerged as an effective strategy to overcome this challenge. With the rapid advancement of additive manufacturing (AM) technologies, their unique ability to fabricate complex, spatially controlled, and non−equilibrium microstructures offers unprecedented opportunities for tailoring heterostructures in HEAs with high precision. This review highlights recent progress in utilizing AM to engineer heterogeneous microstructures in high−performance HEAs. It systematically examines the multiscale heterogeneities induced by the thermal cycling effects inherent to AM techniques such as selective laser melting (SLM) and electron beam melting (EBM). The review further discusses the critical role of these heterostructures in enhancing the synergy between strength and ductility, as well as improving work− hardening behavior. AM enables the design−driven fabrication of tailored microstructures, signaling a shift from traditional “performance−driven” alloy design paradigms toward a new model centered on “microstructural control”. In summary, additive manufacturing provides an ideal platform for constructing heterogeneous HEAs and holds significant promise for advancing high−performance alloy systems. Its integration into alloy design represents both a valuable theoretical framework and a practical pathway for developing next−generation structural materials with multiple performance attributes. Full article
(This article belongs to the Special Issue Recent Advances in High Entropy Alloys)
19 pages, 917 KB  
Article
Development and Test of a Novel High-Precision Inchworm Piezoelectric Motor
by Nan Huang, Jiahao Yin, Fuyuan Feng, Lanyu Zhang, Yuheng Luo and Jian Gao
Micromachines 2025, 16(9), 992; https://doi.org/10.3390/mi16090992 (registering DOI) - 29 Aug 2025
Abstract
The inchworm piezoelectric motor, with the advantages of long stroke and high resolution, is ideally suited for precise positioning in wafer-level electron beam inspection systems. However, the large number of piezoelectric actuators and the complex excitation signal sequences significantly increase the complexity of [...] Read more.
The inchworm piezoelectric motor, with the advantages of long stroke and high resolution, is ideally suited for precise positioning in wafer-level electron beam inspection systems. However, the large number of piezoelectric actuators and the complex excitation signal sequences significantly increase the complexity of system assembly and temporal control. A flexure-based actuation stator structure, along with simplified excitation signal sequences of a high-precision inchworm piezoelectric motor, is proposed. The alternating actuation of upper/lower clamping mechanisms and the driving mechanism fundamentally mitigates backstep effects while generating stepping linear displacement. The inchworm piezoelectric motor achieves precision linear motion operation using only two piezoelectric actuators. The actuation stator is analyzed via the compliance matrix method to derive its output compliance, input stiffness, and displacement amplification ratio. Furthermore, a kinematic model and natural frequency expression incorporating the pseudo-rigid-body method and Lagrange’s equations are established. The actuation stator and inchworm piezoelectric motor are analyzed through both simulations and experiments. The results show that the maximum step displacement of the motor is 16.3 μm, and the maximum speed is 9.78 mm/s, at a 600 Hz operation frequency with a combined alternating piezoelectric voltage of 135 V and 65 V. These findings validate the designed piezoelectric motor’s superior motion resolution, operational stability, and acceptable load capacity. Full article
(This article belongs to the Section E:Engineering and Technology)
15 pages, 4096 KB  
Article
Surface Roughness, Residual Stress, and Optical and Structural Properties of Evaporated VO2 Thin Films Prepared with Different Tungsten Doping Amounts
by Chuen-Lin Tien, Chun-Yu Chiang, Yi-Lin Wang, Ching-Chiun Wang and Shih-Chin Lin
Appl. Sci. 2025, 15(17), 9457; https://doi.org/10.3390/app15179457 - 28 Aug 2025
Abstract
This study investigates the effects of different tungsten (W) doping contents on the optical transmittance, surface roughness, residual stress, and microstructure of evaporated vanadium dioxide (VO2) thin films. W-doped VO2 thin films with varying tungsten concentrations were fabricated using electron [...] Read more.
This study investigates the effects of different tungsten (W) doping contents on the optical transmittance, surface roughness, residual stress, and microstructure of evaporated vanadium dioxide (VO2) thin films. W-doped VO2 thin films with varying tungsten concentrations were fabricated using electron beam evaporation combined with ion-assisted deposition techniques, and deposited on silicon wafers and glass substrates. The optical transmittances of undoped and W-doped VO2 thin films were measured by UV/VIS/NIR spectroscopy and Fourier transform infrared (FTIR) spectroscopy. The root mean square surface roughness was measured using a Linnik microscopic interferometer. The residual stress in various W-doped VO2 films was evaluated using a modified Twyman–Green interferometer. The surface morphological and structural characterization of the W-doped VO2 thin films were performed by field-emission scanning electron microscopy (FE-SEM) and X-ray diffraction (XRD). Raman spectroscopy was used to analyze the structure and vibrational modes of different W-doped VO2 thin films. These results show that the addition of tungsten significantly alters the structural, optical, and mechanical properties of VO2 thin films. Full article
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36 pages, 23263 KB  
Article
RL-TweetGen: A Socio-Technical Framework for Engagement-Optimized Short Text Generation in Digital Commerce Using Large Language Models and Reinforcement Learning
by Chitrakala S and Pavithra S S
J. Theor. Appl. Electron. Commer. Res. 2025, 20(3), 218; https://doi.org/10.3390/jtaer20030218 - 26 Aug 2025
Viewed by 523
Abstract
In the rapidly evolving landscape of digital marketing and electronic commerce, short-form content—particularly on platforms like Twitter (now X)—has become pivotal for real-time branding, community engagement, and product promotion. The rise of Non-Fungible Tokens (NFTs) and Web3 ecosystems further underscores the need for [...] Read more.
In the rapidly evolving landscape of digital marketing and electronic commerce, short-form content—particularly on platforms like Twitter (now X)—has become pivotal for real-time branding, community engagement, and product promotion. The rise of Non-Fungible Tokens (NFTs) and Web3 ecosystems further underscores the need for domain-specific, engagement-oriented social media content. However, automating the generation of such content while balancing linguistic quality, semantic relevance, and audience engagement remains a substantial challenge. To address this, we propose RL-TweetGen, a socio-technical framework that integrates instruction-tuned large language models (LLMs) with reinforcement learning (RL) to generate concise, impactful, and engagement-optimized tweets. The framework incorporates a structured pipeline comprising domain-specific data curation, semantic classification, and intent-aware prompt engineering, and leverages Parameter-Efficient Fine-Tuning (PEFT) with LoRA for scalable model adaptation. We fine-tuned and evaluated three LLMs—LLaMA-3.1-8B, Mistral-7B Instruct, and DeepSeek 7B Chat—guided by a hybrid reward function that blends XGBoost-predicted engagement scores with expert-in-the-loop feedback. To enhance lexical diversity and contextual alignment, we implemented advanced decoding strategies, including Tailored Beam Search, Enhanced Top-p Sampling, and Contextual Temperature Scaling. A case study focused on NFT-related tweet generation demonstrated the practical effectiveness of RL-TweetGen. Experimental results showed that Mistral-7B achieved the highest lexical fluency (BLEU: 0.2285), LLaMA-3.1 exhibited superior semantic precision (BERT-F1: 0.8155), while DeepSeek 7B provided balanced performance. Overall, RL-TweetGen presents a scalable and adaptive solution for marketers, content strategists, and Web3 platforms seeking to automate and optimize social media engagement. The framework advances the role of generative AI in digital commerce by aligning content generation with platform dynamics, user preferences, and marketing goals. Full article
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13 pages, 1824 KB  
Article
Reactive Oxygen Species Yield near Gold Nanoparticles Under Ultrahigh-Dose-Rate Electron Beams: A Monte Carlo Study
by Chloe Doen Kim and James C. L. Chow
Nanomaterials 2025, 15(17), 1303; https://doi.org/10.3390/nano15171303 - 23 Aug 2025
Viewed by 450
Abstract
Ultrahigh dose rate (UHDR) radiotherapy, also known as FLASH radiotherapy (FLASH-RT), has shown potential for increasing tumor control while sparing normal tissue. In parallel, gold nanoparticles (GNPs) have been extensively explored as radiosensitizers due to their high atomic number and ability to enhance [...] Read more.
Ultrahigh dose rate (UHDR) radiotherapy, also known as FLASH radiotherapy (FLASH-RT), has shown potential for increasing tumor control while sparing normal tissue. In parallel, gold nanoparticles (GNPs) have been extensively explored as radiosensitizers due to their high atomic number and ability to enhance the generation of reactive oxygen species (ROS) through water radiolysis. In this study, we investigate the synergistic effects of UHDR electron beams and GNP-mediated radiosensitization using Monte Carlo (MC) simulations based on the Geant4-DNA code. A spherical water phantom with embedded GNPs of varying sizes (5–100 nm) was irradiated using pulsed electron beams (100 keV and 1 MeV) at dose rates of 60, 100, and 150 Gy/s. The chemical yield of ROS near the GNPs was quantified and compared to an equivalent water nanoparticle model, and the yield enhancement factor (YEF) was used to evaluate radiosensitization. Results demonstrated that YEF increased with smaller GNP sizes and at lower UHDR, particularly for 1 MeV electrons. A maximum YEF of 1.25 was observed at 30 nm from the GNP surface for 5 nm particles at 60 Gy/s. The elevated ROS concentration near GNPs under FLASH conditions is expected to intensify DNA damage, especially double-strand breaks, due to increased hydroxyl radical interactions within nanometric distances of critical biomolecular targets. These findings highlight the significance of nanoparticle size and beam parameters in optimizing ROS production for FLASH-RT. The results provide a computational basis for future experimental investigations into the combined use of GNPs and UHDR beams in nanoparticle-enhanced radiotherapy. Full article
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11 pages, 1368 KB  
Article
Ionizing Radiation-Induced Structural Modification of Isoegomaketone and Its Anti-Inflammatory Activity
by Euna Choi, Chang Hyun Jin, Trung Huy Ngo, Jisu Park, Joo-Won Nam and Ah-Reum Han
Molecules 2025, 30(17), 3466; https://doi.org/10.3390/molecules30173466 - 23 Aug 2025
Viewed by 396
Abstract
Isoegomaketone [(E)-1-(furan-3-yl)-4-methylpent-2-en-1-one; 1] is abundant in the essential oil of Perilla species and exhibits various biological activities, such as anticancer and anti-inflammatory effects. In order to discover compounds with reduced toxicity or enhanced biological activity through structural modification of natural [...] Read more.
Isoegomaketone [(E)-1-(furan-3-yl)-4-methylpent-2-en-1-one; 1] is abundant in the essential oil of Perilla species and exhibits various biological activities, such as anticancer and anti-inflammatory effects. In order to discover compounds with reduced toxicity or enhanced biological activity through structural modification of natural product-derived components, isoegomaketone was irradiated with an electron beam at five different doses, and (±)-8-methoxy-perilla ketone (2) was obtained with the highest yield of 3.8% (w/w) at 80 kGy. Its structure was identified by one-dimensional and two-dimensional nuclear magnetic resonance spectroscopy and high-resolution chemical ionization mass spectrometry. Compound 2 inhibited nitric oxide production and inducible nitric oxide synthase mRNA expression in a dose-dependent manner in lipopolysaccharide-stimulated RAW 264.7 cells. It also dose-dependently suppressed the mRNA expression of pro-inflammatory mediators such as IL-1β, IFN-β, and MCP-1, while having no significant effect on IL-6 mRNA levels. Furthermore, ELISA analysis demonstrated that 2 reduced MCP-1 protein expression but did not affect the protein level of TNF-α or IL-6. This study provides a reference for the structural analysis of compounds related to 2 by presenting NMR data acquired with chloroform-d, and is the first to report the anti-inflammatory properties of 2. Full article
(This article belongs to the Special Issue 30th Anniversary of Molecules—Recent Advances in Food Chemistry)
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19 pages, 654 KB  
Review
Targeted Radiotherapy in Primary Cutaneous Lymphomas: Precision, Efficacy, and Evolving Strategies
by Piotr Sobolewski, Mateusz Koper, Piotr Ciechanowicz and Irena Walecka
Cancers 2025, 17(17), 2722; https://doi.org/10.3390/cancers17172722 - 22 Aug 2025
Viewed by 405
Abstract
Primary cutaneous lymphomas (PCLs), including cutaneous T-cell lymphomas (CTCL) and primary cutaneous B-cell lymphomas (PCBCL), are a diverse group of non-Hodgkin lymphomas that primarily affect the skin. Radiotherapy (RT) plays a pivotal role in the treatment of these lymphomas, particularly for localized disease, [...] Read more.
Primary cutaneous lymphomas (PCLs), including cutaneous T-cell lymphomas (CTCL) and primary cutaneous B-cell lymphomas (PCBCL), are a diverse group of non-Hodgkin lymphomas that primarily affect the skin. Radiotherapy (RT) plays a pivotal role in the treatment of these lymphomas, particularly for localized disease, due to its ability to deliver precise, skin-directed treatment. Mycosis fungoides (MF) and Sézary syndrome (SS), the most common subtypes of CTCL, often require skin-directed therapies such as electron beam therapy and superficial brachytherapy to manage localized lesions. Electron beam therapy, including total skin electron beam therapy (TSEBT), has been utilized for decades, offering high response rates but with the risk of cumulative skin toxicity. Recently, low-dose radiotherapy (LDRT) has gained attention as an effective alternative that reduces toxicity while maintaining durable responses. Superficial brachytherapy is another modality that delivers radiation through custom molds, allowing for homogeneous dosing over complex anatomical areas like the face. Both teleradiotherapy and brachytherapy have demonstrated high complete response rates, with low recurrence rates observed when higher doses are used. In the context of primary cutaneous B-cell lymphomas, such as primary cutaneous marginal zone lymphoma (PCMZL) and primary cutaneous follicle center lymphoma (PCFCL), radiotherapy also offers excellent local control, particularly for indolent subtypes. However, more aggressive subtypes, such as diffuse large B-cell lymphoma, leg type (PCDLBCL-LT), may require systemic therapies in addition to radiation. Overall, teleradiotherapy and brachytherapy are essential components of the therapeutic arsenal for primary cutaneous lymphomas, offering effective disease control with manageable toxicity, while ongoing research focuses on optimizing treatment strategies and exploring novel combinations with systemic therapies. Full article
(This article belongs to the Section Cancer Therapy)
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19 pages, 11203 KB  
Article
In Situ TEM Observation of Electric Field-Directed Self-Assembly of PbS and PbSe Nanoparticles
by Iryna Zelenina, Harald Böttner, Marcus Schmidt, Yuri Grin and Paul Simon
Nanomaterials 2025, 15(16), 1275; https://doi.org/10.3390/nano15161275 - 18 Aug 2025
Viewed by 411
Abstract
Nano-sized particles of semiconducting lead sulfide and selenide and their 2D thin layers show high potential in applications, such as field-effect transistors, photodetectors, solar cells, and thermoelectric devices. The generation of PbS and PbSe nanobars and nanocubes is evoked by in situ electron [...] Read more.
Nano-sized particles of semiconducting lead sulfide and selenide and their 2D thin layers show high potential in applications, such as field-effect transistors, photodetectors, solar cells, and thermoelectric devices. The generation of PbS and PbSe nanobars and nanocubes is evoked by in situ electron beam treatment, leading to the formation of thin, extended 2D nanolayers. The initial single crystals are decomposed via sublimation of PbS and PbSe in terms of molecular and atomic fragments, which finally condense on the cold substrate to form nanostructures. The fragments in the gas phase were proven using mass spectrometry. In the case of PbS, Pb+ and PbS+ species could were detected, whereas PbSe disintegrated into Pb+, Se2+, and PbSe+. The threshold current that initiates fragmentation increases from PbTe via PbSe up to PbS, which is in line with the increasing crystal formation energies. The uniform orientation of independently formed nanoparticles on the macroscopic scale can be explained by an external electric field acting on emerging dipolar nanospecies. The external dipole field originates from the sputtered mother crystal, where the electron flux is initiated; thus, a current arises between the crystal’s hot and cold ends. On the contrary, in small single crystals, due to the lack of sufficient charge carriers, only local material excavation is detected instead of extended depletion and subsequent nanoparticle deposition. This fragmentation process may represent a new preparation route that provides lead chalcogenide nanofilms that are free of contamination or surfactant participation, which are typical drawbacks associated with the application of wet chemical methods. Full article
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19 pages, 7427 KB  
Article
Radiation Shielding Evaluation of Carbohydrate Hydrogel Radiotherapy Pads Containing High-Z Fillers: A Geant4 Study
by Hanan Akhdar and Samar Alghamdi
Polymers 2025, 17(16), 2234; https://doi.org/10.3390/polym17162234 - 17 Aug 2025
Viewed by 532
Abstract
This work analyzes the radiation shielding effectiveness of biocompatible hydrogel pads containing carbohydrate-based polymer matrices (Alginate, Chitosan, and Cellulose) integrated with the high atomic number (Z) fillers Bismuth Oxide (Bi2O3) and Zinc Oxide (ZnO). The Monte Carlo-based toolkit, Geant4, [...] Read more.
This work analyzes the radiation shielding effectiveness of biocompatible hydrogel pads containing carbohydrate-based polymer matrices (Alginate, Chitosan, and Cellulose) integrated with the high atomic number (Z) fillers Bismuth Oxide (Bi2O3) and Zinc Oxide (ZnO). The Monte Carlo-based toolkit, Geant4, was used to simulate the deposition of the dose throughout a multilayer phantom that mimics the skin (Epidermis, Dermis, Subcutaneous, and Muscle) with a pad on top irradiated with photon and electron beams from 50 keV to 1000 keV. The results indicated that Bi2O3 succeeded in causing greater absorption of photons at doses, particularly in deep-layer tissues, from the increase in the filler content as well as the pad thickness. The Cellulose–Bi2O3 composites (10 mm thick) not only showed the best deep-shielding property among all investigated combinations but also the Alginate-based pads generally performed better with regard to the surface dose attenuation. The results demonstrate the promising potential of high-Z-doped hydrogels in serving as flexible, light, and biocompatible shielding materials for superficial radiotherapy. Full article
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14 pages, 12986 KB  
Article
Validation of an EGSnrc Monte Carlo Model of a 10 MV Photon Beam for Varian Clinac iX Linac, Including Flattening and Flattening-Free Modes
by Wafa M. Al-Saleh
Quantum Beam Sci. 2025, 9(3), 25; https://doi.org/10.3390/qubs9030025 - 14 Aug 2025
Viewed by 233
Abstract
Modelling of linear accelerators using the Monte Carlo method is critical for precise radiotherapy planning. In addition, detailed and accurate dose estimation to the organ at risk can be assessed and optimized. In this study, EGSnrc Monte Carlo code was utilized to model, [...] Read more.
Modelling of linear accelerators using the Monte Carlo method is critical for precise radiotherapy planning. In addition, detailed and accurate dose estimation to the organ at risk can be assessed and optimized. In this study, EGSnrc Monte Carlo code was utilized to model, tune, and validate a 10 MV photon head model of a Varian Clinac iX linear accelerator for different field sizes, including flattening and flattening-free modes. Gamma analysis was utilized to compare the model with measured data to determine the best parameters for the incident electron on the target. The main results revealed that, for both flattening and flattening-free modes, the incident electron’s optimal energy is 9.5 MeV, with a 0.1 cm circular full width half maximum (FWHM) and a 0.07° angular divergence. The model is suitable for field sizes extending from 1 × 1 to 30 × 30 cm2. The comparison of large field sizes, which includes both 20 × 20 and 30 × 30 cm2, reflects the accuracy of the geometrical model of the flattening filter. Altering the FWHM has a notable effect on the profile, particularly in the penumbral region, although adjusting the angular divergence has little effect. The dose rate for the flattening filter-free beam compared to the flattening filter beam increased by a factor of four. The validated model demonstrates excellent agreement with measured data. Thus, it can provide accurate dose calculations and can be used in future studies to test treatment accuracy and patient safety, especially for advanced radiotherapy techniques. Full article
(This article belongs to the Section Medical and Biological Applications)
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21 pages, 9876 KB  
Article
Laser-Induced Ablation of Hemp Seed-Derived Biomaterials for Transdermal Drug Delivery
by Alexandru Cocean, Georgiana Cocean, Silvia Garofalide, Nicanor Cimpoesu, Daniel Alexa, Iuliana Cocean and Silviu Gurlui
Int. J. Mol. Sci. 2025, 26(16), 7852; https://doi.org/10.3390/ijms26167852 - 14 Aug 2025
Viewed by 311
Abstract
Numerous studies on specific cannabis compounds (cannabinoids and phenolic acids) have demonstrated their therapeutic potential, with their administration methods remaining a key research focus. Transdermal drug delivery (TDD) systems are gaining attention due to their advantages, such as painless administration, controlled release, direct [...] Read more.
Numerous studies on specific cannabis compounds (cannabinoids and phenolic acids) have demonstrated their therapeutic potential, with their administration methods remaining a key research focus. Transdermal drug delivery (TDD) systems are gaining attention due to their advantages, such as painless administration, controlled release, direct absorption into the bloodstream, and its ability to bypass hepatic metabolism. The thin films obtained via pulsed laser deposition consist of micro- and nanoparticles capable of migrating through skin pores upon contact. This study investigates the interaction of phenolic compounds in hemp seeds with pulsed laser beams. The main goal is to achieve the ablation and deposition of these compounds as thin films suitable for TDD applications. The other key objective is optimizing laser energy to enhance the industrial feasibility of this method. Thin layers were deposited on glass and hemp fabric using dual pulsed laser (DPL) ablation on a compressed hemp seed target held in a stainless steel ring. The target was irradiated for 30 min with two synchronized pulsed laser beams, each with parameters of 30 mJ, 532 nm, pulse width of 10 ns, and a repetition rate of 10 Hz. Each beam had an angle of incidence with the target surface of 45°, and the angle between the two beams was also 45°. To improve laser absorption, two approaches were used: (1) HS-DPL/glass and HS-DPL/hemp fabric, in which a portion of the stainless steel ring was included in the irradiated area, and (2) HST-DPL/glass and HST-DPL/hemp fabric—hemp seeds were mixed with turmeric powder, which is known to improve laser interaction and biocompatibility. The FTIR and Micro-FTIR spectroscopy (ATR) performed on thin films compared to the target material confirmed the presence of hemp-derived phenolic compounds, including tetrahydrocannabinol (THC), cannabidiol (CBD), ferulic acid, and coumaric acid, along with other functional groups such as amides. The ATR spectra have been validated against Gaussian 6 numerical simulations. Scanning electron microscopy (SEM) and substance transfer tests revealed the microgranular structure of thin films. Through the analyzes carried out, the following were highlighted: spherical structures (0.3–2 μm) for HS-DPL/glass, HS-DPL/hemp fabric, HST-DPL/glass, and HST-DPL/hemp fabric; larger spherical structures (8–13 μm) for HS-DPL/glass and HST-DPL/glass; angular, amorphous-like structures (~3.5 μm) for HS-DPL/glass; and crystalline-like structures (0.6–1.3 μm) for HST-DPL/glass. Microparticle transfer from thin films on the hemp fabric to the filter paper at a human body temperature (37 °C) confirmed their suitability for TDD applications, aligning with the “whole plant medicine” or “entourage effect” concept. Granular, composite, thin films were successfully developed, capable of releasing microparticles upon contact with a surface whose temperature is 37 °C, specific to the human body. Each of the microparticles in the thin films obtained with the DPL technique contains phenolic compounds (cannabinoids and phenolic acids) comparable to those in hemp seeds, effectively acting as “microseeds.” The obtained films are viable for TDD applications, while the DPL technique ensures industrial scalability due to its low laser energy requirements. Full article
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14 pages, 3326 KB  
Article
Effects of Oxygen Gas Flow During Deposition on the Thermal Shock Life of YSZ Thermal Barrier Coatings Prepared by Electron Beam Physical Vapor Deposition
by Keli Huo, Chunhui Xu, Zhenwu Huang, Jie Xia, Ling Zhang, Xiaoshan Zhang and Tiansheng Li
Coatings 2025, 15(8), 928; https://doi.org/10.3390/coatings15080928 - 8 Aug 2025
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Abstract
Electron beam physical vapor deposited (EB-PVD) thermal barrier coatings (TBCs) are widely used to protect the hot section parts of aircraft engine turbines due to its uniform columnar microstructure and high strain tolerance. The microstructure and thermal shock life of 7 wt% Y [...] Read more.
Electron beam physical vapor deposited (EB-PVD) thermal barrier coatings (TBCs) are widely used to protect the hot section parts of aircraft engine turbines due to its uniform columnar microstructure and high strain tolerance. The microstructure and thermal shock life of 7 wt% Y2O3 stabilized zirconia (YSZ) coatings produced by EB-PVD were investigated as a function of oxygen gas flow during deposition. The surface and cross-section microstructure of EB-PVD YSZ coatings were highly influenced by the oxygen gas flow. When the oxygen gas flow is less than 60 sccm, a sandwich is formed between the bond coat (BC) layer and the YSZ layer, which significantly reduces the thermal shock life of the coating. Full article
(This article belongs to the Special Issue Characterization and Industrial Applications of PVD Coatings)
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