Search Results (6,569)

Dissolving microneedles (DMN) could be considered as a minimally invasive alternative for transdermal delivery of naltrexone hydrochloride (NTX). In the present study, DMN patches with smart design were developed via a two-step micromoulding technique. The systems were composed of drug-free polyvinylpyrrolidone (PVP) and polyvinyl alcohol (PVA) blend microneedle tips, combined with a drug-loaded backing layer based on PVP and Poloxamer 407. The influence of polymer concentration in DMN tips and backing-layer composition on morphology, mechanical properties, drug release and permeation was evaluated. Mechanical studies revealed that intermediate polymer concentration (formulation MN-20%/2:1) provided superior structural integrity (13.57 ± 1.43% height reduction after compression) and efficient penetration up to the fourth Parafilm^® layer. Incorporation of NTX into the backing layer allowed for high drug loading, while a 2:1 PVP:P407 ratio provided higher toughness (1806 g/mm) as well as thermoresponsive and controlled drug release. In vitro permeation studies demonstrated significantly enhanced NTX delivery from DMN systems compared to simple matrix patches—an almost 4-fold increase in flux with 56% permeation of NTX up to 8 h. These findings highlight the importance of polymer composition in DMN design and demonstrate the potential of the developed systems as an effective platform for transdermal delivery of NTX. Full article

Optimizing the structural stability of foundations is challenging in modern geotechnical engineering. This study investigated the mechanism of geocell-reinforced foundations through discrete element modeling based on transparent soil model tests. A three-dimensional particle flow code (PFC^3D) model was developed to investigate the micromechanical soil–geocell interactions in both unreinforced and geocell-reinforced foundations under strip loading. Particle displacement, contact force distribution, and structural deformation within the foundation system were analyzed to quantify the performance of geocell reinforcement. The results show that geocell inclusion enhances structural performance by 2.1 times compared to an unreinforced foundation, increasing the bearing capacity from 60.6 to 126.8 kPa at a defined bearing capacity criterion. The geocell walls act as rigid physical boundaries that microscopically intercept the lateral migration and horizontal extrusion of soil particles. The kinematic trajectories of soil particles beneath the loading plate are forced into a downward realignment, decreasing the displacement vector rotation angle from 42° in the unreinforced soil to 27° in the reinforced soil and effectively mitigating the heave of adjacent surfaces. Furthermore, the quasi-rigid three-dimensional network completely interrupts the continuous steep contact force chains inherent in unreinforced foundations. Concentrated vertical stresses are converted into horizontal components through interfacial friction and mechanical interlocking, resulting in the lateral redistribution of the applied load by a distance of approximately 0.06 m. The geocell–soil composite considered as a flexible raft foundation extends load dispersion and reduces average subsoil pressure. A coupled tension and compression stress state in the horizontal plane is developed within the geocell structure. Forces are channeled along rigid paths by elevated bending moments and stress concentrations at the cell junctions. These findings provide micromechanical insights into the performance of geocell-reinforced-foundation systems. Full article

In order to study the optimal size and sealing performance of the foot-shaped slip ring for reciprocating seal, the loading method of fluid pressure penetration is used to simulate the effect of fluid medium pressure on the seal, and the multi-objective optimization of the geometry of the slip ring is carried out based on optimization software to obtain the best combination of parameters for the foot-shaped slip ring. The effects of slip ring geometry, pre-compression and working pressure on Von Mises stress and contact pressure were investigated using the finite element method. The results show that the optimized geometry of the foot-shaped slip ring can reduce the maximum contact stress on the main sealing surface from 108.5 MPa to 75.22 MPa (a reduction of 30.7%) and decrease the maximum Von Mises stress of the slip ring from 62.84 MPa to 41.57 MPa (a reduction of 33.8%), thereby greatly reducing the wear of the slip ring while ensuring reliable sealing. In the static sealing condition, a smaller pre-compression (1.2–1.3 mm) leads to stress concentration in the O-ring, and the recommended pre-compression range is 1.4–1.6 mm. In the dynamic sealing condition, the effect of pre-compression on the sealing performance is greater than that of reciprocating motion speed on the sealing performance, and the foot-shaped slip ring seal is found to be more suitable for low-speed operation at 0.1–0.2 m/s. The optimized design provides a data-driven methodology for enhancing the reliability and service life of reciprocating seals in high-pressure environments. Full article

Drilling in deep hard formations poses significant challenges for conventional polycrystalline diamond compact (PDC) cutters, which often suffer from low rock-breaking efficiency and premature failure due to severe cutter-face wear, high thermal loads, and stick-slip vibrations. To overcome these limitations, this study proposes a chisel-shaped PDC cutter and systematically investigates its rock-breaking and thermal characteristics. A coupled temperature–displacement finite element model (FEM) of cutter–granite interaction and a single-cutter indentation model were developed based on elastoplastic mechanics and the Drucker–Prager failure criterion. The rock constitutive parameters used in both models were validated through uniaxial compression tests. Using these models, the influences of cutter shape, back rake angle, and depth of cut (DOC) were analyzed. Compared with a conventional cylindrical cutter, the chisel cutter reduces the cutting force by 13.4% and the axial penetration reaction force by 22%. The cutting force of the chisel cutter remains consistently lower across all tested depths. The optimal back rake angle is 20–25°, and the optimal DOC is 1.5 mm. Full-bit simulations further demonstrate that the chisel-cutter bit creates a more concentrated bottomhole stress field, increases the rate of penetration (ROP) by 19.7%, reduces average torque by 11.34%, and produces smoother torque fluctuations, indicating higher drilling stability. Thermal analysis reveals that the chisel cutter exhibits lower and more stable cutter-face temperatures. Both simulation and experimental results confirm that the chisel design reduces the friction contact area between cuttings and the cutter face, thereby lowering temperature accumulation. Field drilling data corroborate the reliability of the conclusions. These findings provide guidance for the design of PDC bits intended for deep hard formations. Full article

Freeze–thaw durability of 3D-printed engineered cementitious composites (3DP-ECC) is strongly affected by print-induced interlayer defects and anisotropy, particularly in cold regions. This study investigated Cast-ECC and Z-direction 3DP-ECC incorporating Yellow River sediment (YRS) as an equal-mass replacement for quartz sand at 0–100%. Compressive, three-point bending, and four-point bending tests, relative dynamic elastic modulus (RDME), XCT, MIP, SEM–EDS, and Weibull damage modeling were used to evaluate degradation up to 150 freshwater freeze–thaw cycles. Moderate YRS replacement (25–50%) improved particle packing, reduced visible defects, and refined the pore structure, thereby enhancing frost resistance. The R50 mixture showed the best residual performance: after 150 cycles, compressive strength decreased from 55 to 46 MPa in Cast-ECC and from 54 to 44 MPa in 3DP-ECC, corresponding to retention rates of 83.6% and 81.5%, respectively. The residual peak load in four-point bending of 3DP-ECC-R50 was 15.4% lower than that of Cast-ECC-R50, confirming the detrimental role of interlayer defects under loading perpendicular to the layers. RDME-based Weibull fitting described the overall damage evolution (R² = 0.876–0.994), while XCT, MIP, and SEM–EDS indicated that interlayer discontinuities, pore-structure evolution, and local microstructural degradation governed anisotropic deterioration. The results support durability-oriented design of YRS-based 3DP-ECC in cold regions. Full article

Short circuits and subsequent fires resulting from objects impacting the bottom of vehicle power battery packs considerably jeopardize electric vehicle (EV) operations. This study investigated underbody impacts in EVs and the overall mechanical properties of battery cells. Key features of road debris were extracted and simplified to establish a geometric parameter structure model and determine realistic battery pack responses to debris impact. Quasi-static compression and dynamic impact tests on a prismatic lithium-ion battery (LIB) and power battery pack followed. Macroscopic mechanical responses, deformation failure modes, and internal jellyroll damage of cells and packs were evaluated, and constitutive equations and failure parameters were derived to develop a finite element model, whose effectiveness and reliability were verified by comparing simulation results with experimental data. Finally, a homogenized model of the prismatic LIB and power battery pack was constructed, which effectively predicted the macroscopic mechanical response and internal short-circuit failure under mechanical loading. However, simulation and test results revealed certain deviations in cell indentations under battery pack bottom impacts, presumably because the FEMs neglect the dynamic strain rate effects of electrolyte and cooling liquid. Overall, this study elucidates safety risks to cells and their key components under power battery pack bottom impacts. Full article

Machine learning approaches to wildfire spread prediction are constrained by the lack of standardized, multi-source, spatiotemporal datasets that fuse terrain, weather, and fire-state information into a single ML-ready format. We present WildfireCube, a reproducible event-centric pipeline and methodology for constructing dense fourth-order spatiotemporal tensors of shape (T, C, H, W) at 30 m spatial and 3 h temporal resolution. Following the analysis-ready data convention established in the Earth Observation community, the pipeline fuses four open data sources: the Copernicus GLO-30 Digital Elevation Model for static terrain derivatives, ERA5-Land reanalysis for hourly weather forcing, Sentinel-2 Level-2A imagery for spectral vegetation and burn-severity indices, and NASA FIRMS active-fire hotspot detections for fire-state reconstruction via ordinary kriging. The resulting 13-channel normalized tensor separates causal drivers into three physically motivated groups: static landscape controls (elevation, slope, aspect, fuel load), dynamic atmospheric forcings (wind components, temperature, precipitation), and evolving fire state (fire-front mask, burn severity, fractional burn, observation confidence). A physics-informed normalization framework maps all channels to bounded ranges using fixed physical constants rather than sample statistics, ensuring cross-event comparability and exact invertibility. We demonstrate the pipeline on 13 wildfire events across the United States, Canada, and Greece (2017–2023), producing a processed catalog exceeding 300 GB compressed and spanning a 14-fold range in burned area, a 27 °C range in mean temperature, and different fire regimes. Event tensors are stored in chunked Zarr archives with Zstandard compression, achieving a 2.58× compression ratio. As future work, the pipeline will be applied to a 40-event target catalog projected to exceed 2 TB of raw data, providing the multi-regime diversity and scale required for training robust deep learning models for spatiotemporal wildfire prediction. Full article

This paper addresses the current development status of a innovative direct high-pressure electrolyser (DHPEL, operating up to 700 bar) and its integration into a microgrid system in which solar energy constitutes the primary energy source and a hybrid energy storage system, comprising a battery and hydrogen, is employed. The DHPEL under development enables the direct production and storage of hydrogen at high pressures, thereby obviating the need for intermediate mechanical compression. In combination with standardized pressure vessels (300–350 bar) or the increasingly widespread use of CFRP-based high-pressure storage tanks (up to 700 bar), the DHPEL concept represents a technically and economically attractive option for microgrids with hybrid energy storage. The hybrid storage concept is based on functional differentiation between the storage media: the battery is intended to act predominantly as a buffer or short-term storage unit, and the hydrogen is designated for long-term energy storage. In principle, this configuration facilitates an autonomous energy supply relying exclusively on renewable energy sources; this is achieved by enabling the surplus solar energy generated in summer to be converted into hydrogen and subsequently utilized in winter. A rule-based energy-management algorithm is presented, prioritizing hydrogen production from surplus energy during the summer period and aiming to minimize interaction with the public electricity grid. This is particularly relevant for high-latitude regions, such as Germany, where solar irradiation is significantly lower in winter than in summer. A quasi-optimal sizing of all components in the microgrid, along with a realistic techno-economic assessment of the overall system, is performed using an energy-management model implemented in Simulink and utilised with realistic boundary conditions. A case study utilizing realistic solar generation and empirically derived electrical load profiles demonstrates the technical and economic viability of seasonal energy shifting from summer to winter (resulting in an autarky degree exceeding 1) within an economically acceptable cost range. Full article

Background: Conventional and refractory wounds frequently remain in a prolonged inflammatory phase associated with excessive reactive oxygen species (ROS) accumulation and disruption of endogenous electrical cues. Methods: A multifunctional nanocomposite hydrogel was fabricated via an amidation condensation reaction, utilizing 3-amino-4-methoxybenzoic acid (AMB)-modified carboxymethyl chitosan (PAMB-CMCS) and decellularized extracellular matrix (dECM) as macromolecular networks, integrated with Astragaloside IV-Loaded Polydopamine/Zeolitic Imidazolate Framework-8 (AS@PDA/ZIF-8) nanoparticles. Results: The hydrogel provided a biomechanically supportive scaffold with compressive strength of 27.24 ± 1.9 kPa and breaking strength of 28.2 ± 2.8 kPa and exhibited electrical conductivity of 29.84 mS/cm, ROS-scavenging activity, and near-infrared (NIR)-responsive photothermal behavior reaching 62.55 °C. The integrated PDA@ZIF-8 nanoplatform further contributed to antibacterial performance and localized AS release, thereby improving the wound microenvironment and accelerating full-thickness cutaneous defect repair. Conclusions: This macromolecule-based composite hydrogel offers a promising therapeutic strategy for complex wound management. Full article

The aim of this study was to explore the compactibility of unidirectional staple carbon fibre laminates in comparison with their uni- and biaxial continuous fibre counterparts. Resin-preimpregnated plies were inserted into a heated compression mould at an elevated mould temperature of 110 °C. By applying stepwise loading, the correlation between consolidation pressure and fibre volume content was derived and related to fibre orientation distribution. The fibre orientation distribution is obtained from photographic image analyses of 2D ply sections of the same samples using the structure tensor approach. For commonly used autoclave prepreg pressure of 6.8 bar results indicate that lower-oriented staple carbon fibre unidirectional laminates with a fibre orientation distribution factor η₀ = 0.74 can potentially reach a maximum of 39% fibre volume fraction, while higher-oriented laminates with η₀ = 0.78 end up at 43%. An exponential extrapolation suggests that a consolidation pressure of ≥90 bar is required to achieve 60% fibre volume content with highly oriented unidirectional staple carbon fibre laminates. Full article

Background: Uncontrolled hemorrhage, especially at non-compressible sites, remains a major cause of preventable trauma deaths. This study reports the development of fibrinogen-loaded calcium carbonate (CaCO₃) microparticles that combine hemostatic activity with self-propelling capability for targeted delivery against blood flow, with a focus on understanding formulation-dependent trade-offs among particle yield, protein loading, clotting performance, and transport behavior. Methods: Microparticles were synthesized via a precipitation method using different carbonate sources and characterized for yield, morphology, size, and fibrinogen encapsulation. Hemostatic function was assessed using rotational thromboelastometry (ROTEM) in fibrinogen-deficient plasma. Propulsion behavior was evaluated following exposure to protonated tranexamic acid (TXA⁺), which triggers CO₂ generation. Particle size and encapsulation were examined by microscopy and fluorescence imaging. Results: The precipitation method produced spherical micrometer-sized particles, with fibrinogen inclusion reducing yield and particle size relative to unload controls. Fluorescence microscopy confirmed successful encapsulation. Encapsulation efficiency varied with formulation, with sodium carbonate-based particles showing higher relative fibrinogen loading. ROTEM analysis demonstrated that fibrinogen-loaded particles significantly improved clot formation, increasing maximum clot firmness compared to fibrinogen-free particles, although performance remained formulation-dependent. TXA⁺-triggered propulsion achieved maximum speeds up to 4.221 cm/s. Fibrinogen-loaded particles exhibited longer activation lag times than unloaded particles, indicating a trade-off between hemostatic functionality and propulsion kinetics. Conclusions: Fibrinogen-loaded CaCO₃ microparticles exhibit both hemostatic activity and chemically triggered motion in vitro. The study identifies key formulation-dependent trade-offs between particle yield, fibrinogen loading, clotting performance, and propulsion behavior. While these findings support the feasibility of combining localization and clot stabilization mechanisms, further studies under physiologically relevant flow conditions and in vivo models are required to evaluate their potential for active delivery in non-compressible hemorrhage. Full article

Water is a key factor affecting the mechanical properties and stability of rock masses in underground engineering. In practical engineering settings, water distribution is commonly spatially heterogeneous, and the relative orientation between water distribution and the stress direction may further complicate the mechanical response and failure behavior of rocks. To investigate this issue under controlled laboratory conditions, Linyi red sandstone was selected, and four groups of specimens with distinct water-bearing states (oven-dried, fully saturated, axially semi-saturated, and radially semi-saturated) were prepared using tailored immersion protocols. Laboratory uniaxial compression tests and simplified discrete element simulations were combined to examine the macroscopic mechanical response, failure localization, and mesoscopic damage evolution of sandstone under directional heterogeneous water distribution. The results indicate that the water-bearing state strongly affects the uniaxial compressive strength and apparent deformation modulus of sandstone; compared with oven-dried specimens, fully saturated specimens show an approximately 40–60% reduction in these parameters, whereas semi-saturated specimens exhibit intermediate values. The relative orientation between the water distribution and loading direction further influences the failure pattern of semi-saturated specimens. Failure in semi-saturated specimens tends to initiate or localize in water-affected regions, while the multi-stage post-peak response of radially semi-saturated specimens can be interpreted as a sequential load-transfer process between saturated and dry regions. Heterogeneous water distribution also affects microcrack development and force-chain redistribution, with the idealized dry–wet transition region acting as a sensitive zone for crack initiation and stress redistribution. This study clarifies the first-order influence of directional heterogeneous water distribution on the mechanical behavior of sandstone and provides support for stability assessment and disaster mitigation in underground rock engineering under complex water-bearing conditions. Full article

Fiber-reinforced polymer (FRP) composites provide an effective strengthening solution for timber members because of their high tensile capacity, low self-weight, corrosion resistance, and practical applicability in rehabilitation works. Although FRP strengthening of timber beams has been widely investigated, most available experimental evidence concerns softwood and glued-laminated systems, whereas comparatively limited data are available for dense tropical hardwoods used in marine and waterfront infrastructure. This study investigates the flexural behavior of Azobé (Lophira alata) hardwood beams strengthened with externally bonded carbon-fiber-reinforced polymer (CFRP) and glass-fiber-reinforced polymer (GFRP) laminates. The main contribution of this work is the application of externally bonded FRP strengthening to Azobé timber members intended for marina pontoon and related waterfront applications, where structural upgrading may be required to accommodate increased service loads. Mechanical characterization of the timber was first conducted through compression and tensile tests. Subsequently, nine beams were tested under three-point bending, including three un-strengthened reference beams, three GFRP-strengthened beams, and three CFRP-strengthened beams. The average ultimate load increased from 26.92 kN for the reference beams to 35.59 kN and 39.85 kN for the GFRP- and CFRP-strengthened beams, respectively. Statistical indicators, including standard deviation, coefficient of variation, standard error, confidence intervals, and two-sample t-tests, were included to account for the limited number of specimens and the natural variability of timber. CFRP exhibited the highest mean response within the present test series; however, the difference between the CFRP- and GFRP-strengthened beams is interpreted as an indicative experimental trend rather than a general statistical conclusion. No visible premature de-bonding was observed, and the strengthened specimens failed mainly by FRP rupture, suggesting bond engagement under the tested configuration. Nevertheless, bond behavior was not directly quantified using strain, slip, or interfacial measurements. The experimental results were also compared with analytical predictions based on the Italian guideline CNR-DT 201/2005 and with a simplified section-level interpretation. Overall, the findings indicate that externally bonded FRP laminates can provide a practical upgrading solution for existing Azobé timber members in marina pontoon and waterfront structures, while larger experimental series and direct bond/strain measurements are required for broader validation. Full article

Additively manufactured cellular architectures frequently exhibit brittle failure under impact due to layer-induced stress concentrations. Through the programming of architectural and material design, specifically combining Fused Deposition Modeling (FDM) lattice topology with hyperelastic polyurea infiltration, this study achieves active control over the macroscopic transition from catastrophic structural fragmentation to stable progressive collapse. To evaluate this, auxetic and honeycomb specimens printed with ABS and glass-fiber-reinforced polyamide (PA-GF) were evaluated in unreinforced and polyurea-infiltrated states under quasi-static compression, three-point bending, and Charpy impact loading. Results show that the compressive response depends primarily on cellular topology; the pure auxetic (A-A) configuration provided the highest stiffness and energy absorption. Polyurea infiltration did not significantly alter elastic stiffness but increased post-yield stability, leading to a 96.6% elastic recovery in PA-GF A-A structures. In flexure, the base polymer governed stiffness, with ABS structures measuring 68% stiffer than PA-GF. Unreinforced ABS achieved 34% higher specific energy absorption (SEA) than PA-GF under compression, with the A-H topology maximizing SEA. Under dynamic impact, PA-GF absorbed an average of 70% more energy than ABS, and the H-A configuration recorded the highest impact resistance. The addition of polyurea shifted the failure mode from brittle fragmentation to stable elastomeric deformation, increasing absorbed impact energy by 52% for ABS and over 30% for PA-GF, preventing catastrophic structural failure. Integrating topological sequencing with elastomeric confinement provides a direct method to control energy dissipation and damage tolerance in 3D-printed cellular composites. Full article

Self-drilling hollow bar micropiles (HBMPs), which integrate drilling, grouting, and reinforcement into a single process, have broad application prospects in mountainous transmission lines and offshore wind power projects. However, existing research has focused mainly on friction piles in soil layers, and there is a lack of systematic understanding of the load-transfer mechanism and bearing capacity calculation method for rock-socketed HBMPs. Based on field static load tests of rock-socketed HBMPs, this study systematically investigates the vertical bearing behavior and capacity calculation method of single rock-socketed HBMPs through a combination of test data analysis, finite element numerical simulation, and theoretical analysis. The field test results show that the load-settlement curves of rock-socketed HBMPs are of a slowly varying type, exhibiting mixed friction-end-bearing characteristics. After data screening, the average Q-s curve of Pile No. 1 and Pile No. 5 was taken as the benchmark, and the representative ultimate bearing capacity of a single pile determined by the 40 mm settlement criterion is 5860 kN. The test data of Pile No. 3 and Pile No. 4 were retained as independent validation data. A three-dimensional finite element model considering the cohesive contact behavior at the pile–rock/soil interface was established using ABAQUS. After calibration with the test results, the error between the simulated and measured bearing capacity is −3.4%, demonstrating good model reliability. Parametric analysis indicates that the bearing capacity increases linearly with the grouting volume increase rate $V_{\mathrm{inc}}$, with the expansion effect being the main enhancement mechanism; the improvement amplitude under hard rock conditions is significantly smaller than that in cohesive soils. The effect of uniaxial compressive strength $q_u$ of hard rock on bearing capacity is negligible because the capacity is controlled by the pile–rock interface shear strength. The bearing capacity increases approximately linearly with the rock-socketed depth $L_r$, and a minimum rock-socketed depth of 1.0 m is recommended. Analysis of the load-transfer mechanism shows that rock-socketed HBMPs rely mainly on shaft resistance (accounting for 90.6%), and the axial force decays significantly along the pile length. Elastic compression of the pile accounts for 78% of the pile head settlement, and the limited displacement at the pile tip leads to insufficient mobilization of end bearing. A modified bearing capacity formula considering the grouting expansion effect is established with shaft resistance as the core. A hierarchical validation strategy is adopted to test its predictive ability: for the finite element cases not participating in parameter calibration, the prediction error is within ±2%; for the field test piles, the prediction error is +7.9%; and for Pile No. 3 and Pile No. 4, the errors are +1.7% and −2.1%, respectively. These values are significantly better than those of existing methods (errors ranging from −72.1% to +54.5%). The research results can provide a theoretical basis for the design of single HBMP bearing capacity under rock-socketed conditions. Full article