Large-scale clinical information sharing (CIS) provides significant advantages for medical treatments, including enhanced service standards and accelerated scheduling of health services. The current CIS suffers many challenges such as data privacy, d...
The current healthcare sector is facing difficulty in satisfying the growing issues, expenses, and heavy regulation of quality treatment. Surely, electronic medical records (EMRs) and protected health information (PHI) are highly sensitive, personall...
Medication reconciliation is crucial to prevent medication errors. In Denmark, primary and secondary care physicians can prescribe medication in the same electronic prescribing system known as the Shared Medication Record (SMR). However, the SMR is n...
Accurately predicting patient clinical outcomes is a complex task that requires integrating diverse factors, including individual characteristics, treatment histories, and environmental influences. This challenge is further exacerbated by missing dat...
Unintended pregnancies are an important public health issue. Long-acting reversible contraceptive methods (LARCs) are reliable, safe, highly effective methods for most women; however they are underutilized in the United States. Shared decision aids w...
Digital twins are essentially digital replicas of physical entities. Their usage is becoming more common across various industries, including healthcare. However, the implementation of digital twins in healthcare is uniquely challenging. This is part...
Widespread coordination and sharing of information regarding adverse drug reactions (ADRs) are important for drug safety assessment. However, the actual status of coordination and sharing of information on ADRs in community pharmacies remains unclear...
We sought to incorporate a community-based solution with a family health history (FHH) clinical support program (MeTree) integrated into well-patient appointments with the novel partnership of a public health state-level health information exchange (...
Hypertrophic cardiomyopathy (HCM) is the most common inherited cardiovascular disease with a prevalence of 1 in 500 people and varying clinical presentations. Although there is much research on HCM, underlying molecular mechanisms are poorly understo...
The importance of clinical information related to specimens is increasing due to the research on human biological specifications being conducted worldwide. In order to utilize data, it is necessary to define the range of data and develop a standardiz...
Introduction: Sharing genetic test results with different stakeholders such as family members, healthcare providers and genetic counselors (HCP/GCs), spouses/partners, and friends is a health behavior of clinical importance in genomic medicine. Metho...
Sexual dysfunction is a prevalent and often under-addressed concern among prostate cancer survivors, significantly affecting quality of life for patients and their partners. The True North Sexual Health and Rehabilitation eClinic (SHAReClinic) is a v...
Enabling individualized decision-making for patients requires an understanding of the family context (FC) by healthcare providers. The FC is everything that makes the family unique, from their names, preferred pronouns, family structure, cultural or...
15 April 2025
Background: Sharing substance use disorder (SUD) data is essential for advancing equitable healthcare and improving outcomes for marginalized populations. However, concerns about privacy, stigma, and adherence to data privacy regulations often hinder...
Large-scale next-generation sequencing (NGS) germline testing is technically feasible today, but variant interpretation represents a major bottleneck in analysis workflows. This includes extensive variant prioritization, annotation, and time-consumin...
A meeting that was organized by the Academy of Pharmaceutical Sciences Biopharmaceutics and Regulatory Sciences focus groups focused on the challenges of Developing Clinically Relevant Dissolution Specifications (CRDS) for Oral Drug Products. Industr...
The reuse of paediatric individual patient data (IPD) from clinical trials (CTs) is essential to overcome specific ethical, regulatory, methodological, and economic issues that hinder the progress of paediatric research. Sharing data through reposito...
3 July 2018
Shared decision-making (SDM) has been recognized as an important tool in the mental health field and considered as a crucial component of patient-centered care. Therefore, the purpose of this study was to develop a strategic tool towards the promotio...
Theoretical consideration predicts that the alteration of local and shared information in the brain is a key element in the mechanism of anesthetic-induced unconsciousness. Ordinal pattern analysis, such as permutation entropy (PE) and symbolic mutua...
EPIICAL (Early treated Perinatally HIV-Infected individuals: Improving Children’s Actual Life) is a consortium of European and non-European research-driven organizations inter-connected with the aim of establishing a clinical and experimental p...
Investigational medicinal products submitted over the course of 3 years and authorized at the Clinical Trials Office of the Italian Medicines Agency as part of a request for authorization of clinical trials were scrutinized to identify those encompas...
The translational research community, in general, and the Clinical and Translational Science Awards (CTSA) community, in particular, share the vision of repurposing EHRs for research that will improve the quality of clinical practice. Many members of...
This study explores perceptions and preferences on receiving genetic risk information about hereditary cancer risk in members of the Swedish public. We conducted qualitative content analysis of five focus group discussions with participants (n = 18)...
31 October 2022
Background. Shared decision-making implies that patients and healthcare professionals make decisions together about clinical exams, available treatments, choice of options, and the benefit or downside of every choice. Patients involved in the shared...
Background/Objectives: Clinical decision support systems (CDSSs) consisting of Computerized Physician Order Entry (CPOE) and oncology pathways serve as the foundation of high-quality cancer care. However, the resources needed to develop and maintain...
The rising prevalence of skin lesions places a heavy burden on global health resources and necessitates an early and precise diagnosis for successful treatment. The diagnostic potential of recent multi-modal skin lesion detection algorithms is limite...
1 November 1997
The purpose of this paper is to share information about the digit-(thumb/finger) sucking behavior including how it begins; the biological, psychological and physiological connections; how it becomes perpetuated; problems related to prolonged sucking...
The detection of phleboviruses (family: Phenuiviridae) in human samples is challenged by the overall diversity and genetic complexity of clinically relevant strains, their predominantly nondescript clinical associations, and a related lack of awarene...
Background/Objectives: Cancer is a leading cause of death for Aboriginal and Torres Strait Islander people, with remoteness increasing the risk for poorer outcomes. Primary health care (PHC) clinics have an important role in cancer screening, diagnos...
9 December 2018
The Internet and social media is an enormous source of information. Health social networks and online collaborative environments enable users to create shared content that afterwards can be discussed. The aim of this paper is to present a novel metho...
From a detailed review of 90 experimental and clinical metabolomic investigations of obesity and metabolic dysfunction-associated steatotic liver disease (MASLD), we have developed metabolomic hallmarks for both obesity and MASLD. Obesity studies wer...
Systemic lupus erythematosus (SLE) is a complex autoimmune disease that affects multiple organs and systems with a broad and heterogeneous spectrum of clinical manifestations. National disease-specific datasets and registries are crucial for clinical...
This study proposes DtMin, a novel protocol for implementing data minimization principles in medical information sharing between healthcare providers (HCPs) and electronic health record providers (EHRPs). DtMin utilizes a multi-type encryption approa...
The treatment of acute pain over the years has changed with increasing alternative therapies and increased scrutiny of opioid prescriptions. Shared Decision Making (SDM) has become a vital tool in increasing patient engagement and satisfaction in tre...
Patients, families, healthcare providers and funders face multiple comparable treatment options without knowing which provides the best quality of care. As a step towards improving this, the REthinking Clinical Trials (REaCT) pragmatic trials program...
Among a litany of malignancies affecting the female reproductive tract, that of the ovary is the most frequently fatal. Moreover, while the steady pace of scientific discovery has fuelled recent ameliorations in the outcomes of many other cancers, th...
Background: Aortic stenosis (AS) has long been considered a degenerative disease and is typically diagnosed in older men at an advanced stage. However, accumulating evidence has highlighted the similarities between AS and atherosclerosis, particularl...
14 August 2018
The purpose of this study is to understand among a convenience sample of 400 adults aged 60 years of age or older (1) reasons for being willing or unwilling to participate in a vaccine clinical research study and (2) overall perceptions about vaccine...
The transfer of information is a demanding issue, particularly due to the presence of a large number of eavesdroppers on communication channels. Sharing medical service records between different clinical jobs is a basic and testing research topic. Th...
This report summarizes the proceedings of the inaugural Clinical Epigenetics Conference that was held in Szczecin, Poland, from 8 June 2022. With focus on epigenetic diseases whose causes, progression, and prognosis are associated with aberrant epige...
This demonstration project explored the feasibility of utilizing data from pediatric primary care providers to evaluate the long-term outcomes of children with disorders identified by newborn screening (NBS). Compliance with national guidelines for c...
14 October 2025
Health professionals commonly reference race and ethnicity to inform health care and administrative decisions. However, health researchers (and, arguably, society at large) misapply race and ethnicity when assuming an inherent relationship of these c...
Clinical text classification presents significant challenges in healthcare informatics due to inherent asymmetries in domain-specific terminology, knowledge distribution across specialties, and imbalanced data availability. We introduce MTTL-Clinical...
Events linked to post-traumatic stress disorder (PTSD) influence psychological and physical health through the generation, exacerbation, and maintenance of symptoms such as anxiety, hyperarousal, and avoidance. Depending upon circumstance, traumatic...
Following breakthrough achievements in molecular neurosciences, the current decade witnesses a trend toward interdisciplinary and multimodal development. Supplementation of neurosciences with tools from computer science solidifies previous knowledge...
Clinical data analysis could lead to breakthroughs. However, clinical data contain sensitive information about participants that could be utilized for unethical activities, such as blackmailing, identity theft, mass surveillance, or social engineerin...
The widespread fragmentation of patient information across heterogeneous systems and the lack of standardized integration mechanisms hinder efficient and comprehensive medical diagnostics. To address these limitations, this work presents an architect...
Advances in information technology have harnessed the application of Quick Response (QR) codes in day-to-day activities, simplifying information exchange. QR codes are witnessed almost everywhere, on consumables, newspapers, information bulletins, et...
Background: Rates of contralateral prophylactic mastectomy (CPM) continue to rise internationally despite evidence-based guidance strongly discouraging its use in most women with unilateral breast cancer. The purpose of the present study was to devel...
Introduction: We aimed to characterize the clinical features of moderate forms of COVID-19 requiring hospitalization and potentially identify predictors for unfavorable outcomes. Methods: Pooled anonymized clinical data from 452 COVID-19 patients hos...
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