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23 pages, 3940 KiB  
Article
Recovery Strategies for Combined Optical Storage Systems Based on System Short-Circuit Ratio (SCR) Thresholds
by Qingji Yang, Baohong Li, Qin Jiang and Qiao Peng
Energies 2025, 18(15), 4112; https://doi.org/10.3390/en18154112 (registering DOI) - 3 Aug 2025
Abstract
The penetration rate of variable energy sources in the current power grid is increasing, with the aim being to expand the use of these energy sources and to replace the traditional black start power supply. This study investigates the black start of a [...] Read more.
The penetration rate of variable energy sources in the current power grid is increasing, with the aim being to expand the use of these energy sources and to replace the traditional black start power supply. This study investigates the black start of a photovoltaic storage joint system based on the system’s short-circuit ratio threshold. Firstly, the principles and control modes of the photovoltaic (PV) system, energy storage system (ESS), and high-voltage direct current (DC) transmission system are studied separately to build an overall model; secondly, computational determinations of the short-circuit ratio under different scenarios are introduced to analyze the strength of the system, and the virtual inertia and virtual damping of the PV system are configured based on this; finally, the change trend of the storage system’s state of charge (SOC) is computed and observed, and the limits of what the system can support in each stage are determined. An electromagnetic transient simulation model of a black start system is constructed in PSCAD/EMTDC, and according to the proposed recovery strategy, the system frequency is maintained in the range of 49.4~50.6 Hz during the entire black start process; the fluctuation in maximum frequency after the recovery of the DC transmission system is no more than 0.1%; and the fluctuation in photovoltaic power at each stage is less than 3%. In addition, all the key indexes meet the requirements for black start technology, which verifies the validity of the strategy and provides theoretical support and a practical reference for the black start of a grid with variable energy sources. Full article
(This article belongs to the Special Issue Analysis and Control of Power System Stability)
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13 pages, 739 KiB  
Article
Improved Precision of COPD Exacerbation Detection in Night-Time Cough Monitoring
by Albertus C. den Brinker, Susannah Thackray-Nocera, Michael G. Crooks and Alyn H. Morice
J. Pers. Med. 2025, 15(8), 349; https://doi.org/10.3390/jpm15080349 (registering DOI) - 2 Aug 2025
Abstract
Background/Objectives: Targeting individuals with certain characteristics provides improved precision in many healthcare applications. An alert mechanism for COPD exacerbations has recently been validated. It has been argued that its efficacy improves considerably with stratification. This paper provides an in-depth analysis of the cough [...] Read more.
Background/Objectives: Targeting individuals with certain characteristics provides improved precision in many healthcare applications. An alert mechanism for COPD exacerbations has recently been validated. It has been argued that its efficacy improves considerably with stratification. This paper provides an in-depth analysis of the cough data of the stratified cohort to identify options for and the feasibility of improved precision in the alert mechanism for the intended patient group. Methods: The alert system was extended using a system complementary to the existing one to accommodate observed rapid changes in cough trends. The designed system was tested in a post hoc analysis of the data. The trend data were inspected to consider their meaningfulness for patients and caregivers. Results: While stratification was effective in reducing misses, the augmented alert system improved the sensitivity and number of early alerts for the acute exacerbation of COPD (AE-COPD). The combination of stratification and the augmented mechanism led to sensitivity of 86%, with a false alert rate in the order of 1.5 per year in the target group. The alert system is rule-based, operating on interpretable signals that may provide patients or their caregivers with better insights into the respiratory condition. Conclusions: The augmented alert system operating based on cough trends has the promise of increased precision in detecting AE-COPD in the target group. Since the design and testing of the augmented system were based on the same data, the system needs to be validated. Signals within the alert system are potentially useful for improved self-management in the target group. Full article
(This article belongs to the Section Personalized Therapy and Drug Delivery)
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17 pages, 8148 KiB  
Article
Inland Flood Analysis in Irrigated Agricultural Fields Including Drainage Systems and Pump Stations
by Inhyeok Song, Heesung Lim and Hyunuk An
Water 2025, 17(15), 2299; https://doi.org/10.3390/w17152299 (registering DOI) - 2 Aug 2025
Abstract
Effective flood management in agricultural fields has become increasingly important due to the rising frequency and intensity of rainfall events driven by climate change. This study investigates the applicability of urban flood analysis models—SWMM (1D) and K-Flood (2D)—to irrigated agricultural fields with artificial [...] Read more.
Effective flood management in agricultural fields has become increasingly important due to the rising frequency and intensity of rainfall events driven by climate change. This study investigates the applicability of urban flood analysis models—SWMM (1D) and K-Flood (2D)—to irrigated agricultural fields with artificial drainage systems. A case study was conducted in a rural area near the Sindae drainage station in Cheongju, South Korea, using rainfall data from an extreme weather event in 2017. The models simulated inland flooding and were validated against flood trace maps provided by the Ministry of the Interior and Safety (MOIS). Receiver Operating Characteristic (ROC) analysis showed a true positive rate of 0.565, a false positive rate of 0.21, and an overall accuracy of 0.731, indicating reasonable agreement with observed inundation. Scenario analyses were also conducted to assess the effectiveness of three improvement strategies: reducing the Manning coefficient, increasing pump station capacity, and widening drainage channels. Among them, increasing pump capacity most effectively reduced flood volume, while channel widening had the greatest impact on reducing flood extent. These findings demonstrate the potential of urban flood models for application in agricultural contexts and support data-driven planning for rural flood mitigation. Full article
21 pages, 875 KiB  
Article
Comprehensive Analysis of Neural Network Inference on Embedded Systems: Response Time, Calibration, and Model Optimisation
by Patrick Huber, Ulrich Göhner, Mario Trapp, Jonathan Zender and Rabea Lichtenberg
Sensors 2025, 25(15), 4769; https://doi.org/10.3390/s25154769 (registering DOI) - 2 Aug 2025
Abstract
The response time of Artificial Neural Network (ANN) inference is critical in embedded systems processing sensor data close to the source. This is particularly important in applications such as predictive maintenance, which rely on timely state change predictions. This study enables estimation of [...] Read more.
The response time of Artificial Neural Network (ANN) inference is critical in embedded systems processing sensor data close to the source. This is particularly important in applications such as predictive maintenance, which rely on timely state change predictions. This study enables estimation of model response times based on the underlying platform, highlighting the importance of benchmarking generic ANN applications on edge devices. We analyze the impact of network parameters, activation functions, and single- versus multi-threading on response times. Additionally, potential hardware-related influences, such as clock rate variances, are discussed. The results underline the complexity of task partitioning and scheduling strategies, stressing the need for precise parameter coordination to optimise performance across platforms. This study shows that cutting-edge frameworks do not necessarily perform the required operations automatically for all configurations, which may negatively impact performance. This paper further investigates the influence of network structure on model calibration, quantified using the Expected Calibration Error (ECE), and the limits of potential optimisation opportunities. It also examines the effects of model conversion to Tensorflow Lite (TFLite), highlighting the necessity of considering both performance and calibration when deploying models on embedded systems. Full article
(This article belongs to the Section Fault Diagnosis & Sensors)
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21 pages, 7537 KiB  
Article
Variable Step-Size FxLMS Algorithm Based on Cooperative Coupling of Double Nonlinear Functions
by Jialong Wang, Jian Liao, Lin He, Xiaopeng Tan and Zongbin Chen
Symmetry 2025, 17(8), 1222; https://doi.org/10.3390/sym17081222 (registering DOI) - 2 Aug 2025
Abstract
Based on the principle of symmetry, we propose a variable step-size FxLMS algorithm with double nonlinear functions cooperative coupling (DNVSS-FxLMS), aiming to optimize the contradiction between convergence rate and steady-state error in the active pressure pulsation control system of hydraulic systems. The algorithm [...] Read more.
Based on the principle of symmetry, we propose a variable step-size FxLMS algorithm with double nonlinear functions cooperative coupling (DNVSS-FxLMS), aiming to optimize the contradiction between convergence rate and steady-state error in the active pressure pulsation control system of hydraulic systems. The algorithm innovatively couples two types of nonlinear mechanisms (rational-fractional and exponential-function-based), constructing a refined error-step mapping relationship to achieve a balance between rapid convergence and low steady-state error. Simulation experiments were conducted considering the complex time-varying operating environment of a simulation-based hydraulic system. The results demonstrate that, when the system undergoes unstable random changes, the DNVSS-FxLMS algorithm converges at least twice as fast as traditional and existing variable step size algorithms, while reducing steady-state error by 2–5 dB. The proposed DNVSS-FxLMS algorithm exhibits significant advantages in convergence rate, steady-state error reduction, and tracking capability, providing a highly efficient and robust solution for real-time active control of hydraulic system pressure pulsation under complex operating conditions. Full article
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24 pages, 673 KiB  
Article
Bridge Tower Warning Method Based on Improved Multi-Rate Fusion Under Strong Wind Action
by Yan Shi, Yan Wang, Lu-Nan Wang, Wei-Nan Wang and Tao-Yuan Yang
Buildings 2025, 15(15), 2733; https://doi.org/10.3390/buildings15152733 (registering DOI) - 2 Aug 2025
Abstract
The displacement of bridge towers is relatively large under strong wind action. Changes in tower displacement can reflect the usage status of the bridge towers. Therefore, it is necessary to conduct performance warning research on tower displacement under strong wind action. In this [...] Read more.
The displacement of bridge towers is relatively large under strong wind action. Changes in tower displacement can reflect the usage status of the bridge towers. Therefore, it is necessary to conduct performance warning research on tower displacement under strong wind action. In this paper, the triple standard deviation method, multiple linear regression method, and interpolation method are used to preprocess monitoring data with skipped points and missing anomalies. An improved multi-rate data fusion method, validated using simulated datasets, was applied to correct monitoring data at bridge tower tops. The fused data were used to feed predictive models and generate structural performance alerts. Spectral analysis confirmed that the fused displacement measurements achieve high precision by effectively merging the low-frequency GPS signal with the high-frequency accelerometer signal. Structural integrity monitoring of wind-loaded bridge towers used modeling residuals as alert triggers. The efficacy of this proactive monitoring strategy has been quantitatively validated through statistical evaluation of alarm accuracy rates. Full article
11 pages, 814 KiB  
Article
Validity and Reliability of the Singer Reflux Symptom Score (sRSS)
by Jérôme R. Lechien
J. Pers. Med. 2025, 15(8), 348; https://doi.org/10.3390/jpm15080348 (registering DOI) - 2 Aug 2025
Abstract
Objectives: To investigate the reliability and validity of the Singer Reflux Symptom Score (sRSS), a new patient-reported outcome questionnaire documenting the severity of reflux symptoms in singing voice is proposed. Methods: Amateur and professional singers consulting the European Reflux Clinic for [...] Read more.
Objectives: To investigate the reliability and validity of the Singer Reflux Symptom Score (sRSS), a new patient-reported outcome questionnaire documenting the severity of reflux symptoms in singing voice is proposed. Methods: Amateur and professional singers consulting the European Reflux Clinic for laryngopharyngeal reflux disease (LPRD) symptoms and findings were prospectively recruited from January 2022 to February 2023. The diagnosis was based on a Reflux Symptom Score (RSS) > 13 and Reflux Sign Assessment (RSA) > 14. A control group of asymptomatic singer subjects was recruited from the University of Mons. The sRSS was rated within a 7-day period to assess test–retest reliability. Internal consistency was measured using Cronbach’s α in patients and controls. A correlation analysis was performed between sRSS and Singing Voice Handicap Index (sVHI) to evaluate convergent validity. Responsiveness to change was evaluated through pre- to post-treatment sRSS changes. The sRSS threshold for suggesting a significant impact of LPRD on singing voice was determined by receiver operating characteristic (ROC) analysis. Results: Thirty-three singers with suspected LPRD (51.5% female; mean age: 51.8 ± 17.2 years) were consecutively recruited. Difficulty reaching high notes and vocal fatigue were the most prevalent LPRD-related singing complaints. The sRSS demonstrated high internal consistency (Cronbach-α = 0.832), test–retest reliability, and external validity (correlation with sVHI: r = 0.654; p = 0.015). Singers with suspected LPRD reported a significant higher sRSS compared to 68 controls. sRSS item and total scores significantly reduced from pre-treatment to 3 months post-treatment except for the abnormal voice breathiness item. ROC analysis revealed superior diagnostic accuracy for sRSS (AUC = 0.971) compared to sRSS-quality of life (AUC = 0.926), with an optimal cutoff at sRSS > 38.5 (sensitivity: 90.3%; specificity: 85.0%). Conclusions: The sRSS is a reliable and valid singer-reported outcome questionnaire for documenting singing symptoms associated with LPRD leading to personalized management of Singers. Future large-cohort studies are needed to evaluate its specificity for LPRD compared to other vocal fold disorders in singers. Full article
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23 pages, 2268 KiB  
Article
Potential for Drought Stress Alleviation in Lettuce (Lactuca sativa L.) with Humic Substance-Based Biostimulant Applications
by Santiago Atero-Calvo, Francesco Magro, Giacomo Masetti, Eloy Navarro-León, Begoña Blasco and Juan Manuel Ruiz
Plants 2025, 14(15), 2386; https://doi.org/10.3390/plants14152386 (registering DOI) - 2 Aug 2025
Abstract
In the present study, we evaluated the potential use of a humic substance (HS)-based biostimulant in mitigating drought stress in lettuce (Lactuca sativa L.) by comparing both root and foliar modes of application. To achieve this, lettuce plants were grown in a [...] Read more.
In the present study, we evaluated the potential use of a humic substance (HS)-based biostimulant in mitigating drought stress in lettuce (Lactuca sativa L.) by comparing both root and foliar modes of application. To achieve this, lettuce plants were grown in a growth chamber on a solid substrate composed of vermiculite and perlite (3:1). Plants were exposed to drought conditions (50% of Field Capacity, FC) and 50% FC + HS applied as radicular (‘R’) and foliar (‘F’) at concentrations: R-HS 0.40 and 0.60 mL/L, respectively, and 7.50 and 10.00 mL/L, respectively, along with a control (100% FC). HSs were applied three times at 10-day intervals. Plant growth, nutrient concentration, lipid peroxidation, reactive oxygen species (ROS), and enzymatic and non-enzymatic antioxidants were estimated. Various photosynthetic and chlorophyll fluorescence parameters were also analyzed. The results showed that HS applications alleviated drought stress, increased plant growth, and reduced lipid peroxidation and ROS accumulation. HSs also improved the net photosynthetic rate, carboxylation efficiency, electron transport flux, and water use efficiency. Although foliar HSs showed a greater tendency to enhance shoot growth and photosynthetic capacity, the differences between the application methods were not significant. Hence, in this preliminary work, the HS-based product evaluated in this study demonstrated potential for alleviating drought stress in lettuce plants at the applied doses, regardless of the mode of application. This study highlights HS-based biostimulants as an effective and sustainable tool to improve crop resilience and support sustainable agriculture under climate change. However, further studies under controlled growth chamber conditions are needed to confirm these results before field trials. Full article
(This article belongs to the Special Issue Biostimulation for Abiotic Stress Tolerance in Plants)
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23 pages, 2657 KiB  
Article
Enrichment Cultures of Extreme Acidophiles with Biotechnological Potential
by Khussain Valiyev, Aliya Yskak, Elena Latyuk, Alena Artykova, Rakhimbayev Berik, Vadim Chashkov and Aleksandr Bulaev
Mining 2025, 5(3), 49; https://doi.org/10.3390/mining5030049 (registering DOI) - 1 Aug 2025
Abstract
The purpose of this work was to obtain specialized enrichment cultures from an original extreme acidophilic consortium of extremely acidophilic microorganisms and to study their microbial community composition and biotechnological potential. At temperatures of 25, 35, 40 and 50 °C, distinct enrichments of [...] Read more.
The purpose of this work was to obtain specialized enrichment cultures from an original extreme acidophilic consortium of extremely acidophilic microorganisms and to study their microbial community composition and biotechnological potential. At temperatures of 25, 35, 40 and 50 °C, distinct enrichments of extremely acidophilic microorganisms used in the processes of bioleaching sulfide ores were obtained using nutrient media containing ferrous sulfate, elemental sulfur and a copper sulfide concentrate as nutrient inorganic substrates, with and without the addition of 0.02% yeast extract. The microbial community composition was studied using the sequencing of the V3–V4 hypervariable region of the 16S rRNA genes. The different growth conditions led to changes in the microbial composition and relative abundance of mesophilic and moderately thermophilic, strict autotrophic and mixotrophic microorganisms in members of the genera Acidithiobacillus, Sulfobacillus, Leptospirillum, Acidibacillus, Ferroplasma and Cuniculiplasma. The dynamics of the oxidation of ferrous iron, sulfur, and sulfide minerals (pyrite and chalcopyrite) by the enrichments was also studied in the temperature range of 25 to 50 °C. The study of enrichment cultures using the molecular biological method using the metabarcoding method of variable V3–24 V4 fragments of 16S rRNA genes showed that enrichment cultures obtained under different conditions differed in composition, which can be explained by differences in the physiological properties of the identified microorganisms. Regarding the dynamics of the oxidation of ferrous ions, sulfur, and sulfide minerals (pyrite and chalcopyrite), each enrichment culture was studied at a temperature range of 25 to 50 °C and indicated that all obtained enrichments were capable of oxidizing ferrous iron, sulfur and minerals at different rates. The obtained enrichment cultures may be used in further work to increase bioleaching by using the suitable inoculum for the temperature and process conditions. Full article
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21 pages, 4169 KiB  
Article
An Anisotropic Failure Characteristic- and Damage-Coupled Constitutive Model
by Ruiqing Chen, Jieyu Dai, Shuning Gu, Lang Yang, Laohu Long and Jundong Wang
Modelling 2025, 6(3), 75; https://doi.org/10.3390/modelling6030075 (registering DOI) - 1 Aug 2025
Abstract
This study proposes a coupled constitutive model that captures the anisotropic failure characteristics and damage evolution of nickel-based single-crystal (SX) superalloys under various temperature conditions. The model accounts for both creep rate and material damage evolution, enabling accurate prediction of the typical three-stage [...] Read more.
This study proposes a coupled constitutive model that captures the anisotropic failure characteristics and damage evolution of nickel-based single-crystal (SX) superalloys under various temperature conditions. The model accounts for both creep rate and material damage evolution, enabling accurate prediction of the typical three-stage creep curves, macroscopic fracture morphologies, and microstructural features under uniaxial tensile creep for specimens with different crystallographic orientations. Creep behavior of SX superalloys was simulated under multiple orientations and various temperature-stress conditions using the proposed model. The resulting creep curves aligned well with experimental observations, thereby validating the model’s feasibility and accuracy. Furthermore, a finite element model of cylindrical specimens was established, and simulations of the macroscopic fracture morphology were performed using a user-defined material subroutine. By integrating the rafting theory governed by interfacial energy density, the model successfully predicts the rafting morphology of the microstructure at the fracture surface for different crystallographic orientations. The proposed model maintains low programming complexity and computational cost while effectively predicting the creep life and deformation behavior of anisotropic materials. The model accurately captures the three-stage creep deformation behavior of SX specimens and provides reliable predictions of stress fields and microstructural changes at critical cross-sections. The model demonstrates high accuracy in life prediction, with all predicted results falling within a ±1.5× error band and an average error of 14.6%. Full article
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18 pages, 941 KiB  
Article
Effects of a 16-Week Green Exercise Program on Body Composition, Sleep, and Nature Connection in Postmenopausal Women
by Helena Moreira, Chiara Tuccella, Emília Alves, Andreia Teixeira, Carlos Moreira, Irene Oliveira, Valerio Bonavolontà and Catarina Abrantes
Int. J. Environ. Res. Public Health 2025, 22(8), 1216; https://doi.org/10.3390/ijerph22081216 (registering DOI) - 1 Aug 2025
Abstract
Physical activity, particularly when practiced in natural settings, has well-established benefits for overall health, sleep, and body composition. These effects are especially important for postmenopausal women, although research specifically targeting this population remains limited. The study evaluated a 16-week multicomponent outdoor exercise program [...] Read more.
Physical activity, particularly when practiced in natural settings, has well-established benefits for overall health, sleep, and body composition. These effects are especially important for postmenopausal women, although research specifically targeting this population remains limited. The study evaluated a 16-week multicomponent outdoor exercise program (cardiorespiratory, strength, balance, coordination, and flexibility training) in postmenopausal women, consisting of three 60 min sessions per week. Participants were non-randomly assigned to an experimental group (EG, n = 55) and a control group (CG, n = 20). Measurements were taken at baseline and after 16 weeks, including body composition, sleep (duration and quality), and connection with nature. No significant differences were observed between groups at baseline. After the intervention, the EG and CG presented significant differences (p ≤ 0.01) in the rates of change in body mass, fat mass (FM; −9.26% and −1.21%, respectively), and visceral fat level (VFL; −13.46 points and −3.80 points). These differences were also observed for the sleep fragmentation index (p ≤ 0.01), but not for connection with nature. A significant interaction effect (p < 0.01) of time × group was observed for %FM, VFL, and appendicular skeletal muscle mass. Exercise duration had an effect (p = 0.043) on participants’ personal and affective identification with nature, and the time × group × medication interaction significantly influenced sleep efficiency (p = 0.034). The exercise program proved effective in reducing total and central adiposity levels; however, it did not lead to improvements in sleep duration, sleep quality, or connection with nature. Full article
11 pages, 1695 KiB  
Article
A Pilot Study of the Effect of Locomotor and Mechanical Loads on Elite Rowers During Competition Days
by Ferenc Ihász, Johanna Takács, Zoltán Alföldi, Lili Kósa, Robert Podstawski, Antonio Ferraz, Bożena Hinca, István Barthalos and Zsolt Bálint Katona
Sports 2025, 13(8), 254; https://doi.org/10.3390/sports13080254 (registering DOI) - 1 Aug 2025
Abstract
(1) Background: Fatigue impacts neuromuscular performance, especially in endurance sports like rowing. The aim is to explore how continuous workload affects explosiveness and fatigue progression. This study examines acute fatigue during repeated race events by assessing vertical jump height, force output, and subjective [...] Read more.
(1) Background: Fatigue impacts neuromuscular performance, especially in endurance sports like rowing. The aim is to explore how continuous workload affects explosiveness and fatigue progression. This study examines acute fatigue during repeated race events by assessing vertical jump height, force output, and subjective fatigue over three consecutive days at the 2024 Hungarian National Rowing Championships. (2) Methods: Nine rowers (five women, four men; mean age 20.17 ± 1.73 years) competed in multiple 2000 m races over three days. Lower limb explosiveness was measured via countermovement jump (CMJ) using a Kistler force plate, pre- and post-race. Heart rate data were recorded with Polar Team Pro®. Subjective fatigue was assessed using the ‘Daily Wellness Questionnaire’. (3) Results: We found a significant difference in the pattern of the medians of the force exerted by males during the jump between the results of the Thursday preliminaries (ThuQMe = 13.3) and the second final (ThuF2Me = −75.5). Women showed no notable changes. (4) Conclusion: Repeated high-intensity races induce neuromuscular fatigue in men, reflected in reduced explosiveness and increased subjective fatigue. Future research should incorporate biochemical markers to deepen the understanding of fatigue mechanisms. Full article
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16 pages, 604 KiB  
Article
Once-Weekly Semaglutide Improves Body Composition in Spanish Obese Adults with Type 2 Diabetes: A 48-Week Prospective Real-Life Study
by Irene Caballero-Mateos, Cristóbal Morales-Portillo and Beatriz González Aguilera
J. Clin. Med. 2025, 14(15), 5434; https://doi.org/10.3390/jcm14155434 (registering DOI) - 1 Aug 2025
Abstract
Objective: The objective of this study was to assess changes in body composition, with a specific focus on fat mass (FM) and fat-free mass (FFM), in obese adults with type 2 diabetes (T2D) treated with once-weekly (OW) subcutaneous (s.c.) semaglutide. Methods: This was [...] Read more.
Objective: The objective of this study was to assess changes in body composition, with a specific focus on fat mass (FM) and fat-free mass (FFM), in obese adults with type 2 diabetes (T2D) treated with once-weekly (OW) subcutaneous (s.c.) semaglutide. Methods: This was a single-center, 12-month, real-world, ambispective study (6-month prospective and 6-month retrospective). Body composition parameters were assessed via segmental multifrequency bioelectrical impedance analysis (SMF-BIA). Results: A total of 117 patients with DM2, with a median age of 56 years, a median HbA1c level of 9.4%, and a median body weight of 102.5 kg, were included in the study. The median body weight, body fat mass, and visceral fat significantly decreased at 6 months, with values of −9.3, −7.5, and −1.8 kg, respectively. There were further reductions from 6 to 12 months, albeit at a slower rate. The median skeletal muscle mass significantly decreased at 6 months (−1.2 kg), although no further significant reductions were observed at 12 months. Conclusions: OW s.c. semaglutide for 12 months significantly improved body composition parameters, mainly at the expense of fat mass loss, with the preservation of skeletal muscle mass. These changes are clinically meaningful, since they impact general metabolic health and are associated with improvements in metabolic control and clinical parameters associated with renal and CV risks, as well as presumable improvements in quality of life. Full article
(This article belongs to the Section Endocrinology & Metabolism)
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19 pages, 1721 KiB  
Article
Demography and Biomass Productivity in Colombian Sub-Andean Forests in Cueva de los Guácharos National Park (Huila): A Comparison Between Primary and Secondary Forests
by Laura I. Ramos, Cecilia M. Prada and Pablo R. Stevenson
Forests 2025, 16(8), 1256; https://doi.org/10.3390/f16081256 (registering DOI) - 1 Aug 2025
Abstract
Understanding species composition and forest dynamics is essential for predicting biomass productivity and informing conservation in tropical montane ecosystems. We evaluated floristic, demographic, and biomass changes in eighteen 0.1 ha permanent plots in the Colombian Sub-Andean forest, including both primary (ca. 60 y [...] Read more.
Understanding species composition and forest dynamics is essential for predicting biomass productivity and informing conservation in tropical montane ecosystems. We evaluated floristic, demographic, and biomass changes in eighteen 0.1 ha permanent plots in the Colombian Sub-Andean forest, including both primary (ca. 60 y old) and secondary forests (ca. 30 years old). Two censuses of individuals (DBH ≥ 2.5 cm) were conducted over 7–13 years. We recorded 516 species across 202 genera and 89 families. Floristic composition differed significantly between forest types (PERMANOVA, p = 0.001), and black oak (Trigonobalanus excelsa Lozano, Hern. Cam. & Henao) forests formed distinct assemblages. Demographic rates were higher in secondary forests, with mortality (4.17% yr), recruitment (4.51% yr), and relative growth rate (0.02% yr) exceeding those of primary forests. The mean aboveground biomass accumulation and the rate of annual change were higher in primary forests (447.5 Mg ha−1 and 466.8 Mg ha−1 yr−1, respectively) than in secondary forests (217.2 Mg ha−1 and 217.2 Mg ha−1 yr−1, respectively). Notably, black oak forests showed the greatest biomass accumulation and rate of change in biomass. Annual net biomass production was higher in secondary forests (8.72 Mg ha−1 yr−1) than in primary forests (5.66 Mg ha−1 yr−1). These findings highlight the ecological distinctiveness and recovery potential of secondary Sub-Andean forests and underscore the value of multitemporal monitoring to understand forest resilience and assess vulnerability to environmental change. Full article
(This article belongs to the Special Issue Forest Inventory: The Monitoring of Biomass and Carbon Stocks)
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14 pages, 898 KiB  
Article
Cardiovascular Risk in Rheumatic Patients Treated with JAK Inhibitors: The Role of Traditional and Emerging Biomarkers in a Pilot Study
by Diana Popescu, Minerva Codruta Badescu, Elena Rezus, Daniela Maria Tanase, Anca Ouatu, Nicoleta Dima, Oana-Nicoleta Buliga-Finis, Evelina Maria Gosav, Damiana Costin and Ciprian Rezus
J. Clin. Med. 2025, 14(15), 5433; https://doi.org/10.3390/jcm14155433 (registering DOI) - 1 Aug 2025
Abstract
Background: Despite therapeutic advances, morbidity and mortality remain high in patients with rheumatoid arthritis (RA) and psoriatic arthritis (PsA), primarily due to increased cardiovascular risk. Objectives: Our study aimed to evaluate the cardiovascular risk profile and biomarker dynamics in patients with RA and [...] Read more.
Background: Despite therapeutic advances, morbidity and mortality remain high in patients with rheumatoid arthritis (RA) and psoriatic arthritis (PsA), primarily due to increased cardiovascular risk. Objectives: Our study aimed to evaluate the cardiovascular risk profile and biomarker dynamics in patients with RA and PsA treated with Janus kinase inhibitors (JAKis). To our knowledge, this is the first study assessing Lp(a) levels in this context. Methods: This prospective, observational study assessed 48 adult patients. The follow-up period was 12 months. Traditional cardiovascular risk factors and biological markers, including lipid profile, lipoprotein(a) [Lp(a)], and uric acid (UA), were assessed at baseline and follow-up. Correlations between JAKi therapy, lipid profile changes, and cardiovascular risk factors were investigated. Cox regression analysis was used to identify predictors of non-major cardiovascular events. Results: A strong positive correlation was observed between baseline and 12-month Lp(a) levels (r = 0.926), despite minor statistical shifts. No major cardiovascular events occurred during follow-up; however, 47.9% of patients experienced non-major cardiovascular events (e.g., uncontrolled arterial hypertension, exertional angina, and new-onset arrhythmias). Active smoking [hazard ratio (HR) 9.853, p = 0.005], obesity (HR 3.7460, p = 0.050), and arterial hypertension (HR 1.219, p = 0.021) were independent predictors of these events. UA (HR 1.515, p = 0.040) and total cholesterol (TC) (HR 1.019, p = 0.034) were significant biochemical predictors as well. Elevated baseline Lp(a) combined with these factors was associated with an increased event rate, particularly after age 60. Conclusions: Traditional cardiovascular risk factors remain highly prevalent and predictive, underscoring the need for comprehensive cardiovascular risk management. Lp(a) remained stable and may serve as a complementary biomarker for risk stratification in JAKi-treated patients. Full article
(This article belongs to the Section Immunology)
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