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19 pages, 3032 KiB  
Review
The Microstructure and Modification of the Interfacial Transition Zone in Lightweight Aggregate Concrete: A Review
by Jian Zhou, Yiding Dong, Tong Qiu, Jiaojiao Lv, Peng Guo and Xi Liu
Buildings 2025, 15(15), 2784; https://doi.org/10.3390/buildings15152784 - 6 Aug 2025
Abstract
The interfacial transition zone (ITZ) significantly influences the mechanical properties and durability of lightweight aggregate concrete (LWAC), yet existing research on the ITZ in LWAC remains fragmented due to varied characterization techniques, inconsistent definitions of ITZ thickness and porosity, and the absence of [...] Read more.
The interfacial transition zone (ITZ) significantly influences the mechanical properties and durability of lightweight aggregate concrete (LWAC), yet existing research on the ITZ in LWAC remains fragmented due to varied characterization techniques, inconsistent definitions of ITZ thickness and porosity, and the absence of standardized performance metrics. This review focuses primarily on structural LWAC produced with artificial and natural lightweight aggregates, with intended applications in high-performance civil engineering structures. This review systematically analyzes the microstructure, composition, and physical properties of the ITZ, including porosity, microhardness, and hydration product distribution. Quantitative data from recent studies are highlighted—for instance, incorporating 3% nano-silica increased ITZ bond strength by 134.12% at 3 days and 108.54% at 28 days, while using 10% metakaolin enhanced 28-day compressive strength by 24.6% and reduced chloride diffusion by 81.9%. The review categorizes current ITZ enhancement strategies such as mineral admixtures, nanomaterials, surface coatings, and aggregate pretreatment methods, evaluating their mechanisms, effectiveness, and limitations. By identifying key trends and research gaps—particularly the lack of predictive models and standardized characterization methods—this review aims to synthesize key findings and identify knowledge gaps to support future material design in LWAC. Full article
(This article belongs to the Section Building Materials, and Repair & Renovation)
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8 pages, 844 KiB  
Opinion
Flawed Metrics, Damaging Outcomes: A Rebuttal to the RI2 Integrity Index Targeting Top Indonesian Universities
by Muhammad Iqhrammullah, Derren D. C. H. Rampengan, Muhammad Fadhlal Maula and Ikhwan Amri
Publications 2025, 13(3), 36; https://doi.org/10.3390/publications13030036 - 4 Aug 2025
Viewed by 122
Abstract
The Research Integrity Risk Index (RI2), introduced as a tool to identify universities at risk of compromised research integrity, adopts an overly reductive methodology by combining retraction rates and delisted journal proportions into a single, equally weighted composite score. While its [...] Read more.
The Research Integrity Risk Index (RI2), introduced as a tool to identify universities at risk of compromised research integrity, adopts an overly reductive methodology by combining retraction rates and delisted journal proportions into a single, equally weighted composite score. While its stated aim is to promote accountability, this commentary critiques the RI2 index for its flawed assumptions, lack of empirical validation, and disproportionate penalization of institutions in low- and middle-income countries. We examine how RI2 misinterprets retractions, misuses delisting data, and fails to account for diverse academic publishing environments, particularly in Indonesia, where many high-performing universities are unfairly categorized as “high risk” or “red flag.” The index’s uncritical reliance on opaque delisting decisions, combined with its fixed equal-weighting formula, produces volatile and context-insensitive scores that do not accurately reflect the presence or severity of research misconduct. Moreover, RI2 has gained significant media attention and policy influence despite being based on an unreviewed preprint, with no transparent mechanism for institutional rebuttal or contextual adjustment. By comparing RI2 classifications with established benchmarks such as the Scimago Institution Rankings and drawing from lessons in global development metrics, we argue that RI2, although conceptually innovative, should remain an exploratory framework. It requires rigorous scientific validation before being adopted as a global standard. We also propose flexible weighting schemes, regional calibration, and transparent engagement processes to improve the fairness and reliability of institutional research integrity assessments. Full article
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30 pages, 1142 KiB  
Review
Beyond the Backbone: A Quantitative Review of Deep-Learning Architectures for Tropical Cyclone Track Forecasting
by He Huang, Difei Deng, Liang Hu, Yawen Chen and Nan Sun
Remote Sens. 2025, 17(15), 2675; https://doi.org/10.3390/rs17152675 - 2 Aug 2025
Viewed by 151
Abstract
Accurate forecasting of tropical cyclone (TC) tracks is critical for disaster preparedness and risk mitigation. While traditional numerical weather prediction (NWP) systems have long served as the backbone of operational forecasting, they face limitations in computational cost and sensitivity to initial conditions. In [...] Read more.
Accurate forecasting of tropical cyclone (TC) tracks is critical for disaster preparedness and risk mitigation. While traditional numerical weather prediction (NWP) systems have long served as the backbone of operational forecasting, they face limitations in computational cost and sensitivity to initial conditions. In recent years, deep learning (DL) has emerged as a promising alternative, offering data-driven modeling capabilities for capturing nonlinear spatiotemporal patterns. This paper presents a comprehensive review of DL-based approaches for TC track forecasting. We categorize all DL-based TC tracking models according to the architecture, including recurrent neural networks (RNNs), convolutional neural networks (CNNs), Transformers, graph neural networks (GNNs), generative models, and Fourier-based operators. To enable rigorous performance comparison, we introduce a Unified Geodesic Distance Error (UGDE) metric that standardizes evaluation across diverse studies and lead times. Based on this metric, we conduct a critical comparison of state-of-the-art models and identify key insights into their relative strengths, limitations, and suitable application scenarios. Building on this framework, we conduct a critical cross-model analysis that reveals key trends, performance disparities, and architectural tradeoffs. Our analysis also highlights several persistent challenges, such as long-term forecast degradation, limited physical integration, and generalization to extreme events, pointing toward future directions for developing more robust and operationally viable DL models for TC track forecasting. To support reproducibility and facilitate standardized evaluation, we release an open-source UGDE conversion tool on GitHub. Full article
(This article belongs to the Section AI Remote Sensing)
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23 pages, 3427 KiB  
Article
Visual Narratives and Digital Engagement: Decoding Seoul and Tokyo’s Tourism Identity Through Instagram Analytics
by Seung Chul Yoo and Seung Mi Kang
Tour. Hosp. 2025, 6(3), 149; https://doi.org/10.3390/tourhosp6030149 - 1 Aug 2025
Viewed by 255
Abstract
Social media platforms like Instagram significantly shape destination images and influence tourist behavior. Understanding how different cities are represented and perceived on these platforms is crucial for effective tourism marketing. This study provides a comparative analysis of Instagram content and engagement patterns in [...] Read more.
Social media platforms like Instagram significantly shape destination images and influence tourist behavior. Understanding how different cities are represented and perceived on these platforms is crucial for effective tourism marketing. This study provides a comparative analysis of Instagram content and engagement patterns in Seoul and Tokyo, two major Asian metropolises, to derive actionable marketing insights. We collected and analyzed 59,944 public Instagram posts geotagged or location-tagged within Seoul (n = 29,985) and Tokyo (n = 29,959). We employed a mixed-methods approach involving content categorization using a fine-tuned convolutional neural network (CNN) model, engagement metric analysis (likes, comments), Valence Aware Dictionary and sEntiment Reasoner (VADER) sentiment analysis and thematic classification of comments, geospatial analysis (Kernel Density Estimation [KDE], Moran’s I), and predictive modeling (Gradient Boosting with SHapley Additive exPlanations [SHAP] value analysis). A validation analysis using balanced samples (n = 2000 each) was conducted to address Tokyo’s lower geotagged data proportion. While both cities showed ‘Person’ as the dominant content category, notable differences emerged. Tokyo exhibited higher like-based engagement across categories, particularly for ‘Animal’ and ‘Food’ content, while Seoul generated slightly more comments, often expressing stronger sentiment. Qualitative comment analysis revealed Seoul comments focused more on emotional reactions, whereas Tokyo comments were often shorter, appreciative remarks. Geospatial analysis identified distinct hotspots. The validation analysis confirmed these spatial patterns despite Tokyo’s data limitations. Predictive modeling highlighted hashtag counts as the key engagement driver in Seoul and the presence of people in Tokyo. Seoul and Tokyo project distinct visual narratives and elicit different engagement patterns on Instagram. These findings offer practical implications for destination marketers, suggesting tailored content strategies and location-based campaigns targeting identified hotspots and specific content themes. This study underscores the value of integrating quantitative and qualitative analyses of social media data for nuanced destination marketing insights. Full article
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20 pages, 586 KiB  
Article
Implementing High-Intensity Gait Training in Stroke Rehabilitation: A Real-World Pragmatic Approach
by Jennifer L. Moore, Pia Krøll, Håvard Hansen Berg, Merethe B. Sinnes, Roger Arntsen, Chris E. Henderson, T. George Hornby, Stein Arne Rimehaug, Ingvild Lilleheie and Anders Orpana
J. Clin. Med. 2025, 14(15), 5409; https://doi.org/10.3390/jcm14155409 - 31 Jul 2025
Viewed by 281
Abstract
Background: High-intensity gait training (HIT) is an evidence-based intervention recommended for stroke rehabilitation; however, its implementation in routine practice is inconsistent. This study examined the real-world implementation of HIT in an inpatient rehabilitation setting in Norway, focusing on fidelity, barriers, and knowledge [...] Read more.
Background: High-intensity gait training (HIT) is an evidence-based intervention recommended for stroke rehabilitation; however, its implementation in routine practice is inconsistent. This study examined the real-world implementation of HIT in an inpatient rehabilitation setting in Norway, focusing on fidelity, barriers, and knowledge translation (KT) strategies. Methods: Using the Knowledge-to-Action (KTA) framework, HIT was implemented in three phases: pre-implementation, implementation, and competency. Fidelity metrics and coverage were assessed in 99 participants post-stroke. Barriers and facilitators were documented and categorized using the Consolidated Framework for Implementation Research. Results: HIT was delivered with improved fidelity during the implementation and competency phases, reflected by increased stepping and heart rate metrics. A coverage rate of 52% was achieved. Barriers evolved over time, beginning with logistical and knowledge challenges and shifting toward decision-making complexity. The KT interventions, developed collaboratively by clinicians and external facilitators, supported implementation. Conclusions: Structured pre-implementation planning, clinician engagement, and external facilitation enabled high-fidelity HIT implementation in a real-world setting. Pragmatic, context-sensitive strategies were critical to overcoming evolving barriers. Future research should examine scalable, adaptive KT strategies that balance theoretical guidance with clinical feasibility to sustain evidence-based practice in rehabilitation. Full article
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13 pages, 769 KiB  
Article
A Novel You Only Listen Once (YOLO) Deep Learning Model for Automatic Prominent Bowel Sounds Detection: Feasibility Study in Healthy Subjects
by Rohan Kalahasty, Gayathri Yerrapragada, Jieun Lee, Keerthy Gopalakrishnan, Avneet Kaur, Pratyusha Muddaloor, Divyanshi Sood, Charmy Parikh, Jay Gohri, Gianeshwaree Alias Rachna Panjwani, Naghmeh Asadimanesh, Rabiah Aslam Ansari, Swetha Rapolu, Poonguzhali Elangovan, Shiva Sankari Karuppiah, Vijaya M. Dasari, Scott A. Helgeson, Venkata S. Akshintala and Shivaram P. Arunachalam
Sensors 2025, 25(15), 4735; https://doi.org/10.3390/s25154735 - 31 Jul 2025
Viewed by 263
Abstract
Accurate diagnosis of gastrointestinal (GI) diseases typically requires invasive procedures or imaging studies that pose the risk of various post-procedural complications or involve radiation exposure. Bowel sounds (BSs), though typically described during a GI-focused physical exam, are highly inaccurate and variable, with low [...] Read more.
Accurate diagnosis of gastrointestinal (GI) diseases typically requires invasive procedures or imaging studies that pose the risk of various post-procedural complications or involve radiation exposure. Bowel sounds (BSs), though typically described during a GI-focused physical exam, are highly inaccurate and variable, with low clinical value in diagnosis. Interpretation of the acoustic characteristics of BSs, i.e., using a phonoenterogram (PEG), may aid in diagnosing various GI conditions non-invasively. Use of artificial intelligence (AI) and improvements in computational analysis can enhance the use of PEGs in different GI diseases and lead to a non-invasive, cost-effective diagnostic modality that has not been explored before. The purpose of this work was to develop an automated AI model, You Only Listen Once (YOLO), to detect prominent bowel sounds that can enable real-time analysis for future GI disease detection and diagnosis. A total of 110 2-minute PEGs sampled at 44.1 kHz were recorded using the Eko DUO® stethoscope from eight healthy volunteers at two locations, namely, left upper quadrant (LUQ) and right lower quadrant (RLQ) after IRB approval. The datasets were annotated by trained physicians, categorizing BSs as prominent or obscure using version 1.7 of Label Studio Software®. Each BS recording was split up into 375 ms segments with 200 ms overlap for real-time BS detection. Each segment was binned based on whether it contained a prominent BS, resulting in a dataset of 36,149 non-prominent segments and 6435 prominent segments. Our dataset was divided into training, validation, and test sets (60/20/20% split). A 1D-CNN augmented transformer was trained to classify these segments via the input of Mel-frequency cepstral coefficients. The developed AI model achieved area under the receiver operating curve (ROC) of 0.92, accuracy of 86.6%, precision of 86.85%, and recall of 86.08%. This shows that the 1D-CNN augmented transformer with Mel-frequency cepstral coefficients achieved creditable performance metrics, signifying the YOLO model’s capability to classify prominent bowel sounds that can be further analyzed for various GI diseases. This proof-of-concept study in healthy volunteers demonstrates that automated BS detection can pave the way for developing more intuitive and efficient AI-PEG devices that can be trained and utilized to diagnose various GI conditions. To ensure the robustness and generalizability of these findings, further investigations encompassing a broader cohort, inclusive of both healthy and disease states are needed. Full article
(This article belongs to the Special Issue Biomedical Signals, Images and Healthcare Data Analysis: 2nd Edition)
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37 pages, 7777 KiB  
Review
Cement-Based Electrochemical Systems for Structural Energy Storage: Progress and Prospects
by Haifeng Huang, Shuhao Zhang, Yizhe Wang, Yipu Guo, Chao Zhang and Fulin Qu
Materials 2025, 18(15), 3601; https://doi.org/10.3390/ma18153601 - 31 Jul 2025
Viewed by 285
Abstract
Cement-based batteries (CBBs) are an emerging category of multifunctional materials that combine structural load-bearing capacity with integrated electrochemical energy storage, enabling the development of self-powered infrastructure. Although previous reviews have explored selected aspects of CBB technology, a comprehensive synthesis encompassing system architectures, material [...] Read more.
Cement-based batteries (CBBs) are an emerging category of multifunctional materials that combine structural load-bearing capacity with integrated electrochemical energy storage, enabling the development of self-powered infrastructure. Although previous reviews have explored selected aspects of CBB technology, a comprehensive synthesis encompassing system architectures, material strategies, and performance metrics remains insufficient. In this review, CBB systems are categorized into two representative configurations: probe-type galvanic cells and layered monolithic structures. Their structural characteristics and electrochemical behaviors are critically compared. Strategies to enhance performance include improving ionic conductivity through alkaline pore solutions, facilitating electron transport using carbon-based conductive networks, and incorporating redox-active materials such as zinc–manganese dioxide and nickel–iron couples. Early CBB prototypes demonstrated limited energy densities due to high internal resistance and inefficient utilization of active components. Recent advancements in electrode architecture, including nickel-coated carbon fiber meshes and three-dimensional nickel foam scaffolds, have achieved stable rechargeability across multiple cycles with energy densities surpassing 11 Wh/m2. These findings demonstrate the practical potential of CBBs for both energy storage and additional functionalities, such as strain sensing enabled by conductive cement matrices. This review establishes a critical basis for future development of CBBs as multifunctional structural components in infrastructure applications. Full article
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23 pages, 7839 KiB  
Article
Automated Identification and Analysis of Cracks and Damage in Historical Buildings Using Advanced YOLO-Based Machine Vision Technology
by Kui Gao, Li Chen, Zhiyong Li and Zhifeng Wu
Buildings 2025, 15(15), 2675; https://doi.org/10.3390/buildings15152675 - 29 Jul 2025
Viewed by 195
Abstract
Structural cracks significantly threaten the safety and longevity of historical buildings, which are essential parts of cultural heritage. Conventional inspection techniques, which depend heavily on manual visual evaluations, tend to be inefficient and subjective. This research introduces an automated framework for crack and [...] Read more.
Structural cracks significantly threaten the safety and longevity of historical buildings, which are essential parts of cultural heritage. Conventional inspection techniques, which depend heavily on manual visual evaluations, tend to be inefficient and subjective. This research introduces an automated framework for crack and damage detection using advanced YOLO (You Only Look Once) models, aiming to improve both the accuracy and efficiency of monitoring heritage structures. A dataset comprising 2500 high-resolution images was gathered from historical buildings and categorized into four levels of damage: no damage, minor, moderate, and severe. Following preprocessing and data augmentation, a total of 5000 labeled images were utilized to train and evaluate four YOLO variants: YOLOv5, YOLOv8, YOLOv10, and YOLOv11. The models’ performances were measured using metrics such as precision, recall, mAP@50, mAP@50–95, as well as losses related to bounding box regression, classification, and distribution. Experimental findings reveal that YOLOv10 surpasses other models in multi-target detection and identifying minor damage, achieving higher localization accuracy and faster inference speeds. YOLOv8 and YOLOv11 demonstrate consistent performance and strong adaptability, whereas YOLOv5 converges rapidly but shows weaker validation results. Further testing confirms YOLOv10’s effectiveness across different structural components, including walls, beams, and ceilings. This study highlights the practicality of deep learning-based crack detection methods for preserving building heritage. Future advancements could include combining semantic segmentation networks (e.g., U-Net) with attention mechanisms to further refine detection accuracy in complex scenarios. Full article
(This article belongs to the Special Issue Structural Safety Evaluation and Health Monitoring)
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27 pages, 6584 KiB  
Article
Evaluating Geostatistical and Statistical Merging Methods for Radar–Gauge Rainfall Integration: A Multi-Method Comparative Study
by Xuan-Hien Le, Naoki Koyama, Kei Kikuchi, Yoshihisa Yamanouchi, Akiyoshi Fukaya and Tadashi Yamada
Remote Sens. 2025, 17(15), 2622; https://doi.org/10.3390/rs17152622 - 28 Jul 2025
Viewed by 340
Abstract
Accurate and spatially consistent rainfall estimation is essential for hydrological modeling and flood risk mitigation, especially in mountainous tropical regions with sparse observational networks and highly heterogeneous rainfall. This study presents a comparative analysis of six radar–gauge merging methods, including three statistical approaches—Quantile [...] Read more.
Accurate and spatially consistent rainfall estimation is essential for hydrological modeling and flood risk mitigation, especially in mountainous tropical regions with sparse observational networks and highly heterogeneous rainfall. This study presents a comparative analysis of six radar–gauge merging methods, including three statistical approaches—Quantile Adaptive Gaussian (QAG), Empirical Quantile Mapping (EQM), and radial basis function (RBF)—and three geostatistical approaches—external drift kriging (EDK), Bayesian Kriging (BAK), and Residual Kriging (REK). The evaluation was conducted over the Huong River Basin in Central Vietnam, a region characterized by steep terrain, monsoonal climate, and frequent hydrometeorological extremes. Two observational scenarios were established: Scenario S1 utilized 13 gauges for merging and 7 for independent validation, while Scenario S2 employed all 20 stations. Hourly radar and gauge data from peak rainy months were used for the evaluation. Each method was assessed using continuous metrics (RMSE, MAE, CC, NSE, and KGE), categorical metrics (POD and CSI), and spatial consistency indicators. Results indicate that all merging methods significantly improved the accuracy of rainfall estimates compared to raw radar data. Among them, RBF consistently achieved the highest accuracy, with the lowest RMSE (1.24 mm/h), highest NSE (0.954), and strongest spatial correlation (CC = 0.978) in Scenario S2. RBF also maintained high classification skills across all rainfall categories, including very heavy rain. EDK and BAK performed better with denser gauge input but required recalibration of variogram parameters. EQM and REK yielded moderate performance and had limitations near basin boundaries where gauge coverage was sparse. The results highlight trade-offs between method complexity, spatial accuracy, and robustness. While complex methods like EDK and BAK offer detailed spatial outputs, they require more calibration. Simpler methods are easier to apply across different conditions. RBF emerged as the most practical and transferable option, offering strong generalization, minimal calibration needs, and computational efficiency. These findings provide useful guidance for integrating radar and gauge data in flood-prone, data-scarce regions. Full article
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25 pages, 1583 KiB  
Article
Predicting China’s Provincial Carbon Peak: An Integrated Approach Using Extended STIRPAT and GA-BiLSTM Models
by Lian Chen, Hailan Chen and Yao Guo
Sustainability 2025, 17(15), 6819; https://doi.org/10.3390/su17156819 - 27 Jul 2025
Viewed by 412
Abstract
As China commits to reaching peak carbon emissions and achieving carbon neutrality, accurately predicting the provincial carbon peak year is vital for designing effective, region-specific policies. This study proposes an integrated approach based on extended STIRPAT and GA-BiLSTM models to predict China’s provincial [...] Read more.
As China commits to reaching peak carbon emissions and achieving carbon neutrality, accurately predicting the provincial carbon peak year is vital for designing effective, region-specific policies. This study proposes an integrated approach based on extended STIRPAT and GA-BiLSTM models to predict China’s provincial carbon peak year. First, based on panel data across 30 provinces in China from 2000 to 2023, we construct a multidimensional indicator system that encompasses socioeconomic factors, energy consumption dynamics, and technological innovation using the extended STIRPAT model, which explains 87.42% of the variation in carbon emissions. Second, to improve prediction accuracy, a hybrid model combining GA-optimized BiLSTM networks is proposed, capturing temporal dynamics and optimizing parameters to address issues like overfitting. The GA-BiLSTM model achieves an R2 of 0.9415, significantly outperforming benchmark models with lower error metrics. Third, based on the model constructed above, the peak years are projected for baseline, low-carbon, and high-carbon scenarios. In the low-carbon scenario, 19 provinces are projected to peak before 2030, which is 8 more than in the baseline scenario. Meanwhile, under the high-carbon scenario, some provinces such as Jiangsu and Hebei may fail to peak by 2040. Finally, based on the predicted carbon peak year, provinces are categorized into four pathways—early, recent, later, and non-peaking—to provide targeted policy recommendations. This integrated framework significantly enhances prediction precision and captures regional disparities, enabling tailored decarbonization strategies that support China’s dual carbon goals of balancing economic growth with environmental protection. The approach provides critical insights for region-specific low-carbon transitions and advances sustainable climate policy modeling. Full article
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32 pages, 9845 KiB  
Article
Real-Time Analysis of Millidecade Spectra for Ocean Sound Identification and Wind Speed Quantification
by Mojgan Mirzaei Hotkani, Bruce Martin, Jean Francois Bousquet and Julien Delarue
Acoustics 2025, 7(3), 44; https://doi.org/10.3390/acoustics7030044 - 24 Jul 2025
Viewed by 324
Abstract
This study introduces an algorithm for quantifying oceanic wind speed and identifying sound sources in the local underwater soundscape. Utilizing low-complexity metrics like one-minute spectral kurtosis and power spectral density levels, the algorithm categorizes different soundscapes and estimates wind speed. It detects rain, [...] Read more.
This study introduces an algorithm for quantifying oceanic wind speed and identifying sound sources in the local underwater soundscape. Utilizing low-complexity metrics like one-minute spectral kurtosis and power spectral density levels, the algorithm categorizes different soundscapes and estimates wind speed. It detects rain, vessels, fin and blue whales, as well as clicks and whistles from dolphins. Positioned as a foundational tool for implementing the Ocean Sound Essential Ocean Variable (EOV), it contributes to understanding long-term trends in climate change for sustainable ocean health and predicting threats through forecasts. The proposed soundscape classification algorithm, validated using extensive acoustic recordings (≥32 kHz) collected at various depths and latitudes, demonstrates high performance, achieving an average precision of 89% and an average recall of 86.59% through optimized parameter tuning via a genetic algorithm. Here, wind speed is determined using a cubic function with power spectral density (PSD) at 6 kHz and the MASLUW method, exhibiting strong agreement with satellite data below 15 m/s. Designed for compatibility with low-power electronics, the algorithm can be applied to both archival datasets and real-time data streams. It provides a straightforward metric for ocean monitoring and sound source identification. Full article
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19 pages, 2614 KiB  
Article
Multiparametric Analysis of PET and Quantitative MRI for Identifying Intratumoral Habitats and Characterizing Trastuzumab-Induced Alterations
by Ameer Mansur, Carlos Gallegos, Andrew Burns, Lily Watts, Seth Lee, Patrick Song, Yun Lu and Anna Sorace
Cancers 2025, 17(15), 2422; https://doi.org/10.3390/cancers17152422 - 22 Jul 2025
Viewed by 215
Abstract
Background/Objectives: This study investigates the utility of multiparametric PET/MRI in delineating changes in physiologically distinct intratumoral habitats during trastuzumab-induced alterations in a preclinical HER2+ breast cancer model. Methods: By integrating diffusion-weighted MRI, dynamic contrast-enhanced MRI, [18F]Fluorodeoxyglucose- and [18F]Fluorothymidine-PET, voxel-wise [...] Read more.
Background/Objectives: This study investigates the utility of multiparametric PET/MRI in delineating changes in physiologically distinct intratumoral habitats during trastuzumab-induced alterations in a preclinical HER2+ breast cancer model. Methods: By integrating diffusion-weighted MRI, dynamic contrast-enhanced MRI, [18F]Fluorodeoxyglucose- and [18F]Fluorothymidine-PET, voxel-wise parametric maps were generated capturing cellular density, vascularity, metabolism, and proliferation. BT-474 tumor-bearing mice have high expression of HER2 and, in response to trastuzumab, an anti-HER2 antibody, effectively show changes in proliferation and tumor microenvironment alterations that result in decreases in tumor volume through time. Results: Single imaging metrics and changes in metrics were incapable of identifying treatment-induced alterations early in the course of therapy (day 4) prior to changes in tumor volume. Hierarchical clustering identified five distinct tumor habitats, which enabled longitudinal assessment of early treatment response. Tumor habitats were defined based on imaging metrics related to biology and categorized as highly vascular (HV), hypoxic responding (HRSP), transitional zone (TZ), active tumor (ATMR) and responding (RSP). The HRSP cluster volume significantly decreased in trastuzumab-treated tumors compared to controls by day 4 (p = 0.015). The volume of ATMR cluster was significantly different at baseline between cohorts (p = 0.03). The TZ cluster, indicative of regions transitioning more to necrosis, significantly decreased in treated tumors (p = 0.031), suggesting regions had already transitioned. Multiparametric image clustering showed a significant positive linear correlation with histological multiparametric mapping, with R2 values of 0.56 (HRSP, p = 0.013, 0.64 (ATMR, p = 0.0055), and 0.49 (responding cluster, p = 0.024), confirming the biological relevance of imaging-derived clusters. Conclusions: These findings highlight the potential utility of multiparametric PET/MRI to capture biological alterations prior to any single imaging metric which has potential for better understanding longitudinal changes in biology, stratifying tumors based on those changes, optimizing therapeutic monitoring and advancing precision oncology. Full article
(This article belongs to the Special Issue Application of Advanced Biomedical Imaging in Cancer Treatment)
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18 pages, 4936 KiB  
Review
The Small Frontier: Trends Toward Miniaturization and the Future of Planetary Surface Rovers
by Carrington Chun, Faysal Chowdoury, Muhammad Hassan Tanveer, Sumit Chakravarty and David A. Guerra-Zubiaga
Actuators 2025, 14(7), 356; https://doi.org/10.3390/act14070356 - 20 Jul 2025
Viewed by 460
Abstract
The robotic exploration of space began only five decades ago, and yet in the intervening years, a wide and diverse ecosystem of robotic explorers has been developed for this purpose. Such devices have greatly benefited from miniaturization trends and the increased availability of [...] Read more.
The robotic exploration of space began only five decades ago, and yet in the intervening years, a wide and diverse ecosystem of robotic explorers has been developed for this purpose. Such devices have greatly benefited from miniaturization trends and the increased availability of high-quality commercial off-the-shelf (COTS) components. This review outlines the specific taxonomic distinction between planetary surface rovers and other robotic space exploration vehicles, such as orbiters and landers. Additionally, arguments are made to standardize the classification of planetary rovers by mass into categories similar to those used for orbital satellites. Discussions about recent noteworthy trends toward the miniaturization of planetary rovers are also included, as well as a compilation of previous planetary rovers. This analysis compiles relevant metrics such as the mass, the distance traveled, and the locomotion or actuation technique for previous planetary rovers. Additional details are also examined about archetypal rovers that were chosen as representatives of specific small-scale rover classes. Finally, potential future trends for miniature planetary surface rovers are examined by way of comparison to similar miniaturized orbital robotic explorers known as CubeSats. Based on the existing relationship between CubeSats and their Earth-based simulation equivalents, CanSats, the importance of a potential Earth-based analog for miniature rovers is identified. This research establishes such a device, coining the new term ‘CanBot’ to refer to pathfinding systems that are deployed terrestrially to help develop future planetary surface exploration robots. Establishing this explicit genre of robotic vehicle is intended to provide a unified means for categorizing and encouraging the development of future small-scale rovers. Full article
(This article belongs to the Special Issue Feature Papers in Actuators for Surface Vehicles)
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20 pages, 16432 KiB  
Article
Application of Clustering Methods in Multivariate Data-Based Prospecting Prediction
by Xiaopeng Chang, Minghua Zhang, Liang Chen, Sheng Zhang, Wei Ren and Xiang Zhang
Minerals 2025, 15(7), 760; https://doi.org/10.3390/min15070760 - 20 Jul 2025
Viewed by 236
Abstract
Mining and analyzing information from multiple sources—such as geophysics and geochemistry—is a key aspect of big data-driven mineral prediction. Clustering, which groups large datasets based on distance metrics, is an essential method in multidimensional data analysis. The Two-Step Clustering (TSC) approach offers advantages [...] Read more.
Mining and analyzing information from multiple sources—such as geophysics and geochemistry—is a key aspect of big data-driven mineral prediction. Clustering, which groups large datasets based on distance metrics, is an essential method in multidimensional data analysis. The Two-Step Clustering (TSC) approach offers advantages by handling both categorical and continuous variables and automatically determining the optimal number of clusters. In this study, we applied the TSC method to mineral prediction in the northeastern margin of the Jiaolai Basin by: (i) converting residual gravity and magnetic anomalies into categorical variables using Ward clustering; and (ii) transforming 13 stream sediment elements into independent continuous variables through factor analysis. The results showed that clustering is sensitive to categorical variables and performs better with fewer categories. When variables share similar distribution characteristics, consistency between geophysical discretization and geochemical boundaries also influences clustering results. In this study, the (3 × 4) and (4 × 4) combinations yielded optimal clustering results. Cluster 3 was identified as a favorable zone for gold deposits due to its moderate gravity, low magnetism, and the enrichment in F1 (Ni–Cu–Zn), F2 (W–Mo–Bi), and F3 (As–Sb), indicating a multi-stage, shallow, hydrothermal mineralization process. This study demonstrates the effectiveness of combining Ward clustering for variable transformation with TSC for the integrated analysis of categorical and numerical data, confirming its value in multi-source data research and its potential for further application. Full article
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21 pages, 625 KiB  
Article
An Effective Hybrid Sampling Strategy for Single-Split Evaluation of Classifiers
by Show-Jane Yen, Yue-Shi Lee and Yi-Jie Tang
Electronics 2025, 14(14), 2876; https://doi.org/10.3390/electronics14142876 - 18 Jul 2025
Viewed by 209
Abstract
Evaluating the classification accuracy of machine learning models typically involves multiple rounds of random training/test splits, model retraining, and performance averaging. However, this conventional approach is computationally expensive and time-consuming, especially for large datasets or complex models. To address this issue, we propose [...] Read more.
Evaluating the classification accuracy of machine learning models typically involves multiple rounds of random training/test splits, model retraining, and performance averaging. However, this conventional approach is computationally expensive and time-consuming, especially for large datasets or complex models. To address this issue, we propose an effective sampling approach that selects a single training/test split that closely approximates the results obtained from repeated random sampling. Our approach ensures that the sampled data closely reflects the classification performance of the original dataset. Our methods integrate advanced distribution distance metrics and feature weighting techniques tailored for numerical, categorical, and mixed-type datasets. The experimental results demonstrate that our method achieves over 95% agreement with multi-run average accuracy while reducing the overhead of computations by more than 90%. This approach offers a scalable, resource-efficient alternative for reliable model evaluation, particularly valuable in time-critical or resource-constrained applications. Full article
(This article belongs to the Special Issue Data Retrieval and Data Mining)
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