Search Results (895)

Seasonal thermal stratification in deep reservoirs easily causes bottom hypoxia and a sharp decrease in oxidation–reduction potential (ORP), leading to the pulsed release of internal phosphorus from sediments. Under climate warming, this has become a hot issue for sustainable reservoir eutrophication control. Taking the Quanmin Reservoir in Southwest China as the research object, this study combined high-resolution profile monitoring and a Box–Behnken response surface experiment to construct a semi-empirical model coupling redox threshold effect and Arrhenius kinetics. Results showed that during thermal stratification, the water body below 18 m formed a significant redox gradient, resulting in a 21-fold vertical difference in phosphorus concentration. The response surface experiment confirmed that ORP dominates phosphorus release, and the temperature (T) effect is strictly redox-dependent: warming only promotes phosphorus release under anaerobic conditions (−50 mV), with a 26% increase in release amount when temperature rises from 10 °C to 30 °C, while temperature has a negligible effect under aerobic conditions (+30 mV). Model fitting yielded an ORP critical threshold of −17.2 ± 4.8 mV and a normalized steepness of 0.033 mV⁻¹, indicating joint control by diffusion and reaction. Based on these results, a synergistic regulatory mechanism of redox threshold and temperature was proposed, providing a quantitative basis for reservoir eutrophication management under climate warming. Maintaining ORP above −17 mV through bottom aeration can effectively block internal phosphorus release from the redox threshold perspective, though practical in situ application is constrained by aeration-induced water mixing and microbial variations, and such precise redox control may save energy, supporting the sustainability of reservoir ecosystems and long-term water quality security. Full article

Nitrogen and phosphorus are the primary pollutants responsible for eutrophication in water bodies, and their effective removal is crucial for water environmental protection. Biochar, owing to its porous structure and surface functional groups, exhibits excellent adsorption performance for nitrogen and phosphorus, which can be significantly enhanced through metal modification. In this study, magnetic biochar (MBC) was prepared from spent mushroom substrate via FeCl₃ impregnation and microwave pyrolysis, and its adsorption performance for NH₄⁺ and PO₄³⁻ was systematically evaluated. The physicochemical properties of MBC were characterized using scanning electron microscopy, thermogravimetric analysis, specific surface area and pore structure analysis, vibrating sample magnetometry, and Fourier transform infrared spectroscopy. The results showed that the saturated magnetization of MBC was 7.86 emu/g, the specific surface area was 37 m²/g, and the material exhibited a mesoporous structure with high thermal stability. The adsorption process followed pseudo-second-order kinetics, and the mechanisms involved electrostatic interactions, surface complexation, and pore filling. Isotherm studies indicated that the maximum adsorption capacities of MBC for NH₄⁺ and PO₄³⁻ were 16.25 mg/g and 14.99 mg/g, respectively. Thermodynamic analysis revealed that the adsorption of NH₄⁺ was exothermic, whereas that of PO₄³⁻ was endothermic. Furthermore, MBC maintained an adsorption efficiency of up to 93% after ten adsorption–desorption cycles, demonstrating excellent reusability. Full article

We investigatewhether a finite local information capacity of spacetime can account for the gravitational phenomena commonly attributed to cold dark matter. Starting from a covariant effective-field-theory description, we modelcoarse-grained entropy deposition as a dynamical scalar field $S\left(x\right)$ whose stress–energy tensor contributes to structure formation. The macroscopic action contains a single dimensionless coupling λ multiplying the canonical kinetic term, ensuring ghost-free dynamics and conservation of the associated stress–energy tensor. In a slow-roll regime, defined by a covariant source term $\Gamma \equiv \ddot{S}+3H\dot{S}=0$, where H is the Hubble parameter and overdot denotes derivative with respect to cosmic time, and $|\ddot{S}|\ll H|\dot{S}|$, the entropy sector behaves as pressureless dust at background and in linear order. Implemented in a modified Cosmic Linear Anisotropy Solving System (CLASS) Boltzmann solver, the entropy component fits Planck satellite 2018 cosmic microwave background (CMB) data, baryon acoustic oscillation (BAO) measurements, and the Pantheon + Type Ia supernova sample for $0.5\lesssim \lambda \lesssim 2$, while preserving the linear growth factor to within 0.2% over Euclid space telescope scales. To regulate ultraviolet contributions, we introduce a holographically motivated prescription in which gravitationally active entropy deposition is confined to causal two-surfaces, yielding a $\rho \propto r^{-2}$ halo envelope with a finite-density core determined by local entropy saturation. Fixing the flux scale $\mathcal{A}$ from astrophysical entropy budgets reproduces Milky-Way-mass halos without introducing fine-tuned length scales. Pilot N-body simulations that evolve the entropy field on a staggered grid reproduce the halo mass function down to ${10}^{10.5}{M}_{\odot }$, mitigate the cusp–core and missing-satellite tensions, and remain consistent with cluster lensing constraints. On linear scales, the model predicts percent-level, scale-dependent deviations in the lensing convergence and matter power spectra, testable by Euclid space telescope, the Roman Space Telescope High Latitude Survey, and the CMB-S4 experiment. Full article

Background/Objectives: This study aimed to quantify the kinetic demands of multiple hops in series, movement tasks that are commonly used in strength and conditioning and physiotherapeutic practice. Focus was placed on comparing the demands of a quintuple hop (QH) task to a triple hop (TH) task, with particular focus on quantifying the eccentric braking stretch-load demands. Methods: Forty-four male university athletes (age 20.1 ± 1.4 years; body mass 71.2 ± 8.6 kg; stature 171.9 ± 5.1 cm) completed the hopping tasks across 54× track-embedded force platforms, where braking and propulsion kinetics were measured. Results: Significant (p < 0.001) averaged increases in maximal vertical (~32%) and horizontal braking impulses (~56%) for both TH and QH tasks were noted across hops. The last two hops of the QH task were found to have greater averaged vertical (~58%) and horizontal (~180%) stretch-load demands than the two initial hops (p < 0.001). Conclusions: This is the first study where an extensive summary of kinetic measures for both TH and QH has been reported. The findings highlight the biomechanical, stretch-load aspects of these exercises, which can help practitioners better prescribe and program hops for injury prevention, rehabilitation, and performance enhancement. Full article

Background/Objectives: Chromium picolinate [Cr(pic)₃] supplementation and strength training (ST) have been proposed as strategies to improve metabolic health in obesity; however, their combined effects on cardiac cellular function remain unclear. This study evaluated the impact of Cr(pic)₃ supplementation associated with ST on body composition, metabolic parameters, cardiac morphology, and cardiomyocyte contractile function in diet-induced obese rats. Methods: Male Wistar rats were fed a high-fat diet and allocated into four groups for 8 weeks: obese sedentary (Ob), obese + ST (ObST), obese + Cr(pic)₃ (ObCr(pic)₃), and obese + ST + Cr(pic)₃ (ObSTCr(pic)₃). Chromium picolinate (80 μg/kg/day) was administered by gavage, and ST was performed using a ladder-climbing protocol three times per week. Nutritional, metabolic, cardiac morphological, and isolated cardiomyocyte contractile parameters were assessed. A significance level of 5% was set for all tests. Results: Neither ST nor Cr(pic)₃, alone or combined, modified adiposity index, glucose tolerance, insulin resistance, lipid profile (except HDL), or cardiac morphology. ST improved maximal load capacity in trained groups, confirming protocol efficacy. HDL levels were higher in the combined intervention group compared with obese sedentary rats. Cardiomyocyte fractional shortening and maximal contraction and relaxation velocities were unchanged among groups. However, the association of ST and Cr(pic)₃ resulted in prolonged time to 50% relaxation, indicating delayed relaxation kinetics without alterations in contractile performance. Conclusions: These findings suggest that Cr(pic)₃ supplementation does not enhance metabolic adaptations to ST and may adversely affect cardiomyocyte relaxation dynamics in obesity. Full article

Contamination of water bodies by emulsified gasoline hydrocarbons, particularly BTEX compounds (benzene, toluene, ethylbenzene, and xylenes), represents a critical environmental challenge due to their toxicity and resistance to conventional treatment methods. In this study, carbonized biosorbents derived from rice husk (CRH) and walnut shell (CWS) were developed for efficient removal of emulsified gasoline from water. The materials were prepared via carbonization under CO₂ atmosphere (300–800 °C), enabling simultaneous carbonization and activation. Structural and surface properties were characterized using Brunauer–Emmett–Teller (BET) analysis, scanning electron microscopy (SEM), Fourier-transform infrared spectroscopy (FTIR), X-ray diffraction (XRD), and X-ray fluorescence spectroscopy (XRF). The results demonstrated a strong dependence of adsorption performance on carbonization temperature, with maximum removal efficiencies of 90.2% (CRH-600) and 96.5% (CWS-700). The superior performance of CWS-700 was associated with its highly developed hierarchical pore structure (up to 670 m² g⁻¹), increased carbon content, and enhanced hydrophobicity. Kinetic studies revealed pseudo-second-order behavior, with equilibrium achieved within 25–30 min at near-neutral pH. Gas chromatographic analysis confirmed the complete removal of BTEX and light hydrocarbons (C1–C9) using CWS-700, highlighting its high selectivity toward aromatic compounds. The adsorption mechanism was attributed to the synergistic effect of micropore filling, hydrophobic interactions, and π-π interactions with aromatic hydrocarbons. The obtained results demonstrate that biomass-derived carbon materials, particularly walnut shell-based sorbents, are promising low-cost candidates for the treatment of complex water systems contaminated with emulsified petroleum hydrocarbons. Full article

Vertical ground reaction force is an important parameter for describing the developmental characteristics of young children’s vertical jumping. However, its application in large-scale physical fitness monitoring and routine teaching practice is greatly limited. Previous studies have used OpenCap to estimate vertical ground reaction force during adult jumping tasks and have provided preliminary validation, but its effectiveness in young children remains unclear. To examine the correlation and agreement of vertical ground reaction force (GRF) estimated by the OpenCap markerless motion capture system during young children’s vertical jumping and to explore the characteristics of vertical GRF estimated by OpenCap during the vertical jump. Kinematic and kinetic data during vertical jumping were synchronously collected from 16 young children using the OpenCap markerless motion capture system and a three-dimensional force platform, with each child completing three trials. Kinematic data were acquired using the OpenCap markerless motion capture system, and the vertical acceleration of the whole-body center of mass was calculated to estimate vertical GRF based on Newton’s second law. Pearson linear correlation analysis and Bland–Altman analysis were used to examine the differences in characteristics between the estimated vertical GRF and the measured vertical GRF. The vertical GRF characteristics estimated by OpenCap showed moderate-to-high correlations with the measured values. Specifically, the time and mean impulse during the push-off phase, flight phase, and landing stabilization phase were highly correlated (r > 0.85), while the peak force and mean force during the push-off phase showed moderate-to-high correlations (r > 0.7). Bland–Altman analysis showed that the bias in time and impulse during the vertical jump was less than 15%, indicating relatively high agreement; however, the bias in peak force during the landing phase exceeded 40%, indicating weak agreement. These results suggest that the OpenCap markerless motion capture system can effectively estimate vertical GRF characteristics during young children’s vertical jumping, with the best performance observed for vertical GRF variables in the push-off phase. The method used in this study may be applied to obtain vertical GRF during young children’s vertical jumping in non-laboratory settings and to assist in evaluating the developmental level of young children’s vertical jump performance. Nevertheless, OpenCap-derived rapid impact variables, particularly landing peak force, should be interpreted with caution. Full article

High-entropy alloys and the broader class of compositionally complex alloys have recently attracted significant attention as promising materials for solid-state hydrogen storage. Their potential arises not only from high configurational entropy but also from the possibility of tailoring phase composition, crystal structure, local chemical environment, and defect states that govern hydrogen sorption thermodynamics and kinetics. This review summarizes current understanding of hydrogen interaction mechanisms in HEAs and discusses the role of body-centered cubic (BCC), face-centered cubic (FCC), and Laves phases in determining hydrogen capacity, reversibility, and cyclic stability. The limitations of commonly used descriptors, including valence electron concentration (VEC), atomic size mismatch δ, enthalpy of mixing ΔH_mix, and Ω parameter, in predicting hydrogen storage behavior are critically analyzed. Particular attention is given to the effects of processing methods, phase transformations during hydrogenation/dehydrogenation, and the energetic heterogeneity of interstitial sites in multicomponent systems. The review highlights that future progress will depend on the transition from empirical alloy discovery toward physically informed multiparametric design integrating CALPHAD, DFT modeling, machine learning, and in situ/operando characterization techniques for the development of efficient and durable hydrogen storage materials. Full article

Bovine herpesvirus type 1 (BoHV-1) causes severe respiratory and reproductive diseases in cattle, leading to significant economic losses worldwide. Current inactivated vaccines in China fail to induce robust cellular immunity and cannot differentiate infected from vaccinated animals (DIVA). To address these limitations, we constructed two triple-gene-deleted BoHV-1 vaccine candidates, ∆T3 (∆TK-∆gE/gI) and ∆g3 (∆gG-∆gE/gI), using Red/ET two-step recombination technology based on an infectious BAC clone. Their safety and immunogenicity were evaluated in a rabbit model. Both deletion mutants exhibited growth kinetics similar to the wild-type strain but with significantly reduced viral titers and plaque areas. The triple-gene deletion mutants showed superior safety compared with single-gene deletion mutants, with minimal clinical signs and low viral shedding. Immunization with ∆T3 and ∆g3 induced robust gB-specific and neutralizing antibody responses. Following challenge with the virulent BoHV-1 BC01 strain, vaccinated rabbits maintained normal body temperatures, showed significantly reduced viral shedding (approximately 100-fold), and exhibited milder pulmonary lesions. These findings demonstrate that ∆T3 high-dose and ∆g3 low-dose regimens are promising DIVA-compatible vaccine candidates, offering an effective strategy for IBR control and eradication programs. Full article

Objective: Posaconazole, a second-generation triazole antifungal used for the prevention or treatment of invasive fungal infections, has been shown to markedly increase tacrolimus exposure in vivo when co-administered, potentially leading to clinically significant adverse events. A physiologically based pharmacokinetic (PBPK) model was developed to predict tacrolimus–posaconazole interactions in renal transplant recipients with different CYP3A5 genotypes, to inform tacrolimus dose adjustment in clinical practice. Methods: First, to obtain the critical inhibition parameters, in vitro enzyme kinetic studies were conducted. Based on these data, a whole-body physiologically based pharmacokinetic (PBPK) model for TAC was developed and validated in PK-Sim. A published, validated posaconazole PBPK model was applied concurrently. Model performance was evaluated against published pharmacokinetic data in healthy volunteers receiving tacrolimus with posaconazole. A virtual Chinese renal transplant recipient was generated by incorporating population-specific physiological parameters, including CYP3A5 genotype-dependent enzyme expression. Results: In vitro experimental results demonstrated that POSA acts as a potent reversible competitive inhibitor of CYP3A4/5-mediated TAC metabolism. The tacrolimus PBPK model adequately captured pharmacokinetics across CYP3A5 genotypes, and tacrolimus pharmacokinetics during co-administration with posaconazole were also predicted. Compared with CYP3A5 expressers, nonexpressers showed greater variability in tacrolimus whole-blood concentrations and greater susceptibility to posaconazole-mediated interactions. The CYP3A5*3*3 genotype was associated with higher C_max and AUC. Dose optimization simulations predicted that after 6–7 days of posaconazole co-administration, nonexpressers would require the reduction of tacrolimus dosing frequency from every 12 h to every 24 h to maintain trough concentrations within 8–15 ng/mL, whereas a 50% dose reduction was predicted to be optimal for expressers. Conclusions: A tacrolimus–posaconazole PBPK drug–drug interaction model was developed for the population of renal transplant recipients and used to simulate tacrolimus trough concentrations across CYP3A5 genotypes and dosing regimens, supporting genotype-informed co-administration in clinical practice. Full article

Fatal free falls (FFF) represent a distinct form of blunt force trauma and pose a significant challenge in forensic investigations, particularly in estimating fall height and differentiating between accidental and suicidal events. Postmortem computed tomography (PMCT) enables detailed assessment of skeletal injuries, including quantitative evaluation of skull fracture patterns. Total Cranial Fracture Length (TCFL), derived from three-dimensional CT skull fracture scoring (3D-CT-SF), has been proposed as an objective indicator of impact severity; however, available evidence remains limited. This study aimed to assess the relationship between TCFL and fall height in fatal free falls and to evaluate the influence of selected anthropometric and biomechanical variables on cranial fracture severity. A retrospective analysis of 76 fatal free-fall cases examined between 2016 and 2024 was conducted using PMCT and autopsy data. TCFL was measured on three-dimensional volume-rendered CT reconstructions of calvarial fractures. Statistical analyses were performed for the entire cohort and separately for accidental and suicidal falls. No significant correlation between TCFL and fall height was observed in the overall cohort or among suicide cases. In contrast, a significant negative correlation between TCFL and fall height category was identified in accidental falls. TCFL showed significant positive correlations with body mass, body mass index (BMI), and kinetic energy, particularly in the suicide subgroup. TCFL is a promising objective parameter for assessing the severity of cranial injury in fatal free-fall cases. While its utility in estimating fall height appears limited in suicidal falls, TCFL may support forensic interpretation of fall dynamics and contribute to distinguishing the manner of death, especially in accidental cases. Further studies in larger, more diverse populations are warranted. Full article

In this study, zinc-modified biochar (ZBC) was prepared from rose willow, and NiCoMn-LDHs@ZBC composites were synthesized using a hydrothermal method. The composites were characterized by X-ray diffraction (XRD), Brunauer–Emmett–Teller (BET) surface area analysis, scanning electron microscopy with energy-dispersive X-ray spectroscopy (SEM-EDS), transmission electron microscopy (TEM), Fourier transform infrared spectroscopy (FTIR), and X-ray photoelectron spectroscopy (XPS). The adsorption mechanism of As(V) from aqueous solution onto NiCoMn-LDHs@ZBC was investigated through a series of arsenic adsorption experiments. The effects of various experimental parameters (including adsorbent composition and ratio, adsorbent dosage, solution pH, contact time, temperature, and coexisting ions) on the adsorption capacity were evaluated. Additionally, adsorption model fitting and kinetic analysis were conducted. The results indicate that the adsorption process follows the pseudo-second-order kinetic model (linear correlation coefficient R² = 0.99), while the isothermal adsorption process adheres to the Langmuir model, with a maximum adsorption capacity of 159.780 mg/g. The adsorption process is primarily dominated by chemisorption and involves three pathways: first, electrostatic attraction between the material surface and arsenic-containing ions; second, ion exchange between arsenic-containing ions and interlayer carbonate ions; and third, coordination reactions between the surface hydroxyl groups (-OH) of NiCoMn-LDHs@ZBC and As, forming As-O-M inner-sphere complexes as adsorption proceeds. Furthermore, the NiCoMn-LDHs@ZBC composite exhibits relatively stable reusability, demonstrating significant potential for the treatment of arsenic pollution in water bodies. Full article

Background/Objectives: BPC-157 (body protection compound 157) is a synthetic pentadecapeptide derived from a gastric protein fragment with reported cytoprotective and regenerative properties across multiple organ systems. Despite over three decades of preclinical research demonstrating consistent biological activity, its pharmaceutical development remains rudimentary, with no approved formulation, no validated dosing regimen, and no completed Phase II clinical trial. This review critically evaluates BPC-157 from a biopharmaceutical and drug development perspective, examining its physicochemical and pharmacokinetic properties, formulation challenges across routes of administration, the pharmacokinetic–pharmacodynamic disconnect that characterizes its preclinical profile, and the regulatory and translational barriers that currently preclude clinical advancement. Methods: A narrative review of the literature was conducted using PubMed/MEDLINE, Embase, and Cochrane Library from database inception to April 2026. Search terms included “BPC-157”, “BPC157”, “body protection compound 157”, “pentadecapeptide”, and “GEPPPGKPADDAGLV”, each combined with “pharmacokinetics”, “formulation”, “biopharmaceutics”, “drug delivery”, “clinical trial”, “toxicology”, and “regulatory”. Patent databases (Espacenet, Google Patents) and regulatory agency websites (FDA, EMA, WADA) were searched independently. Searches were supplemented by forward and backward citation tracking of key references. Articles were selected based on relevance to biopharmaceutical characterization, pharmacokinetics, formulation science, clinical evidence, and regulatory status; pharmacodynamic studies were included insofar as they inform translational development. Evidence was synthesized with emphasis on pharmaceutical characterization, formulation science, and translational feasibility; no formal quality assessment instrument was applied, consistent with the narrative review design. Results: BPC-157 exhibits unusual stability in gastric juice and demonstrates activity via oral, parenteral, and topical routes, yet its human pharmacokinetic profile remains critically undercharacterized despite a recently published formal preclinical ADME study in two species confirming a sub-30-min plasma half-life, linear dose-proportional kinetics, and intramuscular bioavailability of 14–51% depending on species. A plasma half-life of under 30 min—confirmed preclinically and in a preliminary two-subject human pilot—contrasts with prolonged biological effects lasting hours to days—a disconnect with significant implications for dosing strategy and formulation design. No pharmaceutical-grade formulation has been developed or validated. The peptide lacks bcs classification data, permeability characterization, and formal excipient compatibility studies. Available clinical data derive from fewer than 30 subjects across three uncontrolled pilot studies, none of which employed standardized pharmaceutical preparations. Conclusions: BPC-157 presents a compelling but pharmaceutically underdeveloped profile. The primary barrier to clinical translation is not the absence of biological activity, but the absence of fundamental pharmaceutical science: characterized formulations, validated pharmacokinetics, and a coherent drug development strategy. Addressing these biopharmaceutical gaps is a prerequisite for any meaningful clinical program. Full article

Background/Objectives: This study presents the development of an activated carbon/sodium alginate-based gastric-retentive delivery system aimed at enhancing the gastroprotective efficacy of eugenol (Eug) in simulated body fluids. Methods: Hybrid hydrogel beads were fabricated using tea waste-derived activated carbon (AC) as a core material and sodium alginate as a wall material. Results: The system achieved a loading capacity of 3.37 ± 0.11 mg Eug/g hydrogel beads, and in vitro assays revealed a controlled release profile, with cumulative release reaching 0.694 ± 0.006 mg/g hydrogel beads in simulated gastric fluid (SGF) and 0.198 ± 0.002 mg Eug/g hydrogel beads in simulated intestinal fluid (SIF). Conclusions: Kinetic modeling confirmed a predominantly diffusion-controlled process with non-Fickian transport mechanism, indicating combined diffusion and matrix relaxation. By maintaining local therapeutic concentrations in the gastric mucosa, this pH-responsive Alg/Eug@AC system offers a sustainable strategy to overcome Eug’s low bioavailability and provide effective gastroprotection against oxidative damage. Full article

Background: The Closed Kinetic Chain Upper Extremity Stability Test (CKCUEST) is used to assess upper-extremity performance in a closed kinetic chain position. The standard hand placement of 36 inches may favor individuals with larger body dimensions. Methods: Sixty-five healthy adults (44 males, 21 females; 18–33 years) performed the CKCUEST under two conditions: the standard position and a modified position with hand distance set at 50% of arm span. The mean number of touches, standard score, and power score were calculated for each condition. Reliability and the effects of sex and body composition were also examined. Results: Performance was significantly better in the modified position for mean touches (24.4 ± 4.47 vs. 23.0 ± 4.62, p = 0.001), standard score (0.4 ± 0.07 vs. 0.3 ± 0.06, p = 0.001), and power (81.1 ± 18.29 vs. 77.1 ± 22.00, p = 0.001). Both conditions showed excellent reliability (ICC = 0.944–0.946). Females performed significantly fewer touches than males in the standard position (p = 0.001), whereas this difference was not significant in the modified position. Several anthropometric and body composition variables significantly predicted performance. Conclusions: An arm-span-adjusted hand position improves CKCUEST performance and may provide a fairer assessment across individuals with different body dimensions. Full article