Search Results (659)

To address the polarization fading noise in coherent detection phase-sensitive optical time-domain reflectometry (Φ-OTDR) for distributed low-frequency vibration sensing, a Φ-OTDR sensing scheme integrating polarization diversity reception and the variational mode decomposition (VMD) algorithm is proposed. The mechanism of polarization fading induced by fiber birefringence and external perturbations is systematically analyzed. A signal–noise mathematical model for polarization diversity reception is established, and the adaptive decomposition capability of the VMD algorithm for non-stationary phase signals is elaborated. This scheme can accurately separate the additional noise introduced by polarization diversity reception from the target low-frequency vibration signals. Experimental results demonstrate that, compared with the single-path detection scheme, the proposed method eliminates the amplitude attenuation of beat frequency signals caused by polarization mismatch at the optical path level. Meanwhile, it effectively suppresses both the additional noise introduced by polarization diversity and the low-frequency phase drift resulting from unstable laser frequency. It achieves precise phase restoration of vibration signals excited at 50 Hz under three typical sensing distances of 5 km, 10 km, and 30 km. Additionally, it successfully restores low-frequency vibration signals as low as 0.6 Hz at the sensing distance of 30 km. Full article

Background: Standardized and ethically compliant animal models remain essential for improving translational research in Alzheimer’s disease. Although Aβ_1–42-induced rodent models are widely used, methodological variability continues to limit reproducibility. Methods: We explored the feasibility of a stereotactic intrahippocampal Aβ_1–42 rat model established by bilaterally injecting pre-aggregated peptide into the hippocampus of adult Sprague Dawley rats. Model feasibility and targeting accuracy were assessed intraoperatively. Cognitive performance was evaluated using the Y-maze for spatial recognition memory and the novel object recognition (NOR) test. Histological examination was performed using hematoxylin–eosin (H&E) and Congo red staining to assess cytoarchitecture and to provide supportive evidence of amyloid-like deposits. Results: The surgical procedure was well-tolerated, and the injected animals showed reduced performance in behavioural testing, including reduced spatial recognition memory in the Y-maze and decreased discrimination indices in the NOR test. The animals also showed histological changes, including Congo red-positive birefringent structures consistent with amyloid-like congophilic material. Conclusions: This study presents a feasible experimental framework for intrahippocampal Aβ_1–42 administration, showing behavioural and histological changes under the present experimental conditions. However, further validation, including sham-operated controls and molecular characterization, will be required before these findings can be interpreted as specific to Aβ-driven pathology. Full article

Traditional polymer-dispersed liquid crystal (PDLC) faces limitations in smart dimming applications due to high driving voltage and poor high-temperature stability. In this study, a high-birefringence liquid crystal (QYPDLC-901) was used to prepare PDLC films with liquid crystal contents ranging from 72 wt% to 80 wt%, achieved through synergistic regulation of a low-functional acrylic polymer system and a low-intensity curing process. The effects of liquid crystal content, cell gap, and temperature on electro-optical properties were systematically investigated. Optimal performance was obtained at a liquid crystal content of 77 wt%, with a low threshold voltage of 2.9 V, saturation voltage of 7 V, fast response (rise time 4.2 ms, decay time 47 ms), and a favorable balance between high on-state and low off-state transmittance. Microstructural analysis revealed that the superior performance results from uniform droplet dispersion and low interfacial energy. Furthermore, the PDLC exhibited excellent switching stability from 23 °C to 90 °C, maintaining a maximum transmittance of 93% at 90 °C, with increases of only 0.4 V in threshold voltage and 0.1 V in saturation voltage. This study provides an experimental basis for designing smart dimming devices suitable for low-voltage driving and extreme environments. Full article

Vertical-External-Cavity Surface-Emitting Lasers (VECSELs) have gained significant attention over the past two decades due to their versatility in a wide range of photonic applications. This review focuses on VECSEL configurations for dual-wavelength emission, highlighting their use in high-resolution spectroscopy, terahertz (THz) generation, and advanced optical communication. We explore recent developments in VECSEL designs, including systems utilizing birefringent crystals for polarization-based frequency separation and configurations with dual-VECSEL chips or dual-gain regions within a single cavity. These two-wavelength VECSELs enable diverse operation modes, including narrow-linewidth, pulsed, multimode, and frequency-converted emission, with high-brightness output, excellent beam quality, and tunable wavelengths. Additionally, the review discusses advancements in dual-frequency VECSELs, with applications in LIDAR systems for environmental monitoring, highly stable optical clocks, and fiber sensors. We examine improvements in cavity design, semiconductor structures, and power stabilization, which have enhanced frequency stability and spectral purity, making VECSELs suitable for precision metrology and sensing applications. Full article

Birefringence, arising from the low-symmetry structure in orthorhombic LaFeO₃, limits the observation and utilization of magneto-optical effects. In this study, the pure-phase perovskite-typed La_1−xCe_xFe_1−xTi_xO₃/SiO₂ thin films were successfully fabricated via radio-frequency magnetron sputtering, where the co-doping of Ce³⁺ and Ti⁴⁺ ions effectively induced a structure transition from orthorhombic to a highly symmetric cubic phase, eliminating birefringence effect and thus reducing optical transmission loss. At the same time, the doped Ce³⁺ ions also effectively enhanced the magnetic and magneto-optical effects of the system due to their strong spin coupling effect and superexchange interaction with Fe³⁺ ions. The results show that the cubic-phase La_0.5Ce_0.5Fe_0.5Ti_0.5O₃/SiO₂ thin film exhibits excellent magnetic and magneto-optical performance. Their saturation magnetization reaches 180 emu/cm³ with an in-plane easy magnetic axis. And their magnetic circular dichroic ellipticity |ψ_F| reaches 3054 degrees/cm. Full article

Second harmonic (SH) radiation can only be generated in non-centrosymmetric bulk crystals under electric dipole approximation. Nonlinear thin films made from bulk crystals are technologically challenging because of complex and high-temperature fabrication processes. In this work, heterostructures made of two distinct amorphous materials, namely SiO₂ and TiO₂, were prepared through plasma-enhanced atomic layer deposition (PEALD) with deposition temperature of 100 °C. By using the uniaxial dispersion model, we characterized the form birefringence of the deposited films, which can play a crucial role for the phase-matching condition in nonlinear waveguides or other nonlinear optical applications. By applying a fringe-based technique, we determined the largest diagonal component of the effective bulk second-order susceptibility, ${\chi }_{zzz}^{\left(2\right)}$ = 1.30 ± 0.13 pm/V, at a wavelength of 1032 nm. Noteworthy, we observed strong SHG signals from two-component nanolaminates, which are several orders of magnitude larger than those from single layers. The SHG signals from our samples only require the broken inversion symmetry at the interface. Here, optical properties of nanocomposites can be precisely engineered using the promising PEALD technology. Full article

The effect of structure on the properties of cotton fibers is yet to be fully understood even after many years of research. This is due to the presence of convolutions that occur at various intervals in cotton fibers. An attempt was made in this investigation to remove these convolutions using liquid ammonia treatment. The optical and X-ray orientation angles of two varieties of G. hirsutum cotton fibers were investigated at various stages of maturity, and results were compared. An American upland variety was also studied. Four-hour treatment of cotton fibers in liquid ammonia at a temperature of −50 °C ensures a complete change of the lattice structure from cellulose I polymorph to cellulose III polymorph. The cellulose I lattice structure is restored by boiling it in distilled water for 24 h. X-ray diffractograms confirm these conversions. Mature fibers after treatments are devoid of convolutions and are rounded in appearance with no central lumen. The scanning electron micrographs revealed these morphological structures. A close correlation exists between the optical and X-ray orientation measurements and are both strongly dependent on fiber maturity. In all the varieties studied, a maturity ratio of at least 0.8 is required for a cotton fiber to be of commercial value, in terms of strength and durability The progressive build-up of both the primary and secondary walls as the fiber matures shows a gradual decrease in helix angles and, hence, an increase in the orientation of the fibrils, conforming to the constant pitch model. The effect of convolutions on both the optical and X-ray orientation angle is found to be higher than 10%. Full article

We report a highly sensitive label-free optical biosensor based on nematic liquid crystals, for the detection of proteins. The principles of biosensing are based on the change in the liquid crystal alignment induced by biomolecules adsorbed on the cell inner surface, which can be easily detected with a polarizing optical microscope. Although this approach is well-known, we propose here an experimental strategy that allows us to reach a detection limit of the order of 10⁻¹³ g/mL, orders of magnitude higher than the one reported in the literature for similar biosensors. Furthermore, our method leads to assessing a well-defined, specific dependence of protein concentration on cell birefringence, for rapid quantitative biosensing. The proposed biosensor can additionally be used for the detection of antibodies. Full article

Polarisation encoding is widely used in fibre-based Quantum Key Distribution (QKD), but random birefringence in optical fibres causes the transmitted states to drift, requiring active compensation at the receiver. Electronic Polarisation Controllers (EPCs) are commonly used for this purpose, yet the relationship between their control voltages and the resulting polarisation transformation is highly nonlinear and difficult to model. While optimisation algorithms are frequently employed to align and stabilise polarisation states, their comparative performance has not been systematically studied in realistic QKD settings. In this work, we benchmark four optimisation algorithms for electronic polarisation control, using both a numerical model and a 50 km fibre-based experimental setup. We evaluate each algorithm in terms of convergence time, failure rate, and stability, under both initial alignment and continuous drift compensation scenarios. Coordinate Descent achieved the fastest average alignment time (2.1 ms in simulation; 34.6 s experimentally), while Simulated Annealing delivered perfect reliability. We further propose a hybrid control strategy that combines fast initial alignment with high-reliability realignment. This approach was validated over a continuous 2 h QKD simulation with real fibre drift, demonstrating robust polarisation control without manual intervention. Our results provide guidance for algorithm selection in practical QKD deployments and suggest a pathway to resilient, autonomous polarisation tracking in long-distance quantum networks. Full article

Background: The extracellular matrix (ECM) plays a central role in the mechanical strength and functional integration of tissue-engineered matrix (TEM), particularly in cardiovascular and load-bearing applications. Mesenchymal stromal cells (MSCs) from different sources may vary in their ECM-forming potential. Methods: In this study, adipose-derived (hADMSC), bone marrow-derived (hBMSC), and umbilical cord-derived MSCs (hUCMSC) were compared with human dermal fibroblasts (HDFBs) as a reference. Cells were seeded onto polyglycolic acid (PGA)/poly-4-hydroxybutyrate (P4HB) scaffolds and cultured for 3 weeks under static or hydrodynamic conditions using orbital shaking. TEM development was assessed macroscopically, histologically (using H&E and Masson’s trichrome stains), and by polarized light microscopy (Picrosirius Red), alongside biochemical assays that quantified DNA, glycosaminoglycan (GAGs), and hydroxyproline (HYP). Results: Hydrodynamically stimulated culture consistently improved ECM deposition across all groups. TEMs exposed to hydrodynamic stimulation (hydrodynamic conditions) were thicker, more uniformly filled, and exhibited increased collagen deposition compared with static TEMs, which remained thinner and showed persistent scaffold remnants. Polarized light analysis demonstrated that dynamic loading promoted collagen maturation in all groups, as evidenced by an increased prevalence of thick, birefringent collagen fibers indicative of mature collagen. Biochemical analyses showed that HDFB-derived TEMs produced the highest total collagen and ECM content under both static and hydrodynamic conditions; however, these matrices remained comparatively thin and densely packed. In contrast, MSC-derived TEMs formed thicker and more spatially distributed ECM in response to hydrodynamic stimulation. Conclusion: Among the MSC sources, hUCDMSC-derived TEMs exhibited the most advanced collagen maturation and the most uniform collagen distribution under hydrodynamically stimulated culture, whereas hADMSC-derived TEMs showed the greatest matrix thickening and volumetric ECM expansion with intermediate collagen maturation. hBMSC-derived TEMs displayed clear responsiveness to hydrodynamic stimulation but remained limited in overall collagen deposition and fiber maturation. These findings underscore that both hydrodynamic stimulation and cell source are critical not only for maximizing ECM deposition, but also for ensuring physiologically relevant collagen maturation and matrix organization in grafts suitable for clinical translation. Full article

The effect of the confinement of fluorophores (rhodamine 6G) in nano-cavities of porous 3D sculptured coatings made by glancing-angle deposition (GLAD) was investigated by fluorescence-lifetime imaging microscopy (FLIM). Shortening of fluorescence/ photoluminescence lifetime by ∼10% was observed from the dye-permeated (in liquid) structure; however, there was no rotational hindrance of dye molecules. When dried, a strong rotational hindrance $89\%$ was observed for the orientation along the ordinary optical axis (slow-axis), and the hindrance was smaller than $57\%$ for the extraordinary direction (fast axis). Light-intensity distribution inside the nano-structure with a form birefringence was numerically modeled using plane-wave illumination and a dipole source. Nanoscale localization of light intensity due to dipole nature $I\sim 1/radiu{s}^6$ and boundary conditions for E-field allows efficient energy deposition inside the region of lower refractive index (nanogaps). Full article

Hollow-core microstructured optical fibres exhibit excellent properties, such as a low loss, tuneable high birefringence, and low nonlinearity, finding extensive applications across communications, industry, agriculture, medicine, military, and sensing technologies. This paper designs two types of asymmetric hollow-core photonic bandgap fibres featuring a high birefringence and low confinement loss. Both feature a cladding structure of rounded hexagonal honeycomb lattice, while the core structures comprise elliptical hollow cores and rounded rhombic hollow cores, respectively. By adjusting the radius of the cladding air holes and the core structure parameters, this study aims to maximise the birefringence coefficient and minimise the confinement loss. The control variable method is employed to optimise the parameters of two fibres. The simulation results indicate that, at a wavelength of 1.55 μm, the birefringence coefficient of the rhombic core, after parameter optimisation, reaches 1.4 × 10⁻⁴, with the confinement loss achieving 4.4 × 10⁻³ dB/km. Its bending loss remains at the order of 10⁻³ dB/km, indicating that this fibre maintains an exceptionally high transmission efficiency even when wound with a small curvature radius (such as within the resonant cavity of a compact fibre optic gyroscope). The elliptical core’s birefringence coefficient also reaches 3 × 10⁻⁴, with the confinement loss achieving 1.9 × 10⁻¹ dB/km. Specifically, this paper employs bismuth tellurite glass as the substrate material to simulate the performance of elliptical cores. Within a specific refractive index range, the elliptical-core fibre with a bismuth tellurite glass substrate exhibits a confinement loss comparable to quartz glass, whilst its birefringence coefficient reaches as high as 5.8 × 10⁻⁴. Therefore, the hollow-core photonic bandgap fibres designed in this thesis provide valuable reference and innovative significance, both in terms of the performance of two asymmetric core structures and in the exploration of polarisation-maintaining hollow-core photonic bandgap fibres on novel material substrates. Full article

A method for the second-harmonic generation (SHG) in optical fibers by exploiting the third-order nonlinearity under an external electric field is proposed. The analysis begins with the electric polarization vector of the SHG, and the analytical solution for the SHG is presented. When fiber birefringence is neglected, a mode-field matching condition is introduced. The nonlinearity-induced shift in propagation constant is provided based on Gaussian approximation. For a specific case, the power of SHG is calculated. The results show that the SHG power scales quadratically with the nonlinear coefficient. Reducing the effective area of the fiber and increasing the nonlinear coefficient can enhance the SHG power by 1–2 orders of magnitude. Since phase matching strongly affects the SHG process, optimizing the fiber design is crucial. Additionally, the polarization state of SHG is shown to have the same as the equivalent optical field of the injected fundamental wave. This work demonstrates potential for distributed sensing of electric fields and lightning events in high-voltage power grids using optical fibers. Full article

Amyloidosis is a group of disorders caused by extracellular deposition of insoluble fibrillar proteins, leading to progressive organ dysfunction. Cardiac amyloidosis is clinically significant, as myocardial infiltration results in restrictive cardiomyopathy, arrhythmias, and heart failure. The main subtypes are light-chain (AL) and transthyretin (ATTR) amyloidosis, while AA and isolated atrial amyloidosis (IAA) are less common. Accurate subtype identification is crucial for management and prognosis. Diagnosis requires a multimodal approach combining imaging and tissue-based techniques. Echocardiography is usually first-line, showing increased wall thickness, biatrial enlargement, and apical sparing. Cardiac magnetic resonance (CMR) provides superior tissue characterization through late gadolinium enhancement and elevated extracellular volume. Nuclear scintigraphy with 99mTc-labeled tracers enables non-invasive ATTR detection, while amyloid-specific PET tracers show potential for early diagnosis. Histochemical confirmation remains essential. Congo Red staining with apple-green birefringence under polarized light is the diagnostic gold standard, supported by Thioflavin T, PAS, and Alcian Blue stains. Immunohistochemistry and mass spectrometry aid amyloid typing, while electron microscopy provides ultrastructural confirmation. Integrating imaging, histochemical, immunohistochemical, and proteomic techniques enhances early recognition and precise classification, improving therapeutic strategies and patient outcomes. Full article

The simultaneous measurement of strain and temperature using Fiber Bragg Grating (FBG) sensors presents a significant challenge due to the intrinsic cross-sensitivity of the Bragg wavelength. While recent studies have increasingly employed “black-box” machine learning algorithms to address this ambiguity, such approaches often overlook the physical limitations of the sensor’s spectral response. This paper challenges the assumption that advanced algorithms alone can compensate for data that is physically ambiguous. We propose a “Sensor-Algorithm Co-Design” methodology, demonstrating that robust discrimination is achievable only when the sensor architecture exhibits a unique, orthogonal physical signature. Using a rigorous Transfer Matrix Method (TMM) and 4 × 4 polarization analysis, we evaluate three distinct architectures. Quantitative analysis reveals that a standard Quadratically Chirped FBG (QC-FBG) functions as an “ill-conditioned baseline” failing to distinguish measurands due to feature space collapse ($K_{cond}>4600$). Conversely, we validate two robust co-designs: (1) An Amplitude-Modulated Superstructure FBG (S-FBG) paired with an Artificial Neural Network (ANN), utilizing thermally induced duty-cycle variations to achieve high accuracy ($~3.4 °\mathrm{C}$ error) under noise; and (2) A Polarization-Diverse Inverse-Gaussian FBG (IG-FBG) paired with a 4 × 4 K-matrix, exploiting strain-induced birefringence ($K_{cond}\approx 64$). Furthermore, we address the data scarcity issue in AI-driven sensing by introducing a Physics-Informed Neural Network (PINN) strategy. By embedding TMM physics directly into the loss function, the PINN improves data efficiency by 2.2× compared to standard models, effectively bridging the gap between physical modeling and data-driven inference, addressing the critical data scarcity bottleneck identified in recent optical sensing roadmaps. Full article