Search Results (6,472)

Background: One in seven youth experiences a mental disorder, accounting for 13% of the global disease burden. The family environment is a modifiable factor for the prevention of mental disorders. While evidence-based online parenting programs exist, engagement by immigrant families, such as Indian-origin families in Australia, remains low. Objective: To explore perceived barriers of Indian-origin parents and co-create strategies to build cross-cultural bridging interventions to increase their engagement in parenting programs. Method: A qualitative co-design method was used, and participants were selected using a set of inclusion criteria through a criterion-based sampling approach. Eight videoconference workshops were conducted with 23 Indian-origin parents living across Australia, incorporating scenarios, roleplay, and vignettes. Data were analysed using Braun and Clarke’s inductive coding approach. Results: One central theme and six design principles were developed. The central theme, low engagement with parenting programs, encompassed five factors that contribute to low engagement: ‘parenting programs’ is not a concept in India; limited awareness of parenting programs available in Australia; lack of time to engage in parenting programs; misalignment between parenting program content and real-world parenting challenges; and an ‘I know how to parent’ mindset. The six design principles were: acknowledge culture shock and acculturation; use a collaborative approach; include content specific to immigrant parents and children; adopt cross-cultural perspectives; use short and interactive bilingual pedagogic tools; and use focused dissemination and marketing. Conclusions: This study’s findings formed the foundation for developing a cross-cultural bridging intervention to connect Indian-origin parents with existing online parenting programs. Full article

Extracellular vesicles (EVs) are mediators of intercellular communication and serve as promising tools for drug discovery and targeted therapies. These lipid bilayer-bound nanovesicles facilitate the transfer of functional proteins, RNAs, lipids, and other biomolecules between cells, thereby influencing various physiological and pathological processes. This review outlines the molecular mechanisms governing EV biogenesis and cargo sorting, emphasizing the role of key regulatory proteins in modulating selective protein packaging. We explore the critical involvement of EVs in various disease microenvironments, including cancer progression, neurodegeneration, and immunological modulation. Their ability to cross biological barriers and deliver bioactive cargo makes them desirable candidates for precise drug delivery systems, especially in neurological and oncological disorders. Moreover, this review highlights advances in engineering EVs for the delivery of RNA therapeutics, CRISPR-Cas systems, and targeted small molecules. The utility of EVs as diagnostic tools in liquid biopsies and their integration into personalized medicine and companion diagnostics are also discussed. Patient-derived EVs offer dynamic insights into disease states and enable real-time treatment stratification. Despite their potential, challenges such as scalable isolation, cargo heterogeneity, and regulatory ambiguity remain significant hurdles. Recent studies have reported novel pharmacological approaches targeting EV biogenesis, secretion, and uptake pathways, with emerging regulators showing promise as drug targets for modulating EV cargo. Future directions include the standardization of EV analytics, scalable biomanufacturing, and the classification of EV-based therapeutics under evolving regulatory frameworks. This review emphasizes the multifaceted roles of EVs and their transformative potential as therapeutic platforms and biomarker reservoirs in next-generation precision medicine. Full article

Hilly areas serve as critical ecological barriers yet face developmental challenges, drawing increasing attention to how land use transformation affects eco-environmental quality (EEQ). Systematic studies on EEQ drivers in complex terrains remain limited, particularly regarding nonlinear and interactive effects. This study examines Zhejiang’s hilly area—typical of southern China’s hills—using land use data from 2000, 2010, and 2020. Methods including land use transfer matrix, EEQI, hotspot analysis, and XGBoost-SHAP were applied to assess impacts and quantify drivers. Results show a slight but consistent decline in EEQ index (EEQI) (0.7635 to 0.7472), driven primarily by rapid built-up land (BL) expansion (276.41% increase). NDVI was the most influential factor (SHAP: 0.1226, >59%), followed by GDP per unit area and temperature. NDVI showed a threshold effect (>0.65 strengthens benefit), and strong interaction with per capita GDP. A slope-vegetation coupling mechanism was identified: on slopes > 30°, high NDVI significantly amplifies EEQ improvement, highlighting the importance of vegetation conservation on steep slopes. These findings provide a scientific basis for targeted land management in hilly regions of southern China and similar areas. Full article

Neurodegenerative disorders such as Alzheimer’s disease (AD), Parkinson’s disease (PD), and multiple sclerosis (MS) are marked by progressive network dysfunction that challenges conventional, protocol-based neurorehabilitation. In parallel, neuromodulation, encompassing deep brain stimulation (DBS), transcranial magnetic stimulation (TMS), transcranial direct current stimulation (tDCS), vagus nerve stimulation (VNS), and artificial intelligence (AI), has matured rapidly, offering complementary levers to tailor therapy in real time. This narrative review synthesizes current evidence at the intersection of AI and neuromodulation in neurorehabilitation, focusing on how data-driven models can personalize stimulation and improve functional outcomes. We conducted a targeted literature synthesis of peer-reviewed studies identified via PubMed, Embase, Scopus, and reference chaining, prioritizing recent clinical and translational reports on adaptive/closed-loop systems, predictive modeling, and biomarker-guided protocols. Across indications, convergent findings show that AI can optimize device programming, enable state-dependent stimulation, and support clinician decision-making through multimodal biomarkers derived from neural, kinematic, and behavioral signals. Key barriers include data quality and interoperability, model interpretability and safety, and ethical and regulatory oversight. Here we argue that AI-enhanced neuromodulation reframes neurorehabilitation from static dosing to adaptive, patient-specific care. Advancing this paradigm will require rigorous external validation, standardized reporting of control policies and artifacts, clinician-in-the-loop governance, and privacy-preserving analytics. Full article

The purpose of this scoping review is to identify major social determinants of health and barriers affecting access to mental health services in pregnant and postpartum women in the United States. It will also examine the scope of existing evidence-based interventions and dissemination and implementation strategies that were developed and implemented to increase accessibility to mental health treatment in high-risk pregnant and postpartum women. The Arksey and O’Malley Framework guided the review process, along with the Joanna Briggs Institute (JBI) recommendations for the extraction, analysis, and presentation of results in scoping reviews. Additionally, the Preferred Reporting Items for Systematic Reviews and Meta-Analyses extension for Scoping Reviews (PRISMA-SCR) was used as a reference checklist. A total of 21 studies were used for analysis that were published between 2015 and 2025. An examination of social determinants of health (SDOH) influencing factors of mental health determined that those related to neighborhood and built environment had the highest rates. Using the socioecological model, individual barriers exhibited the highest frequency, with the most common themes to these barriers across all studies being language barriers, cultural barriers, and stigma-related challenges, followed by financial and childcare challenges and transportation challenges. Major findings included important evidence that therapeutic relationships with pregnant women who are depressed can be developed and that telehealth interventions improved access for women living in rural areas. Recommendations from this review will inform evidence-based interventions to address the gap in accessibility and affordability of mental health services in US pregnant and postpartum women residing in underserved communities. Full article

Objectives: Skin aging, often accelerated by dietary advanced glycation end products (AGEs), poses both cosmetic and health challenges. This study explores the protective effects of hydroxytyrosol (HT), a potent antioxidant found in olives, against AGEs-induced skin aging in mice. Methods: A total of forty-eight 8-month-old specific pathogen-free (SPF) male C57BL/6J mice were randomly assigned to one of four groups: control, model, low-dose hydroxytyrosol (HT25), and high-dose hydroxytyrosol (HT50). An additional group of six 6-week-old SPF male C57BL/6J mice served as the youth group. The experimental period lasted 16 weeks. Following the intervention, skin, serum, and ileum samples were collected. Results: The results demonstrated that HT50 significantly increased skin moisture, epidermal thickness, and dermal thickness (p < 0.05). HT50 also significantly elevated hydroxyproline levels as well as superoxide dismutase (SOD) and glutathione peroxidase (GSH-Px) activities in the skin while reducing malondialdehyde (MDA) content (p < 0.05). Furthermore, HT50 significantly reduced the levels of interleukin-6 (IL-6), interleukin-1β (IL-1β), and tumor necrosis factor-α (TNF-α) (p < 0.05). Regarding intestinal integrity, hydroxytyrosol intervention (either HT25 or HT50) significantly increased the positive staining ratios of zonula occludens-1 (ZO-1) and occludin in the ileum (p < 0.05). Conclusions: HT improves skin hydration, thickness, and collagen levels while reducing oxidative stress and inflammation. Notably, HT also enhances intestinal barrier function, suggesting a role for the gut–skin axis. These findings highlight HT’s potential as a natural intervention for skin aging. Full article

Groundwater resource management involves complex socio-hydrological systems characterized by dynamic feedback, uncertainty, and common misconceptions among decision-makers. While deterministic models like MODFLOW simulate physical hydrology effectively, they fall short in capturing the social, legal, and behavioral dynamics shaping groundwater use. System dynamics (SD) modeling offers a robust alternative by incorporating feedback loops, delays, and nonlinearities. Yet, model conceptualization remains one of the most challenging steps in SD practice. Experienced modelers often apply a “Lego-like” approach—assembling new models from pre-validated sub-models. However, this strategy depends on access to well-documented sub-model libraries, which are typically unavailable to newcomers. To address this barrier, we systematically review and classify socio-economic sub-models from existing groundwater SD literature, organizing them by system archetypes and generic structures. The resulting modular library offers a practical resource that supports newcomers in building structured, scalable models. This approach improves conceptual clarity, enhances model reusability, and facilitates faster development of SD models tailored to groundwater systems. The study concludes by identifying directions for future research, including expanding the sub-model library, clarifying criteria for base-model selection, improving integration methods, and applying these approaches through diverse case studies to further strengthen the robustness and utility of groundwater SD modeling. Full article

Electromagnetic induction (EMI) devices have become increasingly popular for their soil bulk properties, soil nutrient status, and use in taking non-invasive soil salinity measurements. However, the high cost of data acquisition (DAQ) systems has been a significant barrier to the widespread adoption of these devices. In this study, we addressed this challenge by developing a cost-effective, easy-to-use, open-source DAQ system, transferable to the end user. This system employs a Raspberry Pi 4 model, paired with various components, to monitor the speed and position of the EM38 (Geonics Ltd, Mississauga, ON, Canada) and compare these with a proprietary CR1000 system. Through our results, we demonstrate that the low-cost DAQ system can successfully extract the analogical signal from the device, which is strongly responsive to the variation in the soil’s physical properties. This cost-effective system is characterized by increased flexibility in software processes and provides performance comparable to the proprietary system in terms of its geospatial data and ECb measurements. This was validated by the strong correlation (R² = 0.98) observed between the data collected from both systems. With our zoning analysis, performed using the Kriging technique, we revealed not only similar patterns in the ECb data but also similar patterns to the Normalized Difference Vegetation Index (NDVI) map, suggesting that soil physical characteristics contribute to variability in crop vigor. Furthermore, the developed web application enabled real-time data monitoring and visualization. These findings highlight that the open-source DAQ system is a viable, cost-effective alternative for soil property monitoring in precision farming. Future enhancements will focus on integrating additional sensors for plant vigor and soil temperature, as well as refining the web application, supporting zone classification based on the use of multiple parameters. Full article

The problem of end-of-life (EoL) fibre-reinforced polymer (FRP) wind turbine blades (WTBs) poses a growing challenge due to the absence of an integrated circular value chain currently available on the market. A key barrier is the information gap between the EoL condition of WTB components and their second-life application requirements. This study addresses this question by focusing on the spar cap, which is an internal structural component with high repurposing potential. A framework has been developed to determine the as-received mechanical properties of spar caps from different EoL WTB models, targeting repurpose in the construction sector. The experimental programme encompasses fibre architecture assessment, calcination processes and mechanical tests in both longitudinal and transverse directions of three different WTB models. Results suggest that the spar caps appear to retain their strength and stiffness, with no evidence of degradation from previous service life. However, notable variation in properties is observed. To account for this, a prediction tool is proposed to estimate the as-received mechanical properties based on practically accessible parameters, thereby supporting decision-making. The results of this study contribute to enabling the repurposing of EoL spar cap beams from the wind energy sector for applications in the construction sector. Full article

Autophagy is a fundamental catabolic pathway critical for maintaining cellular homeostasis in the central nervous system (CNS). While neuronal autophagy has been extensively studied, growing evidence highlights the crucial roles of astrocytic autophagy in CNS physiology and pathology. Astrocytes regulate metabolic support, redox balance, and neuroinflammatory responses. These functions are closely linked to autophagic activity. The disruption of astrocytic autophagy contributes to synaptic dysfunction, chronic inflammation, myelin impairment, and blood–brain barrier instability. Dysregulation of astrocytic autophagy has been implicated in the pathogenesis of multiple neurodegenerative diseases, including Alzheimer’s disease, Parkinson’s disease, Huntington’s disease, and amyotrophic lateral sclerosis. This review summarizes the molecular mechanisms of autophagy in astrocytes and delineates its role in intercellular communication with neurons, microglia, oligodendrocytes, and endothelial cells. Furthermore, we will discuss current pharmacological approaches targeting astrocytic autophagy, with particular attention to repurposed agents such as rapamycin, lithium, and caloric restriction mimetics. Although promising in preclinical models, therapeutic translation is challenged by the complexity of autophagy’s dual roles and cell-type specificity. A deeper understanding of astrocytic autophagy and its crosstalk with other CNS cell types may facilitate the development of targeted interventions for neurodegenerative diseases. Full article

Psoriasis is a chronic inflammatory autoimmune skin disease with current treatments often causing significant side effects. This study systematically evaluated the therapeutic potential and mechanisms of polyphenolic compounds in psoriasis treatment. Following PRISMA guidelines, we searched PubMed, Google Scholar, and ScienceDirect databases between January 2008 and September 2023. Studies investigating polyphenolic effects on psoriasis through in vitro, animal, or clinical models were included. Twenty-five studies met inclusion criteria: nine in vitro studies, eleven animal studies, and five clinical trials. Curcumin was most extensively studied, demonstrating 30–60% reductions in inflammatory markers (TNF-alpha, IL-17, IL-22) and significant PASI score improvements. Mechanistic analysis revealed polyphenols primarily target NF-kappaB pathway inhibition and IL-17/Th17 axis suppression, addressing fundamental inflammatory processes in psoriatic pathophysiology. However, limited clinical evidence represents a significant implementation barrier. Polyphenols show potential as adjunctive therapies to conventional topical and systemic treatments. Future research should prioritize large-scale randomized controlled trials with standardized formulations and combination therapy investigations to establish clinical efficacy and overcome bioavailability challenges. Full article

Social acceptability is a critical factor in the successful implementation of emerging energy technologies, particularly hydrogen, which faces both technical and perceptual challenges. This study offers the first systematic investigation of public perceptions of hydrogen technologies in Albania, addressing a key knowledge gap in the Western Balkan countries. Using a structured survey of 440 respondents, it examines awareness, perceived benefits and risks, institutional trust, and willingness to adopt hydrogen solutions. While 84.5% had heard of hydrogen, only 23.6% were familiar with its technologies and just 9.3% felt well-informed—this highlights a major knowledge gap. Public attitudes were largely positive: 73.4% acknowledged hydrogen’s role in reducing emissions and 70.7% its potential to lower energy dependence. However, 34.5% viewed hydrogen as too dangerous near residential areas, and 50% were undecided. The most cited barriers were lack of information (50.5%) and infrastructure (19.5%). Trust in institutions was moderate, and gender differences were significant, with men showing higher awareness and support. Encouragingly, 78% of respondents wanted to learn more, and 63% showed interest in future use. Educational institutions were the most trusted information source. The findings highlight the need for public awareness campaigns, transparent risk communication, and community-oriented policies to foster a socially inclusive hydrogen transition in Albania. Full article

Pregnant and postpartum people (PPPs) face heightened risk for HIV acquisition, yet depression and trauma-related symptoms can undermine adherence to pre-exposure prophylaxis (PrEP). To inform the development of a brief mental health-focused adherence intervention, we explored the impacts of depression and posttraumatic stress disorder (PTSD) symptoms on PrEP use among PPPs in Cape Town, South Africa. Twenty-eight PPPs with elevated symptoms of depression and/or PTSD and recent PrEP adherence challenges completed qualitative interviews. Six antenatal providers were also interviewed. Thematic analysis revealed three key findings with subthemes that deepen exploration of each theme: (1) depression and PTSD symptoms contributed to missed PrEP doses or late pickups by increasing doubt about PrEP efficacy, amplifying pill burden, intensifying avoidance and withdrawal (e.g., hypersomnia and disengagement from providers), and disrupting memory through rumination and emotional overload; (2) most PPPs preferred support from professional counselors, while a minority preferred informal support; and (3) intervention design considerations included aligning patient and provider goals, selecting between individual or group formats, and addressing integration barriers such as staffing and space constraints. Providers affirmed the need for embedded mental health support. Intervention strategies that increase PrEP knowledge and motivation while targeting emotional withdrawal, fatigue, and cognitive overload may improve adherence and reduce HIV risk in this population. Full article

Accessing the built environment poses many challenges for people with disabilities, severely affecting their independence and quality of life. A panel of experts with a lived experience of disabilities co-designed a survey capturing the challenges in New Zealand’s public places. There were 319 survey respondents with impairments related to mobility (66.5%), vision (18.8%), hearing (5.0%), sensory processing and cognition (8.8%). They perceived sports stadiums as the least accessible venue, followed by bars, boutique shops and public toilets. The most accessible venues were supermarkets, libraries and shopping malls. The type of disability affected the main accessibility challenges. Significant outdoor barriers included uneven and cluttered paths, inadequate provision of curb cuts, seating and accessible parking spaces, and obscure wayfinding. Entrance barriers included heavy doors, complex access control, remote ramps and narrow, obscure entrances. Interior problems included cluttered paths and poor signage. The top priorities for improvement were simplifying layouts, keeping paths clear, and providing clear, inclusive signage, communication and assistance for people with varying impairments. Providing lower counters, better colour contrast, hearing loop facilities and better control of lighting and acoustics also improve accessibility. This research contributes novel experiential data from people with disabilities that is critical to achieving an inclusive built environment. Full article

Food packaging is an essential part of the food industry. Packaging materials are indispensable in ensuring product safety, enhancing consumer experience, and supporting sustainable practices. This review provides an update on the role of bio-based polymers, including polylactic acid (PLA), polyhydroxyalkanoates (PHAs), starch-based polymers, and cellulose-based polymers (cellulose acetate (CA), cellulose sulphate (CS), carboxymethyl cellulose (CMC), nanocellulose (NC), and methylcellulose (MC)) for food packaging applications. Properties as mechanical, barrier and antimicrobial, as well as their eco-friendly behavior, are also summarized. The advantages and disadvantages of using bio-based polymers in food packaging are discussed. Present review also addresses the challenges associated with their preparation and highlights the potential future prospects of bio-based polymers for packaging applications. Full article