Search Results (693)

This paper presents a novel methodology for the optimal sizing of solar photovoltaic (PV) systems in distribution networks by determining the monthly optimum tilt and azimuth angles to maximize solar energy capture. Using one year of solar irradiation data, the Grey Wolf Optimizer (GWO) is employed to optimize the tilt and azimuth angles with the objective of maximizing monthly solar insolation. Unlike existing approaches that assume fixed azimuth angles, the proposed method calculates both tilt and azimuth angles for each month, allowing for a more precise alignment with solar trajectories. The optimized orientation parameters are subsequently utilized to determine the optimal number and placement of PV panels, as well as the optimal location and sizing of shunt capacitor (SC) banks, for the IEEE 69-bus distribution system. This optimization is performed under peak load conditions using the GWO, with the objectives of minimizing active power losses, enhancing voltage profile stability, and maximizing PV system penetration. The long-term impact of this approach is assessed through a 20-year energy and economic savings analysis, demonstrating substantial improvements in energy efficiency and cost-effectiveness. Full article

The phosphoinositide 3-kinase (PI3K)/AKT signaling pathway is a crucial regulator of cellular metabolism, proliferation, and survival. It is frequently dysregulated in metabolic, cardiovascular, and neoplastic disorders. Despite the advancements in multi-omics technology, existing methods often fail to provide real-time, pathway-specific insights for precision medicine and drug repurposing. We offer Agentic RAG-Driven Multi-Omics Analysis (ARMOA), an autonomous, hypothesis-driven system that integrates retrieval-augmented generation (RAG), large language models (LLMs), and agentic AI to thoroughly analyze genomic, transcriptomic, proteomic, and metabolomic data. Through the use of graph neural networks (GNNs) to model complex interactions within the PI3K/AKT pathway, ARMOA enables the discovery of novel biomarkers, probable candidates for drug repurposing, and customized therapy responses to address the complexities of PI3K/AKT dysregulation in disease states. ARMOA dynamically gathers and synthesizes knowledge from multiple sources, including KEGG, TCGA, and DrugBank, to guarantee context-aware insights. Through adaptive reasoning, it gradually enhances predictions, achieving 91% accuracy in external testing and 92% accuracy in cross-validation. Case studies in breast cancer and type 2 diabetes demonstrate that ARMOA can identify synergistic drug combinations with high clinical relevance and predict therapeutic outcomes specific to each patient. The framework’s interpretability and scalability are greatly enhanced by its use of multi-omics data fusion and real-time hypothesis creation. ARMOA provides a cutting-edge example for precision medicine by integrating multi-omics data, clinical judgment, and AI agents. Its ability to provide valuable insights on its own makes it a powerful tool for advancing biomedical research and treatment development. Full article

To cost-effectively meet 6G latency requirements, concurrent upstream and direct inter-optical network unit (ONU) communication passive optical networks (PONs) based on flexible point-to-multipoint (P2MP) optical transceivers and intensity modulation and direct detection (IMDD) have been reported to enable direct communications among different ONUs within the same PON without passing data to the optical line terminal (OLT). However, the previously reported P2MP transceivers suffer from high DSP complexity for establishing ultra-dense connections. For such application scenarios, the PON’s remote nodes also have high inter-ONU signal power losses. To effectively solve these technical challenges, this paper experimentally showcases (a) new P2MP transceivers by utilizing parallel multi-channel aggregation/de-aggregation and advanced extended Gaussian function (EGF)-based orthogonal digital filter banks, along with (b) low inter-ONU signal power loss-remote nodes. By introducing these two techniques into a 27 km, >54.31 Gbit/s concurrent upstream and direct inter-ONU communication IMDD PON, comprehensive experimental explorations of the PON’s performances were undertaken for the first time. The remote node is capable of supporting 128 ONUs. The results show that the new P2MP transceivers lead to >75% (>40%) reductions in overall transmitter (receiver multi-channel de-aggregation) DSP complexity, and they can also equip the PONs with an enhanced capability of providing ultra-dense connections. The experimental results also show that the PON allows each ONU to flexibly change its upstream and inter-ONU communication channel count without considerably compromising its performance. Therefore, the PON outperforms those of previously reported works in terms of ensuring low DSP complexity, highly robust transmission performance, and enhanced capabilities of flexibly accommodating numerous applications with diverse requirements regarding traffic characteristics, thus making it suitable for ultra-dense connection application scenarios. Full article

The significant increase in non-performing loans (NPLs) during the escalating recession of the Greek economy motivates us to study the predictive power of credit rating models in periods of economic shocks. In parallel, we examined the responsibilities of bank management in the expansion of NPLs in this adverse environment. Certain studies connect bad loans with turbulent conditions. Our paper weighs the relative significance of both economic shock and management effectiveness using data at an individual level, which provides the originality of our study. We use a unique dataset of small business loans that were granted during 2005 (expansion period) by a large commercial Greek bank, and we explore their performance between 2010 and 2012 (early recession period). In the context of a stepwise methodology, we compare the Bank’s credit scoring model with three other prediction models (binomial logistic regression, decision tree, and multilayer perceptron neural network) to check both the predictive ability of credit scoring models during recession and the effectiveness of bank management. The comparative analysis confirms the management’s responsibilities in granting NPLs, since the Bank’s model exhibited the worst predictive performance. Additionally, we find that adverse external conditions lead to an increase in NPLs and decrease the predictive performance of all credit scoring models. The study offers a reliable methodological tool for lending management in economic downturns. Full article

Aiming at the problem of poor autonomy and weak time performance of reentry trajectory planning for Reusable Launch Vehicle (RLV), an online reentry trajectory planning and guidance method based on Twin Delayed Deep Deterministic Policy Gradient (TD3) is proposed. In view of the advantage that the drag acceleration can be quickly measured by the airborne inertial navigation equipment, the reference profile adopts the design of the drag acceleration–velocity profile in the reentry corridor. In order to prevent the problem of trajectory angle jump caused by the unsmooth turning point of the section, the section form adopts the form of four multiple functions to ensure the smooth connection of the turning point. Secondly, considering the advantages of the TD3 dual Critic network structure and delay update mechanism to suppress strategy overestimation, the TD3 algorithm framework is used to train multiple strategy networks offline and output profile parameters. Finally, considering the reentry uncertainty and the guidance error caused by the limitation of the bank angle reversal amplitude during lateral guidance, the networks are invoked online many times to solve the profile parameters in real time and update the profile periodically to ensure the rapidity and autonomy of the guidance command generation. The TD3 strategy networks are trained offline and invoked online many times so that the cumulative error in the previous guidance period can be eliminated when the algorithm is called again each time, and the online rapid generation and update of the reentry trajectory is realized, which effectively improves the accuracy and computational efficiency of the landing point. Full article

Steady-State Visual Evoked Potentials (SSVEPs) have emerged as an efficient means of interaction in brain–computer interfaces (BCIs), achieving bioinspired efficient language output for individuals with aphasia. Addressing the underutilization of frequency information of SSVEPs and redundant computation by existing transformer-based deep learning methods, this paper analyzes signals from both the time and frequency domains, proposing a stacked encoder–decoder (SED) network architecture based on an xLSTM model and spatial attention mechanism, termed SED-xLSTM, which firstly applies xLSTM to the SSVEP speller field. This model takes the low-channel spectrogram as input and employs the filter bank technique to make full use of harmonic information. By leveraging a gating mechanism, SED-xLSTM effectively extracts and fuses high-dimensional spatial-channel semantic features from SSVEP signals. Experimental results on three public datasets demonstrate the superior performance of SED-xLSTM in terms of classification accuracy and information transfer rate, particularly outperforming existing methods under cross-validation across various temporal scales. Full article

Accurately predicting stock prices is crucial for investment and risk management, but the non-stationarity of the financial market and the complex correlations among stocks pose challenges to traditional models (ARIMA, LSTM, XGBoost), resulting in difficulties in effectively capturing dynamic patterns and limited prediction accuracy. To this end, this paper proposes the Financial Spatio-Temporal Graph Attention Network (FSTGAT), with the following core innovations: temporal modelling through gated causal convolution to avoid future information leakage and capture long- and short-term fluctuations; enhanced spatial correlation learning by adopting the Dynamic Graph Attention Mechanism (GATv2) that incorporates industry information; designing the Multiple-Input-Multiple-Output (MIMO) architecture of industry grouping for the simultaneous learning of intra-group synergistic and inter-group influence; symmetrically fusing spatio-temporal modules to construct a hierarchical feature extraction framework. Experiments in the commercial banking and metals sectors of the New York Stock Exchange (NYSE) show that FSTGAT significantly outperforms the benchmark model, especially in high-volatility scenarios, where the prediction error is reduced by 45–69%, and can accurately capture price turning points. This study confirms the potential of graph neural networks to model the structure of financial interconnections, providing an effective tool for stock forecasting in non-stationary markets, and its forecasting accuracy and industry correlation capturing ability can support portfolio optimization, risk management improvement and supply chain decision guidance. Full article

The application of contagion risk spread modeling within the banking sector is a relatively recent development, emerging as a response to the persistent threat of liquidity risk that has affected financial institutions globally. Liquidity risk is recognized as one of the most destructive financial threats to banks, capable of causing severe and irreparable damage if overlooked or underestimated. This study aims to identify the most effective control strategy for managing financial contagion using a Susceptible–Infected–Recovered (SIR) epidemic model, incorporating time delays in both state and control variables. The proposed strategy seeks to maximize the number of resilient (vulnerable) banks while minimizing the number of infected institutions at risk of bankruptcy. Our goal is to formulate intervention policies that can curtail the propagation of financial contagion and mitigate associated systemic risks. Our model remains a simplification of reality. It does not account for strategic interactions between banks (e.g., panic reactions, network coordination), nor for adaptive regulatory mechanisms. The integration of these aspects will be the subject of future work. We establish the existence of an optimal control strategy and apply Pontryagin’s Maximum Principle to characterize and analyze the control dynamics. To numerically solve the control system, we employ a discretization approach based on forward and backward finite difference approximations. Despite the model’s simplifications, it captures key dynamics relevant to major European banks. Simulations performed using Python 3.12 yield significant results across three distinct scenarios. Notably, in the most severe case (${\alpha }_3=1.0$), the optimal control strategy reduces bankruptcies from 25% to nearly 0% in Spain, and from 12.5% to 0% in France and Germany, demonstrating the effectiveness of timely intervention in containing financial contagion. Full article

The Triatoma rubrovaria subcomplex, comprising several triatomine species, plays a significant role in the transmission of Chagas disease in southern Brazil. Despite morphological distinctions among these species, their genetic differentiation remains poorly understood, particularly in sympatric regions. This study investigates the genetic diversity and phylogenetic relationships through DNA sequencing analysis of five sympatric species within the T. rubrovaria subcomplex (T. rubrovaria, T. carcavalloi, T. klugi, T. circummaculata, and T. pintodiasi), using a 542-bp fragment of the mitochondrial cytochrome b (mtCytb) gene. A total of 84 specimens were collected from six municipalities in Rio Grande do Sul, Brazil, and analyzed alongside laboratory-reared specimens and sequences from the GenBank. Bayesian phylogenetic reconstructions, haplotype networks, and population structure analyses revealed a lack of clear genetic differentiation among the five species, with overlapping intra- and interspecific divergences and shared haplotypes. These findings suggest either a single species exhibiting phenotypic plasticity or a group of incipient species with ongoing gene flow. This study highlights the need for a taxonomic revision and suggests that this group could serve as a valuable model for further genomic research to elucidate potential aspects of phenotypic plasticity and/or sympatric speciation in triatomines. Full article

The electrical power system is composed of three essential sectors, generation, transmission, and distribution, with the latter being crucial for the overall efficiency of the system. Enhancing the capabilities of active distribution networks involves integrating various advanced technologies such as distributed generation units, energy storage systems, banks of capacitors, and electric vehicle chargers. This paper provides an in-depth review of the primary strategies for incorporating these technologies into the distribution network to improve its reliability, stability, and efficiency. It also explores the principal metaheuristic techniques employed for the optimal allocation of distributed generation units, banks of capacitors, energy storage systems, electric vehicle chargers, and network reconfiguration. These techniques are essential for effectively integrating these technologies and optimizing the active distribution network by enhancing power quality and voltage level, reducing losses, and ensuring operational indices are maintained at optimal levels. Full article

The perianal skin is a unique “skin–gut” boundary that serves as a critical hotspot for the exchange and evolution of antibiotic resistance genes (ARGs). However, its role in the dissemination of antimicrobial resistance (AMR) has often been underestimated. To characterize the resistance patterns in the perianal skin environment of patients with perianal diseases and to investigate the drivers of AMR in this niche, a total of 51 bacterial isolates were selected from a historical strain bank containing isolates originally collected from patients with perianal diseases. All the isolates originated from the skin site and were subjected to antimicrobial susceptibility testing, whole-genome sequencing, and co-occurrence network analysis. The analysis revealed a highly structured resistance pattern, dominated by two distinct modules: one representing a classic Staphylococcal resistance platform centered around mecA and the bla operon, and a broad-spectrum multidrug resistance module in Gram-negative bacteria centered around tet(A) and predominantly carried by IncFIB and other IncF family plasmids. Further analysis pinpointed IncFIB-type plasmids as potent vehicles driving the efficient dissemination of the latter resistance module. Moreover, numerous unexplained resistance phenotypes were observed in a subset of isolates, indicating the potential presence of emerging and uncharacterized AMR threats. These findings establish the perianal skin as a complex reservoir of multidrug resistance genes and a hub for mobile genetic element exchange, highlighting the necessity of enhanced surveillance and targeted interventions in this clinically important ecological niche. Full article

In this paper, we study the classification problem of short-time-window steady-state visual evoked potentials (SSVEPs) and propose a novel deep convolutional network named EEGResNet based on the idea of residual connection to further improve the classification performance. Since the frequency-domain features extracted from short-time-window signals are difficult to distinguish, the EEGResNet starts from the filter bank (FB)-based feature extraction module in the time domain. The FB designed in this paper is composed of four sixth-order Butterworth filters with different bandpass ranges, and the four bandwidths are 19–50 Hz, 14–38 Hz, 9–26 Hz, and 3–14 Hz, respectively. Then, the extracted four feature tensors with the same shape are directly aggregated together. Furthermore, the aggregated features are further learned by a six-layer convolutional neural network with residual connections. Finally, the network output is generated through an adaptive fully connected layer. To prove the effectiveness and superiority of our designed EEGResNet, necessary experiments and comparisons are conducted over two large public datasets. To further verify the application potential of the trained network, a virtual simulation of brain computer interface (BCI) based quadrotor control is presented through V-REP. Full article

This study analyzed the heavy metal tolerance and chromium reduction and the potential of plant growth to promote Rhizobium sp. OS-1. By genetic makeup, the Rhizobium strain is nitrogen-fixing and phosphate-solubilizing in metal-contaminated agricultural soil. Among the Rhizobium group, bacterial strain OS-1 showed a significant tolerance to heavy metals, particularly chromium (900 µg/mL), zinc (700 µg/mL), and copper. In the initial investigation, the bacteria strains were morphologically short-rod, Gram-negative, appeared as light pink colonies on media plates, and were biochemically positive for catalase reaction and the ability to ferment glucose, sucrose, and mannitol. Further, bacterial genomic DNA was isolated and amplified with the 16SrRNA gene and sequencing; the obtained 16S rRNA sequence achieved accession no. HE663761.1 from the NCBI GenBank, and it was confirmed that the strain belongs to the Rhizobium genus by phylogenetic analysis. The strain’s performance was best for high hexavalent chromium [Cr(VI)] reduction at 7–8 pH and a temperature of 30 °C, resulting in a total decrease in 96 h. Additionally, the adsorption isotherm Freundlich and Langmuir models fit best for this study, revealing a large biosorption capacity, with Cr(VI) having the highest affinity. Further bacterial chromium reduction was confirmed by an enzymatic test of nitro reductase and chromate reductase activity in bacterial extract. Further, from the metal biosorption study, an Artificial Neural Network (ANN) model was built to assess the metal reduction capability, considering the variables of pH, temperature, incubation duration, and initial metal concentration. The model attained an excellent expected accuracy (R² > 0.90). With these features, this bacterial strain is excellent for bioremediation and use for industrial purposes and agricultural sustainability in metal-contaminated agricultural fields. Full article

Innovation is a strategic driver of sustainable competitive advantage and long-term economic growth. This study proposes an empirical framework to support the sustained development of national innovation capacity by examining key enabling factors. Drawing on an extensive review of the literature, the research investigates the interrelationships among governmental support (GS), innovation agents (IA), university–industry R&D collaborations (UIRD), and innovation cluster development (ICD), and their influence on two critical innovation outcomes, knowledge creation (KC) and knowledge diffusion (KD). Using panel data from G7 countries spanning 2008 to 2018, sourced from international organizations such as the World Bank, the World Intellectual Property Organization, and the World Economic Forum, the study applies regression analysis to test the proposed conceptual model. Results highlight the foundational role of GS in providing a balanced framework to foster collaborative networks among IA and enhancing the effectiveness of UIRD. Furthermore, IA emerges as a pivotal actor in advancing innovation efforts, while the development of innovation clusters is shown to selectively enhance specific innovation outcomes. These findings offer theoretical and practical contributions for policymakers, researchers, and stakeholders aiming to design supportive ecosystems that strengthen sustainable national innovation capacity. Full article

Modulation identification plays a crucial role in contemporary wireless communication systems, especially within 5G and future-generation networks that utilize a variety of multicarrier waveforms. This study introduces an innovative algorithm for automatic modulation classification (AMC) built on a deep residual network (DRN) architecture. The approach is tailored to accurately identify advanced 5G waveform types such as Orthogonal Frequency-Division Multiplexing (OFDM), Filtered OFDM (FOFDM), Filter Bank Multicarrier (FBMC), Universal Filtered Multicarrier (UFMC), and Weighted Overlap and Add OFDM (WOLA), using both 16-QAM and 64-QAM modulation schemes. To our knowledge, this is the first application of deep learning in the classification of such a diverse set of complex 5G waveforms. The proposed model combines the deep learning capabilities of DRNs for feature extraction with Principal Component Analysis (PCA) for dimensionality reduction and feature refinement. A detailed performance evaluation is conducted using metrics like classification recall, precision, accuracy, and F-measure. When compared with traditional machine learning approaches reported in recent studies, our DRN-based method shows significantly improved classification accuracy and robustness. These results highlight the effectiveness of deep residual networks in improving adaptive signal processing and enabling automatic modulation recognition in future wireless communication technologies. Full article