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12 pages, 884 KiB  
Article
Anatomical Risk Patterns for Patellofemoral Instability in Skeletally Immature Patients: A Sex-Stratified MRI Study
by René Schroedter, Amir Koutp, Bernhard Guggenberger, Martin Svehlik, Sebastian Tschauner and Tanja Kraus
J. Clin. Med. 2025, 14(15), 5519; https://doi.org/10.3390/jcm14155519 - 5 Aug 2025
Abstract
Background/Objectives: Lateral patellar dislocation (LPD) is a common pathology of the adolescent knee and a major predisposing factor for patellofemoral instability (PFI). The pathogenesis of PFI involves a combination of anatomical and biomechanical contributors, with increasing evidence pointing to sex-specific differences in knee [...] Read more.
Background/Objectives: Lateral patellar dislocation (LPD) is a common pathology of the adolescent knee and a major predisposing factor for patellofemoral instability (PFI). The pathogenesis of PFI involves a combination of anatomical and biomechanical contributors, with increasing evidence pointing to sex-specific differences in knee morphology. Despite this, the developmental course of these parameters and their variation between sexes remain insufficiently characterized. This study aims to investigate sex-related differences in patellofemoral joint geometry among skeletally immature patients with a history of PFI, focusing on how these anatomical variations evolve with increasing knee size, as represented by femoral condylar width. Methods: A total of 315 knee MRIs from patients under 18 years with documented PFI were retrospectively analyzed. Trochlear morphology, patellar tilt, axial positioning, and sagittal alignment were assessed using established MRI-based parameters. All measurements were normalized to bicondylar width to account for individual knee size. Sex-specific comparisons were performed using independent t-tests and linear regression analysis. Results: Females exhibited significantly smaller femoral widths, shallower trochlear depth (TD), shorter tibial tubercle–posterior cruciate ligament (TTPCL) distances, and lower patellar trochlear index (PTI) values compared to males (p < 0.05). In males, increasing femoral width was associated with progressive normalization of patellar tilt and sagittal alignment parameters. In contrast, these alignment parameters in females remained largely unchanged or worsened across different femoral sizes. Additionally, patellar inclination angle and PTI were significantly influenced by knee size in males (p < 0.05), whereas no such relationship was identified in females. Conclusions: Sex-specific morphological differences in patellofemoral geometry are evident early in development and evolve distinctly with growth. These differences may contribute to the higher prevalence of PFI in females and underscore the importance of considering sex and knee size in anatomical assessments. Full article
(This article belongs to the Special Issue Recent Research Progress in Pediatric Orthopedic Surgery)
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18 pages, 4093 KiB  
Article
Study of Mechanical and Wear Properties of Fabricated Tri-Axial Glass Composites
by Raghu Somanna, Rudresh Bekkalale Madegowda, Rakesh Mahesh Bilwa, Prashanth Malligere Vishveshwaraiah, Prema Nisana Siddegowda, Sandeep Bagrae, Madhukar Beejaganahalli Sangameshwara, Girish Hunaganahalli Nagaraju and Madhusudan Puttaswamy
J. Compos. Sci. 2025, 9(8), 409; https://doi.org/10.3390/jcs9080409 - 1 Aug 2025
Viewed by 211
Abstract
This study investigates the mechanical, morphological, and wear properties of SiO2-filled tri-axial warp-knitted (TWK) glass fiber-reinforced vinyl ester matrix composites, with a focus on void fraction, tensile, flexural, hardness, and wear behavior. Adding SiO2 fillers reduced void fractions, enhancing composite [...] Read more.
This study investigates the mechanical, morphological, and wear properties of SiO2-filled tri-axial warp-knitted (TWK) glass fiber-reinforced vinyl ester matrix composites, with a focus on void fraction, tensile, flexural, hardness, and wear behavior. Adding SiO2 fillers reduced void fractions, enhancing composite strength, with values ranging from 1.63% to 5.31%. Tensile tests revealed that composites with 5 wt% SiO2 (GV1) exhibited superior tensile strength, Young’s modulus, and elongation due to enhanced fiber–matrix interaction. Conversely, composites with 10 wt% SiO2 (GV2) showed decreased tensile performance, indicating increased brittleness. Flexural tests demonstrated that GV1 outperformed GV2, showcasing higher flexural strength, elastic modulus, and deflection, reflecting improved load-bearing capacity at optimal filler content. Shore D hardness tests confirmed that GV1 had the highest hardness among the specimens. SEM analysis revealed wear behavior under various loads and sliding distances. GV1 exhibited minimal wear loss at lower loads and distances, while higher loads caused significant matrix detachment and fiber damage. These findings highlight the importance of optimizing SiO2 filler content to enhance epoxy composites’ mechanical and tribological performance. Full article
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18 pages, 6795 KiB  
Article
Strain-Rate-Dependent Tensile Behaviour and Viscoelastic Modelling of Kevlar® 29 Plain-Woven Fabric for Ballistic Applications
by Kun Liu, Ying Feng, Bao Kang, Jie Song, Zhongxin Li, Zhilin Wu and Wei Zhang
Polymers 2025, 17(15), 2097; https://doi.org/10.3390/polym17152097 - 30 Jul 2025
Viewed by 190
Abstract
Aramid fibre has become a critical material for individual soft body armour due to its lightweight nature and exceptional impact resistance. To investigate its energy absorption mechanism, quasi-static and dynamic tensile experiments were conducted on Kevlar® 29 plain-woven fabric using a universal [...] Read more.
Aramid fibre has become a critical material for individual soft body armour due to its lightweight nature and exceptional impact resistance. To investigate its energy absorption mechanism, quasi-static and dynamic tensile experiments were conducted on Kevlar® 29 plain-woven fabric using a universal material testing machine and a Split Hopkinson Tensile Bar (SHTB) apparatus. Tensile mechanical responses were obtained under various strain rates. Fracture morphology was characterised using scanning electron microscopy (SEM) and ultra-depth three-dimensional microscopy, followed by an analysis of microstructural damage patterns. Considering the strain rate effect, a viscoelastic constitutive model was developed. The results indicate that the tensile mechanical properties of Kevlar® 29 plain-woven fabric are strain-rate dependent. Tensile strength, elastic modulus, and toughness increase with strain rate, whereas fracture strain decreases. Under quasi-static loading, the fracture surface exhibits plastic flow, with slight axial splitting and tapered fibre ends, indicating ductile failure. In contrast, dynamic loading leads to pronounced axial splitting with reduced split depth, simultaneous rupture of fibre skin and core layers, and fibrillation phenomena, suggesting brittle fracture characteristics. The modified three-element viscoelastic constitutive model effectively captures the strain-rate effect and accurately describes the tensile behaviour of the plain-woven fabric across different strain rates. These findings provide valuable data support for research on ballistic mechanisms and the performance optimisation of protective materials. Full article
(This article belongs to the Section Polymer Composites and Nanocomposites)
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14 pages, 1646 KiB  
Article
Morphological and Morphometric Assessment of Adolescent Idiopathic Scoliosis According to Pelvic Axial Rotation—A Retrospective Cohort Study with 397 Patients
by Nevzat Gönder, Cansu Öztürk, Rabia Taşdemir, Zeynep Şencan, Cağrı Karabulut, Ömer Faruk Cihan and Musa Alperen Bilgin
Children 2025, 12(8), 991; https://doi.org/10.3390/children12080991 - 28 Jul 2025
Viewed by 273
Abstract
Background: A precise radiographic evaluation of adolescent idiopathic scoliosis (AIS) is essential for effective treatment planning and follow-up. The pelvic axial rotation (PAR) and horizontal balance of the pelvis are critical factors to consider throughout the treatment and monitoring of AIS. While some [...] Read more.
Background: A precise radiographic evaluation of adolescent idiopathic scoliosis (AIS) is essential for effective treatment planning and follow-up. The pelvic axial rotation (PAR) and horizontal balance of the pelvis are critical factors to consider throughout the treatment and monitoring of AIS. While some previous studies have examined spinal curvature in relation to PAR direction and the direction of the major curve (DMC) in AIS patients, this study aims to explore the relationship between scoliosis morphology, pelvic axial rotation (PAR), and the direction of the major curve in patients with adolescent idiopathic scoliosis. Methods: Radiographic images of 397 patients diagnosed with AIS between 2023 and 2024 at a Tertiary Referral Hospital were retrospectively evaluated. Morphological and morphometric measurements, including sex, Lenke and Risser classifications, lower leg discrepancy, Cobb angle, PAR direction, and major curvature direction, were performed. Results: The mean age of the 397 patients (246 female, 151 male) was 14.47 ± 2.29. There is no significant correlation between PAR and DMC (p = 0.919). No significant differences were found in terms of sex (p = 0.603). Regardless of the PAR direction, major curvature was more common on the left side (57.7%). Furthermore, a positive correlation was noted between the Cobb angle and LLD. Conclusions: Our study contributes to a growing body of literature questioning the deterministic role of PAR in AIS. While previous reports have emphasized the directional correlation between the pelvis and spinal curvature, our findings suggest that pelvic rotation may not be a reliable indicator of curve direction in all patients. This highlights the complexity of AIS biomechanics and underscores the need for individualized radiographic and clinical evaluation rather than a reliance on generalized compensatory models. Full article
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20 pages, 3474 KiB  
Article
Optimization of Structural Parameters for 304 Stainless Steel Specific Spiral Taps Based on Finite Element Simulation
by Jiajun Pi, Wenqiang Zhang and Hailong Yang
Machines 2025, 13(8), 655; https://doi.org/10.3390/machines13080655 - 26 Jul 2025
Viewed by 302
Abstract
To address the issues of large errors, low accuracy, and time-consuming simulations in finite element (FE) models of tapping processes, which hinder the identification of optimal structural parameters, this study integrates FE simulation with experimental testing to optimize the structural parameters of spiral [...] Read more.
To address the issues of large errors, low accuracy, and time-consuming simulations in finite element (FE) models of tapping processes, which hinder the identification of optimal structural parameters, this study integrates FE simulation with experimental testing to optimize the structural parameters of spiral taps specifically designed for stainless steel. Initially, single-factor experiments were conducted to analyze the influence of mesh parameters on experimental outcomes, leading to the identification of optimal mesh coefficients. Subsequently, the accuracy of the FE tapping simulation model was validated by comparing trends in axial force, torque, and chip morphology between simulations and actual tapping experiments. Orthogonal experimental design combined with entropy weight analysis and range analysis was then employed to conduct FE simulations. The results indicated that the optimal structural parameter combination is a helix angle of 43°, cone angle of 19°, and cutting edge relief amount of 0.18 mm. Finally, based on this combination, optimized spiral taps were manufactured and subjected to comparative performance testing. The results demonstrated significant improvements: the average maximum axial force decreased by 33.22%, average maximum torque decreased by 13.41%, average axial force decreased by 38.22%, and average torque decreased by 24.87%. Error analysis comparing corrected simulation results with actual tapping tests revealed axial force and torque error rates of 5.04% and 0.24%, respectively. Full article
(This article belongs to the Section Machine Design and Theory)
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18 pages, 11093 KiB  
Article
CRISPR/Cas9-Mediated Disruption of lrp6a Leads to Abnormal Median Fin Development and Somitogenesis in Goldfish (Carassius auratus)
by Huijuan Li, Rong Zhang, Xiaowen Wang, Lili Liu, Zhigang Yao and Hua Zhu
Int. J. Mol. Sci. 2025, 26(15), 7067; https://doi.org/10.3390/ijms26157067 - 22 Jul 2025
Viewed by 334
Abstract
In this study, we demonstrated that lrp6a, a co-receptor in the Wnt signaling pathway, is essential for proper median fin formation and somitogenesis in goldfish. We analyzed the gene’s sequence features and expression patterns in both wen-type and egg-type goldfish, uncovering distinct [...] Read more.
In this study, we demonstrated that lrp6a, a co-receptor in the Wnt signaling pathway, is essential for proper median fin formation and somitogenesis in goldfish. We analyzed the gene’s sequence features and expression patterns in both wen-type and egg-type goldfish, uncovering distinct tissue-specific expression differences between the two varieties. To explore the functional role of lrp6a, we performed CRISPR/Cas9-mediated gene knockout using eight designed single-guide RNAs (sgRNAs), of which four showed effective targeting. Three high-efficiency sgRNAs were selected and co-injected into embryos to achieve complete gene disruption. Morphological assessments and X-ray microtomography (μCT) imaging of the resulting mutants revealed various abnormalities, including defects in the dorsal, caudal, and anal fins, as well as skeletal deformities near the caudal peduncle. These results confirm that lrp6a plays a key role in median fin development and axial patterning, offering new insights into the genetic regulation of fin formation in teleost fish. Full article
(This article belongs to the Special Issue Fish Genomics and Developmental Biology, 2nd Edition)
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26 pages, 6409 KiB  
Article
Experimental and Numerical Investigation of Cavitation-Induced Pressure Fluctuation Characteristics in the Blade-Tip Region of an Axial Flow Pump
by Haoran Wu, Xi Shen, Chen Ni and Gang Yang
J. Mar. Sci. Eng. 2025, 13(8), 1391; https://doi.org/10.3390/jmse13081391 - 22 Jul 2025
Viewed by 179
Abstract
This paper investigates the pressure fluctuation characteristics induced by cavitation in the blade-tip region of an axial flow pump through experimental and numerical methods. Compared with previous studies, this research not only analyzes the development of cavitation bubbles under varying flow rates but [...] Read more.
This paper investigates the pressure fluctuation characteristics induced by cavitation in the blade-tip region of an axial flow pump through experimental and numerical methods. Compared with previous studies, this research not only analyzes the development of cavitation bubbles under varying flow rates but also explores the transient pressure fluctuation features caused by cavitation. It is found that partial-loading conditions tend to exacerbate cavitation, leading to more pronounced transient flow characteristics. The primary frequency of pressure fluctuations consistently corresponds to the impeller’s rotational frequency and its harmonics, with the magnitude inversely related to flow rate. At the same cavitation stage, lower flow rates exhibit larger amplitudes and more significant fluctuations in high-frequency components. This indicates stronger entrainment disturbance between the cavitation morphology and the mainstream in the blade-tip region at lower flow rates, resulting in more complex flow structures. This study provides a theoretical basis for understanding the mechanisms of pressure fluctuations induced by cavitation in the blade-tip region of axial flow pumps. Full article
(This article belongs to the Section Ocean Engineering)
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17 pages, 1543 KiB  
Article
Evaluation of Periodontal Infrabony Defect Topography via CBCT and Comparisons with Direct Intrasurgical Measurements
by Tiffany See Nok Chen, Nicholas David Sung, Melissa Rachel Fok, Mihai Tarce, Kanoknadda Tavedhikul and Georgios Pelekos
Bioengineering 2025, 12(7), 780; https://doi.org/10.3390/bioengineering12070780 - 18 Jul 2025
Viewed by 449
Abstract
Background: Two-dimensional periapical radiographs (PAs) only offer limited information regarding three-dimensional periodontal infrabony defects. In contrast, cone beam computed tomography (CBCT) enables visualization of the entire defect morphology. This study aimed to evaluate the agreement between CBCT and direct intrasurgical measurements (ISs) regarding [...] Read more.
Background: Two-dimensional periapical radiographs (PAs) only offer limited information regarding three-dimensional periodontal infrabony defects. In contrast, cone beam computed tomography (CBCT) enables visualization of the entire defect morphology. This study aimed to evaluate the agreement between CBCT and direct intrasurgical measurements (ISs) regarding the characteristics of infrabony defects, including measurements of defect depth, width, the type of defect (one-wall, two-wall, three-wall), and defect extension. Methods: Intrasurgical and radiographic assessments were performed by two calibrated examiners on 26 infrabony defects in 17 patients who underwent periodontal surgery. The defect depth, width, type, and extension were compared between intrasurgical observations and PA or CBCT findings. The CBCT assessment was performed mainly using axial reconstructions. Angle measurements were compared between CBCT and PAs. Results: The mean differences between CBCT and intrasurgical measurements were −0.11 ± 0.49 mm for depth and −0.07 ± 0.41 mm for width, with no significant differences. The ICC values were 0.938 and 0.923 for depth and width, respectively. The mean difference in width between PAs and ISs was significantly different (−0.36 ± 0.73 mm; p = 0.002). CBCT demonstrated high agreement with intrasurgical observations for defect type (κ = 0.819) and defect extension (κ = 0.855), while lower agreements were found for PAs. Conclusions: CBCT is a valid assessment modality for infrabony defects. It demonstrated strong agreement with ISs—as the gold standard—for depth and width measurements, and its agreement with ISs regarding defect type and extension appeared to surpass that of PAs. Full article
(This article belongs to the Special Issue Computed Tomography for Oral and Maxillofacial Applications)
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16 pages, 5452 KiB  
Article
Study on the Solidification and Heat Release Characteristics of Flexible Heat Storage Filled with PCM Composite
by Tielei Yan, Gang Wang, Dong Zhang, Changxin Qi, Shuangshuang Zhang, Peiqing Li and Gaosheng Wei
Energies 2025, 18(14), 3760; https://doi.org/10.3390/en18143760 - 16 Jul 2025
Viewed by 312
Abstract
Phase change materials (PCMs) have significant potential for utilization due to their high energy storage density and excellent safety in energy storage. In this research, a flexible heat storage device using the stable supercooling of sodium acetate trihydrate composite is developed, enabling on-demand [...] Read more.
Phase change materials (PCMs) have significant potential for utilization due to their high energy storage density and excellent safety in energy storage. In this research, a flexible heat storage device using the stable supercooling of sodium acetate trihydrate composite is developed, enabling on-demand heat release through controlled solidification initiation. The solidification and heat release characteristics are investigated in experiments. The results indicate that the heat release characteristics of this heat storage device are closely linked to the crystallization process of the PCM. During the experiment, based on whether external intervention was needed for the solidification process, the PCM manifested two separate solidification modes—specifically, spontaneous self-solidification and triggered-solidification. Meanwhile, the heat release rates, temperature changes, and crystal morphologies were observed in the two solidification modes. Compared with spontaneous self-solidification, triggered-solidification achieved a higher peak surface temperature (53.6 °C vs. 46.2 °C) and reached 45 °C significantly faster (5 min vs. 15 min). Spontaneous self-solidification exhibited slower, uncontrollable heat release with dendritic crystals, while triggered-solidification provided rapid, controllable heat release with dense filamentous crystals. This controllable switching between modes offers key practical advantages, allowing the device to provide either rapid, high-power heat discharge or slower, sustained release as required by the application. According to the crystal solidification theory, the different supercooling degrees are the main reasons for the two solidification modes exhibiting different solidification characteristics. During solidification, the growth rate of SAT crystals exhibits substantial disparities across diverse experiments. In this research, the maximum axial growth rate is 2564 μm/s, and the maximum radial growth rate is 167 μm/s. Full article
(This article belongs to the Special Issue Heat Transfer Principles and Applications)
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16 pages, 3138 KiB  
Article
Analysis of Vibration Characteristics of Angular Contact Ball Bearings in Aviation Engines Under Changing Conditions
by Yanfang Dong, Zibo Yan, Jianyong Sun, Wei Yu, Hai Zhang, Wenbo Zhou and Jihao Jin
Aerospace 2025, 12(7), 623; https://doi.org/10.3390/aerospace12070623 - 11 Jul 2025
Viewed by 319
Abstract
This paper addresses the vibration characteristics of angular contact ball bearings in aircraft engines under variable load conditions. Based on multibody dynamics theory, a dynamic model of the bearing was established. Vibration data under actual operating conditions were obtained using an experimental test [...] Read more.
This paper addresses the vibration characteristics of angular contact ball bearings in aircraft engines under variable load conditions. Based on multibody dynamics theory, a dynamic model of the bearing was established. Vibration data under actual operating conditions were obtained using an experimental test platform. This study systematically investigated the influence of rotational speed, axial load, and radial load on the vibration acceleration level of the bearing outer ring. Through a comparison of simulation and experimental data (with an error rate below 10%), the reliability of the model was validated. The results indicate that the bearing vibration acceleration level exhibits a nonlinear increasing relationship with rotational speed. An increase in radial load significantly amplifies the amplitude of acceleration-level fluctuations, while appropriately increasing axial load can reduce bearing vibration intensity. Under variable load coupling conditions, the dynamic interaction between axial and radial forces results in complex nonlinear vibration responses, with a 2 s acceleration time achieving the optimal balance between vibration suppression and efficiency (steady-state average of 70.4 dB). Additionally, the morphological characteristics of the cage center-of-gravity trajectory (such as trajectory disorder and poor smoothness) are closely related to vibration characteristics, revealing the critical role of dynamic load changes in bearing stability. The research results provide a theoretical basis for optimizing the operating conditions, vibration control, and reliability design of aircraft engine bearings. Full article
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31 pages, 17228 KiB  
Article
The Hydrodynamic Performance of a Vertical-Axis Hydro Turbine with an Airfoil Designed Based on the Outline of a Sailfish
by Aiping Wu, Shiming Wang and Chenglin Ding
J. Mar. Sci. Eng. 2025, 13(7), 1266; https://doi.org/10.3390/jmse13071266 - 29 Jun 2025
Viewed by 345
Abstract
This study investigates an aerodynamic optimization framework inspired by marine biological morphology, utilizing the sailfish profile as a basis for airfoil configuration. Through Latin hypercube experimental design combined with optimization algorithms, four key geometric variables governing the airfoil’s hydrodynamic characteristics were systematically analyzed. [...] Read more.
This study investigates an aerodynamic optimization framework inspired by marine biological morphology, utilizing the sailfish profile as a basis for airfoil configuration. Through Latin hypercube experimental design combined with optimization algorithms, four key geometric variables governing the airfoil’s hydrodynamic characteristics were systematically analyzed. Parametric studies revealed that pivotal factors including installation angle significantly influenced the fluid dynamic performance metrics of lift generation and pressure drag. Response surface methodology was employed to establish predictive models for these critical performance indicators, effectively reducing computational resource consumption and experimental validation costs. The refined bio-inspired configuration demonstrated multi-objective performance improvements compared to the baseline configuration, validating the computational framework’s effectiveness for hydrodynamic profile optimization studies. Furthermore, a coaxial dual-rotor vertical axis turbine configuration was developed, integrating centrifugal and axial-flow energy conversion mechanisms through a shared drivetrain system. The centrifugal rotor component harnessed tidal current kinetic energy while the axial-flow rotor module captured wave-induced potential energy. Transient numerical simulations employing dynamic mesh techniques and user-defined functions within the Fluent environment were conducted to analyze rotor interactions. Results indicated the centrifugal subsystem demonstrated peak hydrodynamic efficiency at a 25° installation angle, whereas the axial-flow module achieves optimal performance at 35° blade orientation. Parametric optimization revealed maximum energy extraction efficiency for the centrifugal rotor occurs at λ = 1.25 tip-speed ratio under Re = 1.3 × 105 flow conditions, while the axial-flow counterpart attained optimal performance at λ = 1.5 with Re = 5.5 × 104. This synergistic configuration demonstrated complementary operational characteristics under marine energy conversion scenarios. Full article
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30 pages, 6308 KiB  
Article
Morphological Dynamics of Tram-Led Regeneration: A Space Syntax Study of the Trambesòs Line in Barcelona
by Emilio Reyes-Schade, Sara Molarinho Marques, Ayman Imam, Abdulrhman M. Gbban, Mohammed Alamoudi, Abdulaziz Afandi, Roba Shaheen, Ahmad Fallatah and David Cueto
Sustainability 2025, 17(13), 5880; https://doi.org/10.3390/su17135880 - 26 Jun 2025
Viewed by 505
Abstract
Surface-guided tram systems are increasingly being recognised not only as mobility instruments but also as agents of urban regeneration that reshape spatial and social dynamics. This study evaluates the configurational impact of the Trambesòs tram in Barcelona on accessibility, integration, and urban cohesion [...] Read more.
Surface-guided tram systems are increasingly being recognised not only as mobility instruments but also as agents of urban regeneration that reshape spatial and social dynamics. This study evaluates the configurational impact of the Trambesòs tram in Barcelona on accessibility, integration, and urban cohesion within the Levante del Besòs area. A Space Syntax analysis was conducted in UCL DepthmapX for axial map analysis and visual graph analysis within a 500 m radius around each station. Three typologies of intervention (site-specific, articulation axes, and saturation pieces) guided the assessment. This analysis shows that Avinguda Diagonal and Avinguda Meridiana are primary structural corridors, while stations Glòries, Ca l’Aranyó, and Pere IV recorded the highest accessibility and visual openness. The results indicate that targeted interventions have positive impacts on the Space Syntax metrics regardless of their spatial centrality, highlighting the critical role of this diverse intervention typology in shaping the study area’s spatial configuration and influencing a hierarchy of social appropriation and use. It is concluded that the Trambesòs tram and associated urban interventions have jointly enhanced centrality and permeability in key sectors, and specific peripheral enclaves have local functioning. These findings, focused on spatial and morphological patterns, may support future interventions in urban design and mobility planning. Although the analysis centres on spatial configuration, future research may integrate socioeconomic variables to broaden the understanding of regeneration processes. Full article
(This article belongs to the Section Sustainable Transportation)
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14 pages, 2122 KiB  
Article
Changes to the Intercondylar Ligaments of the Knee in Different Stages of Osteoarthritis—A Retrospective Cross-Sectional Study
by Elisabeth Mandler, Franz Kainberger and Lena Hirtler
J. Clin. Med. 2025, 14(13), 4513; https://doi.org/10.3390/jcm14134513 - 25 Jun 2025
Viewed by 429
Abstract
Background: The intercondylar notch (IN) houses the central ligaments of the knee joint, namely the anterior and posterior cruciate ligaments (ACL and PCL) as well as the anterior and posterior meniscofemoral ligaments (aMFL and pMFL). As not only the available intercondylar space directly [...] Read more.
Background: The intercondylar notch (IN) houses the central ligaments of the knee joint, namely the anterior and posterior cruciate ligaments (ACL and PCL) as well as the anterior and posterior meniscofemoral ligaments (aMFL and pMFL). As not only the available intercondylar space directly influences the encased ligaments, but also the ligaments themselves may influence each other, the purpose of this study was to evaluate the influence of osteoarthritis on central ligament morphology. Methods: Imaging data from the osteoarthritis initiative was used to assess 415 randomly selected patients, equally distributed across five groups based on osteoarthritis severity using the Kellgren and Lawrence classification. MRI scans were used to measure ligament structures in the coronal, axial and sagittal planes. The ACL was evaluated and classified into healthy, pathologic and ruptured. The relationship between osteoarthritis severity and the shape of the IN (A-shape, inverse-U-shape and Ω-shape) was analyzed in relation to ligament morphometrics and ACL condition. Results: The morphology of the ligaments is directly influenced by the development of osteoarthritis. In particular, the Ω-shape, which is associated with severe-grade osteoarthritis, is a risk factor for the development of ACL rupture (p < 0.001). But also, the condition of the ACL influenced the morphometrics of the posterior ligaments, and the PCL as well as the MFLs influenced each other. Conclusions: Statistically significant morphological changes to the encased ligaments in the intercondylar space in osteoarthritis were reported. In particular, the ACL shows a higher risk for pathological changes during ongoing joint degeneration due to osteoarthritis. The other evaluated ligaments—MFLs and PCL—are influenced by the condition of the osseous structures and the shape of the IN as well as by the condition and continuity of the ACL. Full article
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24 pages, 5441 KiB  
Article
Upgoing and Downgoing Wavefield Separation in Vertical Seismic Profiling Guided by Signal Knowledge Representation
by Cai Lu, Liyuan Qu, Jijun Liu and Jianbo Gao
Appl. Sci. 2025, 15(11), 6360; https://doi.org/10.3390/app15116360 - 5 Jun 2025
Viewed by 442
Abstract
Effective vertical seismic profiling (VSP) of upgoing and downgoing wave separation is essential for high-quality imaging. However, VSP wavefield separation is particularly challenging under complex geological conditions. Existing solutions encompass one derived from the mathematical characteristics of upgoing and downgoing waves, employing signal [...] Read more.
Effective vertical seismic profiling (VSP) of upgoing and downgoing wave separation is essential for high-quality imaging. However, VSP wavefield separation is particularly challenging under complex geological conditions. Existing solutions encompass one derived from the mathematical characteristics of upgoing and downgoing waves, employing signal decomposition methodologies, and another that utilizes data-driven machine learning techniques, achieving wavefield separation by training sample data to identify the distinct characteristics of upgoing and downgoing waves. This study introduces a VSP wave-separation method using signal knowledge representation, primarily by constructing knowledge representations of upgoing and downgoing waves. Physics-informed recurrent neural network FWI and Poynting vector physical knowledge representation yielded accurate velocity models. Axial gradient information was utilized to construct morphological knowledge representations of upgoing and downgoing waves. Directional differentiation knowledge representations were established based on kinematic characteristic disparities between upgoing and downgoing waves in the time-depth domain. These wave knowledge representations (KRs) built a dual convolutional autoencoder. Its distinct branches extracted up/down wave information, while the KRs, transformed into loss functions, enabled knowledge-driven unsupervised VSP wave separation. The proposed methodology was validated using a homogeneous layer and Marmousi models, demonstrating the effective separation of upgoing and downgoing waves from the VSP seismic records. Full article
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16 pages, 703 KiB  
Article
Genetic Testing of a High-End ‘Angel Skin’ Precious Coral Necklace Identifies a Species New to the Precious Coral Trade and Potentially New to Science
by Bertalan Lendvay, Laurent E. Cartier, Akitsugu Sato, Michael S. Krzemnicki, Masanori Nonaka, Nina Yasuda, Kenji Takata, Takeshi Hayashibara, Nadja V. Morf and Nozomu Iwasaki
Diversity 2025, 17(6), 395; https://doi.org/10.3390/d17060395 - 3 Jun 2025
Viewed by 645
Abstract
Precious corals from the Corallidae family (Corallium, Hemicorallium, and Pleurocorallium genera) are well known in the high-end jewelry industry due to their colorful and durable axial skeleton. They exist in various colors from white to pink to dark red. One [...] Read more.
Precious corals from the Corallidae family (Corallium, Hemicorallium, and Pleurocorallium genera) are well known in the high-end jewelry industry due to their colorful and durable axial skeleton. They exist in various colors from white to pink to dark red. One highly appreciated shade is the light pink color, the so-called ‘angel skin’. This color is most often associated with Pleurocorallium elatius and Pleurocorallium secundum, species listed in CITES Appendix III. However, this has been based on an assumption of their visual similarity and has never been underpinned by detailed morphologic or genetic data. In this study, we present the analysis of an ‘angel skin’ coral necklace of exceptional size and homogeneous color and quality. Visual observation and Raman spectroscopy confirmed that the necklace consists of genuine, untreated precious coral material. Following minimally destructive sampling, respectively, drilling 2.2, 2.4, and 2.4 milligrams of material from the existing drill-holes, three randomly selected beads from the necklace were subject to a routine genetic identification assay, which is based on sequencing a short, taxonomically informative mitochondrial region. This genetic analysis identified the coral material as not from P. elatius or P. secundum but from another Pleurocorallium species. We subsequently sequenced additional mitochondrial DNA fragments from one ‘angel skin’ coral bead and compared them against a well-represented, curated reference data set of Pleurocorallium, including the first-ever sequencing of Pleurocorallium gotoense, Pleurocorallium johnsoni, Pleurocorallium cf. pusillum, and Pleurocorallium uchidai. We concluded that the analyzed material of the ‘angel skin’ coral necklace belongs to the Pleurocorallium norfolkicum species complex but is not identical to any hitherto analyzed and published Pleurocorallium specimens. A comparison with further taxonomically unidentified precious coral colony fragments identified a single sample fished in Vietnam to be completely identical to the ‘angel skin’ coral bead in the studied DNA regions. Thus, by the analysis of a high-end jewel, we discovered a species new to the jewelry trade and potentially also unknown to science. This implies that the currently considered list of species present in the precious coral trade is incomplete. Full article
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