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16 pages, 3228 KiB  
Article
Wettability of Two-Dimensional Carbon Allotropes from Molecular Simulations
by Margaret E. Thornton, Serban G. Zamfir and Dusan Bratko
Molecules 2025, 30(15), 3296; https://doi.org/10.3390/molecules30153296 - 6 Aug 2025
Abstract
Force-field Monte Carlo and Molecular Dynamics simulations are used to compare wetting behaviors of model carbon sheets mimicking neat graphene, its saturated derivative, graphane, and related planar allotropes penta-graphene, γ-graphyne, and ψ-graphene in contact with aqueous droplets or an aqueous film [...] Read more.
Force-field Monte Carlo and Molecular Dynamics simulations are used to compare wetting behaviors of model carbon sheets mimicking neat graphene, its saturated derivative, graphane, and related planar allotropes penta-graphene, γ-graphyne, and ψ-graphene in contact with aqueous droplets or an aqueous film confined between parallel carbon sheets. Atomistic and area-integrated surface/water potentials are found to be essentially equivalent in capturing moderate differences between the wetting free energies of tested substrates. Despite notable differences in mechanical and electric properties of distinct allotropes, the predicted allotrope/water contact angles span a narrow window of weakly hydrophilic values. Contact angles in the range of 80 ± 10° indicate modest hydration repulsion incapable of competing with van der Waals attraction between carbon particles. Poor dispersibility in neat water is hence a common feature of studied materials. Full article
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28 pages, 930 KiB  
Review
Financial Development and Energy Transition: A Literature Review
by Shunan Fan, Yuhuan Zhao and Sumin Zuo
Energies 2025, 18(15), 4166; https://doi.org/10.3390/en18154166 - 6 Aug 2025
Abstract
Under the global context of climate governance and sustainable development, low-carbon energy transition has become a strategic imperative. As a critical force in resource allocation, the financial system’s impact on energy transition has attracted extensive academic attention. This paper presents the first comprehensive [...] Read more.
Under the global context of climate governance and sustainable development, low-carbon energy transition has become a strategic imperative. As a critical force in resource allocation, the financial system’s impact on energy transition has attracted extensive academic attention. This paper presents the first comprehensive literature review on energy transition research in the context of financial development. We develop a “Financial Functions-Energy Transition Dynamics” analytical framework to comprehensively examine the theoretical and empirical evidence regarding the relationship between financial development (covering both traditional finance and emerging finance) and energy transition. The understanding of financial development’s impact on energy transition has progressed from linear to nonlinear perspectives. Early research identified a simple linear promoting effect, whereas current studies reveal distinctly nonlinear and multidimensional effects, dynamically driven by three fundamental factors: economy, technology, and resources. Emerging finance has become a crucial driver of transition through technological innovation, risk diversification, and improved capital allocation efficiency. Notable disagreements persist in the existing literature on conceptual frameworks, measurement approaches, and empirical findings. By synthesizing cutting-edge empirical evidence, we identify three critical future research directions: (1) dynamic coupling mechanisms, (2) heterogeneity of financial instruments, and (3) stage-dependent evolutionary pathways. Our study provides a theoretical foundation for understanding the complex finance-energy transition relationship and informs policy-making and interdisciplinary research. Full article
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18 pages, 7432 KiB  
Article
Design and Optimization of a Pneumatic Microvalve with Symmetric Magnetic Yoke and Permanent Magnet Assistance
by Zeqin Peng, Zongbo Zheng, Shaochen Yang, Xiaotao Zhao, Xingxiao Yu and Dong Han
Actuators 2025, 14(8), 388; https://doi.org/10.3390/act14080388 - 4 Aug 2025
Viewed by 143
Abstract
Electromagnetic pneumatic microvalves, widely used in knitting machines, typically operate based on a spring-return mechanism. When the coil is energized, the electromagnetic force overcomes the spring force to attract the armature, opening the valve. Upon de-energization, the armature returns to its original position [...] Read more.
Electromagnetic pneumatic microvalves, widely used in knitting machines, typically operate based on a spring-return mechanism. When the coil is energized, the electromagnetic force overcomes the spring force to attract the armature, opening the valve. Upon de-energization, the armature returns to its original position under the restoring force of the spring, closing the valve. However, most existing electromagnetic microvalves adopt a radially asymmetric magnetic yoke design, which generates additional radial forces during operation, leading to armature misalignment or even sticking. Additionally, the inductance effect of the coil causes a significant delay in the armature release response, making it difficult to meet the knitting machine’s requirements for rapid response and high reliability. To address these issues, this paper proposes an improved electromagnetic microvalve design. First, the magnetic yoke structure is modified to be radially symmetric, eliminating unnecessary radial forces and preventing armature sticking during operation. Second, a permanent magnet assist mechanism is introduced at the armature release end to enhance release speed and reduce delays caused by the inductance effect. The effectiveness of the proposed design is validated through electromagnetic numerical simulations, and a multi-objective genetic algorithm is further employed to optimize the geometric dimensions of the electromagnet. The optimization results indicate that, while maintaining the fundamental power supply principle of conventional designs, the new microvalve structure achieves a pull-in time comparable to traditional designs during engagement but significantly reduces the release response time by approximately 80.2%, effectively preventing armature sticking due to radial forces. The findings of this study provide a feasible and efficient technical solution for the design of electromagnetic microvalves in textile machinery applications. Full article
(This article belongs to the Section Miniaturized and Micro Actuators)
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38 pages, 9437 KiB  
Review
Antibacterial Polysaccharides in Dental Implantology
by Lubica Hallmann and Mark Daniel Gerngroß
Mar. Drugs 2025, 23(8), 321; https://doi.org/10.3390/md23080321 - 4 Aug 2025
Viewed by 238
Abstract
Background: The aim of this review is to summarize and evaluate the properties of antibacterial polysaccharides for application in dental implantology to identify knowledge gaps and provide new research ideas. Methods: The electronic databases PubMed, Medline, ProQuest, and Google Scholar were used [...] Read more.
Background: The aim of this review is to summarize and evaluate the properties of antibacterial polysaccharides for application in dental implantology to identify knowledge gaps and provide new research ideas. Methods: The electronic databases PubMed, Medline, ProQuest, and Google Scholar were used to search for peer-reviewed scientific publications published between 2018 and 2025 that provide insights to answer research questions on the role of antibacterial polysaccharides in combating pathogens in dental implantology without triggering immune reactions and inflammation. Further research questions relate to the efficacy against various dental pathogens and the understanding of the antibacterial mechanism, which may enable the development of functionalized polysaccharides with long-term antibacterial activity. Results: Biomedical implants have revolutionized medicine but also increased the risk of infections. Implant infections are a major problem in implantology and lead to implant failure and replacement. An antibacterial coating could be an excellent strategy to extend the lifespan of implants and improve the quality of the patient’s life. Bacterial resistance to antibiotics poses significant challenges for researchers, forcing them to search for new ways to prevent bacterial infections in implantology. Antibacterial natural polymers have recently received considerable research attention due to their long-term antibacterial activity. Polysaccharides from marine sources, such as chitosan and alginate, or pectin, xanthan, etc., from various plants, appear to be promising biopolymers for such applications in implantology due to their antibacterial activity, biocompatibility, and osteogenic properties. The antibacterial activity of these natural biopolymers depends on their chemical and physical properties. Nanopolysaccharides exhibit higher antibacterial activity than conventional polysaccharides, but their toxicity to human cells must be considered. Their antibacterial activity is based on the disruption of bacterial DNA or RNA synthesis, increased cell wall permeability, membrane disruption, and cytoplasmic leakage. Conclusions: Polysaccharides are a class of natural polymers with a broad spectrum of biological activities. They exhibit antioxidant, immunomodulatory, anticoagulant, anticancer, anti-inflammatory, antibacterial, and antiviral activity. Furthermore, polysaccharides are non-cytotoxic and exhibit good biocompatibility with osteogenic cells. Bactericidal polysaccharides are attractive new antibacterial materials against implant infections and open up new perspectives in implantology. Full article
(This article belongs to the Special Issue Marine Biomaterials for Dental Applications)
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11 pages, 4858 KiB  
Communication
Customized Chirality of an Optical Vortex Pair: Helical Dichroism and Enantioselective Force
by Xingxing Han, Haibo Niu, Jing Shi, Weili Dong and Jiajie Wang
Photonics 2025, 12(8), 781; https://doi.org/10.3390/photonics12080781 - 4 Aug 2025
Viewed by 89
Abstract
Tailoring the chirality of an optical vortex is crucial for advancing helical chiroptical spectroscopy techniques in various scenarios and attracts great attention. In contrast to the single vortex, the optical vortex pair exhibits richer, fantastic chirality properties due to its additional adjustment parameters. [...] Read more.
Tailoring the chirality of an optical vortex is crucial for advancing helical chiroptical spectroscopy techniques in various scenarios and attracts great attention. In contrast to the single vortex, the optical vortex pair exhibits richer, fantastic chirality properties due to its additional adjustment parameters. Here, a comprehensive investigation of the chirality for linearly polarized optical vortex pairs based on the vector angular spectrum decomposition method is conducted. The numerical results show that the magnitudes and distributions of local chirality density, helical dichroism, and enantioselective force of the optical vortex pair can be flexibly customized by the position as well as sign combination of vortices, and can vary during free space propagation. The underlying physical mechanism behind these phenomena is ascribed to the interplay of two vortices. Our work can deepen the understanding of the chirality for multiple vortices and open-up the prospect for relevant applications in chiral recognition and manipulation. Full article
(This article belongs to the Special Issue Realization and Application of Vortex Laser)
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36 pages, 10414 KiB  
Article
Forces During the Film Drainage and Detachment of NMC and Spherical Graphite in Particle–Bubble Interactions Quantified by CP-AFM and Modeling to Understand the Salt Flotation of Battery Black Mass
by Jan Nicklas, Claudia Heilmann, Lisa Ditscherlein and Urs A. Peuker
Minerals 2025, 15(8), 809; https://doi.org/10.3390/min15080809 - 30 Jul 2025
Viewed by 254
Abstract
The salt flotation of graphite in the presence of lithium nickel manganese cobalt oxide (NMC) was assessed by performing colloidal probe atomic force microscopy (CP-AFM) on sessile gas bubbles and conducting batch flotation tests with model lithium-ion-battery black mass. The modeling of film [...] Read more.
The salt flotation of graphite in the presence of lithium nickel manganese cobalt oxide (NMC) was assessed by performing colloidal probe atomic force microscopy (CP-AFM) on sessile gas bubbles and conducting batch flotation tests with model lithium-ion-battery black mass. The modeling of film drainage and detachment during particle–bubble interactions provides insight into the fundamental microprocesses during salt flotation, a special variant of froth flotation. The interfacial properties of particles and gas bubbles were tailored with salt solutions containing sodium chloride and sodium acetate buffer. Graphite particles can attach to gas bubbles under all tested conditions in the range pH 3 to pH 10. The attractive forces for spherical graphite are strongest at high salt concentrations and pH 3. The conditions for the attachment of NMC to gas bubbles were evaluated with simulations using the Stokes–Reynolds–Young–Laplace model for film drainage, under consideration of DLVO forces and a hydrodynamic slip to account for irregularities of the particle surface. CP-AFM measurements in the capillary force regime provide additional parameters for the modeling of salt flotation, such as the force and work of detachment. The contact angles of graphite and NMC particles during retraction and detachment from gas bubbles were obtained from a quasi-equilibrium model using CP-AFM data as input. All CP-AFM experiments and theoretical results suggest that pristine NMC particles do not attach to gas bubbles during flotation, which is confirmed by the low rate of NMC recovery in batch flotation tests. Full article
(This article belongs to the Special Issue Particle–Bubble Interactions in the Flotation Process)
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17 pages, 2420 KiB  
Article
Hybrid Obstacle Avoidance Algorithm Based on IAPF and MPC for Underactuated Multi-USV Formation
by Hui Sun, Qing Xue, Mingyang Pan, Zongying Liu and Hangqi Li
J. Mar. Sci. Eng. 2025, 13(8), 1436; https://doi.org/10.3390/jmse13081436 - 27 Jul 2025
Viewed by 290
Abstract
In this paper, we propose a hybrid algorithm that integrates an improved artificial potential field method (IAPF), model predictive control (MPC), and an extended state observer (ESO) to address the obstacle avoidance problem in multi-unmanned surface vehicle (Multi-USV) formations, including both dynamic and [...] Read more.
In this paper, we propose a hybrid algorithm that integrates an improved artificial potential field method (IAPF), model predictive control (MPC), and an extended state observer (ESO) to address the obstacle avoidance problem in multi-unmanned surface vehicle (Multi-USV) formations, including both dynamic and static obstacles, as well as navigation through narrow waterways. Initially, the virtual structure method was applied for formation control. Next, the traditional potential field method was enhanced by employing a saturated attractive potential field and a partitioned repulsive potential field, which improve formation stability and obstacle avoidance accuracy in complex environments. The extended state observer was then employed to estimate and compensate for unknown system dynamics and external disturbances from the marine environment in real time, improving system robustness. On this basis, by leveraging the multi-step predictive optimization capabilities of model predictive control, the proposed algorithm dynamically adjusts control inputs based on the desired trajectories generated from potential field forces, which ensures the stability of formation control and effective obstacle avoidance. The simulation results demonstrate that the proposed algorithm effectively avoids both dynamic and static obstacles in multi-unmanned surface vehicle formations and enables successful navigation through narrow waterways by altering the formation. Full article
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15 pages, 4363 KiB  
Article
Effect of Soft Rock Material Addition on Surface Charge Properties and Internal Force of Aeolian Sandy Soil Particles in the Maowusu Desert
by Zhe Liu, Yang Zhang, Yingying Sun, Yuliang Zhang, Na Wang, Feinan Hu, Yuhu Luo and Tingting Meng
Resources 2025, 14(7), 116; https://doi.org/10.3390/resources14070116 - 21 Jul 2025
Viewed by 295
Abstract
The Maowusu Desert is still suffering from serious ecological and environmental security issues such as wind erosion and desertification, influenced by both natural and human factors. The amendment of aeolian sandy soil with soft rock material presents an effective erosion control strategy, leveraging [...] Read more.
The Maowusu Desert is still suffering from serious ecological and environmental security issues such as wind erosion and desertification, influenced by both natural and human factors. The amendment of aeolian sandy soil with soft rock material presents an effective erosion control strategy, leveraging the complementary structural and compositional properties of both materials to enhance soil stability and rehabilitate degraded environments. However, there are few studies that investigate the effect of soil surface electrochemical properties and particle interaction forces on the structural stability of compound soils with soft rock and sandy soil. This decade-long field study quantified the electrochemical properties and interparticle forces and their synergistic effects on structural stability across five soft rock-to-aeolian sandy soil blend volume ratios (0:1, 1:5, 1:2, 1:1, 1:0) within the 0–30 cm soil profile. The results showed that the soil organic matter (SOM), specific surface area (SSA), and cation exchange capacity (CEC) significantly increased with the incorporation of soft rock material. For five different proportions, with the addition of soft rock and the extension of planting years, the content of SOM increased from 5.65 g·kg−1 to 11.36 g·kg−1, the CEC varied from 4.68 cmol kg−1 to 17.91 cmol kg−1, while the σ0 importantly decreased from 1.8 to 0.47 c m−2 (p < 0.05). For the interaction force at 2.4 nm between soil particles, the absolute value of van der Waals attractive force increased from 0.10 atm to 0.38 atm, and the net force decreased from 0.09 atm to −0.30 atm after the incorporation ratios of soft rock from 0:1 to 1:1. There was a significant negative correlation between the resultant net force between the particles of compound soil and the SSA and CEC. These results indicate that the addition of soft rock material positively improves the surface electrochemical properties and internal forces between aeolian sandy soil particles, further enhancing its structural stability. This study establishes a foundational theoretical framework for advancing our mechanistic understanding of aeolian sand stabilization and ecosystem rehabilitation in the Mu Us Desert. Full article
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25 pages, 14579 KiB  
Article
A Hybrid Path Planning Framework Integrating Deep Reinforcement Learning and Variable-Direction Potential Fields
by Yunfei Bi and Xi Fang
Mathematics 2025, 13(14), 2312; https://doi.org/10.3390/math13142312 - 20 Jul 2025
Viewed by 422
Abstract
To address the local optimality in path planning for logistics robots using APF (artificial potential field) and the stagnation problem when encountering trap obstacles, this paper proposes VDPF (variable-direction potential field) combined with RL (reinforcement learning) to effectively solve these problems. First, based [...] Read more.
To address the local optimality in path planning for logistics robots using APF (artificial potential field) and the stagnation problem when encountering trap obstacles, this paper proposes VDPF (variable-direction potential field) combined with RL (reinforcement learning) to effectively solve these problems. First, based on obstacle distribution, an obstacle classification algorithm is designed, enabling the robot to select appropriate obstacle avoidance strategies according to obstacle types. Second, the attractive force and repulsive force in APF are separated, and the direction of the repulsive force is modified to break the local optimum, allowing the robot to focus on handling current obstacle avoidance tasks. Finally, the improved APF is integrated with the TD3 (Twin Delayed Deep Deterministic Policy Gradient) algorithm, and a weight factor is introduced to adjust the robot’s acting forces. By sacrificing a certain level of safety for a larger exploration space, the robot is guided to escape from local optima and trap regions. Experimental results show that the improved algorithm effectively mitigates the trajectory oscillation of the robot and can efficiently solve the problems of local optimum and trap obstacles in the APF method. Compared with the algorithm APF-TD3 in scenarios with five obstacles, the proposed algorithm reduces the GS (Global Safety) by 8.6% and shortens the length by 8.3%. In 10 obstacle scenarios, the proposed algorithm reduces the GS by 29.8% and shortens the length by 9.7%. Full article
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21 pages, 3490 KiB  
Article
Energy-Efficient CO2 Conversion for Carbon Utilization Using a Gliding Arc/Glow Discharge with Magnetic Field Acceleration—Optimization and Characterization
by Svetlana Lazarova, Snejana Iordanova, Stanimir Kolev, Veselin Vasilev and Tsvetelina Paunska
Energies 2025, 18(14), 3816; https://doi.org/10.3390/en18143816 - 17 Jul 2025
Viewed by 316
Abstract
The dry conversion of CO2 into CO and O2 provides an attractive path for CO2 utilization which allows for the use of the CO produced for the synthesis of valuable hydrocarbons. In the following work, the CO2 conversion is [...] Read more.
The dry conversion of CO2 into CO and O2 provides an attractive path for CO2 utilization which allows for the use of the CO produced for the synthesis of valuable hydrocarbons. In the following work, the CO2 conversion is driven by an arc discharge at atmospheric pressure, producing hot plasma. This study presents a series of experiments aiming to optimize the process. The results obtained include the energy efficiency and the conversion rate of the process, as well as the electrical parameters of the discharge (current and voltage signals). In addition, optical emission spectroscopy diagnostics based on an analysis of C2’s Swan bands are used to determine the gas temperature in the discharge. The data is analyzed according to several aspects—an analysis of the arc’s motion based on the electrical signals; an analysis of the effect of the gas flow and the discharge current on the discharge performance for CO2 conversion; and an analysis of the vibrational and rotational temperatures of the arc channel. The results show significant improvements over previous studies. Relatively high gas conversion and energy efficiency are achieved due to the arc acceleration caused by the Lorentz force. The rotational (gas) temperatures are in the order of 5500–6000 K. Full article
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12 pages, 5751 KiB  
Article
Chaos of Charged Particles in Quadrupole Magnetic Fields Under Schwarzschild Backgrounds
by Qihan Zhang and Xin Wu
Universe 2025, 11(7), 234; https://doi.org/10.3390/universe11070234 - 16 Jul 2025
Viewed by 172
Abstract
A four-vector potential of an external test electromagnetic field in a Schwarzschild background is described in terms of a combination of dipole and quadrupole magnetic fields. This combination is an interior solution of the source-free Maxwell equations. Such external test magnetic fields cause [...] Read more.
A four-vector potential of an external test electromagnetic field in a Schwarzschild background is described in terms of a combination of dipole and quadrupole magnetic fields. This combination is an interior solution of the source-free Maxwell equations. Such external test magnetic fields cause the dynamics of charged particles around the black hole to be nonintegrable, and are mainly responsible for chaotic dynamics of charged particles. In addition to the external magnetic fields, some circumstances should be required for the onset of chaos. The effect of the magnetic fields on chaos is shown clearly through an explicit symplectic integrator and a fast Lyapunov indicator. The inclusion of the quadrupole magnetic fields easily induces chaos, compared with that of the dipole magnetic fields. This result is because the Lorentz forces from the quadrupole magnetic fields are larger than those from the dipole magnetic fields. In addition, the Lorentz forces act as attractive forces, which are helpful for bringing the occurrence of chaos in the nonintegrable case. Full article
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20 pages, 3007 KiB  
Article
Hydrophobic Collagen/Polyvinyl Alcohol/V2CTx Composite Aerogel for Efficient Oil Adsorption
by Erhui Ren, Jiatong Yan, Fan Yang, Hongyan Xiao, Biyu Peng, Ronghui Guo and Mi Zhou
Polymers 2025, 17(14), 1949; https://doi.org/10.3390/polym17141949 - 16 Jul 2025
Viewed by 352
Abstract
The development of effective oil adsorbents has attracted a great deal of attention due to the increasingly serious problem of oil pollution. A light and porous collagen (COL)/polyvinyl alcohol (PVA)/vanadium carbide (V2CTx) composite aerogel was synthesized using a simple [...] Read more.
The development of effective oil adsorbents has attracted a great deal of attention due to the increasingly serious problem of oil pollution. A light and porous collagen (COL)/polyvinyl alcohol (PVA)/vanadium carbide (V2CTx) composite aerogel was synthesized using a simple method of blending, directional freezing, and drying. After modification with methyltriethoxysilane (MTMS) via chemical vapor deposition, the aerogel possessed an excellent hydrophobicity and its water contact angle reached 135°. The hydrophobic COL/PVA/V2CTx composite aerogel exhibits a porous structure with a specific surface area of 49 m2/g. It also possesses prominent mechanical properties with an 80.5 kPa compressive stress at 70% strain, a low density (about 28 mg/cm3), and outstanding thermal stability, demonstrating a 61.02% weight loss from 208 °C to 550 °C. Importantly, the hydrophobic COL/PVA/V2CTx aerogel exhibits a higher oil absorption capacity and stability, as well as a faster absorption rate, than the COL/PVA aerogel when tested with various oils. The hydrophobic COL/PVA/V2CTx aerogel has the capacity to adsorb 80 times its own weight of methylene chloride, with help from hydrophobic interactions, Van der Waals forces, intermolecular interactions, and capillary action. Compared with the pseudo first-order model, the pseudo second-order model is more suitable for oil adsorption kinetics. Therefore, the hydrophobic COL/PVA/V2CTx aerogel can be used as an environmentally friendly and efficient oil adsorbent. Full article
(This article belongs to the Section Polymer Applications)
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16 pages, 11669 KiB  
Article
Design and Electromagnetic Performance Optimization of a MEMS Miniature Outer-Rotor Permanent Magnet Motor
by Kaibo Lei, Haiwang Li, Shijia Li and Tiantong Xu
Micromachines 2025, 16(7), 815; https://doi.org/10.3390/mi16070815 - 16 Jul 2025
Viewed by 323
Abstract
In this study, we present the design and electromagnetic performance optimization of a micro-electromechanical system (MEMS) miniature outer-rotor permanent magnet motor. With increased attention towards higher torque density and lower torque pulsations in MEMS micromotor designs, an adaptation of an external rotor can [...] Read more.
In this study, we present the design and electromagnetic performance optimization of a micro-electromechanical system (MEMS) miniature outer-rotor permanent magnet motor. With increased attention towards higher torque density and lower torque pulsations in MEMS micromotor designs, an adaptation of an external rotor can be highly attractive. However, with the design complexity involved in such high-performance MEMS outer-rotor motor designs, the ultra-miniature 3D coil structures and the thin-film topology surrounding the air gap have been one of the main challenges. In this study, an ultra-thin outer-rotor motor with 3D MEMS silicon-based coils and a MEMS-compatible manufacturing method for the 3D coils is presented. Additionally, finite element simulations are conducted for the thin-film topology around the air gap to optimize performance characteristics such as torque developed, torque pulsations, and back electromotive force amplitude. Ultimately, the average magnetic flux density increased by 37.1%, from 0.361 T to 0.495 T. The root mean square (RMS) value of the back EMF per phase rises by 14.4%. Notably, the average torque is improved by 11.3%, while the torque ripple is significantly reduced from 1.281 mNm to 0.74 mNm, corresponding to a reduction of 49.9% in torque ripple percentage. Full article
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23 pages, 1199 KiB  
Review
Dysregulation of Mitochondrial Function in Cancer Cells
by Ahmed Mahmoud Ahmed Mahmoud Awad and Norwahidah Abdul Karim
Int. J. Mol. Sci. 2025, 26(14), 6750; https://doi.org/10.3390/ijms26146750 - 14 Jul 2025
Viewed by 663
Abstract
In addition to their well-known role in ATP production, mitochondria are vital to cancer cell metabolism due to their involvement in redox regulation, apoptosis, calcium signaling, and biosynthesis. This review explores how cancer cells drive the extensive reprogramming of mitochondrial structure and function, [...] Read more.
In addition to their well-known role in ATP production, mitochondria are vital to cancer cell metabolism due to their involvement in redox regulation, apoptosis, calcium signaling, and biosynthesis. This review explores how cancer cells drive the extensive reprogramming of mitochondrial structure and function, enabling malignant cells to survive hostile microenvironments, evade therapy, and proliferate rapidly. While glycolysis (the Warburg effect) was once thought to be the dominant force behind cancer metabolism, recent updates underscore the pivotal contribution of mitochondrial oxidative phosphorylation (OXPHOS) to tumor development. Cancer cells often exhibit enhanced mitochondrial ATP production, metabolic flexibility, and the ability to switch between energy sources such as glucose, glutamine, and pyruvate. Equally important are changes in mitochondrial morphology and dynamics. Due to disruptions in fusion and fission processes, regulated by proteins like Drp1 and MFN1/2, cancer cells often display fragmented mitochondria, which are linked to increased motility, metastasis, and tumor progression. Moreover, structural mitochondrial alterations not only contribute to drug resistance but may also serve as biomarkers for therapeutic response. Emerging evidence also points to the influence of oncometabolites and retrograde signaling in reshaping mitochondrial behavior under oncogenic stress. Collectively, these insights position mitochondria as central regulators of cancer biology and attractive targets for therapy. By unraveling the molecular mechanisms underlying mitochondrial reprogramming—from energy production to structural remodeling—researchers can identify new approaches to disrupt cancer metabolism and enhance treatment efficacy. Full article
(This article belongs to the Special Issue Mitochondria: Central Players in Cancer)
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25 pages, 2780 KiB  
Article
Motion of Magnetic Microcapsules Through Capillaries in the Presence of a Magnetic Field: From a Mathematical Model to an In Vivo Experiment
by Mikhail N. Zharkov, Mikhail A. Pyataev, Denis E. Yakobson, Valentin P. Ageev, Oleg A. Kulikov, Vasilisa I. Shlyapkina, Dmitry N. Khmelenin, Larisa A. Balykova, Gleb B. Sukhorukov and Nikolay A. Pyataev
Magnetochemistry 2025, 11(7), 60; https://doi.org/10.3390/magnetochemistry11070060 - 14 Jul 2025
Viewed by 335
Abstract
In this paper, we discuss the prediction of the delivery efficiency of magnetic carriers based on their properties and field parameters. We developed a theory describing the behavior of magnetic capsules in the capillaries of living systems. A partial differential equation for the [...] Read more.
In this paper, we discuss the prediction of the delivery efficiency of magnetic carriers based on their properties and field parameters. We developed a theory describing the behavior of magnetic capsules in the capillaries of living systems. A partial differential equation for the spatial distribution of magnetic capsules has been obtained. We propose to characterize the interaction between the magnetic field and the capsules using a single vector, which we call “specific magnetic force”. To test our theory, we performed experiments on a model of a capillary bed and on a living organism with two types of magnetic capsules that differ in size and amount of magnetic material. The experimental results show that the distribution of the capsules in the field correlated with the theory, but there were fewer actually accumulated capsules than predicted by the theory. In the weaker fields, the difference was more significant than in stronger ones. We proposed an explanation for this phenomenon based on the assumption that a certain level of magnetic force is needed to keep the capsules close to the capillary wall. We also suggested a formula for the relationship between the probability of capsule precipitation and the magnetic force. We found the effective value of a specific magnetic force at which all the capsules attracted by the magnet reach the capillary wall. This value can be considered as the minimum level for the field at which it is, in principle, possible to achieve a significant magnetic control effect. We demonstrated that for each type of capsule, there is a specific radius of magnet for which the effective magnetic force is achieved at the largest possible distance from the magnet’s surface. For the capsules examined in this study, the maximum distance where the effective field can be achieved does not exceed 1.5 cm. The results of the study contribute to our understanding of the behavior of magnetic particles in the capillaries of living organisms when exposed to a magnetic field. Full article
(This article belongs to the Special Issue Fundamentals and Applications of Novel Functional Magnetic Materials)
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