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Article

10 Citations

3,141 Views

22 Pages

Arteannuin-B and (3-Chlorophenyl)-2-Spiroisoxazoline Derivative Exhibit Anti-Inflammatory Effects in LPS-Activated RAW 264.7 Macrophages and BALB/c Mice-Induced Proinflammatory Responses via Downregulation of NF-κB/P38 MAPK Signaling

Gifty Sawhney,
Javeed Ur Rasool,
Diksha Saroch,
Mumin Ozturk,
Frank Brombacher,
Bilal Ahmad,
Asha Bhagat,
Asif Ali,
Suraj P. Parihar and
Zabeer Ahmed

Molecules2022, 27(22), 8068;https://doi.org/10.3390/molecules27228068

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20 November 2022

Host inflammatory responses are key to protection against injury; however, persistent inflammation is detrimental and contributes to morbidity and mortality. Herein, we demonstrated the anti-inflammatory role of Arteannuin-B (1) and its new spirocycl...

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Article

6 Citations

3,661 Views

21 Pages

Development of Arteannuin B Sustained-Release Microspheres for Anti-Tumor Therapy by Integrated Experimental and Molecular Modeling Approaches

Yanqing Wang,
Weijuan Huang,
Nannan Wang,
Defang Ouyang,
Lifeng Xiao,
Sirui Zhang,
Xiaozheng Ou,
Tingsha He,
Rongmin Yu and
Liyan Song

Pharmaceutics2021, 13(8), 1236;https://doi.org/10.3390/pharmaceutics13081236

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11 August 2021

Arteannuin B (AB) has been found to demonstrate obvious anti-tumor activity. However, AB is not available for clinical use due to its very low solubility and very short half-life. This study aimed to develop AB long sustained-release microspheres (AB...

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Article

1 Citations

4,851 Views

13 Pages

Four New Compounds Obtained from Cultured Cells of Artemisia annua

Jianhua Zhu,
Peijie Xiao,
Minghua Qian,
Chang Chen,
Chuxin Liang,
Jiachen Zi and
Rongmin Yu

Molecules2017, 22(12), 2264;https://doi.org/10.3390/molecules22122264

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18 December 2017

Four new compounds obtained from cultured cells of Artemisia annua were reported. Products were detected by HPLC-ELSD/GC-MS and isolated by chromatographic methods. The structures of four new compounds, namely 6-hydroxy arteannuin I (1), 1-hydroxy ar...

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Article

23 Citations

5,640 Views

13 Pages

Insights into Heterologous Biosynthesis of Arteannuin B and Artemisinin in Physcomitrella patens

Nur Kusaira Khairul Ikram,
Arman Beyraghdar Kashkooli,
Anantha Peramuna,
Alexander R. van der Krol,
Harro Bouwmeester and
Henrik Toft Simonsen

Molecules2019, 24(21), 3822;https://doi.org/10.3390/molecules24213822

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23 October 2019

Metabolic engineering is an integrated bioengineering approach, which has made considerable progress in producing terpenoids in plants and fermentable hosts. Here, the full biosynthetic pathway of artemisinin, originating from Artemisia annua, was in...

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Article

1 Citations

2,350 Views

18 Pages

Green Extraction of Volatile Terpenes from Artemisia annua L.

Marta Mandić,
Ivona Ivančić,
Matija Cvetnić,
Claudio Ferrante,
Giustino Orlando and
Sanda Vladimir-Knežević

Molecules2025, 30(7), 1638;https://doi.org/10.3390/molecules30071638

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7 April 2025

In the present study, the extraction of volatile terpenes from A. annua with supercritical CO2 (sc-CO2) was optimized by a full factorial design procedure and compared with conventional distillation. The influence of pressure (100–220 bar) and...

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Article

12 Citations

3,695 Views

15 Pages

Simultaneous Quantification of Five Sesquiterpene Components after Ultrasound Extraction in Artemisia annua L. by an Accurate and Rapid UPLC–PDA Assay

Jiaqi Ruan,
Zhengyue Liu,
Feng Qiu,
Henan Shi and
Manyuan Wang

Molecules2019, 24(8), 1530;https://doi.org/10.3390/molecules24081530

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18 April 2019

Objective: To develop an accurate and rapid ultra-performance liquid chromatography (UPLC) coupled with a photodiode array (PDA) method for the simultaneous determination of artemisinin (Art), arteannuin B (Art B), arteannuin C (Art C), dihydroartemi...

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Feature Paper
Article

14 Citations

6,386 Views

12 Pages

Comparative Evaluation of Different Extraction Techniques for Separation of Artemisinin from Sweet Wormwood (Artemisia annua L.)

Marija Banožić,
Aleksandra Weronika Wronska,
Martina Jakovljević Kovač,
Krunoslav Aladić,
Igor Jerković and
Stela Jokić

Horticulturae2023, 9(6), 629;https://doi.org/10.3390/horticulturae9060629

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26 May 2023

Sweet wormwood (Artemisia annua L.) valorization is gaining importance due to the presence of the health-promoting bioactive compound, artemisinin. Considering the wide possible application of artemisinin drug formulations, new, greener technologies...

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Article

11 Citations

3,288 Views

23 Pages

Untargeted Metabolomics Profiling Reveals Beneficial Changes in Milk of Sows Supplemented with Fermented Compound Chinese Medicine Feed Additive

Wanjie Zou,
Linglan Deng,
Huadong Wu,
Zhiyong Liu,
Wei Lu and
Yuyong He

Animals2022, 12(20), 2879;https://doi.org/10.3390/ani12202879

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21 October 2022

Different untargeted metabolomics approaches were used to identify the differential metabolites between milk samples collected from two groups. Sows were supplemented with fermented compound Chinese medicine feed additive at levels of 0 g/d/sow (cont...

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Article

46 Citations

14,420 Views

17 Pages

Effect of Sugars on Artemisinin Production in Artemisia annua L.: Transcription and Metabolite Measurements

Patrick R. Arsenault,
Daniel R. Vail,
Kristin K. Wobbe and
Pamela J. Weathers

Molecules2010, 15(4), 2302-2318;https://doi.org/10.3390/molecules15042302

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30 March 2010

The biosynthesis of the valuable sesquiterpene anti-malarial, artemisinin, is known to respond to exogenous sugar concentrations. Here young Artemisia annua L. seedlings (strain YU) were used to measure the transcripts of six key genes in artemisinin...

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9 Results Found

Arteannuin-B and (3-Chlorophenyl)-2-Spiroisoxazoline Derivative Exhibit Anti-Inflammatory Effects in LPS-Activated RAW 264.7 Macrophages and BALB/c Mice-Induced Proinflammatory Responses via Downregulation of NF-κB/P38 MAPK Signaling

Development of Arteannuin B Sustained-Release Microspheres for Anti-Tumor Therapy by Integrated Experimental and Molecular Modeling Approaches

Four New Compounds Obtained from Cultured Cells of Artemisia annua

Insights into Heterologous Biosynthesis of Arteannuin B and Artemisinin in Physcomitrella patens

Green Extraction of Volatile Terpenes from Artemisia annua L.

Simultaneous Quantification of Five Sesquiterpene Components after Ultrasound Extraction in Artemisia annua L. by an Accurate and Rapid UPLC–PDA Assay

Comparative Evaluation of Different Extraction Techniques for Separation of Artemisinin from Sweet Wormwood (Artemisia annua L.)

Untargeted Metabolomics Profiling Reveals Beneficial Changes in Milk of Sows Supplemented with Fermented Compound Chinese Medicine Feed Additive

Effect of Sugars on Artemisinin Production in Artemisia annua L.: Transcription and Metabolite Measurements