Search Results (899)

Acute coronary syndromes (ACS) remain time-critical clinical emergencies in which early diagnosis and accurate risk stratification determine management and outcomes. Although symptoms, electrocardiography, and high-sensitivity cardiac troponin (hs-cTn) provide a reliable framework for detecting myocardial injury, they offer limited insight into plaque instability, thromboinflammatory activity, vascular repair, and post-infarction remodeling. In this narrative review, we examine the biological rationale and current clinical evidence supporting brain-derived neurotrophic factor (BDNF) as a candidate biomarker in ACS, with particular attention to pre-analytical, analytical, and phenotypic sources of heterogeneity. Available studies show that circulating BDNF concentrations vary substantially according to biological matrix, timing of sampling, ACS subtype, and assay methodology, which likely contributes to inconsistent findings across cohorts. Overall, current evidence does not support BDNF as a diagnostic alternative to hs-cTn in rule-in or rule-out pathways. However, BDNF may have value in biological phenotyping and risk stratification by reflecting platelet activation, endothelial dysfunction, inflammatory signaling, and remodeling processes after ACS. Further progress will require standardized pre-analytical procedures, separate assessment of mature BDNF and proBDNF, serial sampling, and validation in large multicenter studies. Full article

Commutation failures (CFs), which occur when current transfer between valves in line-commutated converter high-voltage direct current (LCC-HVDC) systems is disrupted, pose a challenge in weak alternating current (AC) networks. This paper introduces a coordinated control strategy that combines a fuzzy self-tuning proportional-integral (PI) controller (FSTPIC) and a static synchronous compensator (STATCOM) device to mitigate CFs and enhance system stability. The approach applies the FSTPIC to both converters of the HVDC link, while the STATCOM at the inverter side delivers dynamic reactive power and voltage support during AC faults. We test this strategy on the CIGRE HVDC benchmark system using MATLAB/SIMULINK simulations. The results demonstrate that the proposed method significantly reduces CFs, mitigates transient oscillations, and shortens recovery time compared to conventional control techniques. This coordinated control boosts voltage stability and the system’s ability to ride through faults, confirming its superiority under various fault scenarios in weak-grid conditions. Full article

Synchronous Alternating Current (AC) power systems are increasingly supported by embedded High-Voltage Direct Current (HVDC) links to enhance operational flexibility and ensure security of supply. However, the loss of High-Voltage Alternating Current (HVAC) interconnections in these synchronous areas may lead to transmission network splitting, posing serious challenges to frequency stability due to the reduction in overall system inertia and stiffness. In this paper, a supplementary control layer is proposed to enable embedded HVDC systems, particularly those based on modern Voltage Source Converters (VSCs), to support frequency stability under post-splitting conditions. The proposed control strategy combines Angle-Difference Control (ADC), Frequency-Difference Control (FDC), and feedforward action, enabling fast and coordinated active-power modulation. A single-bus, dynamic multi-area Load Frequency Control (LFC) model is developed, combining the regulation of thermal units, Renewable Energy Sources’ (RESs’) Fast Frequency Response (FFR) with Synthetic Inertia (SI), and VSC-HVDC modulation. The effectiveness of the proposed control layer is demonstrated by applying it to the East Tyrrhenian Link (ETL), an embedded VSC-HVDC interconnection connecting Sicily with the mainland of Italy, under a post-splitting low-inertia condition in which Sicily operates as an islanded synchronous system, i.e., after losing synchronism with the mainland of Italy, in a 2030 scenario condition. The simulation results demonstrate that the proposed controller enables embedded VSC-HVDC systems to actively participate in post-splitting frequency containment and damping, as well as coordinated active power reallocation, thereby enhancing overall system stability and resilience. Full article

Precise manipulation of two-phase flow in micro-confined electrowetting pixels is limited by contact angle hysteresis (CAH). To elucidate this non-equilibrium process, we establish a high-fidelity electrohydrodynamic (EHD) phase-field simulation framework. The model rigorously couples Navier–Stokes equations with molecular kinetic theory (MKT) to characterize energy dissipation at the three-phase contact line (TCL) and further integrates charge transport kinetics. Numerical results reveal CAH is driven by physical pinning and interfacial charge trapping, with the latter dominating interfacial retreat and causing significant residual displacement. Furthermore, analysis shows alternating current (AC) waveforms mitigate charge accumulation and promote depinning via micro-oscillations, minimizing the hysteresis loop compared to direct current (DC) waveforms. Additionally, an overdrive strategy utilizing a suprathreshold Maxwell stress pulse rapidly overcomes static friction. This strategy significantly improves transient dynamics, substantially reducing the time to reach 90% of the steady-state target from 19.6 ms (under standard DC waveform driving) to 7.4 ms. This work provides a comprehensive theoretical basis and design criteria for optimizing active driving strategies in optofluidic and digital microfluidic systems. Full article

Weak alternating electric fields are widely used in neuromodulation techniques such as transcranial alternating current stimulation (tACS), yet the precise biophysical mechanisms underlying neuronal responses remain incompletely understood. Current computational models often neglect the electrical properties of the extracellular microenvironment, limiting their predictive accuracy. Motivated by experimentally observed frequency-dependent modulation of neuronal activity, we developed a two-compartment model of hippocampal CA3 pyramidal neurons in which extracellular resistance is explicitly parameterized and systematically examined as a key factor influencing neuronal response properties under external electric fields. Within a dual-compartment Hodgkin–Huxley framework, the neuron is divided into a “soma–basal dendrite unit” and an “apical dendrite unit,” accounting for voltage polarization induced by external fields. Using phase-locking ratio curves and three-dimensional parameter response surface, we systematically characterized neuronal sensitivity to field parameters and examined how potassium equilibrium potential ($V_K$) and extracellular resistance ($R_{\mathrm{out}}$) modulate these responses. Our results demonstrate that increasing $R_{\mathrm{out}}$ enhances neuronal responsiveness to external fields, while $V_K$ variations primarily regulate intrinsic excitability. These findings provide mechanistic insights into the frequency-dependent modulation of neuronal responses under weak electric fields, consistent with phenomena observed in biological neural systems, and provide a mechanistic and theoretical framework for understanding the joint effects of electric field amplitude and frequency on neuronal sensitivity to weak electric fields, which may help inform future neuromodulation strategies. Full article

We developed an arbitrary Lagrangian–Eulerian (ALE)-based multiphysics model for evaporation from a contact-line-pinned sessile drop of neat water subject to a vertically oriented sinusoidal alternating current (AC) electric field applied across parallel-plate electrodes. The framework fully couples electrostatics, incompressible flow, heat transfer with evaporative cooling, and transient vapour transport in air, and includes an instantaneous, voltage-controlled electrowetting contact-angle response under constant-contact-radius conditions. Validation against published data shows that the model captures both pinned-droplet evaporation and electrically induced deformation. Because Maxwell traction scales with the squared electric-field magnitude, droplet height and contact angle exhibit a robust 2:1 frequency-doubled response, producing two peak–trough events per voltage period. The resulting periodic deformation drives oscillatory interfacial shear and internal recirculation, yielding a synchronous double-peaked evaporative-flux waveform. Gas-side analysis quantifies a time-varying diffusion-layer thickness via a characteristic diffusion length; two thinning events per period coincide with flux maxima, indicating that AC enhancement is dominated by periodic compression of the vapour boundary layer and reduced gas-side mass-transfer resistance. Increasing voltage amplitude (0–60 kV) strongly accelerates volume loss, while frequency has a secondary effect: the cycle-averaged flux rises from 1 to 10 Hz but decreases slightly at 20 Hz due to phase lag and weaker boundary-layer modulation. Full article

In the context of the coordinated development of high-proportion renewable energy integration and alternating current/direct current (AC/DC) hybrid transmission, the sending-end power grid faces challenges such as decreased system strength, contracted stability boundaries, and difficulties in covering high-risk operating conditions. This paper proposes a new renewable energy scale impact analysis method that integrates “typical scenario construction-scale ladder comparison–prediction-driven time series injection” in response to the operational constraints of AC/DC transmission. In terms of method implementation, firstly, a two-layer typical scenario system is constructed under unified transmission constraints and fixed grid boundaries: A regular benchmark scenario covers the main operating range, and a set of high-risk scenarios near the boundaries is obtained through multi-objective intelligent search, which is then refined through clustering to form a computable stress-test scenario library. Here, the boundary scenarios are generated by a multi-objective search that simultaneously drives multiple key section load rates towards their limits, subject to AC power-flow feasibility and operational constraints, and the resulting Pareto candidates are reduced into a compact stress-test library by clustering. Secondly, a ladder scenario with increasing renewable energy scale is constructed, and cross-scale comparisons are carried out within the same scenario system to extract the scale effect and critical laws of key safety indicators. Finally, data resampling and Gated Recurrent Unit multi-step prediction are introduced to generate wind power output time series, enabling the temporal mapping of prediction results to scenario injection quantities, and constructing a closed-loop input interface of “prediction–scenario–grid indicators”. The results demonstrate that the proposed hierarchical framework, under unified AC/DC export constraints, can effectively construct a compact stress-test scenario library with enhanced boundary-risk coverage and can reveal how transient voltage security evolves across renewable expansion scales. By coupling boundary-oriented scenario construction, cross-scale comparable assessment, and forecasting-driven time series injection, the framework improves engineering interpretability and practical applicability compared with conventional scenario sampling/reduction workflows. For the forecasting module, the Gated Recurrent Unit (GRU) model achieves MAPE = 8.58% and RMSE = 104.32 kW on the test set, outperforming Linear Regression (LR)/Random Forest (RF)/Support Vector Regression (SVR) in multi-step ahead prediction. Full article

The electrification of mobility increases the need for efficient local distribution and charging infrastructures. In this context, direct current (DC) architectures may reduce conversion stages, transmission losses, and material demand compared with alternating current (AC) systems. This study aims to quantify the environmental implications of AC- and DC-based grid and charging infrastructures for large-scale rollout in Germany. For this purpose, a dynamic life-cycle assessment (DLCA) is conducted for parking garages, parcel centers, and delivery bases over the period 2023–2045, covering the production and use phases with respect to global warming potential (GWP) and material demand. The results show that DC configurations achieve lower total GWP across all application contexts investigated. For parking garages, DC reduces total GWP by 9.3% compared with AC, while for parcel logistics facilities the reduction amounts to 5.7%. Copper is identified as the dominant material driver, and DC reduces copper demand by 17.1–58.7% depending on the application. A screening-based supply-risk assessment further indicates the elevated relevance of copper due to rising demand and Germany’s import dependence. Overall, the findings provide quantitative evidence that DC-based infrastructures can reduce both environmental impacts and copper demand in large-scale charging infrastructure deployment. Full article

Effective rehabilitation tools are essential for improving language outcomes in chronic aphasia. Speech entrainment is a behavioral treatment that has shown promise in enhancing speech output in nonfluent aphasia, potentially by acting as an external mechanism to synchronize anterior and posterior language regions in the left hemisphere. Transcranial alternating current stimulation has been hypothesized to enhance functional connectivity between brain regions by amplifying endogenous oscillations. This proof-of-concept study explored whether high-definition tACS (HD-tACS) could improve speech fluency in nonfluent aphasia when paired with speech entrainment. In a double-blind, pseudorandomized study, 1 mA of HD-tACS at 7 Hz was applied to anterior and posterior left-hemisphere regions of individuals with nonfluent aphasia (N = 13). Stimulation was applied under three conditions: in-phase, anti-phase, and sham, and paired speech entrainment. Three outcome measures were examined: (1) number of words produced; (2) number of errors, and (3) ‘entrainment’ to the speech entrainment model. Group-level analyses for two of the three outcome measures reveal statistically significant differences between the experimental conditions. In-phase alternating current stimulation yielded more words and better entrainment to the audiovisual model than the sham condition. This study provides promising evidence that HD-tACS could improve speech production in individuals with nonfluent aphasia. These results contribute to growing evidence supporting the therapeutic potential of non-invasive brain stimulation approaches as an adjuvant to traditional behavioral speech-language therapy in stroke survivors. Full article

Reliable and efficient low-voltage distribution networks are critical for scaling mini-grid deployment and advancing universal electricity access, yet prevailing design practices remain manual, heuristic, and difficult to scale. This study presents a fully automated workflow that integrates geospatial feature extraction, distribution network layout, conductor sizing, mixed-integer linear programming-based phase balancing, nonlinear AC power flow validation, and system costing to generate rapid, standard-compliant techno-economic designs for greenfield mini-grid sites. The methodology is demonstrated across 62 rural sites to confirm practicality for large-scale rural electrification planning. Designs were evaluated for single-phase, three-phase, and hybrid low-voltage configurations. When design constraints were relaxed, single-phase networks achieved the lowest median voltage drop (~0.8%) and technical losses (~0.6%); however, under realistic voltage-drop and ampacity limits, compliance relied on conductor oversizing, resulting in low utilization (median loading <20%) and substantially higher costs. Fewer than half of the sites met construction feasibility limits for parallel conductors, and single-phase designs were typically 3–4× more expensive than multi-phase alternatives. Multi-phase layouts delivered comparable technical performance at significantly lower cost. Phase-balancing optimization reduced voltage drop by 15–20% and current unbalance by ~50%, enabling loss reduction and increased load accommodation. Overall, the results demonstrate that automated low-voltage network design can replace manual drafting with scalable, data-driven workflows that reduce soft costs while improving technical performance, constructability, and investment readiness. Full article

Silicon carbide (SiC) MOSFETs are critical for next-generation power electronics, yet their reliability is challenged by alternating-current Bias Temperature Instability (AC BTI). While charge trapping and Recombination-Enhanced Defect Reaction (REDR) are known degradation pathways, the specific role of gate oxide thickness in determining the dominant mechanism remains unclear. This study investigates the degradation behaviors of SiC MOSFETs with varying oxide thicknesses under 150 kHz Dynamic Gate Stress. By maintaining a constant electric field, we decouple the effects of oxide thickness using high-frequency C-V, quasi-static gate current (I_GS) characteristics, and transconductance analysis. Results reveal that thin-oxide devices exhibit parallel C-V shifts and stable transconductance, indicating degradation driven by deep-level charge trapping. Conversely, thick-oxide devices display significant C-V stretch-out, negligible I_GS peak shifts, and severe transconductance degradation, accompanied by irreversible threshold voltage drift. We conclude that despite identical electric fields, the higher driving voltages in thick-oxide devices trigger severe interface state generation consistent with the REDR model, whereas thin-oxide devices are dominated by bulk oxide trapping. These findings highlight the necessity of thickness-dependent optimization strategies for SiC power devices. Full article

Cardiac telerehabilitation has become a promising alternative to traditional programmes for preventing acute coronary syndrome (ACS) in the secondary phase. However, current implementations are still reactive and standardised, lacking personalisation and flexibility in clinical settings. By integrating artificial intelligence (AI), it may be possible to overcome these limitations and provide intelligent, scalable, and patient-centred care. Methods: We conducted a structured literature review across PubMed, Scopus, the Cochrane Library, and Web of Science, targeting English-language studies published from January 2015 to May 2025. Inclusion criteria included adult populations with a history of ACS or high cardiovascular risk, assessing interventions based on AI, telerehabilitation, or their combination. Studies are needed to report clinical, functional, behavioural, or technological outcomes. A thematic narrative synthesis was utilised. Results: AI-enhanced telerehabilitation demonstrates potential advantages over conventional digital care in selected domains, including adaptive risk prediction, personalised exercise modulation, and adherence support. Several systems report real-time adjustment of exercise protocols, early dropout detection, and predictive analytics for rehospitalisation. AI integration may also contribute to personalised behavioural feedback and psychosocial monitoring. Nevertheless, the overall level of evidence remains preliminary and heterogeneous, with most AI-based interventions evaluated in pilot, feasibility, or modelling studies rather than large-scale randomized trials. Conclusions: The integration of AI into telerehabilitation represents a promising evolution in post-ACS care, shifting from predominantly reactive monitoring toward more adaptive and data-driven support models. While early-phase studies suggest feasibility and potential clinical benefit, robust multicentre randomized controlled trials and cost-effectiveness analyses are required before definitive conclusions regarding superiority or widespread implementation can be drawn. Full article

A photovoltaic (PV) and battery-based energy system can provide the necessary and sufficient electric power to off-grid power system networks due to the technological advancements in both performance improvement and lower system cost. The absence of reactive power in direct current (DC) power system networks has several advantages over corresponding alternating current (AC) power system networks. In this paper, we have investigated a case study for the PV farm coupled with a battery energy storage system (BESS) as a stand-alone power system network in the Red Sea New City, Kingdom of Saudi Arabia. The study consists of two cases, which are the DC battery coupling configuration for the AC power network system and the end-to-end DC (EEDC) configuration for the power network system. Using the same size of solar PV farm and battery storage, we have compared the performance of the two case configurations of different power system networks after thirty years of operation. The results show that implementing the EEDC power system network has a major advantage in improved energy efficiency of the power system (directly related to cost-effectiveness) and lower capital investment of the power system that includes electric power generation, transmission, distribution, and utilization for all applications, including artificial intelligence-based data centers. Full article

Extracting reliable corrosion kinetic parameters from polarization curves is particularly challenging for X70 steel under the synergistic effect of microbiologically influenced corrosion (MIC) and alternating current (AC) interference, as both factors significantly distort the electrochemical response. To address this, a novel fitting strategy was developed. In this approach, the overall polarization curve is reconstructed by combining separately modeled anodic and cathodic branches. To preserve the shape of the polarization curve, a slope-consistency constraint was enforced through dynamic penalty factors that balance fitting accuracy with shape preservation during optimization, which was performed using an intelligent algorithm. The results demonstrate the robustness of the proposed strategy, demonstrating low sensitivity to initial guesses and algorithmic parameters. Evaluation confirms that accuracy is maintained even when the data density is reduced by half. Among the parameters extracted, the Tafel slopes and corrosion current density show higher reliability than others. This work provides a robust and effective tool for the kinetic analysis of complex corrosion systems involving MIC and AC. Full article

The integration of renewable energy sources, including photovoltaic (PV) and fuel cell (FC) systems, into AC grids has attracted immense research interest in recent times. Furthermore, incorporating these renewable sources of energy into medium-voltage grids is garnering increased attention because of the obvious benefits of medium-voltage integration at elevated power levels. Photovoltaic applications entail the arrangement of solar panels capable of outputting voltages up to 1.5 kV; nonetheless, fuel cells display restricted output voltage, with a maximum market range of 400 to 700 V. Hence, the efficient integration of renewable energy sources into low-voltage or medium-voltage grids demands the utilization of a step-up direct current (DC–DC) inverter and a converter for connection to the alternating current (AC) grid, in which an efficient step-up converter is critical for the medium-voltage grid. Therefore, this study presents a three-phase buck-boost split-source inverter (BSSI) that resolves the constrained output voltage of the fuel cells. This study focuses on modifying the configuration of a conventional three-phase split-source inverter (SSI) circuit by adding a few components while maintaining the inverter’s modulation. This novel circuit design enables the reduction in voltage strains on the inverter switch components and improves DC-link use in relation to a traditional SSI configuration. For an 800 bus, maximal voltage stress on the primary inverter switches is lowered when compared with the standard SSI that delivers entire DC-bus voltage to switches. A rectifier-based model is employed to simulate the behavior of a renewable energy source. Combining these advantages with the conventional modulation of the inverter offers a more effective design. The buck-boost split-source inverter (BSSI) was analyzed using three distinct modulation techniques: the sinusoidal pulse-width modulation scheme (SPWM), the third-harmonic injected pulse-width modulation (THPWM) scheme, and space vector modulation (SVM). The proposed analysis was validated through MATLAB-SIMULINK and practical outcomes on a 5.0 kW model. The practical and SIMULINK data were found to be closely aligned with the analysis. The circuit developed in this study also ensures efficient DC-to-AC conversion, specifically with regard to low-voltage sources, like fuel cells or photovoltaic (PV) systems. Full article