Search Results (644)

This study evaluated the thermal properties, crystallinity, particle size, morphology, and in vivo local inflammation and persistence of two poly-L-lactic acid (PLLA) injectable implants, Sculptra^® (PLLA-SCA) and GANA V^® (PLLA-GA). PLLA-SCA and PLLA-GA underwent differential scanning calorimetry and X-ray powder diffraction to evaluate their thermal properties and degree of crystallinity. X-ray powder diffraction spectra displayed a sharper, more intense peak for PLLA-GA than PLLA-SCA, with smaller peaks on either side of the main peak of PLLA-GA but not PLLA-SCA. Differential scanning calorimetry thermograms indicated three thermal events for both PLLA-SCA and PLLA-GA. For PLLA-SCA, the first two events occurred between 65 °C and 90 °C, and the third event occurred at 165 °C. For PLLA-GA all three events occurred between 156 °C and 169 °C. Heating samples to 120 °C and cooling to room temperature prior to differential scanning calorimetry resulted in no thermal events being observed between 65–90 °C with either product, while three events were observed with PLLA-GA and one event with PLLA-SCA between 156 °C and 169 °C. The median volume distribution diameter was 46.4 µm for PLLA-SCA and 31.7 µm for PLLA-GA. Scanning electron microscopy showed PLLA-GA particles were irregular in shape, had no sharp edges and had a wrinkled and crimped surface, while PLLA-SCA particles displayed plate-like shapes and had smoother surfaces. In vivo inflammatory reactivity scores indicated a slight reaction for PLLA-SCA at all time points (3.7 ± 1.1, 6.1 ± 1.6, 5.7 ± 1.2 and 6.2 ± 1.2 at 2, 12, 26 and 52 weeks, respectively), while for PLLA-GA, a moderate reaction was observed at 12 and 26 weeks (2.9 ± 1.5, 10.1 ± 1.0, 9.4 ± 0.7 and 7.1 ± 1.3 at 2, 12, 26 and 52 weeks, respectively). PLLA-SCA and PLLA-GA had similar persistence scores at 2, 12 and 26 weeks, while at 52 weeks the score was markedly higher for PLLA-SCA versus PLLA-GA (1.9 ± 0.2 versus 0.7 ± 0.2). In conclusion, PLLA-SCA is more amorphous than PLLA-GA. The single melting point of PLLA-SCA contrasts with the broader spectrum of melting points for PLLA-GA suggests a more homogenous formulation of PLLA-SCA. This, and its less crystalline structure, result in the slower degradation rate and more sustained biological response of PLLA-SCA compared with PLLA-GA. The physiochemical properties of PLLAs affect the biological response in clinical practice and should be taken into consideration when selecting a PLLA treatment for aesthetic use. Full article

Blue calcite mineral formations occurring within Paleozoic marbles of Central Anatolia have been investigated in terms of their mineralogical and geochemical characteristics, as well as their potential for use as ornamental stones or decorative objects. XRD analyses of samples with different color tones (white, grayish-blue, and blue) revealed that the white sample contains only calcite, the grayish-blue samples include calcite and dolomite, while the blue sample contains calcite and quartz. XRF and ICP-MS analyses indicate a marked enrichment of trace elements such as Fe, Cr, and Ni in the blue sample, and Mn and Fe in the grayish-blue samples, suggesting these elements may influence the observed color variations. The presence of dolomite in grayish-blue samples and quartz in the blue sample corresponds to elevated MgO and SiO₂ contents, respectively. Based on their distinct colors, textures, transparency, and other aesthetic properties, the grayish-blue and blue marbles show significant potential for use as decorative stones or ornamental objects. Full article

Background/Objectives: The Psychosocial Impact of Dental Aesthetics Questionnaire (PIDAQ) is a useful tool for investigating the psychosocial impact of malocclusion and dental aesthetics on the quality of life of young adults. This study aimed at developing a culturally adapted Greek version, assessing its validity and reliability. Methods: The questionnaire underwent bilingual translation, followed by cultural adaptation with 10 debriefing interviews. Gr-PIDAQ along with the aesthetic component of the Index of Orthodontic Treatment Need (IOTN-AC) were completed by 270 young adults for the evaluation of its psychometric properties. Fifty dentists also participated, assessing its face validity. Results: Confirmatory factor analysis verified the four-factor structure of the original version of PIDAQ. The ability of Gr-PIDAQ to discriminate between individuals according to the perceived need for improvement in dental appearance was confirmed (p < 0.001). Participants exhibiting greater malocclusion severity as assessed by the IOTN-AC presented higher PIDAQ scores (p < 0.001). Face validity was confirmed by 99.6% of participants and 96% of dentists. Cronbach’s alpha coefficient of the overall scale was 0.94 (the four subscales ranged from 0.78 to 0.9), while excellent repeat measurement agreement was detected (ICC = 0.95, p ˂ 0.001). Conclusions: Our findings suggest that Gr-PIDAQ is a valid and reliable tool that can be used to measure orthodontics-related quality of life in Greek speaking adults. In terms of clinical application, it can be used to assess the orthodontic treatment need and record patients’ perspective both before orthodontic treatment initiation and later during the assessment of its effectiveness, serving as a Patient-Related Outcome Measure (PROM). Full article

In this review we present a comprehensive overview of the published literature related to the use of Hybrid Cooperative Complexes (HCCs) of low- and high-molecular-weight hyaluronic acid in aesthetic medicine. HCCs have been developed to overcome the shortcomings of traditional hyaluronic based dermal fillers. Specifically, HCCs deliver both high- and low-molecular-weight hyaluronic acid (HA), maximizing their complementary effects. They are biocompatible and formulated without the addition of foreign agents. Cooperative hydrogen bonds extend their durability and make them more resistant to hyaluronidase compared to high-molecular-weight HA. The rheological properties of HCC formulations allow for easy exertion through the needle and diffusion in the tissue compared to high-molecular-weight HA alone. In vitro studies have shown that HCCs improve vitality of fibroblasts, keratinocytes and adipocytes, and stimulate production of collagen and elastin. Studies on scratched co-cultures of immortalized human keratinocytes and human dermal fibroblasts demonstrated that HCCs accelerate wound closure. Furthermore, HCCs delayed senescence of mesenchymal stromal cells to a greater extent than high-molecular-weight HA or low-molecular-weight HA alone. Clinical studies show a reduction in wrinkle severity, improvement in skin roughness profile and reduction of skin laxity with pronounced improvement in superficial skin hydration lasting up to 6 months. The formulation intended for restoration of fat compartments demonstrated reduction in cheek volume loss and improvement in skin thickness. Subjects report moderate-to-high satisfaction and are likely to recommend the treatment. Limitations of the published studies are also addressed, as well as reported adverse events and published safety data. Full article

Injectable hydrogels (IHs) have gained considerable interest in biomedical and aesthetic applications due to their minimally invasive delivery, selective localization, and sustained release of bioactive agents. They exhibit flowability during administration and undergo in situ gelation under physiological conditions. These behaviors are influenced by their tunable structural, physical, mechanical, and viscoelastic properties, modulating performance. Rheological parameters, including viscosity (η), storage modulus (G′), loss modulus (G″), and yield stress (τ_y) of IHs with time (t), shear rate ($\stackrel{·}{\gamma }$), and frequency (f), explaining their shear thinning, thixotropy, viscoelasticity, and gelatin kinetics, serve as key quantitative indicators of their injectability, self-healing capability, and structural and mechanical stability. The rheological characteristics reflect molecular interactions and crosslinking mechanisms within IH networks, thereby linking formulation to provide overall performance, including injectability, biodegradability, and controlled release. This review summarizes recent advances in IHs for diverse applications, with a primary focus on their rheological properties. It also briefly addresses their composition, intermolecular interactions, and correlated function and performance. The applications discussed include hemostatic and wound dressings, tissue engineering and regenerative medicine scaffolds, drug delivery systems, reconstructive and aesthetic materials, and functional bioinks for 3D printing. Overall, this review demonstrates that rheological characterization provides an essential framework for the rational engineering of next-generation IH systems. Full article

The rapid urban expansion in the past few decades has resulted in a deficit of urban green space, and green roofs have become an effective way to expand urban green spaces. High nitrogen (N) deposition induced by urban development has threatened the health and sustainability of plants. The aim of this study was to evaluate the responses of plant growth performance and aesthetic value to N deposition in green roofs. Eleven species from four plant functional groups were grown under control, low N addition, and high N addition conditions to assess the effects of N addition on their growth performance, aesthetic value, soil properties, and plant functional traits. Different plant functional groups exhibited distinct traits, and their response to N addition was different. Under high N addition, the growth performance of sod-forming graminoids and tall forbs decreased by 47.0% and 23.7%, and their aesthetic value decreased by 24.4% and 16.2%, respectively. Growth performance of plant functional groups was mainly determined by plant functional traits rather than soil properties. The poor growth performance and aesthetic value of sod-forming graminoids and tall forbs challenged their widespread use under high N addition. This study highlighted the importance of selecting environmentally adaptive species from the perspective of plant functional groups, especially in the context of future high N deposition. Full article

The consolidation of mural paintings presents a significant challenge for conservators, as the treatments applied must not only be effective but also preserve the aesthetic qualities of the artwork. Ongoing research focuses on developing new products that are more efficient, durable, and compatible with the physicochemical and aesthetic characteristics of the original materials, thereby addressing the limitations of existing consolidants. This study examines two consolidants for mural painting restoration: Estel 1200^® (C.T.S., Madrid, Spain), a commercially available and widely used ethyl silicate-based product, and Nanorepair UV^® (Patent: ES-2766074-B2, Pablo de Olavide University, Seville, Spain), a nanocomposite composed of calcium hydroxide nanoparticles doped with zinc quantum dots. On mortar specimens, prepared according to the Roman fresco technique, the application method for the proposed treatments was optimized. The applicability of the treatments for mural painting conservation was studied by colorimetric measurements and SEM imaging to detect and characterize the formation of surface layers. The effectiveness of the treatments was quantitatively evaluated with tape-peeling cycles. The results show that, although both treatments enhance the consolidation state of mural paintings, Nanorepair UV^® proved to be a more effective consolidant, without altering the aesthetic or physicochemical properties of the artwork. Additionally, this treatment allows for straightforward evaluation of its penetration and enables distinction between treated and untreated areas through the fluorescence of the zinc oxide quantum dots. Full article

Non-Fungible Tokens (NFTs) have transformed digital ownership, offering unique representations of assets such as art, collectibles, and virtual property. However, pricing NFTs remains a complex and underexplored issue. This study addresses two core questions: what determines NFT prices? And how are prices set in NFT markets? We conduct a comprehensive literature review and market analysis to identify both endogenous and exogenous price determinants. Trait rarity emerges as the most influential intrinsic factor, while cryptocurrency value stands out as a major external influence, albeit with ambiguous effects. Other factors include visual aesthetics, scarcity, utility in games, social media engagement, and broader market sentiment. As to pricing mechanisms, aside from fixed pricing (which is accepted in all marketplaces), NFT marketplaces primarily utilise auctions for art pieces and collectibles— especially English and Dutch formats—which are effective at capturing the buyer’s willingness-to-pay. Full article

Background and Objectives: This study was conducted in order to develop and validate the Latvian version of the Orofacial Aesthetic Scale (OES-LV) and to assess its psychometric properties in patients with aesthetic, functional or no treatment needs. Materials and Methods: The English version of the OES was translated into Latvian following international guidelines for establishing cultural equivalency of instruments. The test group consisted of 101 subjects comprised of those without treatment requirement, with functional impairment (tooth loss) and with aesthetic treatment needs. Internal consistency, test–retest reliability and convergent validity were investigated. Responsiveness was not tested in the current study. Results: The test–retest assessment of this study was performed on 31 subjects and showed intra-class correlation coefficients ranging from 0.80 to 0.81, which was considered to be good. Cronbach’s α was 0.91, demonstrating the strong internal consistency of the scale. Spearman’s rank correlation coefficients between the OHIP and OES scores varied across subgroups, ranging from −0.35 to −0.57 and showed a negative correlation between OES-LV and selected OHIP items. Conclusions: The Latvian OES demonstrated strong psychometric properties, supporting its use in assessing self-perceived orofacial aesthetics, clinical research, prosthodontic evaluation and dental education. Further studies on responsiveness are recommended. Full article

Cyclo[48]carbon (C48) exhibits an aesthetically pleasant structure featuring a cyclic polyyne, and it serves as a prototypical medium-sized ring that moves us towards an understanding of its overall magnetic behavior in a challenging molecular shape through analysis of its induced magnetic field. The isotropic induced magnetic field (NICS) profile shows a strong deshielding region at the ring center and a shielding region near the carbon rim, indicating antiaromatic behavior. Under a perpendicular magnetic field, a pronounced deshielding cone extends from the ring center, whereas a parallel external field induces a localized shielding near the carbon backbone. This results in significant magnetic anisotropy above and below the ring plane, characteristic of its medium-sized cyclic structure. Decomposition of the magnetic shielding highlights that paramagnetic effects predominantly govern the magnetic response and anisotropy of C48, with diamagnetic contributions playing a minor role. These insights suggest that chemical modifications targeting frontier orbitals could effectively tune the magnetic properties of cyclo[48]carbon, providing a foundation for the design of substituted derivatives with tailored diamagnetic anisotropy for advanced material applications. Full article

Yttria-stabilized zirconia (YSZ) has attracted attention as a ceramic implant material owing to its excellent mechanical strength, biocompatibility, and aesthetic properties. However, YSZ is bioinert and lacks the ability to directly bond with bone. This study aims to enhance the bioactivity of 3D-printed porous YSZ through modified simulated body fluid (m-SBF) pretreatments. The porous YSZ substrates fabricated by fused deposition modeling were first etched with hydrofluoric acid (HF) to increase the surface roughness, followed by immersion in CO₃²⁻, Mg²⁺, and/or Zn²⁺ ion-incorporated m-SBFs. Among the tested solutions, the apatite coating formed in Mg²⁺- and Zn²⁺-containing m-SBF within one day, exhibiting uniform precipitation and a reduced tetragonal-to-monoclinic (t→m) transition. The incorporated Mg²⁺ and Zn²⁺ ions were successfully detected on the apatite coating, with Mg/Ca and Zn/Ca ratios of approximately 4.82% and 3.33%, respectively. Mg²⁺ is known to stimulate osteogenesis, while Zn²⁺ exhibits antibacterial activity. Furthermore, compared with standard SBF under high-temperature and high-pH conditions, the m-SBF induced markedly less t→m phase transition on YSZ substrates, suggesting that m-SBF, as a biomimetic medium for imparting bioactivity, provides a more suitable environment for YSZ substrates. This study demonstrates that HF surface treatment combined with Mg²⁺- and Zn²⁺-containing m-SBF pretreatment effectively imparts bioactivity to 3D-printed YSZ, offering a promising approach for next-generation osteoconductive ceramic implants. Full article

Ceramic dental implants, particularly one-piece zirconia, offer a biocompatible and aesthetic alternative to titanium, with high strength and improved oral hygiene. By eliminating the implant–abutment micro-gap, they reduce bacterial accumulation because of their low plaque affinity and enhance stability. However, challenges remain, including alignment precision, limited retrievability, and sensitivity to mechanical stress. Misalignment can affect occlusal and functional outcomes, and zirconia’s rigidity complicates crown removal and modification. This case report explores the use of PEEK (polyether ether ketone) primary telescopic crowns to overcome these limitations, improving force distribution, enabling minor adjustments, and enhancing prosthetic retrievability in full-mouth zirconia restorations. A 62-year-old male patient seeking a fixed solution to replace removable dentures received 16 one-piece zirconia implants (eight per jaw). PEEK telescopic crowns were used over implant abutment copings, finalized with aesthetic zirconia bridges. The report details surgical and prosthetic procedures, along with a brief literature review on zirconia implants and PEEK applications. PEEK integration in telescopic prosthetic designs marks a notable advancement in prosthodontics. Its shock-absorbing, biocompatible, and stress-modulating properties make it valuable for implant-supported and hybrid restorations. As digital workflows advance, PEEK-based telescopic restorations may increasingly replace traditional metal-based solutions, improving long-term clinical outcomes. Further clinical research on a larger sample is needed. Full article

Eight Views is a time-honored East Asian cultural-landscape paradigm in which eight emblematic natural—cultural scenes fuse regional character, historical memory, and aesthetic ideals into a coherent narrative. It encodes the collective memory and identity of a city (or garden/region), a premodern ‘mental map’ or proto- ‘city brand’. In China, the historic Urban Eight Views are rooted in local environments and traditions and constitute significant, high-value landscape heritage today. Yet rapid urbanization has inflicted severe physical damage on these ensembles. Coupled with insufficient holistic and systemic understanding among managers and the public, this has led, during development and conservation alike, to spatial insularization, fragmentation, and even disappearance, alongside widening divergences in cultural cognition and biases in value judgment. Taking Longmen Haoyue in Chongqing, one of the historic Urban Eight Views, as a case that manifests these issues, this study develops a holistic–relational approach for the urban, historical Eight Views and explores landscape-based pathways to protect the spatial structure and cultural connotations of the heritage that has been severely damaged and is in a state of disappearance or semi-disappearance amid modernization. Methodologically, we employ decomposition analysis to extract the historical information elements of Longmen Haoyue and its internal relational structure and corroborate its persistence through field surveys. We then apply the FAHP method to grade the conservation value and importance of elements within the Eight Views, quantitatively clarifying protection hierarchies and priorities. In parallel, a multidimensional corpus is constructed to analyze online dissemination and public perception, revealing multiple challenges in the evolution and reconstruction of Longmen Haoyue, including symbolic misreading and cultural decontextualization. In response, we propose an integrated strategy comprising graded element protection and intervention, reconstruction of relational structures, and the building of a coherent cultural-semantic and symbol system. This study provides a systematic theoretical basis and methodological support for the conservation of the urban historic Eight Views cultural landscapes, the place-making of distinctive spatial character, and the enhancement of cultural meanings. It develops an integrated research framework, element extraction, value assessment, perception analysis, and strategic response that is applicable not only to the Eight Views heritage in China but is also transferable to World Heritage properties with similar attributes worldwide, especially composite cultural landscapes composed of multiple natural and cultural elements, sustained by narrative traditions of place identity, and facing risks of symbolic weakening, decontextualization, or public misperception. Full article

This study investigates the influence of laser processing parameters on the surface roughness and color formation of AISI 304 stainless steel. Experiments were conducted to explore how raster step, scanning speed, frequency, linear energy density, and overlap coefficient affect the surface characteristics of laser-marked zones. It was found that increasing the raster step from 20 µm to 80 µm led to a consistent increase in surface roughness (from 1.23 µm to 1.47 µm at 20 kHz and 25 mm/s), accompanied by a shift in color from dark brown to lighter yellow hues. In contrast, increasing scanning speed (from 25 mm/s to 125 mm/s) caused a nonlinear reduction in roughness (e.g., from 1.23 µm to 0.76 µm at 20 kHz and Δx = 20 µm), resulting in a lighter surface color. Frequency was identified as a critical factor; increasing it from 20 kHz to 100 kHz resulted in a threefold decrease in roughness (from 1.23 µm to 0.25 µm at 20 µm raster step and 125 mm/s), which correlated with a shift to brighter yellow tones. Higher linear energy density values (1.60–8.00 J/cm) increased roughness and darkened the surface color, while higher overlap coefficients produced the opposite trend. The study highlights the relationship between surface nanostructuring and the formation of stable interference colors, providing quantitative parameters for achieving desired chromatic effects. These findings establish a basis for the industrial application of laser color marking, where both aesthetic differentiation and functional enhancements—such as corrosion resistance, hydrophobicity, and antibacterial properties—are essential. Future research will focus on quantitatively evaluating the functional properties, including corrosion resistance, hydrophobicity, and durability, of the colored surfaces produced under optimized parameters. This research aims to further develop laser marking as a foundational tool for both aesthetic and functional surface engineering. Full article

Beyond mechanical performance and aesthetics, the susceptibility of 3D-printed resins to microbial colonization and biofilm formation represent an important factor influencing dentures’ longevity. Therefore, this study evaluated Candida albicans colonization and mature biofilm formation on three different 3D-printed denture base resins (Bio Denture—BD; Denture Base Cosmos—CD; Smart Print Bio Denture—SP) and compared them to heat-curing resin (HC). Before the microbiological evaluation, the surface roughness (Sa) was assessed. Biofilm viability was determined through colony-forming units per milliliter (CFU/mL) and biofilm morphology was qualitatively examined using a scanning electron microscope (SEM). The composition of the extracellular polymeric substance (EPS) was investigated by measuring the amounts of carbohydrates (µg/mL), proteins (ng/mL), and extracellular DNA (eDNA) (fluorescence unit). One-way ANOVA was performed for eDNA and Sa and Kruskal–Wallis for the other properties (α = 0.05). Higher surface roughness mean values (standard deviation) (p < 0.05) were observed in CD [0.111 (0.013)] compared to HC [0.084 (0.018) and BD [0.078 (0.015)]. For wettability, BD [63.2 (5.2)] and SP [65.2 (3.1)] resins showed a greater wettability (p < 0.05) than HC resin [73.0 (3.5)], while SP showed lower (p < 0.01) protein levels (425 ng/mL) compared to HC (568.6 ng/mL) and BD (554.8 ng/mL) in the EPS. Despite these differences, the 3D-printed denture base resins exhibited microbial load (CFU/mL), EPS composition (carbohydrates and eDNA), and morphological features of C. albicans biofilm comparable to those of conventional heat-cured PMMA. These findings suggest that, despite resin-specific variations, 3D-printed denture base materials exhibit a similar susceptibility to C. albicans colonization and biofilm formation as conventional denture bases, thereby directing future research towards developing new 3D-printed resins with enhanced antimicrobial properties to improve clinical outcomes. Full article