Innovations in Application of Biofunctional Hydrogels

A special issue of Gels (ISSN 2310-2861). This special issue belongs to the section "Gel Analysis and Characterization".

Deadline for manuscript submissions: 25 February 2026 | Viewed by 570

Special Issue Editors

Shaanxi Key Laboratory of Degradable Biomedical Materials, School of Chemical Engineering, Northwest University, Xi’an 710069, China
Interests: hydrogel; tissue engineering; flexible electronics; biomaterial; wound healing; skin

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Guest Editor
Advanced Interdisciplinary Research Center for Flexible Electronics, Academy of Advanced Interdisciplinary Research, Xidian University, Xi’an 710071, China
Interests: collagen degradation; ginsenoside Rk1; inflammation; oxidative stress; skin photoaging

Special Issue Information

Dear Colleagues,

Biofunctional hydrogels have emerged as a transformative class of materials with tunable physicochemical properties and dynamic bioactivity, enabling their widespread application in diverse fields, such as biomedicine, tissue engineering, drug delivery, and soft bioelectronics. Their ability to mimic the extracellular matrix, respond to physiological stimuli, and interact intelligently with living systems makes them highly attractive for next-generation biomedical technologies. This Special Issue aims to highlight recent innovations in the design, synthesis, characterization, and application of biofunctional hydrogels. We place particular emphasis on their functional integration into complex biological environments, such as dynamic tissue interfaces, wound sites, and implantable devices. Topics of interest include, but are not limited to, smart and responsive hydrogels, bioprintable and injectable hydrogels, hydrogel-based biosensors, and systems for targeted therapy or regenerative medicine. We welcome original research articles and comprehensive reviews that showcase interdisciplinary advances, spanning materials science, bioengineering, chemistry, and medicine. By collecting cutting-edge contributions, this Special Issue seeks to deepen our understanding of structure–property–function relationships and to inspire innovative strategies for engineering advanced hydrogel-based platforms with enhanced performance, biocompatibility, and clinical potential.

Dr. Yannan Liu
Dr. Yingchun Li
Guest Editors

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Keywords

  • hydrogel
  • biofunctional
  • tissue engineering
  • biomedical applications
  • soft electronics
  • biomaterial

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Published Papers (1 paper)

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Review

41 pages, 2871 KB  
Review
Inflammation-Responsive Hydrogels in Perioperative Pain and Wound Management: Design Strategies and Emerging Potential
by Young Eun Moon, Jin-Oh Jeong and Hoon Choi
Gels 2025, 11(9), 691; https://doi.org/10.3390/gels11090691 - 1 Sep 2025
Viewed by 459
Abstract
Surgical procedures trigger dynamic inflammatory responses that influence postoperative pain, wound healing, and long-term outcomes. Conventional therapies rely on the systemic delivery of anti-inflammatory and analgesic agents, which often lack spatiotemporal precision and carry significant side effects. Inflammation-responsive hydrogels offer a promising alternative [...] Read more.
Surgical procedures trigger dynamic inflammatory responses that influence postoperative pain, wound healing, and long-term outcomes. Conventional therapies rely on the systemic delivery of anti-inflammatory and analgesic agents, which often lack spatiotemporal precision and carry significant side effects. Inflammation-responsive hydrogels offer a promising alternative by enabling localized, stimulus-adaptive drug release aligned with the evolving biochemical milieu of surgical wounds. These smart biomaterials respond to endogenous triggers, such as reactive oxygen species, acidic pH, and proteolytic enzymes, allowing precise modulation of inflammation and tissue repair. This narrative review outlines the pathophysiological features of perioperative inflammation and the design principles of responsive hydrogel systems, including pH-, reactive oxygen species-, enzyme-sensitive, and multi-stimuli platforms. We evaluated the integration of key payloads, NSAIDs, corticosteroids, α2-adrenergic agonists, and biologics, highlighting their therapeutic synergy and translational relevance. Preclinical studies across soft tissue, orthopedic, thoracic, and abdominal models have demonstrated the efficacy of these systems in modulating immune responses, reducing pain, and enhancing regeneration. Despite these encouraging results, challenges remain, including trigger fidelity, surgical compatibility, and regulatory readiness. Future advances in biosensor integration, logic-based design, and artificial intelligence-guided formulation may accelerate clinical translation. Inflammation-responsive hydrogels represent a transformative strategy for precise perioperative care. Full article
(This article belongs to the Special Issue Innovations in Application of Biofunctional Hydrogels)
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