Search Results (392)

Lower respiratory tract infections caused by Pseudomonas aeruginosa are a global concern. Patients with chronic lung diseases such as cystic fibrosis and non-cystic fibrosis bronchiectasis often do not receive adequate antibiotic delivery through conventional routes. P. aeruginosa employs several mechanisms, including biofilm formation and efflux pumps to limit the accumulation of bactericidal drug concentrations. Direct drug delivery to the lung epithelial lining fluid can increase antibiotic concentration and reduce treatment failure rates. This review discusses current research and developments in inhaled antibiotic formulations for treating P. aeruginosa infections. Recent studies on particle engineering for the dry powder inhalers of antibiotics emphasized three fundamental principles of development: micro, nano, and nano-in-microparticles. Carrier-free microparticles showed potential for high-dose delivery but suffered from poor aerosolization, which could be improved through a drug–drug combination. Amino acids in a co-spray-dried system improved powders’ aerodynamics and reduced moisture sensitivity while incorporating the chitosan/poly(lactic-co-glycolic acid) (PLGA)-modified release of the drug. Nano-in-microsystems, embedding lipid carriers, showed improved antibiofilm activity and controlled release. We also highlight emerging biologics, including antibacterial proteins/peptides, vaccines, bacteriophages, and probiotics. Research on antibiotics and biologics for inhalation suggests excellent safety profiles and encouraging efficacy for some formulations, including antimicrobial peptides and bacteriophage formulations. Further research on novel molecules and synergistic biologic combinations, supported by comprehensive animal lung safety investigations, will be required in future developments. Full article

The advent of electric propulsion for new aircraft designs necessitates the optimization of propeller aerodynamic performance and the reduction of acoustic signatures. Variable-pitch propellers present a promising solution, offering the flexibility to adjust blade angles in response to different flight conditions. The study investigates the performance of blade pitch configurations tailored to specific flight conditions. Rather than a dynamic pitch change, the research evaluates discrete pitch settings coupled with corresponding advance ratios to identify optimal operating points. Findings show that increasing collective pitch in response to a higher advance ratio (forward flight) successfully maintains aerodynamic efficiency and thrust, with an expected increase in torque. While this adjustment leads to an anticipated rise in noise due to higher aerodynamic loading, results reveal that a collective pitch increment of $+5°$ actively suppresses broadband noise at frequencies above 2 kHz. Analysis of the flow field and surface pressure fluctuations indicates this suppression is directly attributed to the mitigation of outboard propeller stall. Ultimately, this work demonstrates the feasibility of using collective pitch adjustments not only to enhance flight performance but also to actively control and suppress components of the propeller noise signature, such as the broadband noise. Full article

Coaxial contra-rotor unmanned aerial vehicles (UAVs) are attractive for their compact structure and aerodynamic efficiency, making them suitable for long-endurance and heavy-payload operations. However, the coaxial configuration introduces strong rotor coupling, phase lag, and additional disturbances, which pose significant challenges for stable control. To overcome these issues, we propose a cascaded Active Disturbance Rejection Control (ADRC-C) framework, in which a two-level control structure is adopted. The outer loop employs a classical ADRC controller to estimate and compensate for the lumped external forces, providing the compensated attitude command to the inner loop. The inner loop, in turn, adopts an $SO\left(3\right)$-based Extended State Observer (ESO) to handle high-frequency torque disturbances through real-time estimation and compensation. The proposed approach is validated through numerical simulations. Results confirm that the cascaded ADRC consistently outperforms conventional PID control in tracking accuracy, transient response, and disturbance rejection, demonstrating strong robustness for demanding coaxial UAV missions. Full article

Tunnels have significantly expanded human activity spaces and alleviated urban congestion and environmental pollution on the surface. However, fires and associated smoke propagation in tunnels pose common and critical challenges in underground space utilization. Previous studies have primarily focused on smoke control under standard atmospheric conditions, emphasizing isolated parameters such as jet velocity or heat release rate (HRR), while overlooking key factors like environmental pressure and fire source proximity that influence smoke buoyancy and containment efficacy. One of the key problems remains unsolved: the comprehensive mechanisms governing transverse air curtain performance in variable-pressure and proximity scenarios. This study utilized Fire Dynamics Simulator (FDS6.7.1) software to conduct numerical simulations, aiming to elucidate the underlying incentives and explore the phenomena of smoke–thermal interactions. The analysis systematically evaluates the influence of four critical parameters: HRR (1–15 MW), fire-to-curtain distance (5–95 m), air curtain jet velocity (6–16 m/s), and ambient pressure (40–140 kPa). Results show that (1) jet velocity emerges as the dominant factor, with exponential enhancement in thermal containment efficiency at velocities above 10 m/s due to intensified shear forces; (2) escalating HRR weakens isolation, leading to disproportionate downstream temperature rises and diminished efficacy; (3) fire proximity within 10 m disrupts curtain integrity via high-momentum smoke impingement, amplifying thermal gradients; and (4) elevated ambient pressure dampens smoke buoyancy while augmenting air curtain momentum, yielding improved containment efficiency and reduced temperatures. This paper is helpful for the design and operation of thermal applications in underground infrastructures, providing predictive models for optimized smoke control systems. The contour maps reveal the field-distribution trends and highlight the significant influence of the air curtain and key governing parameters on the thermal field and smoke control performance. This work delivers pivotal theoretical and practical insights into the advanced design and optimization of aerodynamic smoke control systems in tunnel safety engineering Full article

Wind-induced response poses a significant challenge to the stability of extra-large-span heavy steel box girders during synchronous lifting operations. This study adopted a method combining numerical simulation with on-site monitoring to investigate the aerodynamic characteristics the beam during the overall hoisting process of the Xiaotun Bridge. A high-fidelity finite element model was established using Midas NFX 2024 R1, and fluid–structure interaction (FSI) analysis was conducted, utilizing the RANS k-ε turbulence model to simulate stochastic wind fields. The results show that during the lifting stage from 3 m to 25 m, the maximum horizontal displacement of the steel box girder rapidly increases at wind angles of 90° and 60°, and the peak displacement is reached at 25 m. Under a strong breeze at a 90° wind angle and 25 m lifting height, the maximum lateral displacement was 42.88 mm based on FSI analysis, which is approximately 50% higher than the 28.58 mm obtained from linear static analysis. Subsequently, during the 25 m to 45 m lifting stage, the displacement gradually decreases and exhibits a linear correlation with lifting height. Concurrently, the maximum stress of the lifting lug of the steel box girder increases rapidly in the 3–25 m lifting stage, reaches the maximum at 25 m, and gradually stabilizes in the 25–45 m lifting stage. The lug stress under the same critical condition reached 190.80 MPa in FSI analysis, compared with 123.83 MPa in static analysis, highlighting a significant dynamic amplification. Furthermore, the detrimental coupling effect between mechanical vibrations from the lifting platform and wind loads was quantified; the anti-overturning stability coefficient was reduced by 10.48% under longitudinal vibration compared with lateral vibration, and a further reduction of up to 39.33% was caused by their synergy with wind excitation. Field monitoring validated the numerical model, with stress discrepancies below 9.7%. Based on these findings, a critical on-site wind speed threshold of 9.38 m/s was proposed, and integrated control methods were implemented to ensure construction safety. During on-site lifting, lifting lug stresses were monitored in real time, and if the predefined threshold was exceeded, contingency measures were immediately activated to ensure a controlled termination. Full article

Aerodynamic manoeuvring technology for spacecraft actively utilizes aerodynamic forces to alter orbital trajectories. This approach not only substantially reduces propellant consumption but also expands the range of accessible orbits, representing a key technological pathway to address the demands of increasingly complex yet cost-effective space missions. The theoretical prototype of this technology was proposed by Howard London. Over the course of more than half a century of development, it has evolved into four distinct modes: aeroglide, aerocruise, aerobang, and aerogravity assist. These modes have been engineered and applied in scenarios such as in-orbit manoeuvring of reusable vehicles, rapid response to space missions, and interplanetary exploration. Our research centers on two core domains: trajectory optimization and control guidance. Trajectory optimization employs numerical methods such as pseudo-spectral techniques and sequential convex optimization to achieve multi-objective optimization of fuel and time under constraints, including heat flux and overload. Control guidance focuses on standard orbital guidance and predictive correction guidance, progressively evolving into adaptive and robust control to address atmospheric uncertainties and the challenges of strong nonlinear coupling. Although breakthroughs have been achieved in deep-space exploration missions, critical challenges remain, including constructing high-fidelity models, enhancing real-time computational efficiency, ensuring the explainability of artificial intelligence methods, and designing integrated framework architectures. As these technical hurdles are progressively overcome, this technology will find broader engineering applications in diverse space missions such as lunar return and in-orbit servicing, driving continuous innovation in the field of space dynamics and control. Full article

Small wind turbines operating at low heights frequently experience rapidly fluctuating and highly turbulent wind conditions that challenge conventional reactive pitch-control strategies. Under these non-stationary regimes, sudden gusts produce overspeed events that increase mechanical stress, reduce energy capture, and compromise operational safety. Addressing this limitation requires a control scheme capable of anticipating aerodynamic disturbances rather than responding after they occur. This work proposes a hybrid anticipatory pitch-control approach that integrates a conventional PI regulator with a data-driven rotor-speed prediction model. The main novelty is that short-term rotor-speed forecasting is embedded into a standard PI loop to provide anticipatory action without requiring additional sensing infrastructure or changing the baseline control structure. Using six years of real wind and turbine-operation data, an optimized Random Forest model is trained to forecast rotor speed 20 s ahead based on a 60 s historical window, achieving a prediction accuracy of RMSE = 0.34 rpm and R² = 0.73 on unseen test data. The predicted uses a sliding-window representation of recent wind–rotor dynamics to estimate the rotor speed at a fixed horizon (t + Δt), and the predicted signal is used as the feedback variable in the PI loop. The method is validated through a high-fidelity MATLAB/Simulink model of 14 kW small horizontal-axis wind turbine, evaluated under four wind scenarios, including two previously unseen conditions characterized by steep gust gradients and quasi-stationary high winds. The simulation results show a reduction in overspeed peaks by up to 35–45%, a decrease in the integral absolute error (IAE) of rotor speed by approximately 30%, and a reduction in pitch-actuator RMS activity of about 25% compared with the conventional PI controller. These findings demonstrate that short-term AI-based rotor-speed prediction can significantly enhance safety, dynamic stability, and control performance in small wind turbines exposed to highly variable atmospheric conditions. Full article

Helicopter vibration is an inherent characteristic of rotorcraft operations, arising from transmission dynamics and unsteady aerodynamic loading, posing challenges to flight control and longevity of structural components. Excessive vibration elevates pilot workload and accelerates fatigue damage in critical components. Leveraging advances in optimal control and microelectronics, the active vibration control methods offer superior adaptability compared to the passive techniques, which are limited by added weight and narrow bandwidth. In this study, a comprehensive vibration analysis and optimal control framework are developed for the Bo 105 helicopter rotor blade exhibiting flapping, lead-lag, and torsional (triply coupled) motions, where a Linear Quadratic Regulator (LQR) is employed to suppress vibratory responses. An analytical formulation is constructed to estimate the blade’s sectional properties, used to compute the coupled natural frequencies of vibration by the modified Galerkin method. An orthogonality condition for the coupled flap–lag–torsion dynamics is established to derive the corresponding state-space equations for both hovering and forward-flight conditions. The LQR controller is tuned through systematic variation of the weighting parameter Q, revealing an optimal range of 10²–10⁴ that balances vibration attenuation and control responsiveness. The predicted frequencies of the vibrating rotor blade are compared with the finite element modeling results and published experimental data. The proposed framework captures the triply coupled rotor blade dynamics with optimal control, achieves modal vibration reductions of approximately 60–90%, and provides a clear theoretical benchmark for future actuator-integrated computational and experimental studies. Full article

As an active flow-control technology, the counterflowing jet can reduce drag by reconstructing the flow field structure during the re-entry of a vehicle, thereby mitigating the adverse effects of high overload on personnel. However, variations in the angle of attack (AoA) and nozzle mass flow rate tend to induce transitions in its flow field modes and fluctuations in drag reduction performance. To further investigate the aerodynamic interference characteristics of the counterflowing jet during the re-entry process, this study focused on a 2.6% subscale model of the Apollo return capsule. The Reynolds-averaged Navier–Stokes (RANS) equations turbulence model was employed to numerically analyze the effects of different mass flow rates and freestream AoAs on the flow field modes and the drag behavior. The results indicate that with an increase in AoA, the flow field structure of the long penetration mode (LPM) is likely to be destroyed, and the shock wave shape exhibits significant asymmetric distortion. In contrast, the flow field structure of the short penetration mode (SPM) remains relatively stable; however, the bow shock and Mach disk exhibit two typical offset patterns, whose offset characteristics are jointly regulated by the mass flow rate and AoA. In terms of drag characteristics, the AoA significantly weakens the drag reduction effect of the LPM. In contrast, the SPM can maintain a stable drag reduction efficiency of approximately 50% within a certain AoA range. Nevertheless, as the AoA further increases, the drag reduction effect of the SPM gradually diminishes. Full article

Passenger cars, sports utility vehicles (SUVs), and light trucks/vans, constituting the overwhelming majority of all road vehicles globally, burn about 25% of all fossil fuels, emit significant amounts of greenhouse gas emissions (CO₂), and deteriorate the environment. Nearly three-quarters of the engine power generated by burning fossil fuels is required to overcome aerodynamic resistance (drag) at highway driving speeds. Streamlining the body shape, especially the projected frontal area, can lead to a decrease in aerodynamic drag. Even though drag coefficients have plateaued since the late 1990s, further altering body shape might worsen vehicle cooling. Thus, the primary objective of this study is to explore the potential for aerodynamic drag reduction and improved cooling performance through careful component design unaffected by stylistic restraints. A variety of strategies for protecting the cooling intakes to reduce the drag coefficient are considered. The potential cooling drag reduction was found to be around 7% without compromising the cooling performance, which is in line with predictions for roughly 2.9% and 1.7% fuel consumption reductions for highway and city driving conditions, respectively. The study also reveals that passenger electric cars designed for city driving conditions possess a battery-to-kerb weight ratio of around one-quarter of the kerb weight, and vehicles designed for higher ranges have significantly higher ratios (nearly one-third), resulting in higher rolling resistance and energy consumption. The reduction of battery weight for EVs, streamlining vehicle shapes, and applying active and passive airflow management can help reduce aerodynamic drag and rolling resistance further, enhance driving range, and reduce energy consumption and greenhouse gas emissions. Full article

Hybrid Gas–Magnetic Bearings (HGMBs) are an emerging technology ready to completely change high-speed oil-free rotor support in aerospace electric motors. Because HGMBs combine the stiffness and load capacity of gas bearings with the active control of magnetic bearings, enabling oil-free, contactless rotor support from zero to ultra-high speeds. They offer more load capacity of standalone magnetic bearings while maintaining full levitation across the entire speed range. Dual-mode operation, magnetic at low speeds and gas film at high speeds, minimizes control power and thermal losses, making HGMBs ideal for high-speed aerospace systems such as cryogenic turbopumps, electric propulsion units, and hydrogen compressors. While not universally optimal, HGMBs excel where extreme speed, high load, and stringent efficiency requirements converge. Advances in modeling, control, and manufacturing are expected to accelerate their adoption, marking a shift toward hybrid electromagnetic–aerodynamic rotor support for next-generation aerospace propulsion. This review provides a thorough overview of emerging HGMBs, emphasizing their design principles, performance metrics, application case studies, and comparative advantages over conventional gas or magnetic bearings. We include both a historical perspective and the latest developments, supported by technical data, experimental results, and insights from recent literature. We also present a comparative discussion including future research directions for HGMBs in aerospace electrical machine applications. Full article

Background: Multidrug-resistant (MDR) pulmonary infections represent a critical global health challenge, necessitating innovative therapeutic approaches. Green synthesis methodologies offer sustainable alternatives for nanoparticle fabrication while addressing antimicrobial resistance. Methods: Stimuli-responsive chitosan–silver hybrid nanoparticles (CS–Ag HNPs) were biosynthesized using Pseudomonas fluorescens bacterial extracts and loaded with ciprofloxacin for targeted pulmonary delivery. Comprehensive characterization included dynamic light scattering, transmission electron microscopy, UV–visible spectroscopy, and aerodynamic assessment via next-generation impactor. Antimicrobial efficacy was evaluated against MDR Pseudomonas aeruginosa and Klebsiella pneumoniae, including biofilm disruption studies, and biocompatibility was assessed. Molecular docking analysis elucidated binding mechanisms. Cytotoxicity and epithelial barrier integrity were evaluated using Calu-3 cell models. Results: The biosynthesized NPs exhibited optimal physicochemical properties (180 ± 20 nm, PDI 0.21 ± 0.04, ζ-potential + 32.4 ± 3.1 mV) with high encapsulation efficiency (68.2 ± 4.0%). Aerodynamic analysis revealed excellent inhalation characteristics (MMAD 2.6 μm, FPF 65 ± 5%). The hybrid system demonstrated 4-fold enhanced antimicrobial activity against MDR pathogens and significant biofilm disruption (70% for P. aeruginosa, 65% for K. pneumoniae) compared to free ciprofloxacin. Cell viability remained ≥85% at therapeutic concentrations. Molecular docking revealed enhanced drug-target binding affinity (−11.2 vs. −9.3 kcal/mol) and multi-residue interactions. Conclusions: Green-synthesized CS–Ag HNPs represent a promising sustainable platform for combating pulmonary MDR infections through enhanced antimicrobial efficacy and optimal aerodynamic properties. Full article

Accurate estimation of attitude, line of sight (LOS), and carrier-phase ambiguity is essential for the performance of Guidance, Navigation, and Control (GNC) systems operating under highly dynamic and uncertain conditions. Traditional sensor fusion and filtering methods, although effective, often require precise modeling and high-grade sensors to maintain robustness. This paper investigates a deep learning-based estimation framework for attitude, LOS, and GNSS ambiguity through the fusion of onboard sensors—GNSS, IMU, and semi-active laser (SAL)—and remote sensing information. Two neural network estimators are developed to address the most critical components of the navigation chain: GNSS carrier-phase ambiguity and gravity-vector reconstruction in the body frame, which are integrated into a hybrid guidance and navigation scheme for attitude and LOS determination. These learning-based estimators capture nonlinear relationships between sensor measurements and physical states, improving generalization under degraded conditions. The proposed system is validated in a six-degree-of-freedom (6-DoF) simulation environment that includes full aerodynamic modeling of artillery guided rockets. Comparative analyses demonstrate that the learning-based ambiguity and gravity estimators reduce overall latency, enhance estimation accuracy, and improve guidance precision compared to conventional networks. The results suggest that deep learning-based sensor fusion can serve as a practical foundation for next-generation low-cost GNC systems, enabling precise and reliable operation in scenarios with limited observability or sensor degradation. Full article

Background. Inhalable monoclonal antibodies were explored as therapeutics for respiratory viral infections due to their high specificity, which, however, can become a drawback if virus mutational escape occurs. Serum-derived polyclonal antibodies for prophylaxis reflect the diverse response of the immune system, reducing susceptibility to virus mutations and targeting multiple epitopes. Objectives. The aim of this work was the development of inhalable powders containing serum of rats immunized against SARS-CoV-2. Methods & Results. In a preliminary screening, combinations of sugar and an amino acid outperformed single excipients in terms of retention of protein size and residual moisture content. Four formulations were further developed on neat and albumin-depleted serum: HPβCD/L-leucine in water, HPβCD/L-leucine in phosphate buffer (KP), trehalose/L-leucine in water and HPβCD/glycine in KP. These were subsequently evaluated for aerosol performance and protein stability. All spray-dried formulations afforded respirable particles (MMAD ≤ 5 µm, FPF 70–80%), with L-leucine reducing hygroscopicity and particle aggregation while improving aerosol dispersibility. Conclusions. Albumin did not positively affect aerodynamic properties but provided greater protection of immunoglobulin activity (approximately 80% and 90% in albumin-depleted and neat serum, respectively). Buffer selection had no remarkable impact on the considered parameters. L-leucine with HPβCD offered the best balance of aerodynamic performance and protein stabilization. Full article

Dunes are key geomorphological features controlling airflow and sediment transport. While these processes are well documented under onshore conditions, this study provides the first high-resolution spatial analysis of dune-beach dynamics under offshore winds, integrating wind flow, sediment transport, and topographic data. The investigated site is a low-elevation (<1 m) dune typical of Mediterranean coasts, characterized by a mixed sand–gravel patch and a distinct beach slope break. Results show that dune height strongly controls the magnitude of airflow adjustment. Directional deflections and accelerations remain limited (<15° and <40%, respectively), and the sheltered zone extends only to the downwind dune toe. During strong wind events (gusts > 50%), sediment transport initiates immediately beyond the crest, feeding offshore-directed fluxes. Under weaker winds (gusts < 20%), enhanced surface roughness from the mixed sand–gravel patch and flow stagnation at the slope break shift the active transport zone toward the lower beach, where the most pronounced morphological changes occur. These findings demonstrate that small dunes provide limited aerodynamic shelter and fail to prevent sediment export under offshore winds. They highlight the need to incorporate additional factors (e.g., microtopography, surface properties) when assessing sediment budgets and the long-term evolution of low-relief coastal systems. Full article