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Pharmaceutics
Special Issues
Inhaled Advances: Emerging Trends in Pulmonary Drug Delivery
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Inhaled Advances: Emerging Trends in Pulmonary Drug Delivery

A special issue of Pharmaceutics (ISSN 1999-4923). This special issue belongs to the section "Drug Delivery and Controlled Release".

Deadline for manuscript submissions: 31 October 2025 | Viewed by 443

Special Issue Editors

Dr. Dolores R. Serrano

E-Mail Website1 Website2
Guest Editor
Departament of Pharmaceutics and Food Technology, School of Pharmacy, University Complutense, Avenida Complutense, 28040 Madrid, Spain
Interests: nanomedicines; microparticles; sustained-release formulations; liposomes; nanoparticles; drug targeting; pharmacokinetics
Special Issues, Collections and Topics in MDPI journals
Dr. Brayan Anaya

E-Mail Website
Guest Editor
Department of Pharmaceutics and Food Technology, School of Pharmacy, Complutense University of Madrid, 28040 Madrid, Spain
Interests: pulmonary drug delivery; 3D printing; microparticulate manufacturing

Special Issue Information

Dear Colleagues,

Pulmonary drug delivery has emerged as a vital route for both local and systemic therapies, driven by the unique physiology of the lungs and the growing demand for noninvasive treatment options. This Special Issue aims to bring together cutting-edge research and critical reviews that explore the latest advances in inhaled formulations, microparticulate systems, novel excipients for pulmonary drug delivery, nanocarrier systems, aerosol technologies, and precision targeting strategies. From treating respiratory diseases such as infection, asthma, and Chronic Obstructive Pulmonary Disease (COPD) to systemic applications including vaccines and oncology, contributions are invited to be made to this Special Issue to highlight the versatility and potential of pulmonary delivery platforms.

Dr. Dolores R. Serrano
Dr. Brayan Anaya
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Pharmaceutics is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • pulmonary drug delivery
  • microparticles
  • nanomedicines
  • infectious diseases
  • lung targeting

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Published Papers (1 paper)

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Research

24 pages, 2946 KB  
Article
Comparative In Vitro Deposition Analysis of Formoterol, Glycopyrronium, and Tiotropium Delivered via Capsule-Based DPI
by Adam Sikora, Joanna Chałupka, Kinga Lewandowska, Paulina Drapińska and Michał Piotr Marszałł
Pharmaceutics 2025, 17(9), 1089; https://doi.org/10.3390/pharmaceutics17091089 - 22 Aug 2025
Viewed by 218
Abstract
Dry powder inhalers (DPIs) are the mainstay in the treatment of obstructive pulmonary diseases. However, the performance of DPI formulations is highly dependent on the used inhaler device and the patient’s inspiratory effort. This study aimed to evaluate and compare the aerosolization behavior [...] Read more.
Dry powder inhalers (DPIs) are the mainstay in the treatment of obstructive pulmonary diseases. However, the performance of DPI formulations is highly dependent on the used inhaler device and the patient’s inspiratory effort. This study aimed to evaluate and compare the aerosolization behavior of three commercially available capsule-based DPI medications—formoterol (Foradil®), glycopyrronium (Seebri® Breezhaler), and tiotropium (Spiriva®)—delivered using three different capsule-based inhalers (Aerolizer, Breezhaler, and Handihaler), under varying flow conditions. Methods: The aerodynamic performance of each formulation–inhaler combination was assessed using the Next-Generation Impactor (NGI) and Dosage Unit Sampling Apparatus (DUSA) methodology. Fine particle dose (FPD) and aerodynamic particle size distribution (APSD) were determined at fixed flow rates of 15, 30, 60, and 100 L/min, as well as at inhaler-specific flow rates corresponding to a 4 kPa pressure drop. Chromatographic quantification of active ingredients was performed using validated HPLC methods specific to each drug. Results: The FPD values increased consistently with higher flow rates across all tested formulations and inhalers. At a 4 kPa pressure drop, Aerolizer and Breezhaler achieved significantly higher FPDs compared to Handihaler. Notably, in some instances, non-dedicated inhalers produced greater respirable fractions than the originally intended devices. APSD profiles revealed that drug deposition shifted toward smaller NGI stages at higher inspiratory flows, supporting enhanced deep lung delivery potential under optimal conditions. Conclusions: Device resistance, capsule orientation, and piercing mechanics substantially influence drug aerosolization. Although non-dedicated inhalers may offer improved FPDs in vitro, clinical use should adhere to approved drug–device combinations, as these have been validated for efficacy and safety under real-world conditions. Full article
(This article belongs to the Special Issue Inhaled Advances: Emerging Trends in Pulmonary Drug Delivery)
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