Search Results (234)

Background/Objectives: Oral cavity wound recovery presents unique challenges due to constant moisture exposure and functional mechanical stresses. Nanoscale extracellular vesicles (exosomes) with regenerative properties offer promising therapeutic potential for tissue regeneration, contributing to improved health outcomes. This study evaluated human exosomal preparations in promoting oral mucosal regeneration. Methods: We established standardized full-thickness wounds in the buccal mucosa of SD rats and divided subjects into experimental (receiving 50 billion human exosomes) and control (receiving carrier solution only) groups. Comprehensive wound assessment occurred at predetermined intervals (days 0, 3, 7, and 10) through photographic documentation, histological examination, and quantitative measurement. Results: Exosomal-treated tissues demonstrated statistically significant acceleration in closure rates (p < 0.05), achieving 87.3% reduction by day 10 versus 64.1% in the controls. Microscopic analysis revealed superior epithelial development, reduced inflammatory infiltration, and enhanced collagen architectural organization in exosomal-treated specimens. Semi-quantitative evaluation confirmed consistently superior healing metrics in the experimental group across all assessment timepoints. Conclusions: These findings demonstrate that human exosome preparations significantly enhance oral mucosal regeneration in SD rats, suggesting potential clinical applications for accelerating recovery following oral surgical procedures. Full article

Background/Objectives: The oral cavity represents a convenient route of administration for drugs that exhibit significant hepatic first-pass extraction. In this study, the mucosal permeation properties of selected active pharmaceutical ingredients (APIs) incorporated into oral cavity drug products that are approved by the U.S. Food and Drug Administration were quantified using the human-derived sublingual HO-1-u-1 and buccal EpiOral™ in vitro tissue models. Methods: Epithelial barrier properties were monitored using propranolol and Lucifer Yellow as prototypic transcellular and paracellular markers. APIs were dissolved in artificial saliva, pH 6.7, and transepithelial flux from the apical to the basolateral compartment was quantified using HPLC. Results: Apparent permeability coefficients (Papp) calculated for these APIs in the sublingual HO-1-u-1 tissue model varied from Papp = 2.72 ± 0.06 × 10⁻⁵ cm/s for asenapine to Papp = 6.21 ± 2.60 × 10⁻⁵ cm/s for naloxone. In contrast, the buccal EpiOral™ tissue model demonstrated greater discrimination power in terms of permeation properties for the same APIs, with values ranging from Papp = 3.31 ± 0.83 × 10⁻⁷ cm/s for acyclovir to Papp = 2.56 ± 0.68 × 10⁻⁵ cm/s for sufentanil. The tissue-associated dose fraction recovered at the end of the transport experiment was significantly increased in the buccal EpiOral™ tissue model, reaching up to 8.5% for sufentanil. Conclusions: Experimental permeation data collected for selected APIs in FDA-approved oral cavity products will serve as a training set to aid the development of predictive computational models for improving algorithms that describe drug absorption from the oral cavity. Following a robust in vitro–in vivo correlation analysis, it is expected that such innovative in silico modeling strategies will the accelerate development of generic oral cavity products by facilitating the utility of model-integrated evidence to support decision making in generic drug development and regulatory approval. Full article

The construction sector presently consumes about 40% of global energy and generates 36% of CO₂ emissions, making facade retrofits a priority for decarbonising buildings. This review clarifies how ventilated facades (VFs), wall assemblies that interpose a ventilated air cavity between outer cladding and the insulated structure, address that challenge. First, the paper categorises VFs by structural configuration, ventilation strategy and functional control into four principal families: double-skin, rainscreen, hybrid/adaptive and active–passive systems, with further extensions such as BIPV, PCM and green-wall integrations that couple energy generation or storage with envelope performance. Heat-transfer analysis shows that the cavity interrupts conductive paths, promotes buoyancy- or wind-driven convection, and curtails radiative exchange. Key design parameters, including cavity depth, vent-area ratio, airflow velocity and surface emissivity, govern this balance, while hybrid ventilation offers the most excellent peak-load mitigation with modest energy input. A synthesis of simulation and field studies indicates that properly detailed VFs reduce envelope cooling loads by 20–55% across diverse climates and cut winter heating demand by 10–20% when vents are seasonally managed or coupled with heat-recovery devices. These thermal benefits translate into steadier interior surface temperatures, lower radiant asymmetry and fewer drafts, thereby expanding the hours occupants remain within comfort bands without mechanical conditioning. Climate-responsive guidance emerges in tropical and arid regions, favouring highly ventilated, low-absorptance cladding; temperate and continental zones gain from adaptive vents, movable insulation or PCM layers; multi-skin adaptive facades promise balanced year-round savings by re-configuring in real time. Overall, the review demonstrates that VFs constitute a versatile, passive-plus platform for low-carbon buildings, simultaneously enhancing energy efficiency, durability and indoor comfort. Future advances in smart controls, bio-based materials and integrated energy-recovery systems are poised to unlock further performance gains and accelerate the sector’s transition to net-zero. Emerging multifunctional materials such as phase-change composites, nanostructured coatings, and perovskite-integrated systems also show promise in enhancing facade adaptability and energy responsiveness. Full article

In this paper, a new mechanical vibration technology applied to continuous casting production is studied, which is used to break the dendrite at the solidification front, expand the equiaxed dendrite zone, and improve the center quality of the billet. The exciting force of this vibration technology is provided by a new type of vibration equipment (Vibration roll) independently developed and designed. Firstly, an investigation is conducted into the impacts of vibration acceleration, vibration frequency, and the contact area between the Vibration roll (VR) and the billet surface on the internal stress distribution within the billet shell, respectively. Secondly, the billet with and without vibration treatment was sampled and analyzed through industrial tests. The results show that the area ratio of equiaxed dendrites in transverse specimens treated with vibration technology was 11.96%, compared to 6.55% in untreated specimens. Similarly, for longitudinal samples, the linear ratio of equiaxed dendrites was observed to be 34.56% in treated samples and 22.95% in untreated samples. Compared to the specimens without mechanical vibration, the billet treated with mechanical vibration exhibits an increase in the area ratio and linear ratio of equiaxed dendrite ratio by 5.41% and 11.61%, respectively. Moreover, the probability of bridging at the end of solidification of the billet treated by vibration technology was significantly reduced, and the central porosity and shrinkage cavities of the billet were significantly improved. This study provides the first definitive evidence that the novel mechanical vibration technology can enhance the quality of the billet during the continuous casting process. Full article

Ground subsidence is a significant geotechnical hazard in urban areas, leading to property damage, casualties, and broader societal issues. This study investigates the mechanisms of cavity formation and ground subsidence through laboratory model tests using Korean standard sand and marine clay under controlled conditions. A transparent soil box apparatus was fabricated to simulate sewer pipe damage, with model grounds prepared at various relative densities, groundwater levels, and fines contents. The progression of cavity formation and surface collapse was observed and quantitatively analyzed by measuring the time to cavity formation and ground subsidence, as well as the mass of discharged soil. Results indicate that lower relative density accelerates ground subsidence, whereas higher density increases cavity volume due to greater frictional resistance. Notably, as the fines content increased, a tendency was observed for ground subsidence to be increasingly suppressed, suggesting that cohesive clay particles can limit soil loss under seepage conditions. These findings provide valuable insights for selecting backfill materials and managing subsurface conditions to mitigate ground subsidence risks in urban infrastructure. Full article

High-current electron beams can significantly enhance the productivity of variety of applications including medical radioisotope (RI) production and wastewater purification. High-power superconducting radio frequency (SRF) linacs are capable of producing such high-current electron beams due to the key advantage to operate in continuous wave (CW) mode. However, this requires an injector capable of generating electron bunches with high repetition rate and in CW mode, while minimizing beam losses to avoid damage to SRF cavities due to quenching. RF gating to the grid of a thermionic electron gun is a promising solution, as it ensures CW bunch generation at the repetition rate same as the fundamental or sub-harmonics of the accelerating RF frequency, with minimal beam loss. This paper presents detailed beam dynamics simulations demonstrating that an RF-gated gun operating at 1.3 GHz can generate bunches with 148 ps full width with 8.96 pC charge. Full article

The Polish Free-Electron Laser (PolFEL), which is currently under construction in the National Centre for Nuclear Research in Świerk near Warsaw, will comprise an electron gun and from four to six cryomodules, each accommodating two nine-cell TESLA RF superconducting resonant cavities. To cool the superconducting resonant cavities, the cryomodules will be supplied with superfluid helium at a temperature of 2 K. Other requirements regarding the cooling power of PolFEL result from the need to cool the power couplers for the accelerating cryomodules (5 K) and thermal shields, which limit the heat inleaks due to radiation (40–80 K). The machine will utilize several thermodynamic states of helium, including two-phase superfluid helium, supercritical helium, and low-pressure helium vapours. Supercritical helium will be supplied from a cryoplant by a cryogenic distribution system (CDS)—transfer line and valve boxes—where it will be thermodynamically transformed into a superfluid state. This article presents the architecture of the CDS, discusses several design solutions that could have been decided on with the use of second law analysis, and presents the design methodology of the chosen CDS elements. Full article

Internal soil erosion caused by water infiltration around defective buried pipes poses a significant threat to the long-term stability of underground infrastructures such as pipelines and highway culverts. This study employs a coupled computational fluid dynamics–discrete element method (CFD–DEM) framework to simulate the detachment, transport, and redistribution of soil particles under varying infiltration pressures and pipe defect geometries. Using ANSYS Fluent (CFD) and Rocky (DEM), the simulation resolves both the fluid flow field and granular particle dynamics, capturing erosion cavity formation, void evolution, and soil particle transport in three dimensions. The results reveal that increased infiltration pressure and defect size in the buried pipe significantly accelerate the process of erosion and sinkhole formation, leading to potentially unstable subsurface conditions. Visualization of particle migration, sinkhole development, and soil velocity distributions provides insight into the mechanisms driving localized failure. The findings highlight the importance of considering fluid–particle interactions and defect characteristics in the design and maintenance of buried structures, offering a predictive basis for assessing erosion risk and infrastructure vulnerability. Full article

Repairing and regenerating tissue barriers is a key challenge in regenerative medicine. Stem cells play a crucial role in restoring the structural and functional integrity of key epithelial barrier surfaces, including the skin and mucosa. This review analyzes the role of dental pulp stem cells (DPSCs) and their derivatives, including extracellular vesicles, conditioned medium, and intracellular factors, in accelerating skin wound healing. The key mechanisms include: (1) DPSCs regulating inflammatory microenvironments by promoting anti-inflammatory M2 macrophage polarization; (2) DPSCs activating vascular endothelial growth factor (VEGF) to drive angiogenesis; (3) DPSCs optimizing extracellular matrix (ECM) spatial structure through matrix metalloproteinase/tissue inhibitor of metalloproteinase (MMP/TIMP) balance; and (4) DPSCs enhancing transforming growth factor-β (TGF-β) secretion to accelerate granulation tissue formation. Collectively, these processes promote wound healing. In addition, we explored potential factors that accelerate wound healing in DPSCs, such as oxidative stress, mechanical stimulation, hypertension, electrical stimulation, and organoid modeling. In addition to demonstrating the great potential of DPSCs for skin repair, this review explores their translational prospects in mucosal regenerative medicine. It covers the oral cavity, esophagus, colon, and fallopian tube. Some studies have found that combining DPSCs and their derivatives with drugs can significantly enhance their biological effects. By integrating insights from skin and mucosal models, this review offers novel ideas and strategies for treating chronic wounds, inflammatory bowel disease, and mucosal injuries. It also lays the foundation for connecting basic research results with clinical practice. This represents a significant step forward in tackling these complex medical challenges and lays a solid scientific foundation for developing more targeted and efficient regenerative therapies. Full article

The experimental and computational characterization of a cold model prototype designed to test the electromagnetic properties of a new RFQ (Radio-Frequency Quadrupole) cavity is reported. This cavity is intended to be an essential part of a compact, high-gradient proton accelerator for medical purposes. The RFQ’s design employs a novel RF power-coupler injection solution. One common way to couple the RF power in proton RFQs has been the use of loop-couplers inserted into the mid-section of the RFQ’s lobe sections. This technique has been demonstrated to be reliable and effective but introduces a significant perturbation into the lobe that can be more noticeable when dealing with compact structures. We propose a RF injection scheme that uses direct transition from a coaxial cable to the RFQ by connecting the inner coaxial conductor to the RFQ vane body. As a consequence, the lobe geometry is not perturbed, and the transversal electrical fields are directly excited through the vanes. Moreover, by using a pair of such couplers connected to opposite vanes at a given transversal plane of the RFQ, it is also possible to excite the desired quadrupolar TE210 modes while avoiding the excitation of dipolar TE110 modes. The resonances corresponding to different RFQ modes have been characterized, and the dependence of the amplitude of the modes on the relative phase of the field injected through the RF power ports has been demonstrated both by measurements and simulations. Full article

Designing a transmission line (TL) for a widely tunable, broadband terahertz radiation source presents substantial challenges due to the complexity of beam dynamics and spectral characteristics. Here, we investigate the propagation of the most significant radiation modes expected to traverse the TL, intended for integration with an advanced particle accelerator currently under construction at the Schlesinger Family Center for Compact Accelerators, Radiation Sources and Applications. The total electromagnetic field at the source output is expressed in the frequency domain via cavity eigenmodes and transformed into an optical field representation using the Wigner distribution function (WDF). This formulation enables physically consistent modeling within the constraints of geometric optics and Wigner formalism of the spatiotemporal evolution of the radiation during propagation. The initial TL design is developed and optimized based on this representation. A 3D space–frequency analysis tool for pulsed radiation, based on the WDF, was implemented to characterize field behavior and guide system development. Complementary ray tracing simulations were conducted using the Zemax Optic Studio platform, supporting the assessment of optical feasibility through simulation and system feasibility. Full article

High-gradient accelerating radio frequency (RF) ] cavities are currently being developed in several national laboratories for applications in high-energy physics. Ultra-high accelerating gradients, reaching up to the GV/m range, can be achieved using ultra-compact accelerating structures operating in the sub-terahertz (sub-THz) regime. However, accurately measuring the key RF parameters of such compact structures presents significant experimental challenges, and even minor inaccuracies can lead to substantial errors. Additionally, RF simulations for these cavities often require extensive computational resources. Among the most critical parameters to determine is the reflection coefficient. To provide a fast and accurate analytical estimation, we have developed an electromagnetic theory describing the coupling between a resonant cavity and an RF waveguide. This approach is based on Bethe’s small-aperture polarization method, further developed by Collin. An exact analytical expression for the reflection coefficient is presented, formulated as a function of the physical parameters of the cavity waveguide system and applicable to arbitrary geometries, materials, and frequencies. Full article

Phase change materials (PCMs) are widely used in latent heat thermal energy storage systems (LHTESSs), but their low thermal conductivity limits performance. This study numerically investigates the enhancement of thermal efficiency in LHTESSs using nano-enhanced PCM (NePCM), composed of paraffin wax embedded with copper (Cu) nanoparticles. The NePCM is confined within a trapezoidal cavity, with the base serving as the heat source. Four different cavity heights were analyzed: cases 1, 2, 3, and 4 with the heights D of 24 mm, 18 mm, 15 mm, and 13.5 mm, respectively. The finite element method was employed to solve the governing equations. The influence of two hot base temperatures (333.15 K and 338.15 K) and Cu nanoparticle volume fractions ranging from 0% to 6% was examined. The results show that incorporating Cu nanoparticles at 6 vol% (volume fraction) enhanced thermal conductivity and reduced melting time by 10.71%. Increasing the base temperature to 338.15 K accelerated melting by 65.55%. Among all configurations, case 4 exhibited the best performance, reducing melting duration by 15.12% compared to case 1. Full article

Spent coffee grounds (SCG) are produced in large quantities during coffee brewing, contributing to environmental concerns. Additionally, cationic dyes from textile, paper, and leather wastewater pose a major pollution issue. This study explores SCG as an adsorbent for methylene blue (MB) dye. A novel comparison of SCG cleaning methods with warm water, accelerated solvent extraction (ASE), supercritical fluid extraction (SFE), and ultrasound-induced cavitation (US) is presented. In addition, the chemical modifications of SCG using acetylation, acid (HNO₃), and base (KOH) treatment that have not been reported before are presented. ATR-FTIR confirmed the inclusion of functional groups, for example, the nitro group in SCG treated with HNO₃, and an increase in carboxylic groups in the samples treated with KOH and HNO₃. SEM analysis revealed a consistent porous texture across samples, with SCG-SFE, SCG-US, and SCG-HNO₃ showing smaller pores, and SCG-ASE displaying elongated cavities. Adsorption isotherm tests followed the Freundlich and Langmuir models, indicating favorable adsorption. The Langmuir maximum adsorption capacity (q_max) varied among cleaning methods from 65.69 mg/g (warm water) to 93.32 mg/g (SFE). In contrast, in base- and acid-treated SCG, a three- to four-fold increase in adsorption capacity was observed, with q_max values of 171.60 mg/g and 270.64 mg/g, respectively. These findings demonstrate that SCG washed with warm water and chemically treated achieves adsorption capacities comparable to other biosorbents reported in the literature. Therefore, SCG represents a promising, low-cost, and sustainable material for removing cationic dyes from wastewater, contributing to waste valorization and environmental protection. Full article

Integrated photonic biosensors are revolutionizing lab-on-a-chip technologies by providing highly sensitive, miniaturized, and label-free detection solutions for a wide range of biological and chemical targets. This review explores the foundational principles behind their operation, including the use of resonant photonic structures such as microring and whispering gallery mode resonators, as well as interferometric and photonic crystal-based designs. Special focus is given to the design strategies that optimize light–matter interaction, enhance sensitivity, and enable multiplexed detection. We detail state-of-the-art fabrication approaches compatible with complementary metal-oxide-semiconductor processes, including the use of silicon, silicon nitride, and hybrid material platforms, which facilitate scalable production and seamless integration with microfluidic systems. Recent advancements are highlighted, including the implementation of optofluidic photonic crystal cavities, cascaded microring arrays with subwavelength gratings, and on-chip detector arrays capable of parallel biosensing. These innovations have achieved exceptional performance, with detection limits reaching the parts-per-billion level and real-time operation across various applications such as clinical diagnostics, environmental surveillance, and food quality assessment. Although challenges persist in handling complex biological samples and achieving consistent large-scale fabrication, the emergence of novel materials, advanced nanofabrication methods, and artificial intelligence-driven data analysis is accelerating the development of next-generation photonic biosensing platforms. These technologies are poised to deliver powerful, accessible, and cost-effective diagnostic tools for practical deployment across diverse settings. Full article