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9 Results Found

  • Article
  • Open Access
6 Citations
5,224 Views
13 Pages

14 September 2018

In a global context, the story of the Jesuit compound in Shanghai, since its establishment by French Jesuits in 1847, reflected not only conflicts between rival powers in Europe but also the fight for their interests in the Eastern world. The female...

  • Article
  • Open Access
5 Citations
4,708 Views
18 Pages

28 February 2021

The various endeavors led by Jesuits under the auspices to the Plan Scientifique du Kiang-Nan (Scientific Plan for the Jiangnan region) constituted a defining moment in the history of their mission in modern China. The Jesuits aimed to found a scient...

  • Article
  • Open Access
7 Citations
3,249 Views
11 Pages

Vemurafenib Inhibits Enterovirus A71 Genome Replication and Virus Assembly

  • Bodan Hu,
  • Kenn Ka-Heng Chik,
  • Jasper Fuk-Woo Chan,
  • Jian-Piao Cai,
  • Hehe Cao,
  • Jessica Oi-Ling Tsang,
  • Zijiao Zou,
  • Yin-Po Hung,
  • Kaiming Tang and
  • Shuofeng Yuan
  • + 6 authors

27 August 2022

Enterovirus A71 (EV-A71) infection is a major cause of hand, foot, and mouth disease (HFMD), which may be occasionally associated with severe neurological complications. There is currently a lack of treatment options for EV-A71 infection. The Raf-MEK...

  • Article
  • Open Access
26 Citations
7,907 Views
13 Pages

Screening of an FDA-Approved Drug Library with a Two-Tier System Identifies an Entry Inhibitor of Severe Fever with Thrombocytopenia Syndrome Virus

  • Shuofeng Yuan,
  • Jasper Fuk-Woo Chan,
  • Zi-Wei Ye,
  • Lei Wen,
  • Terance Gi-Wai Tsang,
  • Jianli Cao,
  • Jingjing Huang,
  • Chris Chun-Yiu Chan,
  • Kenn Ka-Heng Chik and
  • Kwok-Yung Yuen
  • + 6 authors

25 April 2019

Severe fever with thrombocytopenia syndrome virus (SFTSV) is an emerging tick-borne bunyavirus that causes severe disease in humans with case-fatality rates of up to 30%. There are currently very limited treatment options for SFTSV infection. We cond...

  • Article
  • Open Access
3 Citations
4,112 Views
14 Pages

In Silico Structure-Based Design of Antiviral Peptides Targeting the Severe Fever with Thrombocytopenia Syndrome Virus Glycoprotein Gn

  • Shuo-Feng Yuan,
  • Lei Wen,
  • Kenn Ka-Heng Chik,
  • Jiang Du,
  • Zi-Wei Ye,
  • Jian-Li Cao,
  • Kai-Ming Tang,
  • Rong-Hui Liang,
  • Jian-Piao Cai and
  • Jasper Fuk-Woo Chan
  • + 7 authors

11 October 2021

Severe fever with thrombocytopenia syndrome virus (SFTSV) is an emerging tick-borne bunyavirus in Asia that causes severe disease. Despite its clinical importance, treatment options for SFTSV infection remains limited. The SFTSV glycoprotein Gn plays...

  • Article
  • Open Access
58 Citations
7,611 Views
18 Pages

Broad-Spectrum Host-Based Antivirals Targeting the Interferon and Lipogenesis Pathways as Potential Treatment Options for the Pandemic Coronavirus Disease 2019 (COVID-19)

  • Shuofeng Yuan,
  • Chris Chun-Yiu Chan,
  • Kenn Ka-Heng Chik,
  • Jessica Oi-Ling Tsang,
  • Ronghui Liang,
  • Jianli Cao,
  • Kaiming Tang,
  • Jian-Piao Cai,
  • Zi-Wei Ye and
  • Jasper Fuk-Woo Chan
  • + 6 authors

10 June 2020

The ongoing Coronavirus Disease 2019 (COVID-19) pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) signals an urgent need for an expansion in treatment options. In this study, we investigated the anti-SARS-CoV-2 activitie...

  • Article
  • Open Access
13 Citations
3,325 Views
12 Pages

Metabolic Profiling Reveals Significant Perturbations of Intracellular Glucose Homeostasis in Enterovirus-Infected Cells

  • Zijiao Zou,
  • Jessica Oi-Ling Tsang,
  • Bingpeng Yan,
  • Kenn Ka-Heng Chik,
  • Chris Chun-Yiu Chan,
  • Jianli Cao,
  • Ronghui Liang,
  • Kaiming Tang,
  • Feifei Yin and
  • Kwok-Yung Yuen
  • + 4 authors

Enterovirus A71 (EV-A71) is a common cause of hand, foot, and mouth disease. Severe EV-A71 infections may be associated with life-threatening neurological complications. However, the pathogenic mechanisms underlying these severe clinical and patholog...