Search Results (10,503)

The epidermal growth factor receptor (EGFR) is a key target for both cancer diagnosis and therapeutic interventions. Assessing EGFR expression before therapy has become routine in clinical practice, yet current methods like biopsy and immunohistochemistry (IHC) have significant limitations, including invasiveness, limited repeatability, and lack of real-time, whole-body data. EGFR-targeted imaging has emerged as a promising alternative. EGFR-targeting peptides, owing to their favorable physicochemical properties and versatility, are increasingly being explored for a variety of applications, including molecular imaging, drug delivery, and targeted therapy. Recent advances have demonstrated the potential of EGFR-targeting peptides conjugated to imaging probes for non-invasive, real-time in vivo tumor detection, precision therapy, and surgical guidance. Here, we provide a comprehensive overview of the latest progress in EGFR-targeting peptides development, with a particular focus on their application in the development of molecular imaging agents, including fluorescence imaging, PET/CT, magnetic resonance imaging, and multimodal imaging. Furthermore, we examine the challenges and future directions concerning the development and clinical application of EGFR-targeting peptide-based imaging probes. Finally, we highlight emerging technologies such as artificial intelligence, mutation-specific peptides, and multimodal imaging platforms, which offer significant potential for advancing the diagnosis and treatment of EGFR-targeted cancers. Full article

Obtaining the echo of individual fish is an important prerequisite for fisheries acoustic applications, such as in situ measurement of fish target strength and assessment of fish abundance using the counting method. It is also the foundation for evaluating the growth status of farmed fish and managing aquaculture risks. The density of farmed fish populations is typically higher, and such high-density aquaculture further increases the difficulty of obtaining individual fish echoes in practical applications. Building upon previous research and considering the behavioral characteristics of fish in aquaculture settings, this study conducted performance simulations, live fish experiments in simulated aquaculture cages, and comparative evaluations of three individual fish broadband echo detection methods based on a broadband signal system: the amplitude pulse width method (APM) based on echo envelopes, the peak detection and time delay estimation method (PDM), and the peak time delay combined with instantaneous frequency method (PDIM). This study assumed a dorsolateral fish orientation, which limits its research scope and applicability. The results showed that the PDIM achieved a detection accuracy of 78.34% and a false recognition rate of 1.32%. The APM based on echo envelopes was insensitive to individual fish echoes and had lower recognition accuracy. The PDM exhibited better individual fish echo capture capabilities, while the PDIM demonstrated superior overlapping echo rejection capabilities. Full article

Under the current context of the large-scale integration of wind and solar power, the coupling of hydropower with wind and solar energy brings significant impacts on grid stability. To fully leverage the regulatory capacity of hydropower, this paper develops a multi-objective optimization scheduling model for hydropower, wind, and solar that balances generation-side power generation benefit and grid-side peak-regulation requirements, with the latter quantified by the mean square error of the residual load. To efficiently solve this model, Latin hypercube initialization, hybrid distance framework, and adaptive mutation mechanism are introduced into the Strength Pareto Evolutionary Algorithm II (SPEAII), yielding an improved algorithm named LHS-Mutate Strength Pareto Evolutionary Algorithm II (LMSPEAII). Its efficiency is validated on benchmark test functions and a reservoir model. Typical extreme scenarios—months with strong wind and solar in the dry season and months with weak wind and solar in the flood season—are selected to derive scheduling strategies and to further verify the effectiveness of the proposed model and algorithm. Finally, K-medoids clustering is applied to the Pareto front solutions; from the perspective of representative solutions, this reveals the evolutionary trends of different objective trade-off schemes and overall distribution characteristics, providing deeper insight into the solution set’s distribution features. Full article

Grafting serves as a crucial propagation technique for superior Camellia oleifera varieties, where rootstock–scion compatibility significantly determines survival and growth performance. To systematically evaluate grafting compatibility in this economically important woody oil crop, we examined 15 rootstock–scion combinations using ‘Xianglin 210’ as the scion, assessing growth traits and conducting physiological assays (enzymatic activities of SOD and POD and levels of ROS and IAA) at multiple timepoints (0–32 days post-grafting). The results demonstrated that Comb. 4 (Xianglin 27 rootstock) exhibited superior compatibility, characterized by systemic antioxidant activation (peaking at 4–8 DPG), rapid auxin accumulation (4 DPG), and efficient sugar allocation. Transcriptome sequencing and WGCNA analysis identified 3781 differentially expressed genes, with notable enrichment in stress response pathways (Hsp70, DnaJ) and auxin biosynthesis (YUCCA), while also revealing key hub genes (FKBP19) associated with graft-healing efficiency. These findings establish that successful grafting in C. oleifera depends on coordinated rapid redox regulation, auxin-mediated cell proliferation, and metabolic reprogramming, with Comb. 4 emerging as the optimal rootstock choice. The identified molecular markers not only advance our understanding of grafting mechanisms in woody plants but also provide valuable targets for future breeding programs aimed at improving grafting success rates in this important oil crop. Full article

Critical Internet of Things (IoT) data in Fifth Generation Vehicular Ad Hoc Networks (5G VANETs) demands Ultra-Reliable Low-Latency Communication (URLLC) to support mission-critical vehicular applications such as autonomous driving and collision avoidance. Achieving the stringent Quality of Service (QoS) requirements for these applications remains a significant challenge. This paper proposes a novel framework integrating Software-Defined Networking (SDN) and Network Functions Virtualisation (NFV) as embedded functionalities in connected vehicles. A lightweight SDN Controller model, implemented via vehicle on-board computing resources, optimised QoS for communications between connected vehicles and the Next-Generation Node B (gNB), achieving a consistent packet delivery rate of 100%, compared to 81–96% for existing solutions leveraging SDN. Furthermore, a Software-Defined Wide-Area Network (SD-WAN) model deployed at the gNB enabled the efficient management of data, network, identity, and server access. Performance evaluations indicate that SDN and NFV are reliable and scalable technologies for virtualised and distributed 5G VANET infrastructures. Our SDN-based in-vehicle traffic classification model for dynamic resource allocation achieved 100% accuracy, outperforming existing Artificial Intelligence (AI)-based methods with 88–99% accuracy. In addition, a significant increase of 187% in flow rates over time highlights the framework’s decreasing latency, adaptability, and scalability in supporting URLLC class guarantees for critical vehicular services. Full article

Temperature dependence of the deformation behavior and the residual stress in 304 stainless steel beams with single-sided Al₂O₃ coatings of varying thicknesses are analyzed using the image relative method. The results demonstrate that, due to the mismatch of thermal expansion coefficient between the coating and substrate, residual stresses were produced, which caused the bending deformation of the single-side coated specimens. Moreover, coating thickness significantly influences the deformation behavior of specimens. Within the elastic deformation regime, the single-side coated specimens would exhibit alternating bending and flattening deformations in response to the fluctuations of temperature. The higher ratio of the coating thickness to the substrate thickness is, the smaller bending curvature of specimens becomes, and the lower residual compressive stresses in the coating are. For the specimens undergoing elastic deformation, residual stresses can be effectively calculated through the Stoney’s formula. However, as the thickness of coating is close to that of substrate (the corresponding specimens would be regarded as the laminated composites), plastic deformation occurs. And the residual stresses in those specimens vary along the direction of the thickness and the length. In addition, the residual stress decreased with increasing temperature because of the stress relaxation. Full article

To study the influence of curing agent structure on the properties of epoxy resin, four types of aromatic diamines with the structure of diphenyl methane (4,4′-methylenedianiline (MDA), 4,4′-methylenebis(2-ethylaniline) (MOEA), 4,4′-methylenebis(2-chloroaniline) (MOCA), and 4,4′-methylenebis(3-chloro-2,6-diethylaniline) (MCDEA)) and a high-performance epoxy resin, 3-(oxiran-2-ylmethoxy)-N,N-bis(oxiran-2-ylmethyl)aniline (AFG-90MH), were used in this study. The resulting resin systems were designated as AFG-90MH-MDA, AFG-90MH-MOEA, AFG-90MH-MOCA, and AFG-90MH-MCDEA. After curing, these systems were named AFG-90MH-MDA-C, AFG-90MH-MOEA-C, AFG-90MH-MOCA-C, and AFG-90MH-MCDEA-C. The influence of the structure of the diamines on the processability, curing reaction activity, and thermal and mechanical properties (including flexural and tensile properties) of the epoxy resins were investigated. These systems demonstrate excellent processability with wide processing windows ranging from 30 °C to 110–160 °C while maintaining low viscosity. Consistent apparent activation energy (E_a) trends via both Kissinger and Flynn-Wall-Ozawa methods were observed. The epoxy systems exhibit the following increasing E_a sequence: AFG-90MH-MDA < AFG-90MH-MOEA < AFG-90MH-MOCA < AFG-90MH-MCDEA. The processability and curing reaction kinetic results indicate that the reactivities of the diamines decrease in the order: MDA > MOEA > MOCA > MCDEA. Polar chlorine substituents in diamines strengthen intermolecular interactions, thereby enhancing mechanical performance. The flexural strength of cured epoxy systems decreases as follows with corresponding values: AFG-90MH-MOCA-C (165 MPa) > AFG-90MH-MDA-C (158 MPa) > AFG-90MH-MCDEA-C (148 MPa) > AFG-90MH-MOEA-C (136 MPa). Diamines with substituents like chlorine or ethyl groups reduce the glass transition temperatures (T_g) of the cured resin systems. However, the cured resin systems with the diamines containing chlorine demonstrate superior thermal performance compared to those with ethyl groups. The cured epoxy systems exhibit the following descending glass transition temperature order with corresponding values: AFG-90MH-MDA-C (213 °C) > AFG-90MH-MOCA-C (190 °C) > AFG-90MH-MCDEA-C (183 °C) > AFG-90MH-MOEA-C (172 °C). Full article

Ischemic stroke is a serious disease that frequently occurs in the elderly and is characterized by a complex pathophysiology and a limited number of effective therapeutic agents. Salvianolic acid A (SAL-A) is a natural product derived from the rhizome of Salvia miltiorrhiza, which possesses diverse pharmacological activities. This study aims to investigate the effect and mechanisms of SAL-A in inhibiting ferroptosis to improve ischemic stroke. Brain injury, oxidative stress and ferroptosis-related analysis were performed to evaluate the effect of SAL-A on ischemic stroke in photochemical induction of stroke (PTS) in mice. Lipid peroxidation levels, antioxidant protein levels, tissue iron content, nuclear factor erythroid 2-related factor 2 (Nrf2), and mitochondrial morphology changes were detected to explore its mechanism. SAL-A significantly attenuated brain injury, reduced malondialdehyde (MDA) and long-chain acyl-CoA synthase 4 (ACSL4) levels. In addition, SAL-A also amplified the antioxidative properties of glutathione (GSH) when under glutathione peroxidase 4 (GPX4), and the reduction in ferrous ion levels. In vitro, brain microvascular endothelial cells (b.End.3) exposed to oxygen-glucose deprivation/reoxygenation (OGD/R) were used to investigate whether the anti-stroke mechanism of SAL-A is related to Nrf2. Following OGD/R, ML385 (Nrf2 inhibitor) prevents SAL-A from inhibiting oxidative stress, ferroptosis, and mitochondrial dysfunction in b.End.3 cells. In conclusion, SAL-A inhibits ferroptosis to ameliorate ischemic brain injury, and this effect is mediated through Nrf2. Full article

Ulcerative colitis (UC) is a chronic inflammatory bowel disease associated with disrupted lipid metabolism. This study aimed to uncover novel molecular subtypes and biomarkers by integrating sphingolipid metabolism-related genes (SMGs) with machine learning approaches. Using data from the GEO and GeneCards databases, 29 UC-related SMGs were identified. Consensus clustering was employed to define distinct molecular subtypes of UC, and a diagnostic model was developed through various machine learning algorithms. Further analyses—including functional enrichment, transcription factor prediction, single-cell localization, potential drug screening, molecular docking, and molecular dynamics simulations—were conducted to investigate the underlying mechanisms and therapeutic prospects of the identified genes in UC. The analysis revealed two molecular subtypes of UC: C1 (metabolically dysregulated) and C2 (immune-enriched). A diagnostic model based on three key genes demonstrated high accuracy in both the training and validation cohorts. Moreover, the transcription factor FOXA2 was predicted to regulate the expression of all three genes simultaneously. Notably, mebendazole and NVP-TAE226 emerged as promising therapeutic agents for UC. In conclusion, SMGs are integral to UC molecular subtyping and immune microenvironment modulation, presenting a novel framework for precision diagnosis and targeted treatment of UC. Full article

Target detection is essential in intelligent transportation and autonomous control of unmanned aerial vehicles (UAVs), with single-stage detection algorithms used widely due to their speed. However, these algorithms face limitations in detecting small targets, especially in aerial photography from unmanned aerial vehicles (UAVs), where small targets are often occluded, multi-scale semantic information is easily lost, and there is a trade-off between real-time processing and computational resources. Existing algorithms struggle to effectively extract multi-dimensional features and deep semantic information from images and to balance detection accuracy with model complexity. To address these limitations, we developed FFG-YOLO, a lightweight small-target detection method for UAVs based on YOLOv8. FFG-YOLO incorporates three modules: a feature enhancement block (FEB), a feature concat block (FCB), and a global context awareness block (GCAB). These modules strengthen feature extraction from small targets, resolve semantic bias in multi-scale feature fusion, and help differentiate small targets from complex backgrounds. We also improved the positioning accuracy of small targets using the Wasserstein distance loss function. Experiments showed that FFG-YOLO outperformed other algorithms, including YOLOv8n, in small-target detection due to its lightweight nature, meeting the stringent real-time performance and deployment requirements of UAVs. Full article

Bioinspired soft adhesive systems capable of stable and intelligent object manipulation are critical for next-generation robotics. In this study, a soft gripper combining an octopus-inspired suction mechanism with a frog-inspired hexagonal friction pattern was developed to enhance adhesion performance under diverse surface conditions and orientations. The hexagonal pattern, inspired by frog toe pads, contributed to improved stability against tilting and shear forces. The integrated strain gauge enabled real-time monitoring of gripping states and facilitated the detection of contact location and changes in load distribution during manipulation. The system demonstrated robust adhesion under both dry and wet conditions, with adaptability to various object geometries and inclinations. These results suggest broad potential for bioinspired gripping platforms in fields such as collaborative robotics, medical tools, and underwater systems. Full article

Vaccinium oldhamii, a blueberry species native to Korea, is a deciduous shrub in the Ericaceae family. Its fruit possesses various pharmacological properties, including anti-inflammatory effects and potential for treating osteoporosis. This study evaluated the effects of five fertilization concentration levels using Multifeed 20 (N:P:K = 20:20:20) on the growth and physiological characteristics of one-year-old V. oldhamii container seedlings. Treatments included 0 g·L⁻¹ (control), 0.5, 1.0, 1.5, and 2.0 g·L⁻¹. Increases in stem thickness, root length, and total dry weight were observed in the control, 0.5, 1.0, and 1.5 g·L⁻¹ treatments, whereas growth declined at 2.0 g·L⁻¹. Mortality rates exceeded 15% at concentrations above 1.0 g·L⁻¹. Photosynthetic capacity and chlorophyll content increased with fertilization. However, while growth improved with increasing fertilizer up to a certain level, it declined at the highest concentration. A fertilization rate of 0.5 g·L⁻¹ proved to be the most economically and environmentally efficient for producing healthy seedlings. This study provides the first fertilization threshold for V. oldhamii, offering practical guidance for nursery production and forming a foundation for future domestication strategies. Full article

This paper addresses the critical challenge of selecting suitable pile foundations in port engineering by systematically investigating the axial bearing behavior of large-diameter steel pipe piles and prestressed high-strength concrete (PHC) piles. The study integrates both numerical simulations and field tests within the context of the Yancheng Dafeng Port Security Facilities Project. A self-balanced static load numerical model for PHC piles was developed using Plaxis 3D, enabling the simulation of load-displacement responses, axial force transfer, and side resistance distribution. The accuracy of the model was verified through a comparison with field static load test data. With the verified model parameters, the internal force distribution of steel pipe piles was analysed by modifying material properties and adjusting boundary conditions. A comparative analysis of the two pile types was conducted under identical working conditions. The results reveal that the ultimate bearing capacities of the 1# steel pipe pile and the 2# PHC pile are 6734 kN and 6788 kN, respectively. Despite the PHC pile having a 20% larger diameter, its ultimate bearing capacity is comparable to that of the steel pipe pile, suggesting a more efficient utilisation of material strength in the latter. Further numerical simulations indicate that, under the same working conditions, the ultimate bearing capacity of the steel pipe pile exceeds that of the PHC pile by 18.43%. Additionally, the axial force distribution along the steel pipe pile shaft is more uniform, and side resistance is mobilised more effectively. The reduction in side resistance caused by construction disturbances, combined with the slenderness ratio (L/D = 41.7) of the PHC pile, results in 33.87% of the pile’s total bearing capacity being attributed to tip resistance. The findings of this study provide crucial insights into the selection of optimal pile types for terminal foundations, considering factors such as bearing capacity, environmental conditions, and economic viability. Full article

This communication presents an accurate and computationally efficient approach for wideband radar cross-section (RCS) estimation and scattering point reconstruction using infinitesimal dipole modeling (IDM) with compressive sensing. The proposed method eliminates the need for field sampling at numerous frequency points across the wideband range through Green’s function adjustment. Additionally, compressive sensing is employed for induced current calculation to reduce both frequency and angular sampling requirements. Numerical validation demonstrates that the method achieves a 50% reduction in field sample data and an 82.3% reduction in IDM processing time while maintaining comparable accuracy through Green’s function adjustment. Furthermore, compared to approaches without compressive sensing, the method shows a 55.1% and a 75.5% reduction in error in averaged RCS for VV-pol and HH-pol, respectively. The proposed method facilitates efficient wideband RCS estimation of various targets while significantly reducing measurement complexity and computational cost. Full article