Search Results (857)

Municipal wastewaters pose a severe risk to the environment and human health when discharged untreated. This is due to their high content of pathogens, such as viruses and bacteria, which can cause diseases like cholera. Herein, the research and development of porphyrin-modified polyethersulfone (PES) ultrafiltration (UF) membranes was conducted to improve bacterial inactivation in complex municipal wastewater and enhance the fouling resistance and filtration performance. The synthesis and fabrication of porphyrin nanofillers and the resultant membrane characteristics were studied. The incorporation of porphyrin-based nanofillers improved the membrane’s hydrophilicity, morphology, and flux (247 Lm⁻² h⁻¹), with the membrane contact angle (CA) decreasing from 90° to ranging between 58° and 50°. The membrane performance was monitored for its flux, antifouling properties, reusability potential, municipal wastewater, and humic acid. The modified membranes demonstrated an effective application in wastewater treatment, achieving notable antibacterial activity, particularly under light exposure. The In-BP@SW/PES membrane demonstrated effective antimicrobial photodynamic effects against both Gram-positive S. aureus and Gram-negative E. coli. It achieved at least a 3-log reduction in bacterial viability, meeting Food and Drug Administration (FDA) standards for efficient antimicrobial materials. Among the variants tested, membranes modified with In-PB@SW nanofillers exhibited superior antifouling properties with flux recovery ratios (FRRs) of 78.9% for the humic acid (HA) solution and 85% for the municipal wastewater (MWW), suggesting a strong potential for long-term filtration use. These results highlight the promise of porphyrin-functionalized membranes as multifunctional tools in advanced water treatment technologies. Full article

Background: Uterine fibroids (UFs) and endometriosis are gynecological conditions that significantly increase morbidity among women of reproductive age. Relugolix, a novel gonadotropin-releasing hormone receptor antagonist, is approved in combined therapy for the management of symptoms related to these disorders. However, its potential impact on bone mineral density (BMD) and osteoporosis risk should be considered when using a gonadotropin-releasing hormone (GnRH) antagonist. This systematic review aims to evaluate the effects of daily relugolix intake in monotherapy and combination therapy on BMD, ensuring safe long-term management. Methods: A systematic literature review was conducted following PRISMA 2020 guidelines. Searches were performed in PubMed, Medline, and the Cochrane Library. Relevant clinical guidelines from international societies were also reviewed. Studies assessing the impact of relugolix on BMD were selected, and data on treatment efficacy, adverse effects, and bone health outcomes were synthesized. Results: Relugolix monotherapy has been associated with significant BMD loss due to its potent estrogen-suppressing effect. To mitigate this, combination therapy with estradiol and norethisterone acetate has been developed. Although initial monotherapy before transitioning to combination therapy results in transient BMD reduction, clinical trials have demonstrated that relugolix combination therapy maintains BMD over two years while effectively reducing endometriosis- and UF-related symptoms. Conclusions: Relugolix combination therapy is an effective and well-tolerated treatment for UFs and endometriosis, minimizing the risk of hypoestrogenism-related bone loss while maintaining clinical benefits. Although monotherapy may lead to transient BMD reduction, combination therapy appears to stabilize bone health. Full article

Membrane technology is primarily used for the separation and purification of biotechnological products, which contain proteins and enzymes. Membrane fouling during crossflow filtration remains a significant challenge. This study aims to initially validate crossflow filtration models, particularly related to pore-blocking mechanisms, through a comparative analysis with dead-end filtration models. One crossflow microfiltration (MF) and six consecutive ultrafiltration (UF) stages were implemented to concentrate laccase extracts from Pleurotus ostreatus 202 fungi. The complete pore-blocking mechanism significantly impacts the MF, UF 1000, UF 100 and UF 10 stages, with the highest related filtration constant (Kb_F) estimated at 12.60 × 10⁻⁴ (m⁻¹). Although the intermediate pore-blocking mechanism appears across all filtration stages, UF 100 is the most affected, with an associated filtration constant (Ki_F) of 16.70 (m⁻¹). This trend is supported by the highest purification factor (6.95) and the presence of 65, 62 and 56 kDa laccases in the retentate. Standard pore blocking occurs at the end of filtration, only in the MF and UF 1000 stages, with filtration constants (Ks_F) of 29.83 (s^−0.5m^−0.5) and 31.17 (s^−0.5m^−0.5), respectively. The absence of cake formation and the volume of permeate recovered indicate that neither membrane was exposed to exhaustive fouling that could not be reversed by backwashing. Full article

Uterine leiomyoma (uterine fibroids, UF) are benign myometrium tumors that affect up to 70% of the female population and may lead to severe clinical symptoms. Despite the high prevalence, pathogenesis of UF is not understood and involves cytokines, steroid hormones, and growth factors. Additionally, an increased deposition and remodelling of the extracellular matrix is characteristic for UF. Vitamin D seems to play a new role in UF. Interestingly, hypovitaminosis D correlates with a higher prevalence of myomas and the severity of the myomas. Administration of vitamin D in women with insufficiency (serum level <30 ng/mL) restored the vitamin D status and reduced the mild symptoms of myomas. In addition, inflammatory processes may play a role. In the past years, it has become clear that cessation of inflammation is an active process driven by a class of lipid mediator molecules called specialized pro-resolving mediators (SPM). Inadequate resolution of inflammation is related to several chronic inflammatory diseases and several studies have proven the crucial role of SPMs in improving these diseases. In this review, we will give an overview on processes involved in UF growth and will give an overview on the modern view regarding the concept of inflammation and the role of SPMs in resolution of inflammation, especially in chronic inflammatory diseases. Full article

This study investigates the spatio-temporal dynamics of Climate Potential Productivity (CPP) in Central Africa during 1901–2019 using the Thornthwaite Memorial model coupled with Mann–Kendall tests based on high spatial and temporal resolution data. The results demonstrate the climate–vegetation interactions under global warming: (1) Central Africa exhibited a statistically significant warming trend (r² = 0.33, p < 0.01) coupled with non-significant rainfall reduction, suggesting an emerging warm–dry climate regime that parallels meteorological trends observed in North Africa. (2) Central Africa exhibited an overall increasing trend in CPP, with temporal fluctuations closely aligned with precipitation variability. Specifically, the CPP in Central Africa has undergone three distinct phases: an increasing phase (1901–1960), a decreasing phase (1960–1980), and a slow recovery phase (1980–2019). The multiple intersection points between the UF and UB curves indicate that Central Africa’s CPP has been significantly affected by climate change under global warming. (3) The correlation of CPP–Temperature was mainly positive, mainly distributed in the Lower Guinea Plateau and the northern part of the Congo Basin (r² = 0.26, p < 0.1). The relationship of CPP–Precipitation showed predominantly a very strong positive correlation (r² = 0.91, p < 0.01). Full article

Recent advances in deep learning have significantly advanced micro-expression recognition, yet most existing methods process the entire facial region holistically, struggling to capture subtle variations in facial action units, which limits recognition performance. To address this challenge, we propose the Optical Flow Magnification and Cosine Similarity Feature Fusion Network (MCNet). MCNet introduces a multi-facial action optical flow estimation module that integrates global motion-amplified optical flow with localized optical flow from the eye and mouth–nose regions, enabling precise capture of facial expression nuances. Additionally, an enhanced MobileNetV3-based feature extraction module, incorporating Kolmogorov–Arnold networks and convolutional attention mechanisms, effectively captures both global and local features from optical flow images. A novel multi-channel feature fusion module leverages cosine similarity between Query and Key token sequences to optimize feature integration. Extensive evaluations on four public datasets—CASME II, SAMM, SMIC-HS, and MMEW—demonstrate MCNet’s superior performance, achieving state-of-the-art results with 92.88% UF1 and 86.30% UAR on the composite dataset, surpassing the best prior method by 1.77% in UF1 and 6.0% in UAR. Full article

In this study we searched for correlations between polymorphic variants that determine sex hormone-binding globulin concentration (SHBG_con) and uterine fibroids (UFs). The work was performed on a sample of 1542 women (569 with UFs and 973 without UFs [control]), from whom we obtained experimental data on the distribution of nine single-nucleotide polymorphisms (SNPs) affecting the SHBG_con (data confirmed in genome-wide association studies [GWASs]). When searching for associations with UFs, both the independent effects of SNPs and the effects of their SNP–SNP interactions (SNP-SNP_ints) were taken into account during the “deep study” of the functionality of seven important UF loci and 115 strongly linked [r² ≥ 0.80] variants (an in silico methodology was used). As the results show, two SHBG_con-related SNPs correlated with UF risk: rs3779195 [T/A] BAIAP2L1 (OR_AA = 0.38; 95%CI_AA = 0.20–0.91; p_perm(AA) = 0.023) and rs440837 [A/G] ZBTB10 (OR_GG = 1.93; 95%CI_GG = 1.17–3.14; p_perm(GG) = 0.010). At the same time, seven SHBG_con-related SNPs interacting with each other (four models of such SNP-SNP_ints [p_perm ≤ 0.01)] were found to influence UF risk. These SHBG_con-related SNPs, determining susceptibility to UF, showed strong functional relevance and were involved in pathways of gene transcription regulation, interactions with hormone ligand-binding receptors, the content control of SHBG, testosterone, liver enzymes, lipids, etc. This study’s results demonstrate the effect of significant SHBG_con-related genetic determinants of UF risk. Full article

As sensitive parts of the water treatment process, reverse osmosis (RO) membranes are the most important for desalination and wastewater treatment. But the performance of RO membranes deteriorates over time due to fouling, necessitating frequent replacements. One of the environmental challenges is the disposal of End-of-Life (EoL) RO membranes, which are made of non-biodegradable polymers. The reuse of EoL membranes as a sustainable approach for waste saving and resource efficiency has recently attracted considerable attention. The present work provides a comprehensive overview of the strategies for reusing EoL RO membranes as sustainable alternatives to conventional disposal methods. Furthermore, the fundamental principles of RO technology, the primary types and impacts of membrane fouling, and advanced cleaning and regeneration techniques are discussed. The conversion of EoL membranes into nanofiltration (NF), ultrafiltration (UF), and forward osmosis (FO) membranes is also covered in this review, as well as their uses in brackish water desalination, dye/salt separation, groundwater treatment, and household wastewater reuse. Environmental and economic benefits, as well as technical, social, and regulatory challenges, are also discussed. Finally, the review highlights innovative approaches and future directions for incorporating EoL membrane reuse into circular economy models, outlining its potential to improve sustainability and reduce operational costs in water treatment systems. Full article

Sugar production generates wastewater rich in dissolved solids and organic matter, and improper disposal poses severe environmental risks, exacerbates water scarcity, and creates regulatory challenges. Conventional treatment methods, such as evaporation and chemical precipitation, are energy-intensive and often ineffective at removing fine particulates and dissolved impurities. This study evaluates membrane-based separation as a sustainable alternative for water reclamation and sugar recovery from sugar industry effluents, focusing on replacing evaporation with membrane processes, ensuring high permeate quality, and mitigating membrane fouling. Cross-flow filtration experiments were conducted on a lab-scale membrane system at 70 °C to suppress microbial growth, comparing direct reverse osmosis (RO) of the raw effluent to an integrated ultrafiltration (UF)–RO process. Direct RO resulted in rapid membrane fouling. A tight UF (5 kDa) pre-treatment before RO significantly mitigated fouling and improved performance, enabling 28% water recovery and 79% sugar recovery, maintaining permeate conductivity below 0.5 mS/cm, sustaining stable flux, and reducing membrane blocking. Additionally, the UF and RO membranes were tested via SEM, EDS, and FTIR to elucidate the fouling mechanisms. Full article

In this work, we present the fabrication of low-cost, stable nanocellulose colloidal suspensions with an average particle size of approximately 160 nm, produced via a straightforward, solvent-free ultrasonication process that eliminates the need for corrosive chemicals or energy-intensive mechanical treatments. The resulting nanocellulose suspensions were utilized as reinforcing additives in urea-formaldehyde (UF) resins, which were subsequently applied in the production of particle boards. This approach addresses the increasing EU regulatory constraints regarding low formaldehyde-to-urea (F/U) molar ratios and the broader need for biobased, eco-friendly alternatives in the wood adhesive industry. Mechanical testing of the nanocellulose reinforced boards revealed notable improvements in the internal bond strength and modulus of rupture, along with a significant decrease in formaldehyde release compared to boards produced with conventional UF resins. These findings highlight the potential of ultrasonication-derived nanocellulose as an environmentally friendly, cost-effective additive to enhance the mechanical performance and reduce the environmental impact of UF-based wood composites. Full article

In this study, camel milk (CM) and Gir cow milk (GCM) were fermented through cofermentation via yeast–lactic cultures, i.e., Lacticaseibacillus rhamnosus (M9, MTCC 25516) and Saccharomyces cerevisiae (WBS2A, MG101828), and their antioxidant and antidiabetic effectiveness were studied. To optimize the growth conditions, the level of proteolysis was evaluated by exploring various inoculation levels (1.5, 2.0 and 2.5%) as well as incubation durations (0, 12, 24, 36 and 48 h). Peptides were extracted and purified through 2D gel electrophoresis as well as SDS–PAGE. Water-soluble extracts (WSEs) of ultrafiltered (UF) peptide fractions were evaluated via reversed-phase high-performance liquid chromatography (RP-HPLC) to identify the peptide segments. By applying the Peakview tool, peptide sequences obtained from liquid chromatography–mass spectrometry (LC/MS) were reviewed by comparison with those in the BIOPEP database. Furthermore, the elevated levels of TNF-α, IL-6, IL-1β and nitric oxide (NO) in RAW 267.4 cells treated with lipopolysaccharide (LPS) are considerably lower than those in cultured CM and GCM. Protein macromolecules in CMs and GCMs have been captured via confocal laser scanning microscopy (CLSM) and Fourier transform infrared (FTIR) spectroscopy both before and after fermentation. Full article

Acid hydrolysis can be more efficient than water hydrolysis, particularly in breaking down cured adhesives found in waste panels within a shorter reaction time, which could benefit large-scale industrial processes. This study evaluates the effects of various acid hydrolysis conditions on the thermal, physical, and chemical properties of recycled particles intended for particleboard production. Particleboards were recycled using oxalic acid and ammonium chloride at different concentrations and reaction times at 122 °C. The thermal stability of the particles was determined by thermogravimetric analysis. Particle size distribution, particle morphology, nitrogen content, pH and acid/base buffer capacity were analyzed. The effect of the recycled particles on the urea-formaldehyde (UF) curing was assessed using differential scanning calorimetry and the gel time method. The recycled particles exhibited a higher thermal degradation beyond 200 °C, indicating their thermal stability for manufacturing new panels. The acid treatments did not damage the anatomical structure of the particles, preserving the prosenchymatous elements. The nitrogen content of recycled particles decreased by up to 90% when oxalic acid was used, compared to raw board particles. Recycled particles exhibited a lower pH, with a maximum reduction of 44%. They also showed a decreased acid buffer capacity and an increased base buffer capacity compared to raw board particles. This effect was particularly pronounced in treatments that included ammonium chloride. The recycled particles did not significantly affect the peak polymerization temperature of the UF adhesive. However, some treatments affected the gel time of the adhesive, particularly those using 30% ammonium chloride. The results indicate that particleboards can be effectively recycled through acid hydrolysis, mainly with oxalic acid, which provides better results than hydrolysis using water alone. Oxalic acid showed increased selectivity in eliminating the cured UF adhesive, resulting in recycled particles suitable for manufacturing new panels. Full article

This study assessed the effect of ultrafiltration (UF) on the quality of soft white cheese made from goat skim milk (GSM) and aimed to identify the optimal UF parameters for protein concentration while minimizing energy consumption. UF was applied to pasteurized GSM by altering transmembrane pressure (TMP) and permeate flux density (J) while monitoring the volume reduction factor (VRF). The acidity, viscosity, dry extract, proteins and Ca, Na, K, Mg and Fe contents increased significantly during concentration. Post-ultrafiltration, both UF and non-UF GSMs were coagulated using modified rennet doses (150, 200 and 300 µL/L). The resulting cheeses underwent chemical analysis, yield calculation and textural property assessment. The findings highlighted that milk protein concentration was the primary limiting factor for coagulation, with rennet dose having a lesser impact. The UF-GSM produced the best results, yielding approximately 30% cheese with a soft texture and greater nutritional value (proteins, Ca, Mg and Fe). Full article

This study investigates the potential for sustainable concrete production using industrial by-products: used foundry sand (UFS) and coal bottom ash (CBA). These materials were partially substituted for natural aggregates to reduce environmental impact and promote circular economy practices. UFS was used as a replacement for fine aggregate, while both fine and coarse CBA were tested as substitutes for sand and gravel, respectively. The materials were characterized using X-ray diffraction (XRD), scanning electron microscopy (SEM), and energy-dispersive X-ray spectroscopy (EDS) to evaluate their mineralogical and microstructural properties. Six concrete mixtures were prepared with varying replacement levels (up to 70% total aggregate substitution) at a constant water-to-cement ratio of 0.50. Compressive strength tests were conducted at 28 days, supported by microstructural observations. Results showed that high levels of UFS and CBA led to reduced strength, mainly due to weak interfacial bonding and porous ash particles. However, moderate replacement levels (e.g., 20% fine CBA) maintained high strength with good structural integrity. The study concludes that both UFS and CBA can be used effectively in concrete when carefully dosed. The findings support the use of industrial waste in construction, provided that material properties are well understood and replacement levels are optimized. Full article

The application of an ultrafiltration (UF) process with periodic membrane cleaning with the use of alkaline detergent solutions was proposed for the recovery of wash water from car wash effluent. In order to test the resistance of the membranes to the degradation caused by the cleaning solutions, a pilot plant study was carried out for almost two years. The installation included an industrial module with FP100 tubular membranes made of polyvinylidene fluoride (PVDF). The module was fed with synthetic effluent obtained by mixing foaming agents and hydrowax. To limit the fouling phenomenon, the membranes were cleaned cyclically with P3 Ultrasil 11 solution (pH = 11.7) or Insect solution (pH = 11.5). During plant shutdowns, the membrane module was maintained with a sodium metabisulphite solution. Changes in the permeate flux, turbidity, COD, and surfactant rejection were analysed during the study. Scanning electron microscopy (SEM), atomic force microscopy (AFM), differential scanning calorimetry (DSC), and Fourier-transform infrared spectroscopy (FTIR) analysis were used to determine the changes in the membrane structure. As a result of the repeated chemical cleaning, the pore size increased, resulting in a more than 50% increase in permeate flux. However, the quality of the recovered wash water did not deteriorate, as an additional separation layer was formed on the membrane surface due to the fouling phenomenon. Full article