Next Article in Journal
Gut–Brain Axis in Mood Disorders: A Narrative Review of Neurobiological Insights and Probiotic Interventions
Previous Article in Journal
Natural Metabolites as Modulators of Sensing and Signaling Mechanisms: Unlocking Anti-Ovarian Cancer Potential
 
 
Search for Articles:
Title / Keyword
Author / Affiliation / Email
Journal
Article Type
 
 
Advanced Search
 
Section
Special Issue
Volume
Issue
Number
Page
 
Journals
Biomedicines
Volume 13
Issue 8
10.3390/biomedicines13081832
biomedicines-logo
Submit to this Journal Review for this Journal Propose a Special Issue
► Article Menu

Article Menu

share Share announcement Help format_quote Cite
first_page
settings
Order Article Reprints
Font Type:
Arial Georgia Verdana
Font Size:
Aa Aa Aa
Line Spacing:
Column Width:
Background:
This is an early access version, the complete PDF, HTML, and XML versions will be available soon.
Review

Narrative Review of Chronic Inflammation in Uterine Myoma: Lack of Specialized Pro-Resolving Lipid Mediators (SPMs) and Vitamin D as a Potential Reason for the Development of Uterine Fibroids

by
Pedro-Antonio Regidor
1,*,
Manuela Mayr
2,
Fernando Gonzalez Santos
3,
Beatriz Lazcoz Calvo
4,
Rocio Gutierrez
5 and
Jose Miguel Rizo
5
1
Exeltis Pharmaceuticals Holding S.L., Adalperostr. 84, 85737 Ismaning, Germany
2
Exeltis Germany, Adalperostr. 84, 85737 Ismaning, Germany
3
Independent Researcher, Concepcion Arenal n2, 13600 Alcázar de San Juán, Spain
4
Exeltis Pharmaceuticals Holding S.L., Manuel Pombo Angulo 28, 28050 Madrid, Spain
5
OTC Chemo, Manuel Pombo Angulo 28, 28050 Madrid, Spain
*
Author to whom correspondence should be addressed.
Biomedicines 2025, 13(8), 1832; https://doi.org/10.3390/biomedicines13081832 (registering DOI)
Submission received: 7 May 2025 / Revised: 20 July 2025 / Accepted: 21 July 2025 / Published: 26 July 2025
(This article belongs to the Special Issue Biological Role of Oxidative Stress in Inflammatory Processes)
Review Reports Versions Notes

Abstract

Uterine leiomyoma (uterine fibroids, UF) are benign myometrium tumors that affect up to 70% of the female population and may lead to severe clinical symptoms. Despite the high prevalence, pathogenesis of UF is not understood and involves cytokines, steroid hormones, and growth factors. Additionally, an increased deposition and remodelling of the extracellular matrix is characteristic for UF. Vitamin D seems to play a new role in UF. Interestingly, hypovitaminosis D correlates with a higher prevalence of myomas and the severity of the myomas. Administration of vitamin D in women with insufficiency (serum level <30 ng/mL) restored the vitamin D status and reduced the mild symptoms of myomas. In addition, inflammatory processes may play a role. In the past years, it has become clear that cessation of inflammation is an active process driven by a class of lipid mediator molecules called specialized pro-resolving mediators (SPM). Inadequate resolution of inflammation is related to several chronic inflammatory diseases and several studies have proven the crucial role of SPMs in improving these diseases. In this review, we will give an overview on processes involved in UF growth and will give an overview on the modern view regarding the concept of inflammation and the role of SPMs in resolution of inflammation, especially in chronic inflammatory diseases.
Keywords: uterine myoma; inflammation; vitamin D; specialized pro-resolving mediators (SPMs) uterine myoma; inflammation; vitamin D; specialized pro-resolving mediators (SPMs)

Share and Cite

MDPI and ACS Style

Regidor, P.-A.; Mayr, M.; Santos, F.G.; Calvo, B.L.; Gutierrez, R.; Rizo, J.M. Narrative Review of Chronic Inflammation in Uterine Myoma: Lack of Specialized Pro-Resolving Lipid Mediators (SPMs) and Vitamin D as a Potential Reason for the Development of Uterine Fibroids. Biomedicines 2025, 13, 1832. https://doi.org/10.3390/biomedicines13081832

AMA Style

Regidor P-A, Mayr M, Santos FG, Calvo BL, Gutierrez R, Rizo JM. Narrative Review of Chronic Inflammation in Uterine Myoma: Lack of Specialized Pro-Resolving Lipid Mediators (SPMs) and Vitamin D as a Potential Reason for the Development of Uterine Fibroids. Biomedicines. 2025; 13(8):1832. https://doi.org/10.3390/biomedicines13081832

Chicago/Turabian Style

Regidor, Pedro-Antonio, Manuela Mayr, Fernando Gonzalez Santos, Beatriz Lazcoz Calvo, Rocio Gutierrez, and Jose Miguel Rizo. 2025. "Narrative Review of Chronic Inflammation in Uterine Myoma: Lack of Specialized Pro-Resolving Lipid Mediators (SPMs) and Vitamin D as a Potential Reason for the Development of Uterine Fibroids" Biomedicines 13, no. 8: 1832. https://doi.org/10.3390/biomedicines13081832

APA Style

Regidor, P.-A., Mayr, M., Santos, F. G., Calvo, B. L., Gutierrez, R., & Rizo, J. M. (2025). Narrative Review of Chronic Inflammation in Uterine Myoma: Lack of Specialized Pro-Resolving Lipid Mediators (SPMs) and Vitamin D as a Potential Reason for the Development of Uterine Fibroids. Biomedicines, 13(8), 1832. https://doi.org/10.3390/biomedicines13081832

Note that from the first issue of 2016, this journal uses article numbers instead of page numbers. See further details here.

Article Metrics

Back to TopTop